\u5206\u5b50\u6a19\u7684\u85ac\u3067\u3042\u308b\u30bf\u30eb\u30bb\u30d0\u306f\u767a\u58f2\u5f53\u6642\u306f\u304c\u3093\u7d30\u80de\u306eEGFR\u306e\u30a8\u30eb\u30ed\u30c1\u30cb\u30d6\u3060\u3051\u3092\u963b\u5bb3\u3057\u3066\u526f\u4f5c\u7528\u3082\u8d77\u304d\u306a\u3044\u85ac\u3068\u3057\u3066\u5927\u304d\u306a\u671f\u5f85\u3068\u3082\u3063\u3066\u8fce\u3048\u3089\u308c\u305f\u3002\u3057\u304b\u3057\u3002\u5b9f\u969b\u526f\u4f5c\u7528\u306e\u554f\u984c\u306f\u5c3d\u304d\u308b\u3053\u3068\u304c\u306a\u3044\u3002
\n\u3069\u3053\u308d\u304b\u3001\u73fe\u5728\u3053\u308c\u3089\u306e\u5206\u5b50\u6a19\u7684\u85ac\u306e\u526f\u4f5c\u7528\u306b\u306f\u9593\u8cea\u6027\u80ba\u708e\u306a\u3069\u306e\u81f4\u547d\u7684\u306a\u3082\u306e\u304c\u591a\u304f\u8d77\u3053\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u3044\u308b\u3002
\n\u7d50\u5c40\u85ac\u3067\u526f\u4f5c\u7528\u3082\u306a\u304f\u3001\u304c\u3093\u6cbb\u7642\u3092\u884c\u3046\u3053\u3068\u306f\u307b\u307c\u4e0d\u53ef\u80fd\u3060\u308d\u3046\u3002
\n\u3084\u306f\u308a\u81ea\u7136\u7642\u6cd5\u3068\u7d44\u307f\u5408\u308f\u305b\u305f\u4e0a\u3067\u3001IPT\u306e\u3088\u3046\u306b\u5c11\u91cf\u3067\u6297\u304c\u3093\u5264\u3092\u4f7f\u3046\u65b9\u6cd5\u304c\u6700\u3082\u52b9\u7387\u7684\u3060\u308d\u3046\u3002
\n************************************************<\/p>\n
2012\/07\/01
\n \u5831\u9053\u4e8b\u52d9\u5c40\uff1a Jason Bardi (415) 502-6397<\/p>\n
\u80ba\u764c\u306e\u6cbb\u7642\u306b\u30bf\u30eb\u30bb\u30d0\u3092\u670d\u7528\u3057\u3066\u3044\u308b\u60a3\u8005\u306f\u3001\u3044\u3064\u751f\u3058\u308b\u304b\u308f\u304b\u3089\u306a\u3044\u8010\u6027\u306e\u554f\u984c\u306b\u3073\u304f\u3073\u304f\u3057\u3066\u3044\u308b\u3002\u3064\u307e\u308a\u3001\u30bf\u30eb\u30bb\u30d0\u3092\u670d\u7528\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u6700\u521d\u306f\u816b\u760d\u304c\u7e2e\u5c0f\u3057\u305f\u3068\u3057\u3066\u3082\u3001\u9593\u9055\u3044\u306a\u304f\u3044\u3064\u304b\u306f\u816b\u760d\u304c\u518d\u5897\u60aa\u3059\u308b\u65e5\u306f\u3084\u3063\u3066\u304f\u308b\u306e\u3067\u3042\u308b\u3002\u305d\u3057\u3066\u3001\u591a\u304f\u306e\u60a3\u8005\u306b\u3068\u3063\u3066\u3001\u305d\u306e\u65e5\u306f\u3042\u307e\u308a\u306b\u3082\u65e9\u304f\u3084\u3063\u3066\u304f\u308b\u306e\u3067\u3042\u308b\u3002<\/p>\n
\u73fe\u5728\u3001\u30ab\u30ea\u30d5\u30a9\u30eb\u30cb\u30a2\u5927\u5b66\u30b5\u30f3\u30d5\u30e9\u30f3\u30b7\u30b9\u30b3\u6821\uff08UCSF\uff09Helen Diller Family\u7dcf\u5408\u304c\u3093\u30bb\u30f3\u30bf\u30fc\u306e\u7814\u7a76\u30c1\u30fc\u30e0\u306f\u3001\u30d2\u30c8\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308bAXL\u306b\u3088\u308a\u30bf\u30eb\u30bb\u30d0\u306b\u5bfe\u3059\u308b\u8010\u6027\u7372\u5f97\u304c\u4fc3\u9032\u3055\u308c\u308b\u3001\u307e\u305f\u3001AXL\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u3067\u3001\u30bf\u30eb\u30bb\u30d0\u306b\u5bfe\u3059\u308b\u8010\u6027\u7372\u5f97\u304c\u9632\u6b62\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u305f\u3002<\/p>\n
\u3053\u306e\u767a\u898b\u306fNature Genetics\u8a8c2012\u5e747\u67081\u65e5\u53f7\u3067\u767a\u8868\u3055\u308c\u305f\u304c\u3001\u3053\u308c\u306b\u3088\u308a\u3001\u30bf\u30eb\u30bb\u30d0\u3068AXL\u963b\u5bb3\u5264\u306e\u7d44\u307f\u5408\u308f\u305b\u3068\u3044\u3063\u305f\u300c\u30d7\u30ec\u30b7\u30b8\u30e7\u30f3\u30fb\u30e1\u30c7\u30a3\u30b7\u30f3\u300d\uff08\u907a\u4f1d\u5b50\u7570\u5e38\u7b49\u306b\u57fa\u3065\u3044\u305f\u7cbe\u5ea6\u306e\u9ad8\u3044\u533b\u7642\uff09\u306e\u958b\u767a\u306b\u7d50\u3073\u3064\u304f\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<\/p>\n
\u300c\u5b9f\u9a13\u7684\u306b\u306fAXL\u306e\u6d3b\u6027\u5316\u3092\u963b\u5bb3\u3059\u308b\u3068\u3001\u30bf\u30eb\u30bb\u30d0\u306b\u5bfe\u3059\u308b\u8010\u6027\u3092\u514b\u670d\u3067\u304d\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u65b0\u898f\u306e\u3088\u308a\u52b9\u679c\u7684\u306a\u6cbb\u7642\u85ac\u3078\u306e\u9053\u304c\u958b\u304b\u308c\u307e\u3059\u3002\u300d\u3068\u3001Trever Bivona\u535a\u58eb\uff08\u8840\u6db2\u5b66\u30fb\u816b\u760d\u5b66\u52a9\u6559\uff09\u306f\u8ff0\u3079\u305f\u3002<\/p>\n
\u5b9f\u9a13\u306b\u304a\u3044\u3066\u3001Bivona\u535a\u58eb\u304c\u7387\u3044\u308b\u7814\u7a76\u30c1\u30fc\u30e0\u304c\u7528\u3044\u305fAXL\u963b\u5bb3\u5264\u306f\u3001\u81e8\u5e8a\u7684\u306b\u7528\u3044\u308b\u306e\u306b\u5fc5\u305a\u3057\u3082\u671b\u307e\u3057\u3044\u85ac\u3068\u306f\u3044\u3048\u306a\u3044\u3002\u3057\u304b\u3057\u3001\u73fe\u5728\u3001\u7814\u7a76\u30c1\u30fc\u30e0\u306f\u3001Kevan Shokat\u6c0f\uff08\u30cf\u30ef\u30fc\u30c9\u30fb\u30d2\u30e5\u30fc\u30ba\u533b\u5b66\u7814\u7a76\u6240\u6cbb\u9a13\u8cac\u4efb\u533b\u5e2b\u517cUCSF\u7d30\u80de\u30fb\u5206\u5b50\u85ac\u7406\u5b66\u90e8\u9580\u6559\u6388\uff09\u3068\u5171\u540c\u7814\u7a76\u3092\u884c\u3044\u3001\u81e8\u5e8a\u8a66\u9a13\u306b\u5411\u3051\u3066\u3001\u3088\u308a\u52b9\u679c\u306e\u9ad8\u3044AXL\u963b\u5bb3\u5264\u3092\u958b\u767a\u3057\u3066\u3044\u308b\u3002<\/p>\n
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\u672c\u8ad6\u6587\u300cActivation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer\uff08AXL\u30c1\u30ed\u30b7\u30f3\u30ad\u30ca\u30fc\u30bc\u306e\u6d3b\u6027\u5316\u306b\u3088\u308a\u3001\u80ba\u764c\u3067EGFR\u6a19\u7684\u85ac\u306b\u5bfe\u3059\u308b\u8010\u6027\u304c\u751f\u3058\u308b\uff09\u300d\uff08\u8457\u8005\uff08\u4ee5\u4e0b\u3001\u656c\u79f0\u7565\uff09\uff1aZhenfeng Zhang\u3001Jae Cheol Lee\u3001Luping Lin\u3001Victor Olivas\u3001Valerie Au\u3001Thomas LaFramboise\u3001Mohamed Abdel-Rahman\u3001Xiaoqi Wang\u3001Alan D Levine\u3001Jin Kyung Rho\u3001Yun Jung Choi\u3001Chang-Min Choi\u3001Sang-We Kim\u3001Se Jin Jang\u3001Young Soo Park\u3001Woo Sung Kim\u3001Dae Ho Lee\u3001Jung\uff0dShin Lee\u3001Vincent A Miller\u3001Maria Arcila\u3001Marc Ladanyi\u3001Philicia Moonsamy\u3001Charles Sawyers\u3001Titus J Boggon\u3001Patrick C Ma\u3001Carlota Costa\u3001Miquel Taron\u3001Rafael Rosell\u3001Balazs Halmos\u3001Trever G Bivona\uff09\u306f\u3001Nature Genetics\u30a6\u30a7\u30d6\u30b5\u30a4\u30c8\u4e0a\u3067\u30a2\u30af\u30bb\u30b9\u53ef\u80fd\u3067\u3042\u308b\u3002<\/p>\n
UCSF\u306e\u4ed6\u306b\u3082\u3001\u672c\u7814\u7a76\u306e\u8457\u8005\u306f\u3001\u30b1\u30fc\u30b9\u30fb\u30a6\u30a7\u30b9\u30bf\u30f3\u30fb\u30ea\u30b6\u30fc\u30d6\u5927\u5b66\uff08\u30af\u30ea\u30fc\u30d6\u30e9\u30f3\u30c9\u5e02\uff09\u3001\u30b3\u30ed\u30f3\u30d3\u30a2\u5927\u5b66\uff08\u30cb\u30e5\u30fc\u30e8\u30fc\u30af\u5e02\uff09\u3001\u851a\u5c71\u5927\u5b66\u6821\uff08\u5927\u97d3\u6c11\u56fd\u30bd\u30a6\u30eb\u7279\u5225\u5e02\uff09\u3001\u30e1\u30e2\u30ea\u30a2\u30eb\u30fb\u30b9\u30ed\u30fc\u30f3\u30fb\u30b1\u30bf\u30ea\u30f3\u30b0\u764c\u30bb\u30f3\u30bf\u30fc\uff08\u30cb\u30e5\u30fc\u30e8\u30fc\u30af\u5e02\uff09\u3001\u30a4\u30a7\u30fc\u30eb\u5927\u5b66\u3001Germans Trias i Pujol\u5927\u5b66\u75c5\u9662\uff08\u30b9\u30da\u30a4\u30f3\u30d0\u30eb\u30bb\u30ed\u30ca\u5e02\uff09\u3001\u304a\u3088\u3073USP Dexeus\u5927\u5b66\u7814\u7a76\u6240\uff08\u30b9\u30da\u30a4\u30f3\u30d0\u30eb\u30bb\u30ed\u30ca\u5e02\uff09\u3068\u63d0\u643a\u3057\u3066\u3044\u308b\u3002<\/p>\n
\u672c\u7814\u7a76\u306f\u3001\u52a9\u6210\u91d1K08 1K08CA154787\u30fbP01 CA129243\u3092\u4ecb\u3057\u3066\u3001\u7c73\u56fd\u56fd\u7acb\u885b\u751f\u7814\u7a76\u6240\u306b\u3088\u308b\u652f\u63f4\u3092\u53d7\u3051\u305f\u3002\u307e\u305f\u3001Uniting Against Lung Cancer\u7814\u7a76\u8cde\u3001National Lung Cancer Partnership Young Investigator \u8cde\u3001La Caixa\u8ca1\u56e3\u306b\u3088\u308b\u52a9\u6210\u91d1\u3001\u7c73\u56fd\u764c\u5354\u4f1a\u7814\u7a76\u5968\u5b66\u91d1\u3001\u304a\u3088\u3073\u97d3\u56fd\u5065\u5eb7\u6280\u8853\u7814\u7a76\u958b\u767a\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u3092\u4ecb\u3057\u3066\u3001\u8ffd\u52a0\u652f\u63f4\u3092\u53d7\u3051\u305f\u3002<\/p>\n
******
\n \u6e21\u908a\u5cb3 \u8a33
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