{"id":2298,"date":"2016-02-16T10:30:20","date_gmt":"2016-02-16T01:30:20","guid":{"rendered":"https:\/\/www.taiyou-clinic.jp\/blog\/?p=2298"},"modified":"2016-02-16T10:30:20","modified_gmt":"2016-02-16T01:30:20","slug":"%e3%82%b0%e3%83%ab%e3%82%b3%e3%82%b5%e3%83%9f%e3%83%b3%e3%81%8c%e5%a4%89%e5%bd%a2%e6%80%a7%e8%86%9d%e9%96%a2%e7%af%80%e7%97%87%e3%81%ae%e7%99%ba%e7%97%87%e3%80%81%e9%80%b2%e8%a1%8c%e3%81%ae%e4%ba%88","status":"publish","type":"post","link":"https:\/\/www.taiyou-clinic.jp\/blog\/archives\/2298","title":{"rendered":"\u30b0\u30eb\u30b3\u30b5\u30df\u30f3\u304c\u5909\u5f62\u6027\u819d\u95a2\u7bc0\u75c7\u306e\u767a\u75c7\u3001\u9032\u884c\u306e\u4e88\u9632\u52b9\u679c\u304c\u3042\u308b"},"content":{"rendered":"<p><strong>\u30b0\u30eb\u30b3\u30b5\u30df\u30f3\u304c\u5909\u5f62\u6027\u819d\u95a2\u7bc0\u75c7\u3092\u4e88\u9632\u3059\u308b\uff1a<span>PROOF<\/span><\/strong><strong>\u7814\u7a76<\/strong><\/p>\n<p>\u80a5\u6e80\u5973\u6027\u306b\u9650\u3063\u3066\u306e\u7814\u7a76\u3060\u304c\u5b9f\u969b\u306e\u60a3\u8005\u3055\u3093\u3082\u80a5\u6e80\u5973\u6027\u306b\u7279\u306b\u591a\u3044\u306e\u304c\u7279\u5fb4\u3060\u3002<\/p>\n<p>\u5909\u5f62\u6027\u819d\u95a2\u7bc0\u75c7\u306f\u591a\u304f\u306e\u9ad8\u9f62\u80a5\u6e80\u5973\u6027\u306b\u591a\u3044\u75be\u60a3\u3067\u3042\u308b\u3002<\/p>\n<p>\u30b0\u30eb\u30b3\u30b5\u30df\u30f3\u304c\u75db\u307f\u306b\u52b9\u304f\u3068\u8a00\u3046\u7814\u7a76\u306f\u3042\u3063\u305f\u304c\u3001\u4eca\u56de\u306f\u4e88\u9632\u52b9\u679c\u3067\u3042\u308b\u3002\u3064\u307e\u308a\u767a\u751f\u3068\u4fe1\u4ef0\u3092\u4e88\u9632\u3059\u308b\u50cd\u304d\u304c\u3042\u308b\u3068\u8a00\u3046\u7d50\u8ad6\u3060\u3002<\/p>\n<p><span>*******************************<\/span><\/p>\n<p><span>http:\/\/www.dhcblog.com\/kamohara\/<\/span><\/p>\n<p>\u95a2\u7bc0\u75be\u60a3\u7814\u7a76\u306e\u5c02\u9580\u30b8\u30e3\u30fc\u30ca\u30eb<span>(<\/span>\u96fb\u5b50\u7248<span>)<\/span>\u306b\u3001\u80a5\u6e80\u5973\u6027\u306b\u304a\u3044\u3066\u3001\u30b0\u30eb\u30b3\u30b5\u30df\u30f3\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u6295\u4e0e\u306b\u3088\u308b\u5909\u5f62\u6027\u819d\u95a2\u7bc0\u75c7\u30ea\u30b9\u30af\u4f4e\u6e1b<span>(<\/span>\u4e88\u9632<span>)<\/span>\u52b9\u679c\u3092\u793a\u3057\u305f\u81e8\u5e8a\u7814\u7a76\u304c\u3001\u6b27\u5dde<span>(<\/span>\u30aa\u30e9\u30f3\u30c0\u30fb\u30d9\u30eb\u30ae\u30fc\u30fb\u30a4\u30bf\u30ea\u30a2<span>)<\/span>\u306e\u30b0\u30eb\u30fc\u30d7\u304b\u3089\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002<span> (<em>Semin Arthritis Rheum<\/em>. 2015 Nov 19.) <\/span><\/p>\n<p>&nbsp;<\/p>\n<p>\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u30b0\u30eb\u30b3\u30b5\u30df\u30f3\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306b\u3088\u308b\u80a5\u6e80\u5973\u6027\u3067\u306e\u5909\u5f62\u6027\u819d\u95a2\u7bc0\u75c7\u306e\u4e88\u9632\u52b9\u679c\u304c\u691c\u8a3c\u3055\u308c\u307e\u3057\u305f\u3002<span> (PROOF<\/span>\u7814\u7a76\u306e\u4e00\u74b0\u3067\u3059\u3002<span>) (PRevention of knee Osteoarthritis in Overweight Females study) <\/span>\u5177\u4f53\u7684\u306b\u306f\u3001<span> BMI27<\/span>\u4ee5\u4e0a\u306e\u80a5\u6e80\u5973\u6027<span>407<\/span>\u540d<span>(50-60<\/span>\u6b73<span>)<\/span>\u3092\u5bfe\u8c61\u306b\u3001<span> (<\/span>\u5909\u5f62\u6027\u819d\u95a2\u7bc0\u75c7\u3068\u8a3a\u65ad\u3055\u308c\u3066\u3044\u306a\u3044\u5065\u5e38\u8005\u306e\u80a5\u6e80\u5973\u6027\u304c\u5bfe\u8c61\u3067\u3059<span>) <\/span><\/p>\n<p><span>(1) <\/span>\u5bfe\u7167\u7fa4<span>102<\/span>\u540d<span>(<\/span>\u98df\u4e8b\u904b\u52d5\u306e\u6307\u5c0e\u306f\u306a\u304f\u3001\u507d\u85ac\u6295\u4e0e<span>) (2) <\/span>\u30c6\u30a4\u30e9\u30fc\u30e1\u30a4\u30c9\u306e\u98df\u4e8b\u3068\u904b\u52d5\u7642\u6cd5<span>+<\/span>\u507d\u85ac\u6295\u4e0e\u7fa4\uff1a<span>101<\/span>\u540d\u3001<span> (3) <\/span>\u30b0\u30eb\u30b3\u30b5\u30df\u30f3\u786b\u9178\u5869\u6295\u4e0e<span>+<\/span>\u98df\u4e8b\u904b\u52d5\u975e\u4ecb\u5165\u7fa4\uff1a<span>102<\/span>\u540d<span> (4) <\/span>\u30b0\u30eb\u30b3\u30b5\u30df\u30f3\u786b\u9178\u5869\u6295\u4e0e<span>+<\/span>\u30c6\u30a4\u30e9\u30fc\u30e1\u30a4\u30c9\u306e\u98df\u4e8b\u3068\u904b\u52d5\u7642\u6cd5\u5b9f\u65bd\u7fa4\uff1a<span>102<\/span>\u540d \u306e<span>4<\/span>\u7fa4\u306b\u3064\u3044\u3066\u3001<span>2.5<\/span>\u5e74\u9593\u306e\u30d5\u30a9\u30ed\u30fc\u30a2\u30c3\u30d7\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u3002 \u30a2\u30a6\u30c8\u30ab\u30e0\u3068\u3057\u3066\u3001 \u819d\u95a2\u7bc0\u306e\u6a19\u6e96\u64ae\u5f71\u304c\u4ecb\u5165\u524d\u5f8c\u3067\u6e2c\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<span> (MTP view) <\/span><\/p>\n<p>\u30b0\u30eb\u30b3\u30b5\u30df\u30f3\u6295\u4e0e\u7fa4\u306f\u3001 \u30b0\u30eb\u30b3\u30b5\u30df\u30f3\u786b\u9178\u5869\u3068\u3057\u3066<span>1<\/span>\u65e5\u3042\u305f\u308a<span>1500mg<\/span>\u304c<span>1<\/span>\u56de\u6295\u4e0e\u3055\u308c\u307e\u3057\u305f\u3002<span> (<\/span>\u507d\u85ac\u3068\u306e\u4e8c\u91cd\u76f2\u691c\u8a66\u9a13\u3067\u3059\u3002<span>) <\/span>\u819d<span>OA(<\/span>\u5909\u5f62\u6027\u819d\u95a2\u7bc0\u75c7<span>)<\/span>\u306e\u767a\u75c7\u306f\u3001\u95a2\u7bc0\u9593\u9699\u72ed\u5c0f\u5316<span>(&amp;#8805;1mm)<\/span>\u306b\u3066\u5224\u65ad\u3055\u308c\u3066\u3044\u307e\u3059\u3002 \u89e3\u6790\u306e\u7d50\u679c\u3001<span> 2.5<\/span>\u5e74\u5f8c\u306b\u3001 \u5bfe\u7167\u7fa4\u3067\u306f\u3001<span>11.8%<\/span>\u306e\u88ab\u9a13\u8005\u304c\u819d<span>OA<\/span>\u3068\u8a3a\u65ad\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u30b0\u30eb\u30b3\u30b5\u30df\u30f3\u6295\u4e0e\u306e<span>2<\/span>\u3064\u306e\u7fa4\u3067\u306f\u3001\u98df\u4e8b\u7642\u6cd5\u3068\u306e\u4f75\u7528\u306e\u6709\u7121\u306b\u95a2\u308f\u3089\u305a\u3001 \u819d<span>OA<\/span>\u767a\u75c7\u7387\u306e\u4f4e\u6e1b<span>(<\/span>\u4e88\u9632\u52b9\u679c<span>)<\/span>\u304c\u898b\u51fa\u3055\u308c\u3066\u3044\u307e\u3059\u3002 \u30c6\u30a4\u30e9\u30fc\u30e1\u30a4\u30c9\u306e\u98df\u4e8b\u904b\u52d5\u7642\u6cd5\u306e\u307f\u306e\u7fa4\u3067\u306f\u3001\u30ea\u30b9\u30af\u4f4e\u6e1b\u52b9\u679c\u306f\u793a\u3055\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<p>\u6b21\u306b\u3001 \u30b0\u30eb\u30b3\u30b5\u30df\u30f3\u306e\u6295\u4e0e\u7fa4<span>(204<\/span>\u540d<span>)<\/span>\u3068\u3001\u975e\u6295\u4e0e\u7fa4<span>(203<\/span>\u540d<span>)<\/span>\u306e\u6bd4\u8f03\u3067\u306f\u3001 \u30b0\u30eb\u30b3\u30b5\u30df\u30f3\u6295\u4e0e\u306b\u3088\u308a\u819d<span>OA<\/span>\u306e\u767a\u75c7\u30ea\u30b9\u30af\u304c<span>59<\/span>\uff05\u6709\u610f\u306b\u4f4e\u4e0b\u3057\u3066\u3044\u307e\u3057\u305f\u3002<span> (<\/span>\u95a2\u7bc0\u9593\u9699\u306b\u3088\u308b\u8a55\u4fa1\uff1a<span>OR = 0.41, 95% CI: 0.20-0.85, P = 0.02) <\/span>\u306a\u304a\u3001 \u30c6\u30a4\u30e9\u30fc\u30e1\u30a4\u30c9\u306e\u98df\u4e8b\u3068\u904b\u52d5\u7642\u6cd5\u5b9f\u65bd\u7fa4<span>203<\/span>\u540d\u3068\u3001\u975e\u5b9f\u65bd\u7fa4<span>204<\/span>\u540d\u306e\u6bd4\u8f03\u3067\u306f\u6709\u610f\u3055\u306f\u8a8d\u3081\u3089\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n<p>\u4ee5\u4e0a\u306e\u30c7\u30fc\u30bf\u304b\u3089\u3001 \u4e2d\u9ad8\u5e74\u306e\u80a5\u6e80\u5973\u6027\u306b\u304a\u3044\u3066\u3001 \u30b0\u30eb\u30b3\u30b5\u30df\u30f3\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8<span>(<\/span>\u786b\u9178\u5869<span>1500mg\/<\/span>\u65e5<span>)<\/span>\u306e<span>2<\/span>\u5e74\u534a\u306e\u6295\u4e0e\u306b\u3088\u308a\u3001 \u5909\u5f62\u6027\u819d\u95a2\u7bc0\u75c7\u306e\u65b0\u898f\u767a\u75c7\u30ea\u30b9\u30af\u4f4e\u6e1b\u52b9\u679c\u304c\u793a\u5506\u3055\u308c\u307e\u3059\u3002 \u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001<span>mJSN<\/span>\u95a2\u7bc0\u9593\u9699\u304c\u6307\u6a19\u3068\u306a\u3063\u3066\u304a\u308a\u3001\u5ba2\u89b3\u6027\u304c\u62c5\u4fdd\u3055\u308c\u3066\u3044\u307e\u3059\u3002 \u307e\u305f\u3001\u98df\u4e8b\u3068\u904b\u52d5\u306e\u4ecb\u5165\u7fa4\u3067\u306f\u3001\u6709\u610f\u306a\u4e88\u9632\u52b9\u679c\u306f\u898b\u51fa\u3055\u308c\u3066\u304a\u3089\u305a\u3001\u6e1b\u91cf\u306e\u6709\u7528\u6027\u304c\u671f\u5f85\u3088\u308a\u3082\u5927\u304d\u304f\u306a\u304b\u3063\u305f\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002 \u3053\u308c\u307e\u3067\u3001\u30b0\u30eb\u30b3\u30b5\u30df\u30f3\u306f\u6709\u75c5\u8005\u3078\u306e\u4ecb\u5165\u306b\u3088\u308b\u6709\u52b9\u6027\u3092\u793a\u3057\u305f\u30c7\u30fc\u30bf\u304c\u591a\u304b\u3063\u305f\u306e\u3067\u3059\u304c\u3001\u4eca\u56de\u306f\u3001\u4e88\u9632\u7684\u306a\u610f\u7fa9\u3092\u793a\u3057\u305f\u3053\u3068\u306b\u610f\u7fa9\u304c\u3042\u308b\u3068\u8003\u3048\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30b0\u30eb\u30b3\u30b5\u30df\u30f3\u304c\u5909\u5f62\u6027\u819d\u95a2\u7bc0\u75c7\u3092\u4e88\u9632\u3059\u308b\uff1aPROOF\u7814\u7a76 \u80a5\u6e80\u5973\u6027\u306b\u9650\u3063\u3066\u306e\u7814\u7a76\u3060\u304c\u5b9f\u969b\u306e\u60a3\u8005\u3055\u3093\u3082\u80a5\u6e80\u5973\u6027\u306b\u7279\u306b\u591a\u3044\u306e\u304c\u7279\u5fb4\u3060\u3002 \u5909\u5f62\u6027\u819d\u95a2\u7bc0\u75c7\u306f\u591a\u304f\u306e\u9ad8\u9f62\u80a5\u6e80\u5973\u6027\u306b\u591a\u3044\u75be\u60a3\u3067\u3042\u308b\u3002 \u30b0\u30eb\u30b3\u30b5\u30df\u30f3\u304c\u75db\u307f\u306b\u52b9\u304f\u3068\u8a00\u3046\u7814\u7a76\u306f [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[4,17],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts\/2298"}],"collection":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/comments?post=2298"}],"version-history":[{"count":1,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts\/2298\/revisions"}],"predecessor-version":[{"id":2299,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts\/2298\/revisions\/2299"}],"wp:attachment":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/media?parent=2298"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/categories?post=2298"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/tags?post=2298"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}