{"id":2273,"date":"2015-12-28T17:39:36","date_gmt":"2015-12-28T08:39:36","guid":{"rendered":"https:\/\/www.taiyou-clinic.jp\/blog\/?p=2273"},"modified":"2015-12-28T17:39:36","modified_gmt":"2015-12-28T08:39:36","slug":"%e7%99%8c%e3%81%ab%e3%81%aa%e3%81%a3%e3%81%9f%ef%bc%9f%e7%a8%ae%e3%82%92%e9%a3%9f%e3%81%b9%e3%81%aa%e3%81%95%e3%81%84","status":"publish","type":"post","link":"https:\/\/www.taiyou-clinic.jp\/blog\/archives\/2273","title":{"rendered":"\u764c\u306b\u306a\u3063\u305f\uff1f\u7a2e\u3092\u98df\u3079\u306a\u3055\u3044"},"content":{"rendered":"

\u30d6\u30c9\u30a6\u306e\u7a2e\u3001\uff5e\u30d9\u30ea\u30fc\u306e\u7a2e\u5b50\u304c\u304c\u3093\u7d30\u80de\u3092\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\uff08\u81ea\u7136\u6b7b\uff09\u306b\u307f\u3061\u3073\u304f\u3053\u3068\u306f\u6709\u540d\u3067\u3042\u308b\u3002\u4ee5\u4e0b\u306e\u533b\u5b66\u96d1\u8a8c\u306b\u8ad6\u6587\u304c\u8f09\u3063\u3066\u3044\u308b\u306e\u3067\u53c2\u7167\u3055\u308c\u305f\u3044\u3002<\/p>\n

Induction of Apoptosis in Human Leukemia Cells by Grape Seed Extract Occurs via Activation of JNK<\/strong><\/p>\n

Ning Gao<\/a>,1,2\u00a0Amit Budhraja<\/a>,2\u00a0Senping Cheng<\/a>,2\u00a0Hua Yao<\/a>,2\u00a0Zhuo Zhang<\/a>,2\u00a0and\u00a0\u00a0Xianglin Shi<\/a>2<\/p>\n

The publisher\u2019s final edited version of this article is available free at\u00a0Clin Cancer Res<\/a><\/p>\n

\u00a0<\/span><\/p>\n

****************************************************<\/span><\/p>\n

MD <\/span>\u30a6\u30a4\u30fc\u30af\u30b9\u30d6\u30e9\u30c3\u30c9\u30d5\u30a9\u30fc\u30c9\u306b\u3088\u3063\u3066 2015 <\/span>\u5e74 12 <\/span>\u6708 21 <\/span>\u65e5\u306b\u63b2\u793a\u3055\u308c\u308b |0 <\/span>\u4ef6\u306e\u30b3\u30e1\u30f3\u30c8<\/p>\n

\u30a6\u30a4\u30fc\u30af\u30b9\u535a\u58eb\u30b3\u30e1\u30f3\u30c8:<\/span><\/p>\n

\u30d6\u30c9\u30a6\u7a2e\u5b50\u62bd\u51fa\u7269\u306b\u3088\u308b\u3072\u3068\u767d\u8840\u75c5\u7d30\u80de\u306e\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306e\u8a98\u5c0e\u306e\u4e0b\u62bd\u8c61\u5316\u3053\u306e\u8a18\u4e8b\u306f\u307e\u3060\u975e\u6bd2\u6027\u9ad8\u5ea6\u6cbb\u7642\u81ea\u7136\u30aa\u30d7\u30b7\u30e7\u30f3\u3067\u306e\u304c\u3093\u306e\u5bfe\u51e6\u65b9\u6cd5\u306e\u5225\u306e\u4f8b\u3067\u3059\u3002\u6559\u3048\u3066\u304f\u3060\u3055\u3044: <\/span>\u306a\u305c\u3042\u306a\u305f\u306e\u764c\u5c02\u9580\u533b\u6559\u3048\u3066\u304f\u308c\u306a\u3044\u3053\u306e\u300ccentisble<\/span>\u300d(<\/span>\u5b89\u5168\u306a\u3001\u52b9\u679c\u7684\u304b\u3064\u30b3\u30b9\u30c8\u52b9\u679c\u7684\u306a) <\/span>\u6cbb\u7642\u306b\u3064\u3044\u3066?<\/span>\u5f7c\u307e\u305f\u306f\u5f7c\u5973\u306e\u30bd\u30a6\u30eb\uff08\u5546\u54c1\u540d\uff09\u306b\u3064\u3044\u3066\u77e5\u3063\u3066\u3044\u308b\u304c\u3001\u304c\u3093\u3068\u306e\u6226\u3044\u306b\u5f37\u529b\u306a\u30a8\u30a4\u30ba\u3068\u3068\u3082\u306b\u9b42\u306f\u3001\u30d6\u30c9\u30a6\u7a2e\u5b50\u62bd\u51fa\u7269: <\/span>\u30d6\u30e9\u30c3\u30af \u30af\u30df\u30f3\u306e\u7a2e\u5b50\u3068\u9ed2\u30e9\u30ba\u30d9\u30ea\u30fc\u7a2e\u5b50?<\/span><\/p>\n

\u00a0<\/span><\/p>\n

\u81e8\u5e8a\u764c\u7814\u7a76 2009<\/span>\u5e74 1 <\/span>\u6708 1 <\/span>\u65e5;15 (1): 140-149<\/span>\u3002<\/p>\n

\u8981\u7d04\u3067\u306fJNK <\/span>\u306e\u6d3b\u6027\u5316\u3092\u4ecb\u3057\u3066\u767a\u751f\u3059\u308b\u30d6\u30c9\u30a6\u7a2e\u5b50\u62bd\u51fa\u7269\u306b\u3088\u308b\u3072\u3068\u767d\u8840\u75c5\u7d30\u80de\u306b\u304a\u3051\u308b\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\u306e\u8a98\u5c0e\u306b\u3064\u3044\u3066\u8ff0\u3079\u3066\u3044\u308b\u30fb\u30fb\u30fb\u30fb<\/p>\n

Cip1\/p21<\/span>\u3068JNK<\/span>\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u304c\u4eba\u9593\u306e\u767d\u8840\u75c5\u7d30\u80de\u3067GSE<\/span>\u306b\u3088\u3063\u3066\u8a98\u767a\u3055\u308c\u305f\u30a2\u30dd\u30d7\u30c8\u30fc\u30b7\u30b9\u306b\u9b45\u529b\u7684\u306a\u76ee\u6a19\u3092\u610f\u5473\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u3092\u793a\u5506\u3059\u308b\u3002<\/p>\n

\u672c\u7814\u7a76\u306e\u7d50\u679c\u306b\u306f\u3001\u767d\u8840\u75c5\u3068\u304a\u305d\u3089\u304f\u4ed6\u306e\u8840\u6db2\u5b66\u7684\u306amalignancies<\/span>\u2026\u201d\u306b\u5bfe\u3059\u308b\u5316\u5b66\u7684\u4e88\u9632\u3067\u3042\u308b\u304b\u6cbb\u7642\u7684\u306a\u5e72\u6e09\u306b\u3001GSE<\/span>\u306e\u3088\u3046\u306a\u85ac\u5264\u306e\u7de8\u5165\u3078\u306e\u542b\u307f\u304c\u3042\u308b\u3053\u3068\u304c\u3067\u304d\u305f<\/p>\n

*********************************************<\/span><\/p>\n

Got Cancer? Eat the Seeds<\/p>\n

Posted on December 21, 2015 by Bradford S. Weeks, MD<\/a> | 0 Comments<\/a><\/p>\n

Dr. Weeks\u2019 Comment: \u00a0This article abstracted below \u00a0Induction of Apoptosis in Human Leukemia Cells by Grape Seed Extract<\/a>\u00a0 is yet another example of how cancer can be addressed with non-toxic highly therapeutic natural options. Tell me: \u00a0why does your oncologist not tell you about this \u201ccentisble\u201d (safe, effective and cost- effective) remedy? Does he or she know about SOUL and that grape seed extract is in SOUL<\/a> along with the powerful aids in the fight against cancer: black cumin seed<\/a> and black raspberry seed<\/a>?<\/p>\n

Clin Cancer Res. 2009 Jan 1; 15(1): 140\u2013149.\u00a0<\/a><\/p>\n

Induction of Apoptosis in Human Leukemia Cells by Grape Seed Extract Occurs via Activation of JNK<\/strong><\/p>\n

Ning Gao<\/a>,1,2\u00a0Amit Budhraja<\/a>,2\u00a0Senping Cheng<\/a>,2\u00a0Hua Yao<\/a>,2\u00a0Zhuo Zhang<\/a>,2\u00a0and\u00a0\u00a0Xianglin Shi<\/a>2<\/p>\n

The publisher\u2019s final edited version of this article is available free at\u00a0Clin Cancer Res<\/a><\/p>\n

Purpose:<\/strong><\/p>\n

To characterize the functional role of JNK and other apoptotic pathways in grape seed extract (GSE)-induced apoptosis in human leukemia cells by using pharmacologic and genetic approaches.<\/p>\n

\u201c\u2026.In summary, the present study has provided evidence that grape seed extract (GSE) induces human leukemia cell death with the activation of caspases-3, -8, and -9 as well as PARP cleavage, and that GSE-induced apoptosis is proceeded by the activation of JNK and thus up-regulation of Cip1\/p21. The data presented here suggest that Cip1\/p21 and JNK signaling pathway may represent attractive targets to GSE-induced apoptosis in human leukemia cells. The results of this study could have implications for the incorporation of agents such as GSE into the chemopreventive or therapeutic intervention against leukemia and possibly other hematologic malignancies<\/u>\u2026\u201d<\/em><\/strong><\/p>\n

\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

\u30d6\u30c9\u30a6\u306e\u7a2e\u3001\uff5e\u30d9\u30ea\u30fc\u306e\u7a2e\u5b50\u304c\u304c\u3093\u7d30\u80de\u3092\u30a2\u30dd\u30c8\u30fc\u30b7\u30b9\uff08\u81ea\u7136\u6b7b\uff09\u306b\u307f\u3061\u3073\u304f\u3053\u3068\u306f\u6709\u540d\u3067\u3042\u308b\u3002\u4ee5\u4e0b\u306e\u533b\u5b66\u96d1\u8a8c\u306b\u8ad6\u6587\u304c\u8f09\u3063\u3066\u3044\u308b\u306e\u3067\u53c2\u7167\u3055\u308c\u305f\u3044\u3002 Induction of Apoptosis in Human Leukemia […]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[12],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts\/2273"}],"collection":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/comments?post=2273"}],"version-history":[{"count":2,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts\/2273\/revisions"}],"predecessor-version":[{"id":2275,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts\/2273\/revisions\/2275"}],"wp:attachment":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/media?parent=2273"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/categories?post=2273"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/tags?post=2273"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}