\n
![\"\"](\"https:\/\/www.taiyou-clinic.jp\/blog\/wp-content\/uploads\/2012\/06\/image.jpg\" "\\"image\\"")
<\/a><\/p>\n\u767a\u764c\u7269\u8cea\u306f\u764c\u5e79\u7d30\u80de\u3068\u3064\u306a\u304c\u3063\u305f\u3001\u3057\u304b\u3057\u3001\u30db\u30a6\u30ec\u30f3\u30bd\u30a6\u306f\u52a9\u3051\u308b\u3053\u3068\u304c\u3067\u304d\u308b<\/strong><\/strong><\/p>\n ScienceDaily\uff082012\u5e746\u670820\u65e5\uff09\uff0d\u30aa\u30ec\u30b4\u30f3\u5dde\u7acb\u5927\u5b66\u306eResearchers\u306f\u3001\u30de\u30a4\u30af\u30edRNA\u3068\u764c\u5e79\u7d30\u80de\u306b\u5bfe\u3059\u308b\u305d\u306e\u8907\u5408\u306e\u751f\u7269\u5b66\u7684\u52b9\u679c\u306b\u3001\u6599\u7406\u3055\u308c\u305f\u8089\u3067\u65e2\u77e5\u306e\u767a\u764c\u7269\u8cea\u306e\u4f5c\u7528\u3092\u521d\u3081\u3066\u8ffd\u8de1\u3057\u305f\u3002<\/p>\n \u6240\u898b\u306f\u764c\u306e\u5f8c\u6210\u5b66\uff08\u5f8c\u5929\u7684\u306a\u98df\u4e8b\u3084\u751f\u6d3b\u7fd2\u6163\u304c\u907a\u4f1d\u5b50\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3068\u3044\u3046\u8003\u3048\u65b9\uff09\u306e\u5f79\u5272\u306e\u767a\u9054\u3059\u308b\u8a8d\u8b58\u306e\u4e00\u90e8\u3067\u3042\u308b\u3001\u307e\u305f\u306f\u3001DNA\u914d\u5217\u60c5\u5831\u304c\u4e0d\u5909\u306e\u5834\u5408\u3067\u3042\u3063\u3066\u3082\u3001\u907a\u4f1d\u5b50\u767a\u73fe\u3068\u7d30\u80de\u884c\u52d5\u304c\u3042\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u65b9\u6cd5\u306f\u5909\u5316\u3057\u305f\u3002<\/p>\n \u79d1\u5b66\u8005\u3082\u3001\u30db\u30a6\u30ec\u30f3\u30bd\u30a6\u306e\u6d88\u8cbb\u304c\u767a\u764c\u7269\u8cea\u306e\u640d\u50b7\u52b9\u679c\u3092\u90e8\u5206\u7684\u306b\u6291\u5236\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3068\u308f\u304b\u3063\u305f\u3002\u5b9f\u9a13\u52d5\u7269\u3068\u4e00\u7dd2\u306e\u8a66\u9a13\u3067\u306f\u300158\u30d1\u30fc\u30bb\u30f3\u30c8\u304b\u308932\u30d1\u30fc\u30bb\u30f3\u30c8\u307e\u3067\u3001\u305d\u308c\u306f\u307b\u307c\u534a\u5206\u306b\u7d50\u8178\u816b\u760d\u306e\u767a\u751f\u7387\u3092\u4e0b\u3052\u305f\u3002<\/p>\n \u56fd\u7acb\u885b\u751f\u7814\u7a76\u6240\u3067\u652f\u3048\u3089\u308c\u308b\u50cd\u304d\u3067\u306f\u3001OSU\u306e\u30e9\u30a4\u30ca\u30b9\u30fb\u30dd\u30fc\u30ea\u30f3\u30b0\u7814\u7a76\u6240\u306e\u7814\u7a76\u306f\u3001\u5b66\u8853\u8a8cMolecular Nutrition\u3068Food Research<\/em>\u3067\u6700\u8fd1\u5831\u544a\u3055\u308c\u305f\u3002<\/p>\n \u300c\u50b7\u5bb3\u6027\u7d30\u80de\u304c\u3055\u307e\u3056\u307e\u306a\u624b\u6bb5\u306b\u3088\u3063\u3066\u8d77\u3053\u3063\u3066\u3001\u764c\u306e\u9032\u884c\u306f\u3001\u8907\u5408\u306e\u3001\u591a\u6bb5\u968e\u30d7\u30ed\u30bb\u30b9\u3067\u3042\u308b\u300d\u3068\u3001Mansi Parasramka\uff08LPI\u3092\u3082\u3064\u535a\u58eb\u53f7\u7d42\u4e86\u306e\u5b66\u8005\uff09\u304c\u8a00\u3063\u305f\u3002\u300c\u672c\u7814\u7a76\u306f\u3001\u30de\u30a4\u30af\u30edRNA\u306e\u5909\u66f4\u304c\u5927\u8178\u764c\u5f62\u6210\u3067\u764c\u5e79\u7d30\u80de\u6a19\u8b58\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3053\u3068\u3092\u793a\u3057\u305f\u3002<\/p>\n \u300c\u30de\u30a4\u30af\u30edRNA\u306f\u3001\u7d30\u80de\u3067\u975e\u5e38\u306b\u5927\u304d\u3044\u3053\u3068\u3092\u3059\u308b\u975e\u5e38\u306b\u5c0f\u3055\u3044\u56e0\u5b50\u3067\u3042\u308b\u300d\u3068\u3001\u5f7c\u5973\u304c\u8a00\u3063\u305f\u3002<\/p>\n \u4f1d\u7d71\u7684\u306b\u3001\u764c\u306fDNA\u914d\u5217\u307e\u305f\u306f\u6291\u5236\u3055\u308c\u3066\u3044\u306a\u3044\u7d30\u80de\u6210\u9577\u3092\u8003\u616e\u306b\u5165\u308c\u305f\u7a81\u7136\u5909\u7570\u306e\u5909\u5316\u306b\u8d77\u56e0\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u305f\u3002\u305d\u308c\u306f\u3001\u307e\u3060\u771f\u3067\u3042\u308b\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u5f8c\u6210\u5b66\u306b\u5bfe\u3059\u308b\u95a2\u5fc3\u3082\u3001\u5897\u52a0\u3057\u3066\u3044\u308b\u3002\u305d\u3053\u306b\u304a\u3044\u3066\u3001\u98df\u4e8b\u306e\u3088\u3046\u306a\u56e0\u5b50\u3001\u74b0\u5883\u6bd2\u7d20\u3068\u751f\u6d3b\u69d8\u5f0f\u306f\u3001\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\uff0d \u30de\u30a4\u30af\u30edRNA\u306e\u5f62\u6210\u306f\u3053\u306e\u5f8c\u6210\u7684\u306a\u65b9\u7a0b\u5f0f\u306b\u542b\u307e\u308c\u308b\uff0d\u4e00\u5ea6\u306f\u300c\u30b8\u30e3\u30f3\u30afDNA\u300d\u3067\u3042\u308d\u3046\u3068\u601d\u3063\u305f\uff0d\u305d\u3057\u3066\u305d\u308c\u306f\u3001\u7814\u7a76\u8005\u306f\u308f\u304b\u308b\u305f\u3081\u306b\u56f0\u3063\u3066\u3044\u305f\u3002\u5f7c\u3089\u304cDNA\u306e\u3069\u306e\u9818\u57df\u304c\u8868\u3055\u308c\u308b\u304b\u3001\u9759\u307e\u308b\u304b\u306b\u3064\u3044\u3066\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u3053\u3068\u3092\u73fe\u5728\u77e5\u3089\u308c\u3066\u3044\u308b\u3002<\/p>\n \u4f55\u767e\u3082\u306e\u30de\u30a4\u30af\u30edRNA\u304c\u3042\u308b\u3001\u305d\u3057\u3066\u3001OSU\u79d1\u5b66\u8005\u306f\u305d\u308c\u3089\u306e\u5b9f\u9a13\u3067679\u3092\u30e2\u30cb\u30bf\u30fc\u3057\u305f\u3002\u5f7c\u3089\u304c\u6b63\u3057\u304f\u50cd\u304b\u306a\u3044\u3068\u304d\u3001\u60aa\u3044\u3053\u3068\u306f\u8d77\u3053\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u305d\u3057\u3066\u3001\u764c\u306b\u3064\u306a\u304c\u3063\u3066\u3044\u308b\u7570\u5e38\u306a\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u542b\u3080\u3002<\/p>\n \u300c\u6700\u8fd1\u306e\u7814\u7a76\u306f\u3001\u30de\u30a4\u30af\u30edRNA\u304c\u6b63\u5e38\u3068\u60a3\u90e8\u7d44\u7e54\u3067\u7d30\u80de\u6a5f\u80fd\u3092\u8abf\u6574\u3057\u3066\u3044\u308b\u9375\u3068\u306a\u308b\u5f8c\u6210\u7684\u306a\u6a5f\u5e8f\u306e\u3046\u3061\u306e1\u3064\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\u300d\u3068\u3001\u30ed\u30c3\u30c9\u30fb\u30c0\u30c3\u30b7\u30e5\u30a6\u30c3\u30c9\u3001Cancer Prevention\u306e\u305f\u3081\u306e\u30d8\u30ec\u30f3P. Rumbel\u6559\u6388\u3068LPI\u306eCancer Chemoprotection Program\u306e\u8cac\u4efb\u8005\u304c\u8a00\u3063\u305f\u3002<\/p>\n \u300c\u3057\u304b\u3057\u3001DNA\u306e\u6c38\u7d9a\u7684\u306a\u907a\u4f1d\u5b50\u306e\u5909\u5316\u3067\u3042\u308b\u7a81\u7136\u5909\u7570\u3068\u7570\u306a\u3063\u305f\u300d\u3068\u3001\u5f7c\u304c\u8a00\u3063\u305f\u3001\u300c\u30c0\u30a4\u30a8\u30c3\u30c8\u304a\u3088\u3073\u597d\u307e\u3057\u3044\u751f\u6d3b\u69d8\u5f0f\u9078\u629e\u307e\u305f\u306f\u85ac\u7269\u6cbb\u7642\u3092\u7d4c\u3066\u3055\u3048\u3001\u5f8c\u6210\u5b66\u3068\u30de\u30a4\u30af\u30edRNA\u5909\u66f4\u306b\u3064\u3044\u3066\u306e\u3088\u3044\u77e5\u3089\u305b\u306f\u3001\u6211\u3005\u304c\u6b63\u5e38\u306a\u7d30\u80de\u6a5f\u80fd\u3092\u5fa9\u5143\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3042\u308b\u3002\u300d<\/p>\n \u5f8c\u6210\u5b66\u306f\u751f\u7269\u5b66\u7684\u306b\u57fa\u672c\u7684\u306b\u3042\u3089\u3086\u308b\u4eba\u3092\u30e6\u30cb\u30fc\u30af\u306b\u3059\u308b\u3068\u3001\u30c0\u30c3\u30b7\u30e5\u30a6\u30c3\u30c9\u304c\u8a00\u3063\u305f\u3001\u305d\u308c\u3089\u306e\u907a\u4f1d\u5b66\u3068\u305d\u308c\u3089\u306e\u74b0\u5883\u306e\u88fd\u54c1\u3002\u305d\u308c\u306f\u3001\u4e00\u5375\u6027\u53cc\u751f\u5150\u3055\u3048\u542b\u3080\u3002<\/p>\n \u65b0\u3057\u3044\u691c\u67fb\u306e\u8abf\u67fb\u7d50\u679c\u306f\u30de\u30a4\u30af\u30edRNA\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u306e\u9032\u6b69\u3001\u764c\u5e79\u7d30\u80de\u306b\u5bfe\u3059\u308b\u305d\u308c\u3089\u306e\u52b9\u679c\u3068\u75be\u60a3\u306e\u9032\u884c\u3067\u4e2d\u65ad\u3059\u308b\u5236\u5fa1\u30d7\u30ed\u30bb\u30b9\u306b\u81f3\u3089\u306a\u3051\u308c\u3070\u306a\u3089\u306a\u3044\u3068\u3001OSU\u79d1\u5b66\u8005\u304c\u8a00\u3063\u305f\u3002\u3053\u308c\u306f\u3042\u308b\u65e5\u764c\u306e\u6d0b\u670d\u5c4b\u4ed5\u7acb\u3066\u306e\u307e\u305f\u306f\u300c\u7279\u5b9a\u306e\u60a3\u8005\u300d\u6cbb\u7642\u306b\u81f3\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3068\u3001\u30c0\u30c3\u30b7\u30e5\u30a6\u30c3\u30c9\u304c\u8a00\u3063\u305f\u3002<\/p>\n Cancer STEM cells and spinach<\/p>\n Carcinogens Linked to Cancer Stem Cells, but Spinach Can Help<\/strong><\/p>\n ScienceDaily (June 20, 2012)\u00a0\u2014 Researchers at Oregon State University have for the first time traced the actions of a known carcinogen in cooked meat to its complex biological effects on microRNA and cancer stem cells.<\/p>\n The findings are part of a growing awareness of the role of epigenetics in cancer, or the ways in which gene expression and cell behavior can be changed even though DNA sequence information is unaltered.<\/p>\n The scientists also found that consumption of spinach can partially offset the damaging effects of the carcinogen. In tests with laboratory animals, it cut the incidence of colon tumors almost in half, from 58 percent to 32 percent.<\/p>\n The research at OSU\u2019s Linus Pauling Institute was recently reported in the journal\u00a0Molecular Nutrition and Food Research<\/em>, in work supported by the National Institutes of Health.<\/p>\n \u201cCancer development is a complex, multi-step process, with damaged cells arising through various means,\u201d said Mansi Parasramka, a postdoctoral scholar with LPI. \u201cThis study showed that alterations of microRNAs affect cancer stem cell markers in colon cancer formation.<\/p>\n \u201cMicroRNAs are very small factors that do very big things in cells,\u201d she said.<\/p>\n Traditionally, cancer was thought to be caused by changes in DNA sequence, or mutations, that allowed for uncontrolled cell growth. That\u2019s still true. However, there\u2019s also increasing interest in the role played by epigenetics, in which such factors as diet, environmental toxins, and lifestyle affect the expression of genes \u2014 not just in cancer, but also cardiovascular disease, diabetes, and neurological disorders.<\/em><\/strong><\/p>\n Included in this epigenetic equation is the formation of microRNAs \u2014 once thought to be \u201cjunk DNA\u201d \u2014 which researchers were at a loss to understand. It\u2019s now known that they influence which areas of DNA get expressed or silenced.<\/p>\n There are hundreds of microRNAs, and the OSU scientists monitored 679 in their experiments. When they don\u2019t work right, bad things can happen, including abnormal gene expression leading to cancer.<\/p>\n \u201cRecent research is showing that microRNAs are one of the key epigenetic mechanisms regulating cellular functions in normal and diseased tissues,\u201d said Rod Dashwood, the Helen P. Rumbel Professor for Cancer Prevention and director of LPI\u2019s Cancer Chemoprotection Program.<\/p>\n \u201cBut unlike mutations which are permanent genetic changes in DNA,\u201d he said, \u201cthe good news about epigenetics and microRNA alterations is that we may be able to restore normal cell function, via diet and healthy life style choices, or even drug treatments.\u201d<\/p>\n Epigenetics essentially makes every person biologically unique, Dashwood said, a product of both their genetics and their environment. That includes even identical twins.<\/p>\n The findings of the new study should lead to advances in understanding microRNAs, their effects on cancer stem cells, and the regulatory processes disrupted in disease development, the OSU scientists said. This might lead one day to tailored or \u201cpatient specific\u201d therapies for cancer, Dashwood said.<\/p>\n \u5f8c\u5929\u7684\u306a\u98df\u4e8b\u3084\u751f\u6d3b\u7fd2\u6163\u306e\u5909\u66f4\u3067\u30ac\u30f3\u306e\u907a\u4f1d\u5b50\u304c\u4fee\u98fe\u3092\u53d7\u3051\u3066\u6b63\u5e38\u7d30\u80de\u3078\u5909\u308f\u3063\u3066\u3057\u307e\u3046\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3002\u79c1\u304c\u884c\u3063\u3066\u3044\u308b\u7d71\u5408\u533b\u7642\u3067\u306f\u98df\u4e8b\u3001\u904b\u52d5\u7fd2\u6163\u3001\u30b9\u30c8\u30ec\u30b9\u7ba1\u7406\u3001\u89e3\u6bd2\u306a\u3069\u3092\u5b9f\u8df5\u3059\u308b\u3053\u3068\u3067\u304c\u3093\u7d30\u80de\u3092\u6bba\u3059\u3053\u3068\u3082\u5143\u6c17\u306b\u3059\u308b\u3053\u3068\u3082\u3067\u304d […]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3,4],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts\/461"}],"collection":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/comments?post=461"}],"version-history":[{"count":0,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts\/461\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/media?parent=461"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/categories?post=461"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/tags?post=461"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\n\u305d\u308c\u306f\u764c\u3060\u3051\u3067\u306a\u304f\u5fc3\u8840\u7ba1\u75be\u60a3\uff08\u7cd6\u5c3f\u75c5\uff09\u306b\u3082\u3001\u795e\u7d4c\u969c\u5bb3\u306b\u5bfe\u3057\u3066\u3082\u5f53\u3066\u306f\u307e\u308b\u306e\u3067\u3042\u308b\u3002<\/strong><\/strong><\/p>\n
\u5b66\u8853\u8a8c\u53c2\u7167<\/strong>\uff1a<\/p>\n\n
Journal Reference<\/strong>:<\/p>\n\n