{"id":2742,"date":"2017-11-08T19:58:26","date_gmt":"2017-11-08T10:58:26","guid":{"rendered":"https:\/\/www.taiyou-clinic.jp\/blog\/?p=2742"},"modified":"2017-11-08T19:58:26","modified_gmt":"2017-11-08T10:58:26","slug":"%e3%81%8c%e3%82%93%e7%99%ba%e7%97%87%e5%8e%9f%e5%9b%a0%e3%81%ae%e5%a4%a7%e5%8d%8a%e3%81%afdna%e3%81%ae%e8%a4%87%e8%a3%bd%e3%82%a8%e3%83%a9%e3%83%bc","status":"publish","type":"post","link":"https:\/\/www.taiyou-clinic.jp\/blog\/archives\/2742","title":{"rendered":"\u304c\u3093\u767a\u75c7\u539f\u56e0\u306e\u5927\u534a\u306fDNA\u306e\u8907\u88fd\u30a8\u30e9\u30fc"},"content":{"rendered":"<p>\u304c\u3093\u767a\u75c7\u539f\u56e0\u306e\u5927\u534a\u306f<span>DNA<\/span>\u306e\u8907\u88fd\u30a8\u30e9\u30fc<span>\u00a0 <\/span><\/p>\n<p><span>\u00a0<\/span><\/p>\n<p>\u3053\u306e\u7814\u7a76\u767a\u8868\u306e\u6301\u3064\u610f\u5473\u306f\u5927\u304d\u3044\u3060\u308d\u3046\u3002\u80ba\u304c\u3093\u3084\u4e73\u764c\u3001\u524d\u7acb\u817a\u304c\u3093\u306a\u3069\u306e\u591a\u304f\u306e\u4eba\u3005\u3068\u95a2\u9023\u3059\u308b\u304c\u3093\u304c\u5b9f\u306f\uff24\uff2e\uff21\u30b3\u30d4\u30fc\u306e\u9593\u9055\u3044\u304b\u3089\u8d77\u304d\u3066\u3044\u3066\u74b0\u5883\u3084\u907a\u4f1d\u304c\u95a2\u4fc2\u306a\u3044\u3068\u3057\u305f\u3089\u3069\u3046\u3059\u308b\u3060\u308d\u3046\u304b\uff1f<\/p>\n<p>\u3057\u304b\u3057\u3001\u3053\u306e\u907a\u4f1d\u5b50\u306e\u30b3\u30d4\u30fc\u3068\u3044\u3046\u8003\u3048\u304c\u307e\u305f\u96e3\u3057\u3044\u3002\u907a\u4f1d\u5b50\u306e\u30b3\u30d4\u30fc\u306f\uff24\uff2e\uff21\u3092\uff32\uff2e\uff21\u304c\u30b3\u30d4\u30fc\u3057\u3066\u8ee2\u5199\u3057\u3066\u4f5c\u3063\u3066\u3086\u304f\u306e\u3060\u304c\u3001\u305d\u306e\u904e\u7a0b\u3067\u3069\u3093\u306a\u30c8\u30e9\u30d6\u30eb\u304c\u8d77\u304d\u308b\u306e\u3060\u308d\u3046\u304b\uff1f\u3084\u306f\u308a\u3053\u3053\u3067\u3082\u7cbe\u795e\u7684\u30b9\u30c8\u30ec\u30b9\u3084\u5916\u90e8\u304b\u3089\u306e\u7269\u8cea\u7684\u30b9\u30c8\u30ec\u30b9\u306b\u3088\u3063\u3066\u4f53\u5185\u306e\u60c5\u5831\u4f1d\u9054\u7269\u8cea\u306b\u7570\u5e38\u304c\u51fa\u308b\u3053\u3068\u304c\u5927\u304d\u306a\u8981\u56e0\u3067\u306f\u306a\u3044\u3060\u308d\u3046\u304b\u3002<\/p>\n<p>\u3053\u3053\u3067\u7cbe\u795e\u795e\u7d4c\u514d\u75ab\u5b66\u306e\u8003\u3048\u3067\u884c\u304f\u3068\u3001\u60c5\u5831\u4f1d\u9054\u7269\u8cea\u306f\u3059\u3079\u3066\u8133\u304a\u3088\u3073\u5fc3\u304b\u3089\u767a\u3057\u3066\u3044\u308b\u306e\u3067\u91cf\u5b50\u8ad6\u7684\u306a\u9806\u756a\u3067\u8003\u3048\u305f\u3089\u3001\u5fc3\uff1d\u610f\u601d\u306b\u3088\u3063\u3066\u5909\u5316\u3059\u308b\u3002<\/p>\n<p>\u75c5\u6c17\u306f\u5fc3\u306b\u76f8\u5f53\u4f9d\u5b58\u3057\u3066\u3044\u308b\u3068\u601d\u3048\u308b\u306e\u3060\u3002<\/p>\n<p><span>\u00a0<\/span><\/p>\n<p><span>\u00a0<\/span><\/p>\n<p><span>http:\/\/www.natureasia.com\/ja-jp\/ndigest\/v14\/n6\/%E3%81%8C%E3%82%93%E7%99%BA%E7%97%87%E5%8E%9F%E5%9B%A0%E3%81%AE%E5%A4%A7%E5%8D%8A%E3%81%AFDNA%E3%81%AE%E8%A4%87%E8%A3%BD%E3%82%A8%E3%83%A9%E3%83%BC\/85984<\/span><\/p>\n<p><span>Nature <\/span>\u30c0\u30a4\u30b8\u30a7\u30b9\u30c8<span> Vol. 14 No. 6 | doi : 10.1038\/ndigest.2017.170606 <\/span><\/p>\n<p><span>\u00a0<\/span><\/p>\n<p>\u539f\u6587\uff1a<span>Nature (2017-04-23) | doi: 10.1038\/nature.2017.21696 | DNA typos to blame for most cancer mutations \uf0f6 <\/span><\/p>\n<p><span>\u00a0<\/span><\/p>\n<p><span>Heidi Ledford<\/span><\/p>\n<p><span>\u00a0<\/span><\/p>\n<p><span>\u00a0<\/span><\/p>\n<p>\u74b0\u5883\u8981\u56e0\u3084\u907a\u4f1d\u8981\u56e0\u304c\u3001\u304c\u3093\u30ea\u30b9\u30af\u306b\u53ca\u307c\u3059\u5f71\u97ff\u306f\u3001\u7814\u7a76\u8005\u304c\u8003\u3048\u3066\u3044\u308b\u307b\u3069\u5927\u304d\u304f\u306a\u3044\u304b\u3082\u3057\u308c\u306a\u3044\u3002<\/p>\n<p><span>\u00a0<\/span><\/p>\n<p>\u7d30\u80de\u304c\u5206\u88c2\u3059\u308b\u969b\u306b<span>DNA<\/span>\u8907\u88fd\u904e\u7a0b\u3067\u8aa4\u308a\u304c\u8d77\u3053\u308b\u3053\u3068\u304c\u3042\u308b\u3002\u304c\u3093\u3092\u5f15\u304d\u8d77\u3053\u3059\u5909\u7570\u306e\u7d04<span>3<\/span>\u5206\u306e<span>2<\/span>\u306f\u3053\u308c\u304c\u539f\u56e0\u3067\u3042\u308a\u3001\u74b0\u5883\u8981\u56e0\u306b\u3088\u308b\u5909\u7570\u306f<span>29<\/span>\uff05\u3001\u53d7\u3051\u7d99\u3044\u3060\u5909\u7570\u306f<span>5<\/span>\uff05\u7a0b\u5ea6\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002<span> | <\/span><\/p>\n<p><span>\u00a0<\/span><\/p>\n<p>\u304c\u3093\u3092\u5f15\u304d\u8d77\u3053\u3059\u5909\u7570\u306e<span>3<\/span>\u5206\u306e<span>2<\/span>\u8fd1\u304f\u306f\u3001\u7d30\u80de\u304c<span>DNA<\/span>\u3092\u30b3\u30d4\u30fc\u3059\u308b\u969b\u306b\u8d77\u304d\u305f\u30a8\u30e9\u30fc\u304c\u539f\u56e0\u3067\u3042\u308b\u3053\u3068\u304c\u6570\u5b66\u30e2\u30c7\u30eb\u304b\u3089\u793a\u5506\u3055\u308c\u305f\u3002\u3053\u306e\u77e5\u898b\u306f\u3001\u30b8\u30e7\u30f3\u30ba\u30db\u30d7\u30ad\u30f3\u30b9\u5927\u5b66\u30b7\u30c9\u30cb\u30fc\u30ad\u30f3\u30e1\u30eb\u304c\u3093\u30bb\u30f3\u30bf\u30fc\uff08\u7c73\u56fd\u30e1\u30ea\u30fc\u30e9\u30f3\u30c9\u5dde\u30dc\u30eb\u30c1\u30e2\u30a2\uff09\u306e\u6570\u5b66\u8005<span>Cristian Tomasetti<\/span>\u304a\u3088\u3073\u907a\u4f1d\u5b66\u8005<span>Bert Vogelstein<\/span>\u3089\u306b\u3088\u308a<span>2017<\/span>\u5e74<span>3<\/span>\u6708<span>23<\/span>\u65e5\u306b<span>Science<\/span>\u306b\u767a\u8868\u3055\u308c\u305f<span>1<\/span>\u3002\u74b0\u5883\u8981\u56e0\u3084\u5185\u7684\u8981\u56e0\u304c\u304c\u3093\u30ea\u30b9\u30af\u306b\u53ca\u307c\u3059\u5f71\u97ff\u304c\u3069\u306e\u7a0b\u5ea6\u306a\u306e\u304b\u306b\u3064\u3044\u3066\u3001\u9577\u304f\u8b70\u8ad6\u304c\u7d9a\u3044\u3066\u3044\u308b\u4e2d\u3001\u3053\u306e\u7814\u7a76\u7d50\u679c\u306f\u6700\u65b0\u306e\u8ad6\u62e0\u3068\u306a\u308b\u3002\u307e\u305f\u8457\u8005\u3089\u306f\u3001\u304c\u3093\u3092\u5f15\u304d\u8d77\u3053\u3059\u5909\u7570\u306e\u591a\u304f\u304c\u53d7\u3051\u7d99\u3044\u3060\u3082\u306e\u3067\u306f\u306a\u3044\u3053\u3068\u3001\u307e\u305f\u3001\u751f\u6d3b\u69d8\u5f0f\u306e\u9078\u629e\u3092\u5909\u3048\u308b\u306a\u3069\u306b\u3088\u3063\u3066\u9632\u6b62\u3067\u304d\u306a\u3044\u3068\u8003\u3048\u3089\u308c\u308b\u3053\u3068\u3082\u793a\u3057\u305f\u3002<span>Vogelstein<\/span>\u306f\u3001\u300c\u3053\u308c\u306f\u300e\u304c\u3093\u3068\u306e\u95d8\u3044\u65b9\u300f\u3092\u5909\u3048\u5f97\u308b\u767a\u898b\u3067\u3059\u300d\u3068\u8a00\u3046\u3002<\/p>\n<p><span>\u00a0<\/span><\/p>\n<p>\u300c\u7814\u7a76\u8005\u305f\u3061\u306f\u3001\u304c\u3093\u3092\u5f15\u304d\u8d77\u3053\u3059\u5909\u7570\u304c\u751f\u3058\u308b\u969b\u306e\u74b0\u5883\u8981\u56e0\u306e\u5f79\u5272\u3092\u5f37\u8abf\u3059\u308b\u50be\u5411\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u5909\u7570\u3092\u6575\u3068\u8003\u3048\u308b\u3068\u3001\u5168\u3066\u306e\u6575\u304c\u6211\u3005\u306e\u4f53\u306e\u5916\u306b\u3042\u308b\u306a\u3089\u3001\u6575\u304c\u4fb5\u5165\u3057\u3066\u304f\u308b\u306e\u3092\u9632\u3050\u65b9\u6cd5\u306f\u660e\u3089\u304b\u3067\u3059\u3002\u3057\u304b\u3057\u3001\u591a\u304f\u306e\u6575\u3001\u3064\u307e\u308a\u304c\u3093\u3092\u5f15\u304d\u8d77\u3053\u3059\u5909\u7570\u306e\u5834\u5408\u306f<span>3<\/span>\u5206\u306e<span>2<\/span>\u8fd1\u304f\u304c\u3001\u5b9f\u969b\u306b\u306f\u6211\u3005\u306e\u4f53\u306e\u5185\u306b\u3042\u308b\u306a\u3089\u3001\u5168\u304f\u7570\u306a\u308b\u6226\u7565\u304c\u5fc5\u8981\u3067\u3057\u3087\u3046\u300d\u3068<span>Vogelstein<\/span>\u306f\u8aac\u660e\u3059\u308b\u3002\u300c\u305d\u306e\u6226\u7565\u3068\u306f\u3001\u4e88\u9632\u306b\u52a0\u3048\u3001\u65e9\u671f\u306e\u767a\u898b\u3084\u6cbb\u7642\u306b\u91cd\u70b9\u3092\u7f6e\u3044\u305f\u3082\u306e\u3067\u3057\u3087\u3046\u300d\u3068\u5f7c\u306f\u8a00\u3046\u3002<\/p>\n<p><span>\u00a0<\/span><\/p>\n<p>\u8907\u88fd\u30a8\u30e9\u30fc<\/p>\n<p><span>\u00a0<\/span><\/p>\n<p>\u7d30\u80de\u304c\u5206\u88c2\u3059\u308b\u305f\u3073\u306b\u3001\u305d\u306e<span>DNA<\/span>\u8907\u88fd\u904e\u7a0b\u3067\u306f\u30a8\u30e9\u30fc\u304c\u751f\u3058\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002<span>Vogelstein<\/span>\u3068<span>Tomasetti<\/span>\u304c<span>2015<\/span>\u5e74\u306b\u767a\u8868\u3057\u305f\u89e3\u6790\u7d50\u679c<span>2<\/span>\u306f\u3001\u4e00\u90e8\u306e\u304c\u3093\u304c\u4ed6\u306e\u304c\u3093\u3088\u308a\u591a\u304f\u898b\u3089\u308c\u308b\u7406\u7531\u3092\u8aac\u660e\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u304b\u3089\u8a71\u984c\u3092\u547c\u3093\u3060\u3002\u5f7c\u3089\u304c\u5c0e\u304d\u51fa\u3057\u305f\u7d50\u8ad6\u306f\u3001\u81d3\u5668\u306e\u5e79\u7d30\u80de\u306e\u5206\u88c2\u56de\u6570\u306e\u9055\u3044\u304c\u3001\u305d\u306e\u90e8\u4f4d\u306b\u304c\u3093\u304c\u751f\u3058\u308b\u983b\u5ea6\u3068\u76f8\u95a2\u3059\u308b\u3001\u3068\u3044\u3046\u3082\u306e\u3067\u3042\u3063\u305f\u3002\u3064\u307e\u308a\u3001\u305d\u308c\u307b\u3069\u4e00\u822c\u7684\u306b\u304c\u3093\u304c\u898b\u3089\u308c\u306a\u3044\u8133\u306a\u3069\u306e\u90e8\u4f4d\u3067\u306f\u3001\u4e00\u822c\u7684\u306b\u304c\u3093\u304c\u898b\u3089\u308c\u308b\u5927\u8178\u306a\u3069\u306e\u90e8\u4f4d\u3088\u308a\u3082\u5e79\u7d30\u80de\u306e\u5206\u88c2\u56de\u6570\u304c\u5c11\u306a\u3044\u3001\u3068\u3044\u3046\u3053\u3068\u3067\u3042\u308b\uff08<span>Nature <\/span>\u30c0\u30a4\u30b8\u30a7\u30b9\u30c8<span> 2016<\/span>\u5e74<span>3<\/span>\u6708\u53f7\u300c\u304c\u3093\u306e\u4e3b\u306a\u539f\u56e0\u306f\u300e\u4e0d\u904b\u300f\uff1f\u300d\u53c2\u7167\uff09\u3002<\/p>\n<p><span>\u00a0<\/span><\/p>\n<p>\u304c\u3093\u767a\u75c7\u306e\u539f\u56e0\u3068\u306a\u308b\u3082\u306e\u306e\u4e2d\u306b\u306f\u3001\u55ab\u7159\u3084\u65e5\u5149\u3078\u306e\u66b4\u9732\u306a\u3069\u306e\u3088\u3046\u306b\u907f\u3051\u3089\u308c\u308b\u3082\u306e\u3082\u3042\u308b\u3002<\/p>\n<p><span>\u00a0<\/span><\/p>\n<p>\u3053\u306e\u7814\u7a76\u306e\u7d50\u8ad6\u306f\u3001\u300c\u304c\u3093\u4e88\u9632\u306e\u53d6\u308a\u7d44\u307f\u306b\u306f\u610f\u5473\u304c\u306a\u3044\u300d\u3068\u3044\u3046\u8003\u3048\u306b\u81f3\u308b\u6050\u308c\u304c\u3042\u3063\u305f\u3053\u3068\u304b\u3089\u3001\u6570\u767e\u3082\u306e\u691c\u8a3c\u8ad6\u6587\u3092\u751f\u307f\u51fa\u3059\u3053\u3068\u3068\u306a\u3063\u305f<span>3<\/span>\u3002\u300c\u74b0\u5883\u8981\u56e0\u306b\u3088\u3063\u3066\u751f\u3058\u308b\u304c\u3093\u306e\u5272\u5408\u306b\u3064\u3044\u3066\u306e\u8b70\u8ad6\u304c\u518d\u71c3\u3057\u307e\u3057\u305f\u300d\u3068\u3001\u30b9\u30a4\u30b9\u9023\u90a6\u5de5\u79d1\u5927\u5b66\u30c1\u30e5\u30fc\u30ea\u30c3\u30d2\u6821\uff08\u30d0\u30fc\u30bc\u30eb\uff09\u3067\u304c\u3093\u306e\u6570\u5b66\u30e2\u30c7\u30eb\u3092\u5c02\u9580\u3068\u3057\u3066\u3044\u308b<span>Robert Noble<\/span>\u306f\u8a00\u3046\u3002<\/p>\n<p><span>\u00a0<\/span><\/p>\n<p><span>Vogelstein<\/span>\u306f\u3001\u300c\u304c\u3093\u3092\u5f15\u304d\u8d77\u3053\u3059\u5909\u7570\u3092\u751f\u3058\u3055\u305b\u5f97\u308b\u3082\u306e\u3068\u3057\u3066\u3001\u55ab\u7159\u3084\u65e5\u5149\u3078\u306e\u66b4\u9732\u306a\u3069\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u7814\u7a76\u306b\u3088\u3063\u3066\u3001\u65e2\u77e5\u306e\u304c\u3093\u306e\u539f\u56e0\u306b\u5bfe\u3059\u308b\u53d6\u308a\u7d44\u307f\u306b\u7570\u8b70\u3092\u7533\u3057\u7acb\u3066\u308b\u3064\u3082\u308a\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u75ab\u5b66\u7814\u7a76\u304b\u3089\u3001\u304c\u3093\u306e\u7d04<span>42<\/span>\uff05\u306f\u4e88\u9632\u304c\u53ef\u80fd\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u304a\u308a\u3001\u79c1\u306e\u7d50\u679c\u306f\u305d\u308c\u306b\u77db\u76fe\u3059\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u300d\u3068\u8ff0\u3079\u3066\u3044\u308b\uff08<span>Vogelstein<\/span>\u306e\u7814\u7a76\u3067\u306f\u3001\u304c\u3093\u3092\u5f15\u304d\u8d77\u3053\u3059\u5909\u7570\u306e\u6570\u3092\u898b\u3066\u3044\u308b\u3002\u4e00\u822c\u7684\u306b\u3001\u304c\u3093\u767a\u75c7\u306b\u306f\u305d\u306e\u3088\u3046\u306a\u5909\u7570\u304c<span>2<\/span>\u3064\u4ee5\u4e0a\u5fc5\u8981\u3067\u3042\u308b\u305f\u3081\u3001\u5909\u7570\u306e\u3046\u3061\u306e<span>1<\/span>\u3064\u304c\u74b0\u5883\u8981\u56e0\u306b\u3088\u308a\u751f\u3058\u308b\u306e\u3067\u3042\u308c\u3070\u3001\u304c\u3093\u306e\u767a\u75c7\u306f\u5b8c\u5168\u306b\u4e88\u9632\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u3042\u308b\uff09\u3002<\/p>\n<p><span>\u00a0<\/span><\/p>\n<p>\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u3053\u306e<span>2015<\/span>\u5e74\u306e\u8ad6\u6587\u3088\u308a\u3082<span>2<\/span>\u3064\u306e\u70b9\u304c\u88dc\u5f37\u3055\u308c\u3066\u3044\u308b\u3002\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u7c73\u56fd\u4ee5\u5916\u306e\u56fd\u306b\u3082\u89e3\u6790\u304c\u62e1\u5927\u3055\u308c\u3001<span>69<\/span>\u30ab\u56fd\u306e\u304c\u3093\u767a\u751f\u7387\u306b\u95a2\u3059\u308b\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u304c\u542b\u307e\u308c\u3066\u3044\u308b\u3002\u3055\u3089\u306b\u3001\u4e73\u304c\u3093\u3068\u524d\u7acb\u817a\u304c\u3093\u3068\u3044\u3046<span>2<\/span>\u3064\u306e\u4e00\u822c\u7684\u306a\u304c\u3093\u3082\u65b0\u305f\u306b\u52a0\u3048\u3089\u308c\u3066\u3044\u308b\u3002\u300c\u62e1\u5927\u89e3\u6790\u306e\u7d50\u679c\u304b\u3089<span>2015<\/span>\u5e74\u306e\u8ad6\u6587\u306e\u7d50\u8ad6\u304c\u88cf\u4ed8\u3051\u3089\u308c\u307e\u3057\u305f\u300d\u3068<span>Tomasetti<\/span>\u306f\u8a00\u3046\u3002<\/p>\n<p><span>\u00a0<\/span><\/p>\n<p>\u6b21\u306b<span>Tomasetti<\/span>\u3089\u306f\u3001\u304c\u3093\u3092\u5f15\u304d\u8d77\u3053\u3059\u5909\u7570\u3078\u306e\u74b0\u5883\u3001\u907a\u4f1d\u3001\u30e9\u30f3\u30c0\u30e0\u306a<span>DNA<\/span>\u8907\u88fd\u30a8\u30e9\u30fc\u306e\u76f8\u5bfe\u7684\u306a\u5bc4\u4e0e\u306b\u3064\u3044\u3066\u8a08\u7b97\u3057\u305f\u3002\u5f7c\u306e\u7814\u7a76\u30c1\u30fc\u30e0\u306f\u3001\u4e3b\u306b<span>UK<\/span>\u304c\u3093\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u306e\u30c7\u30fc\u30bf\u3092\u5229\u7528\u3057\uff08\u4e00\u90e8\u306b\u3064\u3044\u3066\u306f\u304c\u3093\u30b2\u30ce\u30e0\u5869\u57fa\u914d\u5217\u89e3\u8aad\u30c7\u30fc\u30bf\u3092\u7528\u3044\u305f\uff09\u3001\u7279\u5b9a\u306e\u74b0\u5883\u66b4\u9732\u306e\u6307\u6a19\u3068\u306a\u308b\u5909\u7570\u3092\u63a2\u7d22\u3057\u305f\u3002<\/p>\n<p><span>\u00a0<\/span><\/p>\n<p>\u3059\u308b\u3068\u3001\u304c\u3093\u306b\u3088\u3063\u3066\u3053\u308c\u3089\u306e\u8981\u56e0\u304c\u5bc4\u4e0e\u3059\u308b\u5272\u5408\u304c\u7570\u306a\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u5206\u304b\u3063\u305f\u3002\u4f8b\u3048\u3070\u3001\u80ba\u304c\u3093\u306e\u4e00\u7a2e\u3067\u3042\u308b\u80ba\u817a\u304c\u3093\u3067\u306f\u3001\u304c\u3093\u3092\u5f15\u304d\u8d77\u3053\u3059\u5168\u3066\u306e\u5909\u7570\u306e\u3046\u3061<span>65<\/span>\uff05\u304c\u74b0\u5883\u8981\u56e0\uff08\u307e\u305f\u306f\u907a\u4f1d\u8981\u56e0\uff09\u3067\u3001\u8907\u88fd\u30a8\u30e9\u30fc\u306f<span>35<\/span>\uff05\u3092\u5360\u3081\u308b\u306e\u307f\u3067\u3042\u3063\u305f\u306e\u306b\u5bfe\u3057\u3001\u524d\u7acb\u817a\u3001\u8133\u3001\u9aa8\u306e\u304c\u3093\u3067\u306f\u3001\u304c\u3093\u306e\u30c9\u30e9\u30a4\u30d0\u30fc\u5909\u7570\u306e<span>95<\/span>\uff05\u4ee5\u4e0a\u304c\u3001<span>DNA<\/span>\u3092\u30b3\u30d4\u30fc\u3059\u308b\u969b\u306b\u751f\u3058\u308b\u30e9\u30f3\u30c0\u30e0\u306a\u30a8\u30e9\u30fc\u306b\u3088\u3063\u3066\u751f\u3058\u3066\u3044\u305f\u3002<\/p>\n<p><span>\u00a0<\/span><\/p>\n<p>\u7dcf\u5408\u7684\u306b\u3001<span>32<\/span>\u7a2e\u985e\u306e\u304c\u3093\u306b\u3064\u3044\u3066\u306e\u8a08\u7b97\u304b\u3089\u3001\u304c\u3093\u3092\u5f15\u304d\u8d77\u3053\u3059\u5909\u7570\u306e\u7d04<span>66<\/span>\uff05\u304c<span>DNA<\/span>\u8907\u88fd\u306e\u969b\u306e\u30e9\u30f3\u30c0\u30e0\u306a\u30a8\u30e9\u30fc\u306b\u3088\u3063\u3066\u751f\u3058\u3066\u304a\u308a\u3001\u74b0\u5883\u8981\u56e0\u306b\u3088\u308b\u5909\u7570\u306f<span>29<\/span>\uff05\u306e\u307f\u3067\u3001\u53d7\u3051\u7d99\u3044\u3060\u5909\u7570\u306f<span>5<\/span>\uff05\u3067\u3042\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u305f\u3002<\/p>\n<p><span>\u00a0<\/span><\/p>\n<p>\u660e\u78ba\u306b\u306a\u308b<\/p>\n<p><span>\u00a0<\/span><\/p>\n<p>\u300c\u4eca\u56de\u306e\u7814\u7a76\u306b\u7528\u3044\u3089\u308c\u305f\u65b9\u6cd5\u306f\u3001\u89e3\u6790\u3092\u7c21\u7d20\u5316\u3059\u308b\u305f\u3081\u306b\u591a\u304f\u306e\u4eee\u5b9a\u306b\u4f9d\u5b58\u3057\u306a\u3051\u308c\u3070\u306a\u308a\u307e\u305b\u3093\u304c\u3001\u59a5\u5f53\u306a\u3082\u306e\u3067\u3059\u300d\u3068<span>Noble<\/span>\u306f\u8a00\u3046\u3002<\/p>\n<p><span>\u00a0<\/span><\/p>\n<p>\u30cb\u30e5\u30fc\u30e8\u30fc\u30af\u5dde\u7acb\u5927\u5b66\u30b9\u30c8\u30fc\u30cb\u30fc\u30d6\u30eb\u30c3\u30af\u6821\u304c\u3093\u30bb\u30f3\u30bf\u30fc\uff08\u7c73\u56fd\uff09\u306e\u6240\u9577<span>Yusuf Hannun<\/span>\u306f\u3001\u5869\u57fa\u914d\u5217\u30c7\u30fc\u30bf\u3084\u75ab\u5b66\u30c7\u30fc\u30bf\u3092\u57fa\u76e4\u3068\u3057\u3066\u74b0\u5883\u8981\u56e0\u3084\u907a\u4f1d\u8981\u56e0\u3092\u5b8c\u5168\u306b\u4e88\u6e2c\u3059\u308b\u65b9\u6cd5\u306f\u307e\u3060\u77e5\u3089\u308c\u3066\u3044\u306a\u3044\u305f\u3081\u3001\u4eca\u56de\u306e\u7814\u7a76\u304c\u305d\u308c\u3089\u306e\u8981\u56e0\u306e\u5bc4\u4e0e\u3092\u904e\u5c0f\u8a55\u4fa1\u3057\u3066\u3044\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3068\u61f8\u5ff5\u3057\u3066\u3044\u308b\u3002\u4f8b\u3048\u3070\u3001\u300c\u3042\u308b\u4eba\u306e\u80ba\u304c\u3093\u306b\u55ab\u7159\u304c\u3069\u306e\u7a0b\u5ea6\u5f71\u97ff\u3092\u53ca\u307c\u3057\u305f\u304b\u3092\u898b\u7a4d\u3082\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u304c\u3001\u5927\u6c17\u6c5a\u67d3\u3084\u30e9\u30c9\u30f3\u66b4\u9732\u306e\u5f71\u97ff\u3092\u5b8c\u5168\u306b\u6349\u3048\u308b\u3053\u3068\u306f\u3082\u3063\u3068\u96e3\u3057\u3044\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u300d\u3068<span>Hannun<\/span>\u306f\u8a00\u3046\u3002<\/p>\n<p><span>\u00a0<\/span><\/p>\n<p>\u300c\u5168\u4f53\u3068\u3057\u3066\u3001\u3053\u306e\u3088\u3046\u306a\u8b70\u8ad6\u306f\u3001\u304c\u3093\u306e\u539f\u56e0\u306e\u3088\u308a\u826f\u3044\u30e2\u30c7\u30eb\u958b\u767a\u3092\u76ee\u6307\u3059\u5206\u91ce\u3092\u6d3b\u6027\u5316\u3059\u308b\u306e\u306b\u5f79\u7acb\u3061\u307e\u3057\u305f\u3002\u8b70\u8ad6\u3092\u901a\u3057\u3066\u305f\u304f\u3055\u3093\u306e\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u3001\u305d\u308c\u304c\u975e\u5e38\u306b\u5f79\u7acb\u3063\u3066\u3044\u308b\u306e\u3067\u3059\u300d\u3068<span>Noble<\/span>\u306f\u8a00\u3046\u3002<\/p>\n<p><span>\u00a0<\/span><\/p>\n<p><span>Vogelstein<\/span>\u306f\u3001\u3053\u306e\u7d50\u679c\u306b\u3088\u308a\u3001\u60a3\u8005\u3068\u305d\u306e\u5bb6\u65cf\u3001\u7279\u306b\u304c\u3093\u306e\u5b50\u3069\u3082\u3092\u6301\u3064\u89aa\u304c\u3001\u304c\u3093\u306e\u7f79\u60a3\u3067\u611f\u3058\u308b\u7f6a\u306e\u610f\u8b58\u3092\u5c11\u3057\u3067\u3082\u8efd\u6e1b\u3067\u304d\u305f\u3089\u3068\u601d\u3063\u3066\u3044\u308b\u3002\u591a\u304f\u306e\u4eba\u304c\u5229\u7528\u3059\u308b\u30a4\u30f3\u30bf\u30fc\u30cd\u30c3\u30c8\u3092\u7528\u3044\u3066\u304c\u3093\u306e\u539f\u56e0\u3092\u691c\u7d22\u3059\u308b\u3068\u3001\u3042\u308b\u751f\u6d3b\u69d8\u5f0f\u3042\u308b\u3044\u306f\u907a\u4f1d\u5b50\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u3068\u3044\u3046\u7b54\u3048\u304c\u5f97\u3089\u308c\u308b\u3053\u3068\u304c\u591a\u3044\u3002\u300c\u304c\u3093\u306f\u4f55\u3092\u3057\u3066\u3044\u305f\u3068\u3057\u3066\u3082\u767a\u75c7\u3057\u305f\u306e\u3060\u3068\u7406\u89e3\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002\u304c\u3093\u3068\u3044\u3046\u3059\u3067\u306b\u56f0\u96e3\u306a\u72b6\u6cc1\u306b\u3001\u7f6a\u306e\u610f\u8b58\u3092\u52a0\u3048\u308b\u5fc5\u8981\u306f\u3042\u308a\u307e\u305b\u3093\u300d\u3068<span>Vogelstein<\/span>\u306f\u8a00\u3046\u3002<\/p>\n<p><span>\u00a0<\/span><\/p>\n<p>\uff08\u7ffb\u8a33\uff1a\u4e09\u8c37\u7950\u8cb4\u5b50\uff09<\/p>\n<p><span>\u00a0<\/span><\/p>\n<p><span>\uf15c<\/span>\u53c2\u8003\u6587\u732e<\/p>\n<ol>\n<li><span> Tomasetti, C., Li, L. &amp; Vogelstein, B. Science 355, 1330\u20131334 (2017). <\/span><\/li>\n<li><span> Tomasetti, C. &amp; Vogelstein, B. Science 347, 78\u201381 (2015). <\/span><\/li>\n<li><span> Nowak, M.A. &amp; Waclaw, B. Science 355, 1266\u20131267 (2017).<\/span><\/li>\n<\/ol>\n<p><span>\u00a0<\/span><\/p>\n<p><span>\u00a0<\/span><\/p>\n<p><span>\u00a0<\/span><\/p>\n<p><span>\u00a0<\/span><\/p>\n<p><span>\u00a0<\/span><\/p>\n<p><span>\u00a0<\/span><\/p>\n<p><span>\u00a0<\/span><\/p>\n<p><span>\u00a0<\/span><\/p>\n<p><span>\u00a0<\/span><\/p>\n<p><span>\u00a0<\/span><\/p>\n<p><span>\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u304c\u3093\u767a\u75c7\u539f\u56e0\u306e\u5927\u534a\u306fDNA\u306e\u8907\u88fd\u30a8\u30e9\u30fc\u00a0 \u00a0 \u3053\u306e\u7814\u7a76\u767a\u8868\u306e\u6301\u3064\u610f\u5473\u306f\u5927\u304d\u3044\u3060\u308d\u3046\u3002\u80ba\u304c\u3093\u3084\u4e73\u764c\u3001\u524d\u7acb\u817a\u304c\u3093\u306a\u3069\u306e\u591a\u304f\u306e\u4eba\u3005\u3068\u95a2\u9023\u3059\u308b\u304c\u3093\u304c\u5b9f\u306f\uff24\uff2e\uff21\u30b3\u30d4\u30fc\u306e\u9593\u9055\u3044\u304b\u3089\u8d77\u304d\u3066\u3044\u3066\u74b0\u5883\u3084\u907a\u4f1d\u304c\u95a2\u4fc2\u306a\u3044\u3068\u3057\u305f\u3089\u3069\u3046\u3059\u308b\u3060\u308d\u3046 [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[16],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts\/2742"}],"collection":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/comments?post=2742"}],"version-history":[{"count":1,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts\/2742\/revisions"}],"predecessor-version":[{"id":2743,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts\/2742\/revisions\/2743"}],"wp:attachment":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/media?parent=2742"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/categories?post=2742"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/tags?post=2742"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}