\u30d3\u30bf\u30df\u30f3\uff23\u306e\u65b0\u305f\u306a\u6297\u304c\u3093\u4f5c\u7528\u304c\u8ad6\u6587\u3068\u3057\u3066\u767a\u8868\u3055\u308c\u307e\u3057\u305f\u3002
\n\u3044\u307e\u307e\u3067\u30d3\u30bf\u30df\u30f3\uff23\u306e\u304c\u3093\u6cbb\u7642\u306b\u95a2\u308f\u3063\u3066\u304d\u3066\u3001\u672c\u5f53\u306b\u601d\u3046\u306e\u304c\u3053\u3046\u3044\u3063\u305f\u6709\u610f\u306a\u8ad6\u6587\u304c\u6ca2\u5c71\u51fa\u3066\u3044\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u30d3\u30bf\u30df\u30f3\uff23\u306f\u4fdd\u967a\u8a3a\u7642\u306b\u306f\u306a\u3089\u306a\u3044\u3060\u308d\u3046\u3068\u3044\u3046\u4e88\u6e2c\u304c\u7c21\u5358\u306b\u7acb\u3061\u307e\u3059\u3002<\/p>\n
\u3053\u308c\u306f\u65e5\u672c\u306e\u3044\u3084\u3001\u4e16\u754c\u7684\u306a\u50be\u5411\u3060\u3068\u3044\u3048\u307e\u3059\u304c\u3069\u3046\u3082\u30d3\u30bf\u30df\u30f3\uff23\u306e\u3088\u3046\u306a\u5b89\u4fa1\u3067\u526f\u4f5c\u7528\u306e\u306a\u3044\u6297\u304c\u3093\u5264\u306f\u8a8d\u53ef\u3092\u3055\u308c\u306b\u304f\u3044\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u601d\u308f\u308c\u308b\u7bc0\u304c\u3042\u308a\u307e\u3059\u3002
\n\u30d3\u30bf\u30df\u30f3\uff23\u306b\u9650\u3089\u305a\u3001\u305d\u306e\u4ed6\u306e\u6297\u304c\u3093\u4f5c\u7528\u3092\u6301\u3064\u30a6\u30af\u30e9\u30a4\u30f3\u3084\u4f4e\u5bb9\u91cf\u30ca\u30eb\u30c8\u30ec\u30ad\u30bd\u30f3\u306a\u3069\u3082\u305d\u306e\u90e8\u985e\u3067\u3059\u3002
\n\u3044\u305a\u308c\u3082\u526f\u4f5c\u7528\u304c\u6b86\u3069\u306a\u304f\u3001\u304b\u3064\u6297\u304c\u3093\u5264\u306e\u3088\u3046\u306b\uff11\uff10\uff10\uff4d\uff47\u3067\uff15\u4e07\u5186\u3082\uff11\uff10\u4e07\u5186\u3082\u3057\u307e\u305b\u3093\u3002<\/p>\n
\u60a3\u8005\u3055\u3093\u306e\u305f\u3081\u306b\u3082\u3053\u3046\u3044\u3063\u305f\u526f\u4f5c\u7528\u304c\u5c11\u306a\u304f\u3066\u52b9\u679c\u304c\u3042\u308b\u3068\u8a3c\u660e\u3055\u308c\u3066\u3044\u308b\u6cbb\u7642\u6cd5\u3092\u85a6\u3081\u3066\u3044\u304d\u305f\u3044\u3068\u5f37\u304f\u601d\u3044\u307e\u3059\u3002<\/p>\n
\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a
\n\u30d3\u30bf\u30df\u30f3\u30f3\uff23\u306f\u81b5\u81d3\u764c\u7d30\u80de\u306b\u5bfe\u3059\u308b\u30b2\u30df\u30b7\u30bf\u30d3\u30f3\u306e\u6297\u816b\u760d\u52b9\u679c\u3092\u5897\u5f37\u3059\u308b
\n\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500<\/p>\n
\u56fd\u7acb\u885b\u751f\u7814\u7a76\u6240\uff08\uff2e\uff29\uff28\uff09\u306eLevine\u6559\u6388\u3068\u30ab\u30f3\u30b6\u30b9\u5927\u5b66\u306eDrisko\u6559\u6388\u3089\u306e
\n\u30b0\u30eb\u30fc\u30d7\u306e\u5171\u540c\u7814\u7a76\u3067\u3001\u304b\u3089\u65b0\u3057\u3044\u30d3\u30bf\u30df\u30f3\uff23\u306e\u6297\u816b\u760d\u52b9\u679c\u306b\u95a2\u3059\u308b\u8ad6\u6587\u304c
\n\u51fa\u307e\u3057\u305f\u3002\u8ad6\u6587\u984c\u540d\u306f\u300c\u81b5\u81d3\u764c\u306e\u524d\u81e8\u5e8a\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u85ac\u7406\u5b66\u7684\u9ad8\u6fc3\u5ea6\u306e\u30a2
\n\u30b9\u30b3\u30eb\u30d3\u30f3\u9178\uff08\u30d3\u30bf\u30df\u30f3\uff23\uff09\u306f\u30b2\u30df\u30b7\u30bf\u30d3\u30f3\u3068\u76f8\u4e57\u7684\u306b\u4f5c\u7528\u3059\u308b\u300d\u3067\u3059\u3002
\n\uff18\u7a2e\u985e\u306e\u81b5\u81d3\u764c\u306e\u57f9\u990a\u7d30\u80de\u306b\u304a\u3044\u3066\u3001\u30d3\u30bf\u30df\u30f3\uff23\u3092\u6dfb\u52a0\u3059\u308b\u3053\u3068\u3067\u30b2\u30df\u30b7\u30bf
\n\u30d3\u30f3\u306e\u6297\u816b\u760d\u52b9\u679c\u304c\u5897\u5f37\u3057\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u30de\u30a6\u30b9\u306b\u79fb\u690d\u3057\u305f\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u3082
\n\u30d3\u30bf\u30df\u30f3\uff23\u3068\u30b2\u30df\u30b7\u30bf\u30d3\u30f3\u306e\u4f75\u7528\u306f\u816b\u760d\u91cd\u91cf\u306e\u5897\u52a0\u304c\u6700\u3082\u6291\u5236\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n
Espey MG, Chen P, Chalmers B, Drisko J, Sun AY, Levine M, Chen Q :
\nPharmacologic ascorbate synergizes with gemcitabine in preclinical
\nmodels of pancreatic cancer. Free Radic Biol Med. 2011 Mar 12.<\/p>\n
<Abstract>
\nConventional treatment approaches have had little impact on the course
\nof pancreatic cancer, which has the highest fatality rate among cancers.
\nGemcitabine, the primary therapeutic agent for pancreatic carcinoma,
\nproduces minimal survival benefit as a single agent. Therefore, numerous
\nefforts have focused on gemcitabine combination treatments. Using a
\nratio design, this study established that combining pharmacologically
\nachievable concentrations of ascorbate with gemcitabine resulted in a
\nsynergistic cytotoxic response in eight pancreatic tumor cell lines.
\nSensitization was evident regardless of inherent gemcitabine resistance
\nand epithelial-mesenchymal phenotype. Our analysis suggested that the
\npromiscuous oxidative actions of H(2)O(2) derived from pharmacologic
\nascorbate can culminate in synergism independent of the cancer cell's
\nunderlying phenotype and resistance to gemcitabine monotherapy.
\nGemcitabine-ascorbate combinations administered to mice bearing
\npancreatic tumor xenografts consistently enhanced inhibition of growth
\ncompared to gemcitabine alone, produced 50% growth inhibition in a
\ntumor type not responsive to gemcitabine, and demonstrated a gemcitabine
\ndose-sparing effect. These data support the testing of pharmacologic
\nascorbate in adjunctive treatments for cancers prone to high failure
\nrates with conventional therapeutic regimens, such as pancreatic cancer.<\/p>\n","protected":false},"excerpt":{"rendered":"
\u30d3\u30bf\u30df\u30f3\uff23\u306e\u65b0\u305f\u306a\u6297\u304c\u3093\u4f5c\u7528\u304c\u8ad6\u6587\u3068\u3057\u3066\u767a\u8868\u3055\u308c\u307e\u3057\u305f\u3002 \u3044\u307e\u307e\u3067\u30d3\u30bf\u30df\u30f3\uff23\u306e\u304c\u3093\u6cbb\u7642\u306b\u95a2\u308f\u3063\u3066\u304d\u3066\u3001\u672c\u5f53\u306b\u601d\u3046\u306e\u304c\u3053\u3046\u3044\u3063\u305f\u6709\u610f\u306a\u8ad6\u6587\u304c\u6ca2\u5c71\u51fa\u3066\u3044\u308b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u30d3\u30bf\u30df\u30f3\uff23\u306f\u4fdd\u967a\u8a3a\u7642\u306b\u306f\u306a\u3089\u306a\u3044\u3060\u308d\u3046\u3068\u3044\u3046\u4e88\u6e2c\u304c\u7c21\u5358 […]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts\/310"}],"collection":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/comments?post=310"}],"version-history":[{"count":0,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts\/310\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/media?parent=310"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/categories?post=310"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/tags?post=310"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}