\u3053\u306e\u7814\u7a76\u306b\u3088\u308b\u3068\u3001\u3046\u3064\u72b6\u614b\u306f\u60a3\u8005\u306e\u5bff\u547d\u306b\u5f71\u97ff\u3059\u308b\u3002\u9006\u306b\u8a00\u3046\u3068\u3001\u3046\u3064\u72b6\u614b\u306b\u306a\u3089\u306a\u3051\u308c\u3070\u7d50\u679c\u306f\u9055\u3063\u3066\u304f\u308b\u3002\u305d\u308c\u306f\u6b7b\u3092\u3069\u3046\u6349\u3048\u308b\u304b\u3060\u308d\u3046\u3002\u5b97\u6559\u7684\u5fc3\u7406\u306e\u8a71\u3060\u308d\u3046\u304c\u3001\u6b7b\u751f\u89b3\u304c\u975e\u5e38\u306b\u91cd\u8981\u3060\u3002\u79c1\u306e\u60a3\u8005\u3067\u3082\u6b7b\u3092\u6050\u308c\u3066\u3044\u306a\u3044\u30ad\u30ea\u30b9\u30c8\u6559\u306e\u4fe1\u8005\u304c\u3044\u305f\u3002\u6700\u5f8c\u307e\u3067\u5468\u308a\u306b\u611f\u8b1d\u3057\u3066\u4ea1\u304f\u306a\u3063\u305f\u304c\u3001\u901a\u5e38\u306e\u751f\u5b58\u671f\u9593\u3088\u308a\u306f\u306f\u308b\u304b\u306b\u9577\u304b\u3063\u305f\u3002<\/p>\n
\u3057\u304b\u3057\u3001\u533b\u5e2b\u3068\u3057\u3066\u306f\u3082\u3063\u3068\u9577\u751f\u304d\u304c\u53ef\u80fd\u306a\u65b9\u6cd5\u3092\u6a21\u7d22\u3057\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3002
\n\u305d\u308c\u306f\u307e\u3055\u3057\u304f\u3001\u7cbe\u795e\u795e\u7d4c\u514d\u75ab\u5b66\u3060\u308d\u3046\u3068\u78ba\u4fe1\u3057\u3066\u3044\u308b\u3002
\n*********************************************************<\/p>\n
\u3046\u3064\u75c7\u72b6\u3068\u764c\u751f\u5b58\u306e\u95a2\u9023\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f
\n MD\u30a2\u30f3\u30c0\u30fc\u30bd\u30f3\u304c\u3093\u30bb\u30f3\u30bf\u30fc
\n 2012\u5e748\u67082\u65e5<\/p>\n
\u30c6\u30ad\u30b5\u30b9\u5927\u5b66MD\u30a2\u30f3\u30c0\u30fc\u30bd\u30f3\u304c\u3093\u30bb\u30f3\u30bf\u30fc\u306e\u7814\u7a76\u306b\u3088\u3063\u3066\u3001\u65b0\u305f\u306b\u8a3a\u65ad\u3055\u308c\u305f\u8ee2\u79fb\u6027\u814e\u81d3\u764c\u60a3\u8005\u306b\u304a\u3051\u308b\u3046\u3064\u75c7\u72b6\u304c\u751f\u5b58\u306b\u95a2\u9023\u3057\u3066\u304a\u308a\u3001\u708e\u75c7\u6027\u907a\u4f1d\u5b50\u8abf\u7bc0\u306b\u3088\u3063\u3066\u3001\u3053\u306e\u95a2\u9023\u3092\u8aac\u660e\u3057\u5f97\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u305f\u3002<\/p>\n
PLoS ONE\u8a8c\u306b\u767a\u8868\u3055\u308c\u305f\u7814\u7a76\u306f\u3001\u60a3\u8005\u306e\u5fc3\u7406\u72b6\u614b\u3001\u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3\u306e\u8abf\u7bc0\u3084\u708e\u75c7\u6027\u907a\u4f1d\u5b50\u767a\u73fe\u306e\u5f79\u5272\u306e\u9593\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u3055\u3089\u306b\u63a2\u3063\u3066\u3044\u308b\u3002\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u306f\u3001\u3046\u3064\u75c5\u306b\u3088\u3063\u3066\u3055\u3089\u306b\u4e0d\u826f\u306a\u8ee2\u5e30\u3068\u306a\u308b\u3053\u3068\u3092\u793a\u5506\u3057\u3066\u3044\u308b\u304c\u3001\u95a2\u4e0e\u3057\u3066\u3044\u308b\u7279\u5b9a\u306e\u8981\u56e0\u306b\u3064\u3044\u3066\u306e\u7591\u554f\u306f\u6b8b\u308b\u3002<\/p>\n
\u300c\u79c1\u305f\u3061\u306e\u8abf\u67fb\u7d50\u679c\u3001\u307e\u305f\u4ed6\u306e\u3082\u306e\u3082\u3001\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9\u3084\u793e\u4f1a\u798f\u7949\u306f\u751f\u7269\u5b66\u7684\u30d7\u30ed\u30bb\u30b9\u306b\u4f5c\u7528\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u764c\u95a2\u9023\u306e\u8ee2\u5e30\u306b\u5f71\u97ff\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\u300d\u3068\u3001MD\u30a2\u30f3\u30c0\u30fc\u30bd\u30f3\u306e\u4e00\u822c\u816b\u760d\u3068\u884c\u52d5\u79d1\u5b66\u79d1\u306e\u6559\u6388\u3067\u3042\u308a\u3001\u7d71\u5408\u533b\u7642\u30d7\u30ed\u30b0\u30e9\u30e0\u306e\u8cac\u4efb\u8005\u3067\u3082\u3042\u308bLarenzo Cohen\u535a\u58eb\u306f\u8ff0\u3079\u305f\u3002 \u8abf\u67fb\u7d50\u679c\u306f\u3001\u751f\u547d\u3092\u8105\u304b\u3059\u75c5\u6c17\u306b\u76f4\u9762\u3057\u3066\u3044\u3066\u3082\u3001\u4eba\u3005\u304c\u82e6\u75db\u306b\u3046\u307e\u304f\u5411\u304d\u5408\u3046\u624b\u52a9\u3051\u3092\u3059\u308b\u4e00\u822c\u306b\u8a8d\u3081\u3089\u308c\u305f\u6cbb\u7642\u6cd5\u304c\u3042\u308b\u305f\u3081\u3001\u30e1\u30f3\u30bf\u30eb\u30d8\u30eb\u30b9\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u304c\u6a19\u6e96\u7684\u306a\u30b1\u30a2\u306e\u4e00\u90e8\u3067\u3042\u308b\u3079\u304d\u3053\u3068\u3082\u793a\u5506\u3057\u3066\u3044\u308b\u3002<\/p>\n
\u300c\u79c1\u305f\u3061\u306f\u3001\u7279\u306b\u751f\u5b58\u306e\u4e88\u6e2c\u56e0\u5b50\u3068\u3057\u3066\u5fc3\u7406\u793e\u4f1a\u7684\u8981\u56e0\u3092\u8abf\u3079\u308b\u3053\u3068\u306b\u8208\u5473\u3092\u6301\u3063\u3066\u3044\u305f\u300d\u3068Cohen\u535a\u58eb\u306f\u7d9a\u3051\u305f\u3002 \u300c\u8abf\u67fb\u7d50\u679c\u306b\u3088\u3063\u3066\u3001\u79c1\u305f\u3061\u304c\u4eca\u3084\u3046\u3064\u3068\u751f\u5b58\u306e\u95a2\u9023\u3092\u8aac\u660e\u3059\u308b\u6709\u671b\u306a\u751f\u7269\u5b66\u7684\u7d4c\u8def\u306e\u4e00\u90e8\u3092\u7406\u89e3\u3057\u5f97\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002\u300d<\/p>\n
\u4e3b\u7b46\u8005\u3067\u3042\u308bCohen\u535a\u58eb\u3068\u5f7c\u306e\u540c\u50da\u3089\u306f\u30012000\u5e744\u6708\u304b\u30892005\u5e7411\u6708\u306bMD\u30a2\u30f3\u30c0\u30fc\u30bd\u30f3\u306e\u65b0\u305f\u306b\u8a3a\u65ad\u3055\u308c\u305f\u8ee2\u79fb\u6027\u814e\u7d30\u80de\u764c\u60a3\u8005217\u4eba\u3092\u8abf\u3079\u305f\u3002\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u3001\u60a3\u8005\u3089\u306f\u5927\u91cf\u306e\u8cea\u554f\u7d19\u306b\u8a18\u5165\u3092\u884c\u3044\u3001\u8840\u6db2\u30b5\u30f3\u30d7\u30eb\u3092\u63d0\u4f9b\u3057\u305f\u3002<\/p>\n
\u8abf\u67fb\u3067\u306f\u3001\u3046\u3064\u75c7\u72b6\u3001\u751f\u6d3b\u306eQOL\u3001\u793e\u4f1a\u7684\u652f\u63f4\u3001\u5bfe\u51e6\u65b9\u6cd5\u3001\u5b97\u6559\u3068\u7cbe\u795e\u6027\u3092\u6e2c\u5b9a\u3057\u305f\u3002\u53c2\u52a0\u8005\u306f\u307e\u305f\u3001\u671d\u9ad8\u304f\u306a\u308a\u65e5\u4e2d\u3092\u901a\u3057\u3066\u4e0b\u304c\u3063\u3066\u3044\u304f\u30b9\u30c8\u30ec\u30b9\u30db\u30eb\u30e2\u30f3\u3067\u3042\u308b\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u306e\u5909\u52d5\u3092\u6e2c\u308b\u305f\u3081\u306b\u30013\u65e5\u95931\u65e5\u3042\u305f\u308a5\u56de\u553e\u6db2\u306e\u30b5\u30f3\u30d7\u30eb\u3092\u63d0\u4f9b\u3057\u305f\u3002\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u91cf\u306e\u5897\u52a0\u304c\u3046\u3064\u75c7\u72b6\u306e\u60a3\u8005\u3067\u898b\u3089\u308c\u3001\u7d30\u80de\u306e\u5909\u5316\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3068Cohen\u535a\u58eb\u306f\u8ff0\u3079\u305f\u3002<\/p>\n
\u89e3\u6790\u6642\u306b\u3001\u60a3\u8005\u306e64\uff05\u304c\u6b7b\u4ea1\u306e\u305f\u3081\u306b\u6e1b\u5c11\u3057\u3066\u304a\u308a\u3001\u8a3a\u65ad\u304b\u3089\u6b7b\u4ea1\u307e\u3067\u306e\u5e73\u5747\u671f\u9593\u306f1.8\u5e74\u3067\u3042\u3063\u305f\u3002\u5168\u4f53\u3068\u3057\u3066\u3001\u60a3\u8005\u306e23\uff05\u304c\u3001\u81e8\u5e8a\u7684\u306b\u3046\u3064\u75c7\u72b6\u3092\u5448\u3057\uff0816\u4ee5\u4e0a\u306e\u30b9\u30b3\u30a2\uff09\u3001\u75be\u60a3\u95a2\u9023\u5371\u967a\u56e0\u5b50\u3092\u5236\u5fa1\u3057\u305f\u5f8c\u3067\u3055\u3048\u3001\u751f\u5b58\u671f\u9593\u306e\u77ed\u3055\u3068\u95a2\u9023\u3057\u3066\u3044\u305f\u3002\u540c\u69d8\u306b\u3001\u671d\u304b\u3089\u5915\u65b9\u307e\u3067\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u306e\u5897\u6e1b\u3092\u8868\u3059\u52fe\u914d\u304c\u5e73\u5766\u3067\u3042\u308b\u3053\u3068\u304c\u751f\u5b58\u671f\u9593\u306e\u77ed\u3055\u306b\u95a2\u9023\u3057\u3066\u3044\u305f\u3002<\/p>\n
\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306b\u3088\u3063\u3066\u7cf8\u53e3\u3092\u3064\u304b\u3080<\/p>\n
\u3046\u3064\u75c7\u72b6\u306b\u95a2\u9023\u3059\u308b\u6b7b\u4ea1\u7387\u306e\u5897\u52a0\u30ea\u30b9\u30af\u304c\u708e\u75c7\u8a98\u767a\u6027\u907a\u4f1d\u5b50\u767a\u73fe\u306b\u7531\u6765\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u304b\u3069\u3046\u304b\u3092\u5224\u65ad\u3059\u308b\u305f\u3081\u306b\u3001\u5168\u30b2\u30ce\u30e0\u30d7\u30ed\u30d5\u30a1\u30a4\u30ea\u30f3\u30b0(whole-genome profiling)\u306f\u6700\u3082\u9ad8\u3044\u3046\u3064\u75c7\u72b6\u30b9\u30b3\u30a2\u306e\u60a3\u800515\u4eba\u3068\u3001\u30ea\u30b9\u30af\u304c\u9069\u5408\u3057\u305f\u6700\u3082\u4f4e\u3044\u3046\u3064\u75c7\u72b6\u306e\u30b9\u30b3\u30a2\u3092\u6301\u306415\u4eba\u306e\u60a3\u8005\u304b\u3089\u7d44\u7e54\u30b5\u30f3\u30d7\u30eb\u3092\u884c\u3063\u305f\u3002<\/p>\n
\u300c\u79c1\u305f\u3061\u306f\u3001NF-\u0138B\u306e\u3088\u3046\u306a\u7279\u5b9a\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u304c\u3001\u7d30\u80de\u5185\u306e\u708e\u75c7\u306e\u8abf\u7bc0\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u77e5\u3063\u3066\u3044\u308b\u300d\u3068MD\u30a2\u30f3\u30c0\u30fc\u30bd\u30f3\u306e\u5a66\u4eba\u816b\u760d\u79d1\u306e\u6559\u6388\u3067\u3001\u3053\u306e\u7814\u7a76\u306e\u5171\u8457\u8005\u3067\u3042\u308bAnil Sood\u533b\u5e2b\u306f\u8ff0\u3079\u305f\u3002 \u300c\u79c1\u305f\u3061\u306e\u76ee\u6a19\u306f\u3001\u3053\u308c\u3089\u306e\u7d4c\u8def\u304c\u3046\u3064\u75c7\u72b6\u306e\u60a3\u8005\u306b\u304a\u3044\u3066\u3088\u308a\u9ad8\u3044\u30ec\u30d9\u30eb\u3067\u767a\u73fe\u3057\u305f\u304b\u3069\u3046\u304b\u3092\u5224\u65ad\u3059\u308b\u3053\u3068\u3067\u3042\u308a\u3001\u79c1\u305f\u3061\u306f\u5b9f\u969b\u306b\u305d\u3046\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3059\u30c7\u30fc\u30bf\u3092\u898b\u51fa\u3057\u305f\u3002\u300d<\/p>\n
\u8abf\u67fb\u306b\u3088\u308b\u3068\u3001\u5408\u8a08\u3067116\u306e\u907a\u4f1d\u5b50\u8ee2\u5199\u304c\u3001\u9ad8\u3044\u3046\u3064\u75c7\u72b6\u30b9\u30b3\u30a2\u306e\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u5e73\u574750\uff05\u4ee5\u4e0a\u3001\u4e0a\u6607\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u898b\u51fa\u3055\u308c\u305f\u3002\u305d\u306e\u30c7\u30fc\u30bf\u306b\u3088\u3063\u3066\u3001\u60a3\u8005\u306e\u5fc3\u7406\u72b6\u614b\u3068\u751f\u5b58\u671f\u9593\u306e\u95a2\u9023\u304c\u708e\u75c7\u751f\u7269\u5b66\u3068\u30b3\u30eb\u30c1\u30be\u30fc\u30eb\u306e\u52fe\u914d\u306e\u8abf\u7bc0\u4e0d\u5168\u306b\u7531\u6765\u3059\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u305f\u3002<\/p>\n
\u4eca\u5f8c\u5fc5\u8981\u3068\u3055\u308c\u308b\u7814\u7a76<\/p>\n
\u7b46\u8005\u3089\u306f\u3001\u30b9\u30c8\u30ec\u30b9\u304c\u502b\u7406\u7684\u3067\u306f\u306a\u3044\u3068\u3057\u306a\u304c\u3089\u4eba\u9593\u3092\u30e2\u30c7\u30eb\u3068\u3057\u3066\u5fc3\u7406\u7684\u30b9\u30c8\u30ec\u30b9\u3068\u764c\u751f\u5b58\u3068\u306e\u9593\u306e\u56e0\u679c\u95a2\u4fc2\u3092\u5224\u65ad\u3059\u308b\u96e3\u3057\u3055\u3092\u542b\u3081\u3066\u3001\u7814\u7a76\u306b\u591a\u304f\u306e\u5236\u9650\u304c\u3042\u308b\u3053\u3068\u3092\u6307\u6458\u3057\u3066\u3044\u308b\u3002\u3053\u306e\u7814\u7a76\u3067\u306f\u6271\u308f\u308c\u306a\u304b\u3063\u305f\u3046\u3064\u75c7\u72b6\u3068\u751f\u5b58\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u5f97\u308b\u4ed6\u306e\u8981\u56e0\u3082\u5b58\u5728\u3059\u308b\u3060\u308d\u3046\u3002\u307e\u305f\u3001\u60a3\u8005\u306e\u8a3a\u65ad\u524d\u306b\u9ad8\u30ec\u30d9\u30eb\u306e\u30b9\u30c8\u30ec\u30b9\u304c\u5b58\u5728\u3057\u305f\u304b\u3069\u3046\u304b\u306b\u3055\u3089\u306a\u308b\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3042\u308b\u3068Cohen\u535a\u58eb\u306f\u8ff0\u3079\u305f\u3002<\/p>\n
\u6b21\u6bb5\u968e\u3067\u306f\u3001\u884c\u52d5\u5206\u6790\u3084\u85ac\u7406\u5b66\u7684\u4ecb\u5165\u3092\u7528\u3044\u3066\u3046\u3064\u75c5\u3092\u7ba1\u7406\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u8efd\u5ea6\u3001\u4e2d\u7a0b\u5ea6\u307e\u305f\u306f\u91cd\u5ea6\u306e\u6c17\u5206\u969c\u5bb3\u60a3\u8005\u306e\u751f\u5b58\u3068\u764c\u306e\u8a3a\u65ad\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u5f97\u308b\u304b\u3069\u3046\u304b\u3092\u6e2c\u308b\u81e8\u5e8a\u8a66\u9a13\u3092\u5b9f\u65bd\u3059\u308b\u3064\u3082\u308a\u3060\u3068Cohen\u535a\u58eb\u306f\u8ff0\u3079\u305f\u3002<\/p>\n
\u3053\u306e\u7814\u7a76\u306f\u3001the Dana Foundation\u3001the Mary and David Wolff Family Foundation\u3001\u7c73\u56fd\u4fdd\u5065\u793e\u4f1a\u798f\u7949\u7701\u3001\u7c73\u56fd\u7acb\u885b\u751f\u7814\u7a76\u6240\u3001MD\u30a2\u30f3\u30c0\u30fc\u30bd\u30f3\u304c\u3093\u30bb\u30f3\u30bf\u30fcSupport Grand\u304b\u3089\u306e\u52a9\u6210\u91d1\u306b\u3088\u3063\u3066\u63f4\u52a9\u3055\u308c\u305f\u3002<\/p>\n
Cohen\u535a\u58eb\u3068Sood\u533b\u5e2b\u306b\u52a0\u3048\u3066\u3001\u3053\u306e\u7814\u7a76\u306b\u3064\u3044\u3066\u306eMD\u30a2\u30f3\u30c0\u30fc\u30bd\u30f3\u306e\u7b46\u8005\u306f\u4ee5\u4e0b\u3067\u3042\u308b\u3002Nicholas Jennings, Department of Gynecologic Oncology; Sarah Prinsloo, Ph.D. and Qi Wei, Department of General Oncology; Luis Vence, Ph.D., Laszlo Radvanyi, Ph.D., and Diane Kentor, Department of Melanoma Medical Oncology; Louis Pisters, M.D. and Shellie Scott, Department of Urology; Nizar Tannir, M.D. and Eric Jonasch, M.D., Department of Genitourinary Medical Oncology; and Pheroze Tamboli, M.D., Department of Pathology. Other authors include Steven Cole, Ph.D. and Jesusa Arevalo, UCLA David Geffen School of Medicine; and Clemens Kirschbaum, Ph.D, Technical University of Dresden Germany<\/p>\n","protected":false},"excerpt":{"rendered":"
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