{"id":2632,"date":"2016-12-01T12:23:55","date_gmt":"2016-12-01T03:23:55","guid":{"rendered":"https:\/\/www.taiyou-clinic.jp\/blog\/?p=2632"},"modified":"2016-12-01T12:23:55","modified_gmt":"2016-12-01T03:23:55","slug":"%e3%83%9e%e3%82%a4%e3%82%af%e3%83%ad-rna-%e3%81%ae%e3%83%90%e3%82%a4%e3%82%aa%e3%83%9e%e3%83%bc%e3%82%ab%e3%83%bc%e3%81%a8%e3%81%97%e3%81%a6%e3%81%ae%e5%bf%9c%e7%94%a8","status":"publish","type":"post","link":"https:\/\/www.taiyou-clinic.jp\/blog\/archives\/2632","title":{"rendered":"\u30de\u30a4\u30af\u30ed RNA \u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u306e\u5fdc\u7528"},"content":{"rendered":"<p>\u30de\u30a4\u30af\u30ed<span> RNA <\/span>\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u306e\u5fdc\u7528<\/p>\n<p><span>\u00a0<\/span><\/p>\n<p>\u30de\u30a4\u30af\u30ed<span>RNA<\/span>\u306f\u4f53\u6db2\u306b\u5fc5\u305a\u542b\u307e\u308c\u3066\u304a\u308a\u3001\u304c\u3093\u306e\u767a\u898b\u306b\u3082\u5f79\u7acb\u3064\u3082\u306e\u3060\u3002\u3053\u306e\u30de\u30a4\u30af\u30ed<span>RNA<\/span>\u306e\u50cd\u304d\u3068\u3057\u3066\u306f\u3001\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u764c\u306e\u767a\u751f\u3092\u6291\u5236\u3057\u3066\u3044\u308b\u3002\u3060\u304b\u3089\u30de\u30a4\u30af\u30ed<span>RNA<\/span>\u304c\u4f53\u5185\u3067\u6e1b\u5c11\u3057\u3066\u3044\u308b\u3068\u764c\u6291\u5236\u907a\u4f1d\u5b50\u306e\u50cd\u304d\u304c\u4f4e\u4e0b\u3057\u3066\u304c\u3093\u304c\u767a\u751f\u3057\u305f\u308a\u3059\u308b\u3002\u8840\u7ba1\u5897\u6b96\u56e0\u5b50\u306e\u6291\u5236\u56e0\u5b50\u304c\u6e1b\u5c11\u3059\u308b\u3068\u8840\u7ba1\u5897\u6b96\u304c\u6d3b\u6027\u5316\u3059\u308b\u3068\u8a00\u3063\u305f\u5177\u5408\u3067\u3042\u308b\u3002<\/p>\n<p>\u7814\u7a76\u3067\u306f\u3053\u308c\u3089\u306e\u30de\u30a4\u30af\u30ed<span>RNA<\/span>\u3092\u6b63\u5e38\u5316\u3059\u308b\u305f\u3081\u306e\u7269\u8cea\u304c\u3042\u308b\u304b\u3069\u3046\u304b\uff1f\u751f\u85ac\u306b\u305d\u306e\u50cd\u304d\u304c\u308b\u304b\u3069\u3046\u304b\u304c\u76db\u3093\u306b\u304a\u3053\u306a\u308f\u308c\u3066\u3044\u308b\u3002\u3064\u307e\u308a\u3001\u30de\u30a4\u30af\u30ed<span>RNA<\/span>\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3059\u308b\u3053\u3068\u3067\u764c\u3092\u6291\u5236\u3057\u3088\u3046\u3068\u3044\u3046\u5275\u85ac\u306e\u767a\u898b\u3067\u3042\u308b\u3002<\/p>\n<p>\u3053\u306e\u907a\u4f1d\u5b50\u3092\u5de6\u53f3\u3059\u308b\u50cd\u304d\u306f\u30a8\u30d4\u30b8\u30a7\u30cd\u30c6\u30a4\u30c3\u30af\u3068\u8a00\u3044\u3001\u3053\u308c\u304b\u3089\u306e\u533b\u5b66\u306e\u5927\u304d\u306a\u30c8\u30ec\u30f3\u30c9\u306b\u306a\u308b\u3060\u308d\u3046\u3002<\/p>\n<p><span>\u00a0<\/span><\/p>\n<p><span>********************************************<\/span><\/p>\n<p><span>http:\/\/www.abcam.co.jp\/epigenetics\/focus-on-mirna-biomarkers-1<\/span><\/p>\n<p>\u30de\u30a4\u30af\u30ed<span> RNA<\/span>\uff08<span>miRNA<\/span>\uff09\u3092\u3055\u307e\u3056\u307e\u306a\u75be\u60a3\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u7528\u3044\u308b\u7814\u7a76\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002<span>miRNA <\/span>\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u306e\u53ef\u80fd\u6027\u3068\u6700\u8fd1\u306e\u77e5\u898b\u3092\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n<p><strong>\u306a\u305c<span> miRNA <\/span><\/strong><strong>\u304c\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u9069\u3057\u3066\u3044\u308b\u306e\u304b\uff1f<\/strong><\/p>\n<p>\u75be\u60a3\u306e\u4e88\u6e2c\u3084\u8a3a\u65ad\u3001\u75c7\u72b6\u306e\u89b3\u5bdf\u306a\u3069\u306e\u6307\u6a19\u3068\u3057\u3066\u5229\u7528\u3055\u308c\u308b\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u306e\u91cd\u8981\u6027\u306f\u6539\u3081\u3066\u8ff0\u3079\u308b\u307e\u3067\u3082\u3042\u308a\u307e\u305b\u3093\u3002\u65e9\u671f\u306e\u8a3a\u65ad\u304c\u6cbb\u7642\u6307\u91dd\u306e\u6c7a\u5b9a\u306b\u91cd\u8981\u306a\u75be\u60a3\u3084\u3001\u73fe\u6642\u70b9\u3067\u8a3a\u65ad\u6cd5\u304c\u78ba\u7acb\u3057\u3066\u3044\u306a\u3044\u75be\u60a3\u306e\u4e2d\u306b\u306f\u9069\u5207\u306a\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u304c\u5b58\u5728\u3057\u306a\u3044\u3082\u306e\u3082\u3042\u308a\u3001\u305d\u3046\u3057\u305f\u75be\u60a3\u3067\u306e\u5fc5\u8981\u6027\u3082\u53eb\u3070\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u8fd1\u5e74\u3001\u5c0f\u5206\u5b50\u975e\u30b3\u30fc\u30c9<span> RNA<\/span>\uff08<span>small noncoding RNA; small ncRNA<\/span>\uff09\u304c\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u6709\u7528\u3067\u3042\u308b\u3068\u306e\u5831\u544a\u304c\u5897\u3048\u3001\u4e16\u754c\u4e2d\u306e\u7814\u7a76\u8005\u304b\u3089\u6ce8\u76ee\u3092\u96c6\u3081\u3066\u3044\u307e\u3059\u3002\u30de\u30a4\u30af\u30ed<span> RNA<\/span>\uff08<span>miRNA<\/span>\uff09\u306b\u304a\u3044\u3066\u3082\u3001\u305d\u306e\u7814\u7a76\u304c\u9032\u3080\u306b\u3064\u308c\u3001\u75be\u60a3\u306b\u3088\u3063\u3066\u56fa\u6709\u306e<span> mRNA <\/span>\u767a\u73fe\u30d1\u30bf\u30fc\u30f3\u793a\u3059\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u304d\u3066\u304a\u308a\u3001<span>miRNA <\/span>\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u306e\u5229\u7528\u306b\u671f\u5f85\u304c\u9ad8\u307e\u3063\u3066\u304d\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u307e\u305f\u8840\u6db2\u3001\u5c3f\u3001\u553e\u6db2\u3068\u3044\u3063\u305f\u3001\u751f\u4f53\u304b\u3089\u306e\u63a1\u53d6\u304c\u5bb9\u6613\u306a\u4f53\u6db2\u4e2d\u306b\u5b89\u5b9a\u3057\u3066\u5b58\u5728\u3057\u3066\u3044\u308b\u3053\u3068\u3082\u3001<span>miRNA <\/span>\u304c\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u9069\u3057\u3066\u3044\u308b\u70b9\u306e\u4e00\u3064\u3067\u3059\u3002\u3053\u306e \uff4d<span>RNA <\/span>\u306f\u73fe\u5728<span> qPCR <\/span>\u3084\u30a2\u30ec\u30a4\u306a\u3069<span><a href=\"http:\/\/www.abcam.co.jp\/kits\/review-of-mirna-assay-methods-qpcr-arrays-and-sequencing\" class=\"broken_link\" rel=\"nofollow\">\u3055\u307e\u3056\u307e\u306a\u65b9\u6cd5<\/a><\/span>\u3067\u306e\u6e2c\u5b9a\u3001\u89e3\u6790\u304c\u8a66\u307f\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><strong>\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u306e<span> miRNA <\/span><\/strong><strong>\u3068\u524d\u7acb\u817a\u764c<\/strong><\/p>\n<p>\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u306e<span> miRNA <\/span>\u306e\u7814\u7a76\u304c\u6700\u3082\u9032\u3093\u3067\u3044\u308b\u306e\u306f\u304c\u3093\u306e\u5206\u91ce\u3067\u3001\u304c\u3093\u306e\u30bf\u30a4\u30d7\u3068<span> miRNA <\/span>\u767a\u73fe\u30d1\u30bf\u30fc\u30f3\u306e\u95a2\u9023\u306b\u3064\u3044\u3066\u306e\u89e3\u6790\u304c\u76db\u3093\u306b\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u304c\u3093\u306e\u8a3a\u65ad\u3001\u6cbb\u7642\u3001\u7d4c\u904e\u89b3\u5bdf\u6cbb\u7642\u306b\u304a\u3044\u3066\u306f\u3001\u304c\u3093\u306e\u30bf\u30a4\u30d7\u3092\u3067\u304d\u308b\u3060\u3051\u65e9\u304f\u5224\u5225\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3068\u306a\u308b\u305f\u3081\u3067\u3059\u3002<\/p>\n<p>\u304c\u3093\u306e\u7a2e\u985e\u306b\u3088\u3063\u3066<span> miRNA <\/span>\u767a\u73fe\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u304c\u56fa\u6709\u306e\u30d1\u30bf\u30fc\u30f3\u3092\u793a\u3059\u3053\u3068\u306f\u3001<span>miRNA <\/span>\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u306e\u6709\u7528\u6027\u306b\u3064\u306a\u304c\u308b\u91cd\u8981\u306a\u767a\u898b\u3067\u3057\u305f\uff08<span><a href=\"http:\/\/www.pnas.org\/content\/105\/30\/10513\" class=\"broken_link\" rel=\"nofollow\">Mitchell <em>et al.<\/em>, 2008<\/a><\/span>\uff09\u3002\u4f8b\u3048\u3070<span> miRNA <\/span>\u304c\u524d\u7acb\u817a\u764c\u306e\u8a3a\u65ad\u306b\u5fdc\u7528\u3067\u304d\u308b\u53ef\u80fd\u6027\u306b\u3064\u3044\u3066\u3001<span>2 <\/span>\u5831\u306e\u8ad6\u6587\u304c\u767a\u8868\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u524d\u7acb\u817a\u764c\u306b\u304a\u3044\u3066\u306f\u816b\u760d\u304c\u3001\u5373\u6642\u306e\u6cbb\u7642\u304c\u5fc5\u8981\u306a\u60aa\u6027\u5ea6\u306e\u9ad8\u3044\u3082\u306e\u3067\u3042\u308b\u304b\u3001\u307e\u305f\u306f\u73fe\u6642\u70b9\u3067\u305d\u306e\u5fc5\u8981\u306f\u306a\u3044\u306e\u304b\u3092\u5224\u65ad\u3059\u308b\u3053\u3068\u306f\u3001\u5f93\u6765\u306e\u65b9\u6cd5\u3067\u306f\u7c21\u5358\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<span>Mihelich <\/span>\u3089\u306f\u524d\u7acb\u817a\u764c\u60a3\u8005\u306e\u8840\u6e05\u3088\u308a<span> miRNA <\/span>\u3092\u63a1\u53d6\u3057\u3066\u89e3\u6790\u3057\u3001<span>14 <\/span>\u7a2e\u985e\u306e<span> miRNA <\/span>\u306e\u767a\u73fe\u30d1\u30bf\u30fc\u30f3\u304c\u3001\u60aa\u6027\u5ea6\u304c\u9ad8\u3044\u816b\u760d\u306e\u60a3\u8005\u3068\u60aa\u6027\u5ea6\u304c\u6bd4\u8f03\u7684\u4f4e\u3044\u816b\u760d\u306e\u60a3\u8005\u3067\u306f\u7570\u306a\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\uff08<span><a href=\"http:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0124245\">Mihelich <em>et al<\/em>. 2015<\/a><\/span>\uff09\u3002\u3053\u308c\u3092\u5229\u7528\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u5373\u6642\u306e\u6cbb\u7642\u304c\u5fc5\u8981\u306e\u306a\u3044\u60a3\u8005\u306b\u5bfe\u3059\u308b\u904e\u5270\u306a\u6cbb\u7642\u3092\u9632\u3050\u3053\u3068\u304c\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u307e\u305f\u524d\u7acb\u817a\u764c\u306b\u3064\u3044\u3066\u306f\u3001<span>miRNA <\/span>\u306e\u89e3\u6790\u304c\u9aa8\u8ee2\u79fb\u306e\u5224\u5b9a\u306b\u6709\u7528\u3068\u306e\u5831\u544a\u3082\u3042\u308a\u307e\u3059\u3002\u524d\u7acb\u817a\u764c\u306e\u9aa8\u3078\u306e\u8ee2\u79fb\u306f\u3088\u304f\u8a8d\u3081\u3089\u308c\u3001\u60a3\u8005\u306e\u751f\u5b58\u7387\u3068\u5bc6\u63a5\u306a\u95a2\u4fc2\u304c\u3042\u308a\u307e\u3059\u3002<span>3 <\/span>\u7a2e\u985e\u306e<span> miRNA<\/span>\u3001<span>miR-15<\/span>\u3001<span>miR-16<\/span>\u3001<span>miR-21 <\/span>\u306e\u91cf\u3068\u524d\u7acb\u817a\u764c\u306e\u9aa8\u3078\u306e\u8ee2\u79fb\u306e\u983b\u5ea6\u304c\u3001\u9ad8\u3044\u95a2\u9023\u6027\u3092\u6301\u3064\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<span><a href=\"http:\/\/www.nature.com\/onc\/journal\/vaop\/ncurrent\/full\/onc2015176a.html\">Bonci <em>et al<\/em>., 2015<\/a><\/span>\uff09\u3002<\/p>\n<p><strong>\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u306e<span> miRNA <\/span><\/strong><strong>\u3068\u80ba\u764c<\/strong><\/p>\n<p><span>miRNA <\/span>\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u306e\u7814\u7a76\u3001\u5fdc\u7528\u304c\u9032\u3093\u3067\u3044\u308b\u764c\u3068\u3057\u3066\u306f\u80ba\u764c\u3082\u3042\u308a\u307e\u3059\u3002\u65e9\u671f\u306e\u691c\u51fa\u304c\u96e3\u3057\u3044\u764c\u306e\u4e00\u3064\u3067\u3042\u308b\u80ba\u764c\u306b\u304a\u3044\u3066\u3001<span>miRNA <\/span>\u3092\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u7528\u3044\u3001\u55ab\u7159\u8005\u306a\u3069\u306e\u80ba\u764c\u4e88\u5099\u8ecd\u304b\u3089\u3001\u672c\u5f53\u306b\u80ba\u764c\u306b\u306a\u308b\u4eba\u3092\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3059\u308b\u3053\u3068\u304c\u8a66\u307f\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u4e00\u3064\u306f<span> Continuous Observation of Smoking Subjects <\/span>\u306e\u80ba\u764c\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u30fb\u30d7\u30ed\u30b0\u30e9\u30e0\u3088\u308a\u53c2\u52a0\u8005\u3092\u52df\u308a\u3001\u8840\u4e2d<span> 13-miRNA <\/span>\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u306e\u6709\u7528\u6027\u3092\u8abf\u3079\u305f\u8a66\u9a13\u3067\u3001\u3053\u3053\u3067\u306f<span> 74.9% <\/span>\u306e\u6b63\u78ba\u6027\u3067\u80ba\u764c\u3092\u767a\u898b\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\uff08<span><a href=\"http:\/\/jnci.oxfordjournals.org\/content\/107\/6\/djv063.short\">Montani <em>et al.<\/em>, 2015<\/a><\/span>\uff09\u3002\u3082\u3046\u4e00\u3064\u306f<span> Multicenter Italian Lung Detection <\/span>\u306e\u4e00\u90e8\u3068\u3057\u3066\u884c\u308f\u308c\u305f\u8a66\u9a13\u3067\u3001\u3053\u3053\u3067\u306f<span> 87% <\/span>\u306e\u611f\u5ea6\u3068<span> 81% <\/span>\u306e\u7279\u7570\u6027\u3067\u80ba\u764c\u3092\u767a\u898b\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\uff08<span><a href=\"http:\/\/jco.ascopubs.org\/content\/32\/8\/768.full\" class=\"broken_link\" rel=\"nofollow\">Sozzi <em>et al<\/em>., 2014<\/a><\/span>\uff09\u3002\u3053\u306e\u3088\u3046\u306a\u6709\u671b\u306a\u7d50\u679c\u304b\u3089\u3001<span>miRNA <\/span>\u3092\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u5229\u7528\u3057\u305f\u80ba\u764c\u306e\u65e9\u671f\u8a3a\u65ad\u306e\u5b9f\u7528\u5316\u306f\u8fd1\u3065\u3044\u3066\u3044\u308b\u3068\u8a00\u3048\u307e\u3059\u3002<\/p>\n<p><strong>\u304c\u3093\u4ee5\u5916\u3078\u306e\u5fdc\u7528<\/strong><\/p>\n<p><span>miRNA <\/span>\u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3078\u306e\u5fdc\u7528\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u308b\u306e\u306f\u3001\u304c\u3093\u3060\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u3055\u307e\u3056\u307e\u306a\u5faa\u74b0\u5668\u75be\u60a3\u3084\u795e\u7d4c\u75be\u60a3\u306b\u304a\u3044\u3066\u3001\u75be\u60a3\u56fa\u6709\u306e\u767a\u73fe\u30d1\u30bf\u30fc\u30f3\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<span><a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eci.12475\/abstract;jsessionid=929F73DB924F3B50E644D7925746CB6B.f02t01\" class=\"broken_link\" rel=\"nofollow\">Min &amp; Chan, 2015<\/a>; <a href=\"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnmol.2013.00039\/abstract\">Rao <em>et al<\/em>., 2013<\/a><\/span>\uff09\u3002<\/p>\n<p>\u7279\u306b\u7814\u7a76\u304c\u76db\u3093\u306b\u884c\u308f\u308c\u3066\u3044\u308b\u75be\u60a3\u306e\u4e00\u3064\u306f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3067\u3059\u3002\u3053\u306e\u75be\u60a3\u306b\u5bfe\u3059\u308b\u4e88\u9632\u6cd5\u3084\u6cbb\u7642\u85ac\u306b\u3064\u3044\u3066\u306f\u3055\u307e\u3056\u307e\u306a\u65b9\u5411\u304b\u3089\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u4e2d\u306e\u5927\u304d\u306a\u30c6\u30fc\u30de\u306e\u4e00\u3064\u306b\u65e9\u671f\u8a3a\u65ad\u6cd5\u306e\u958b\u767a\u304c\u3042\u308a\u307e\u3059\uff08<span><a href=\"http:\/\/www.alzheimersanddementia.com\/article\/S1552-5260%2814%2900066-1\/abstract\" class=\"broken_link\" rel=\"nofollow\">Blennow <em>et al.<\/em>, 2015<\/a>; <a href=\"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2015.00040\/abstract\">Framminella <em>et al.<\/em>, 2015<\/a><\/span>\uff09\u3002\u6700\u8fd1\u306e\u7814\u7a76\u3067\u3001\u8133\u810a\u9ac4\u6db2\uff08<span>CSF<\/span>\uff09\u306b\u304a\u3051\u308b<span> miRNA <\/span>\u306e\u30d1\u30bf\u30fc\u30f3\u304c\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u3068\u5065\u5e38\u8005\u3067\u9055\u3044\u304c\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<span>3 <\/span>\u7a2e\u985e\u306e<span> miRNA <\/span>\u306b\u3064\u3044\u3066\u6bd4\u8f03\u3057\u305f\u3068\u3053\u308d\u3001<span>95.5% <\/span>\u306e\u6b63\u78ba\u6027\u3067\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u3092\u540c\u5b9a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u305f\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\uff08<span><a href=\"http:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0126423\">Denk et al., 2015<\/a><\/span>\uff09\u3002<\/p>\n<p><strong>\u4eca\u5f8c\u306e\u5c55\u671b<\/strong><\/p>\n<p>\u3053\u308c\u307e\u3067\u6319\u3052\u3066\u304d\u305f\u3082\u306e\u4ee5\u5916\u3067\u3082\u3001\u3055\u307e\u3056\u307e\u306a\u75be\u60a3\u306b\u3064\u3044\u3066<span> miRNA <\/span>\u3092\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u5229\u7528\u3059\u308b\u305f\u3081\u306e\u8a66\u307f\u304c\u76db\u3093\u306b\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u7814\u7a76\u3001\u63a2\u7d22\u3092\u9032\u3081\u308b\u306b\u5f53\u305f\u3063\u3066\u306f\u3001\u591a\u7a2e\u985e\u306e<span> miRNA <\/span>\u306b\u3064\u3044\u3066\u591a\u304f\u306e\u30b5\u30f3\u30d7\u30eb\u3092\u540c\u6642\u306b\u6e2c\u5b9a\u3001\u89e3\u6790\u3067\u304d\u308b\u3088\u3046\u306a\u30a2\u30c3\u30bb\u30a4\u7cfb\u3092\u5229\u7528\u3059\u308b\u306e\u304c\u52b9\u7387\u7684\u3067\u3059\u3002<\/p>\n<p>\u30a2\u30d6\u30ab\u30e0\u306e <span><a href=\"http:\/\/www.abcam.co.jp\/nav\/multiplex-mirna-assays\/circulating\" class=\"broken_link\" rel=\"nofollow\">Multiplex Circulating miRNA Assays<\/a> <\/span>\u306f\u3001\u3053\u306e\u3088\u3046\u306a\u7528\u9014\u306b\u6700\u9069\u306a\u30ad\u30c3\u30c8\u3067\u3059\u3002\u8840\u6e05\u3084\u8840\u6f3f\u306a\u3069\u306e\u4f53\u6db2\u30b5\u30f3\u30d7\u30eb\u304b\u3089\u3001<span>RNA <\/span>\u7cbe\u88fd\u3092\u5fc5\u8981\u3068\u305b\u305a\u306b<span> miRNA <\/span>\u3092\u691c\u51fa\u3067\u304d\u308b\u70b9\u3082\u5927\u304d\u306a\u7279\u9577\u3067\u3059\u3002<\/p>\n<ul>\n<li><span><a href=\"http:\/\/www.abcam.co.jp\/kits\/microrna-profiling-directly-from-low-amounts-of-plasma-or-serum-using-the-multiplex-circulating-mirna-assay-with-firefly\" class=\"broken_link\" rel=\"nofollow\"><strong>\u4f53\u6db2\u304b\u3089 RNA <\/strong><strong>\u7cbe\u88fd\u30b9\u30c6\u30c3\u30d7\u7121\u3057\u306b\u30de\u30eb\u30c1\u30d7\u30ec\u30c3\u30af\u30b9 miRNA <\/strong><strong>\u89e3\u6790<\/strong><\/a><\/span><\/li>\n<li><span><a href=\"http:\/\/www.abcam.co.jp\/kits\/firefly-particle-technology\" class=\"broken_link\" rel=\"nofollow\"><strong>1 <\/strong><strong>\u30a6\u30a7\u30eb\u3042\u305f\u308a\u6700\u5927 68 <\/strong><strong>\u7a2e\u985e\u306e miRNA <\/strong><strong>\u89e3\u6790<\/strong><\/a><\/span><\/li>\n<li><span><a href=\"http:\/\/www.abcam.co.jp\/kits\/everything-you-need-to-run-a-multiplex-mirna-assay\" class=\"broken_link\" rel=\"nofollow\"><strong>\u30de\u30eb\u30c1\u30d7\u30ec\u30c3\u30af\u30b9 miRNA <\/strong><strong>\u89e3\u6790\u306b\u5fc5\u8981\u306a\u88fd\u54c1<\/strong><\/a><\/span><\/li>\n<\/ul>\n<p><span>\u00a0<\/span><\/p>\n<p><strong><span>References<\/span><\/strong><\/p>\n<ul>\n<li><span><a href=\"http:\/\/www.alzheimersanddementia.com\/article\/S1552-5260%2814%2900066-1\/abstract\" class=\"broken_link\" rel=\"nofollow\">Blennow K, Dubois, B Fagan AM, Lewczuk P, de Leon MJ, Hampel H (2015). Clinical utility of cerebrospinal fluid biomarkers in the diagnosis of early Alzheimer\u2019s disease. <em>Alzheimers Dement<\/em> 11, 58\u201369.<\/a><\/span><\/li>\n<li><span><a href=\"http:\/\/www.nature.com\/onc\/journal\/vaop\/ncurrent\/full\/onc2015176a.html\">Bonci D, Coppola V, Patrizii M, Addario A, Cannistraci A, Francescangeli F, Pecci R, Muto G, Collura D, Bedini R, Zeuner A, Valtieri M, Sentinelli S, Benassi MS, Gallucci M, Carlini P, Piccolo S, De Maria R (2015). A microRNA code for prostate cancer metastasis [published online ahead of print 15 June, 2015]. <em>Oncogene<\/em>, doi:10.1038\/onc.2015.176.<\/a><\/span><\/li>\n<li><span><a href=\"http:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0126423\">Denk J, Boelmans K, Siegismund C, Lassner D, Arlt S, Jahn H (2015). MicroRNA profiling of CSF reveals potential biomarkers to detect Alzheimer\u2019s disease. <em>PLoS ONE<\/em> 10, e0126423.<\/a><\/span><\/li>\n<li><span><a href=\"http:\/\/journal.frontiersin.org\/article\/10.3389\/fphys.2015.00040\/abstract\">Femminella GD, Ferrara N, Rengo G (2015). The emerging role of microRNAs in Alzheimer\u2019s disease. <em>Front Physiol <\/em>6, 40.<\/a><\/span><\/li>\n<li><span><a href=\"http:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0124245\">Mihelich BL, Maranville JC, Nolley R, Peehl DM, Nonn L (2015). Elevated serum microRNA levels associate with absence of high-grade prostate cancer in a retrospective cohort. <em>PLoS ONE<\/em> 10, e0124245.<\/a><\/span><\/li>\n<li><span> <a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/eci.12475\/abstract;jsessionid=929F73DB924F3B50E644D7925746CB6B.f02t01\" class=\"broken_link\" rel=\"nofollow\">Min PK, Chan SY (2015). The biology of circulating microRNAs in cardiovascular disease. <em>Eur J Clin Invest <\/em>45, 860\u201374.<\/a><\/span><\/li>\n<li><span><a href=\"http:\/\/www.pnas.org\/content\/105\/30\/10513\" class=\"broken_link\" rel=\"nofollow\">Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, Peterson A, Noteboom J, O\u2019Briant KC, Allen A, Lin DW, Urban N, Drescher CW, Knudsen BS, Stirewalt DL, Gentleman R, Vessella RL, Nelson PS, Martin DB, Tewari M (2008). Circulating microRNAs as stable blood-based markers for cancer detection. <em>Proc Natl Acad Sci USA<\/em> 105, 10513\u20138.<\/a><\/span><\/li>\n<li><span><a href=\"http:\/\/jnci.oxfordjournals.org\/content\/107\/6\/djv063.short\">Montani F, Marzi MJ, Dezi F, Dama E, Carletti RM, Bonizzi G, Bertolotti R, Bellomi M, Rampinelli C, Maisonneuve P, Spaggiari L, Veronesi G, Nicassio F, Di Fiore P, Bianchi F (2015). miR-Test: A blood test for lung cancer early detection. <em>J Natl Cancer Inst<\/em> 107.<\/a><\/span><\/li>\n<li><span><a href=\"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnmol.2013.00039\/abstract\">Rao P, Benito E, Fischer A (2013). MicroRNAs as biomarkers for CNS disease. <em>Front Mol Neurosci<\/em> 6, 39.<\/a><\/span><\/li>\n<li><span><a href=\"http:\/\/jco.ascopubs.org\/content\/32\/8\/768.full\" class=\"broken_link\" rel=\"nofollow\">Sozzi G, Boeri M, Rossi M, Verri C, Suatoni P, Bravi F, Roz L, Conte D, Grassi M, Sverzellati N, Marchiano A, Negri E, La Vecchia C, Pastorino U (2014). Clinical utility of a plasma-based miRNA signature classifier within computed tomography lung cancer screening: a correlative MILD trial study. <em>J Clin Oncol<\/em> 32, 768\u2013773.<\/a><\/span><\/li>\n<\/ul>\n<p><span>\u00a0<\/span><\/p>\n<p><span>\u00a0<\/span><\/p>\n<p><span>\u00a0<\/span><\/p>\n<p><span>\u00a0<\/span><\/p>\n<p><span>\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30de\u30a4\u30af\u30ed RNA \u306e\u30d0\u30a4\u30aa\u30de\u30fc\u30ab\u30fc\u3068\u3057\u3066\u306e\u5fdc\u7528 \u00a0 \u30de\u30a4\u30af\u30edRNA\u306f\u4f53\u6db2\u306b\u5fc5\u305a\u542b\u307e\u308c\u3066\u304a\u308a\u3001\u304c\u3093\u306e\u767a\u898b\u306b\u3082\u5f79\u7acb\u3064\u3082\u306e\u3060\u3002\u3053\u306e\u30de\u30a4\u30af\u30edRNA\u306e\u50cd\u304d\u3068\u3057\u3066\u306f\u3001\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u6291\u5236\u3059\u308b\u3053\u3068\u3067\u764c\u306e\u767a\u751f\u3092\u6291\u5236\u3057\u3066\u3044\u308b\u3002\u3060\u304b\u3089\u30de\u30a4\u30af\u30ed [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts\/2632"}],"collection":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/comments?post=2632"}],"version-history":[{"count":1,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts\/2632\/revisions"}],"predecessor-version":[{"id":2633,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts\/2632\/revisions\/2633"}],"wp:attachment":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/media?parent=2632"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/categories?post=2632"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/tags?post=2632"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}