{"id":1721,"date":"2013-12-06T14:51:38","date_gmt":"2013-12-06T05:51:38","guid":{"rendered":"https:\/\/www.taiyou-clinic.jp\/blog\/?p=1721"},"modified":"2013-12-06T14:51:38","modified_gmt":"2013-12-06T05:51:38","slug":"%e3%82%a2%e3%83%b3%e3%83%88%e3%82%b7%e3%82%a2%e3%83%8b%e3%83%b3%e3%81%ab%e3%82%88%e3%82%8b%e8%84%82%e8%b3%aa%e4%bb%a3%e8%ac%9d%e6%94%b9%e5%96%84%e4%bd%9c%e7%94%a8%e3%80%80","status":"publish","type":"post","link":"https:\/\/www.taiyou-clinic.jp\/blog\/archives\/1721","title":{"rendered":"\u30a2\u30f3\u30c8\u30b7\u30a2\u30cb\u30f3\u306b\u3088\u308b\u8102\u8cea\u4ee3\u8b1d\u6539\u5584\u4f5c\u7528\u3000"},"content":{"rendered":"

\u30a2\u30f3\u30c8\u30b7\u30a2\u30cb\u30f3\u306b\u306f\u3055\u307e\u3056\u307e\u306a\u85ac\u7406\u52b9\u679c\u304c\u3042\u308b\u3088\u3046\u3060\u3002\u4eca\u56de\u306f\u8102\u8cea\u4ee3\u8b1d\u306e\u6539\u5584\u3067\u3042\u308b\u3002<\/p>\n

\u305d\u306e\u307b\u304b\u306b\u306f<\/p>\n

\u8840\u7ba1\u6a5f\u80fd\u6539\u5584\u52b9\u679c\u3084\uff12\u578b\u7cd6\u5c3f\u75c5\u306e\u30ea\u30b9\u30af\u4f4e\u4e0b\u4f5c\u7528\u3001\u5fc3\u7b4b\u4fdd\u8b77\u4f5c\u7528\u3001\u6297\u708e\u75c7\u4f5c\u7528\u306a\u3069\u3067\u3042\u308b\u3002<\/p>\n

\u4eca\u56de\u306f\u8102\u8cea\u4ee3\u8b1d\u6539\u5584\u306b\u95a2\u3059\u308b\u65b0\u305f\u306a\u77e5\u898b\u304c\u51fa\u3066\u304d\u305f\u3088\u3046\u3060\u3002<\/p>\n

\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a<\/p>\n

http:\/\/www.dhcblog.com\/kamohara\/<\/p>\n

\u81e8\u5e8a\u5185\u5206\u6ccc\u4ee3\u8b1d\u5b66\u306e\u5c02\u9580\u30b8\u30e3\u30fc\u30ca\u30eb(\u96fb\u5b50\u7248)\u306b\u3001\u30a2\u30f3\u30c8\u30b7\u30a2\u30cb\u30f3\u306b\u3088\u308b\u8102\u8cea\u4ee3\u8b1d\u6539\u5584\u4f5c\u7528\u3092\u793a\u3057\u305f\u81e8\u5e8a\u7814\u7a76\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002
\n(J Clin Endocrinol Metab.<\/i> 2013 Nov 27)<\/p>\n

\u30a2\u30f3\u30c8\u30b7\u30a2\u30cb\u30f3\u306f\u3001\u690d\u7269\u306b\u5b58\u5728\u3059\u308b\u6a5f\u80fd\u6027\u98df\u54c1\u6210\u5206\u30fb\u30d5\u30a1\u30a4\u30c8\u30b1\u30df\u30ab\u30eb\u985e\u306e1\u7a2e\u3067\u3059\u3002
\n\u8d64\u7d2b\u8272\u306e\u8272\u7d20\u3067\u3042\u308a\u3001\u690d\u7269\u304c\u81ea\u3089\u3092\u7d2b\u5916\u7dda\u3084\u9178\u5316\u969c\u5bb3\u3001\u5bb3\u866b\u306a\u3069\u304b\u3089\u5b88\u308b\u305f\u3081\u306b\u7523\u751f\u3057\u3066\u304a\u308a\u3001\u6297\u9178\u5316\u4f5c\u7528\u3084\u6297\u708e\u75c7\u4f5c\u7528\u3092\u6709\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u30d6\u30eb\u30fc\u30d9\u30ea\u30fc\/\u30d3\u30eb\u30d9\u30ea\u30fc\u306e\u30a2\u30f3\u30c8\u30b7\u30a2\u30cb\u30f3\u304c\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8<\/a>\u3068\u3057\u3066\u5e83\u304f\u5229\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002
\n\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u30a2\u30f3\u30c8\u30b7\u30a2\u30cb\u30f3\u306b\u3088\u308b\u8102\u8cea\u4ee3\u8b1d\u3078\u306e\u5f71\u97ff\u304a\u3088\u3073\u30d1\u30e9\u30aa\u30ad\u30bd\u30ca\u30fc\u30bc(Paraoxonase 1; PON1)\u3078\u306e\u4f5c\u7528\u304c\u691c\u8a3c\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

(\u30d1\u30e9\u30aa\u30ad\u30bd\u30ca\u30fc\u30bc: PON-1\u306f\u3001\u8840\u6db2\u4e2d\u306b\u3066HDL\u306e \u30a2\u30dd\u30ea\u30dd\u86cb\u767dA1\u306b\u7d50\u5408\u3057\u3066\u5b58\u5728\u3057\u3001\u30ea\u30dd\u86cb\u767d\u306e\u9178\u5316\u4fdd\u8b77\u4f5c\u7528\u3092\u793a\u3059\u6297\u9178\u5316\u9175\u7d20\u306e\u4e00\u3064\u3067\u3059\u3002
\n\u52d5\u8108\u786c\u5316\u3084\u751f\u6d3b\u7fd2\u6163\u75c5\u3068\u306e\u95a2\u9023\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u8102\u8cea\u7570\u5e38\u75c7\u3067\u306f\u8840\u6e05PON-1\u6d3b\u6027\u306f\u4f4e\u5024\u3092\u793a\u3057\u307e\u3059\u3002)<\/p>\n

\u5177\u4f53\u7684\u306b\u306f\u3001\u8102\u8cea\u7570\u5e38\u75c7\u60a3\u8005122\u540d\u3092\u5bfe\u8c61\u306b\u3001\u30fb\u30a2\u30f3\u30c8\u30b7\u30a2\u30cb\u30f3\u6295\u4e0e\u7fa4(320mg\u3001\u52062)\u30fb\u507d\u85ac\u6295\u4e0e\u7fa4
\n\u306e2\u7fa4(\u5404\u7fa4n = 61)\u306b\u3064\u3044\u306624\u9031\u9593\u306e\u4ecb\u5165\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u3002
\n(\u4e8c\u91cd\u76f2\u691c\u30e9\u30f3\u30c0\u30e0\u5316\u507d\u85ac\u5bfe\u7167\u8a66\u9a13\u3068\u3057\u3066\u5b9f\u65bd\u3002)<\/p>\n

\u89e3\u6790\u306e\u7d50\u679c\u3001\u507d\u85ac\u7fa4\u306b\u6bd4\u3079\u3066\u3001\u30a2\u30f3\u30c8\u30b7\u30a2\u30cb\u30f3\u6295\u4e0e\u306b\u3088\u3063\u3066\u3001HDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u6709\u610f\u306a\u5897\u52a0(P < 0.018)\u3001LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u306e\u6709\u610f\u306a\u4f4e\u4e0b(P<0.001)\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n

\u30a2\u30f3\u30c8\u30b7\u30a2\u30cb\u30f3\u6295\u4e0e\u7fa4\u3067\u306f\u3001\u507d\u85ac\u7fa4\u306b\u6bd4\u3079\u3066\u3001HDL-PON1 \u6d3b\u6027\u306e\u6709\u610f\u306a\u4ea2\u9032\u3082\u898b\u51fa\u3055\u308c\u3066\u3044\u307e\u3059\u3002
\n(P<0.001)<\/p>\n

\u307e\u305f\u3001HDL\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5f15\u304d\u629c\u304d\u80fd (cholesterol efflux capacity\u3001\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u6392\u51fa\u80fd)\u306f\u3001
\n\u507d\u85ac\u7fa4\u306b\u6bd4\u3079\u3066\u3001
\n\u30a2\u30f3\u30c8\u30b7\u30a2\u30cb\u30f3\u7fa4\u6295\u4e0e\u7fa4\u306b\u304a\u3044\u3066\u6709\u610f\u306a\u4ea2\u9032\u3092\u8a8d\u3081\u3066\u3044\u307e\u3059\u3002(0.2% increase) (P<0.001)<\/p>\n

\u3055\u3089\u306b\u3001\u30a2\u30f3\u30c8\u30b7\u30a2\u30cb\u30f3\u7fa4\u3067\u306f\u3001HDL\u5024\u3084\u30a2\u30dd\u30ea\u30dd\u30bf\u30f3\u30d1\u30af\u8ceaA1\u3067\u88dc\u6b63\u5f8c\u3067\u3082\u3001
\nHDL-PON1\u6d3b\u6027\u306e\u4ea2\u9032\u3068\u3001HDL\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5f15\u304d\u629c\u304d\u80fd\u306e\u5897\u52a0\u3068\u306e\u9593\u306b\u6709\u610f\u306a\u76f8\u95a2\u304c\u898b\u51fa\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

\u305d\u306e\u4ed6\u3001\u30a2\u30f3\u30c8\u30b7\u30a2\u30cb\u30f3\u7fa4\u3067\u306f\u3001HDL-PON1\u6d3b\u6027\u306e\u963b\u5bb3\u306b\u3088\u3063\u3066\u3001HDL\u306e\u6297\u9178\u5316\u80fd\u306e\u6291\u5236\u3001
\nHDL\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5f15\u304d\u629c\u304d\u80fd\u306e\u6291\u5236\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u4ee5\u4e0a\u306e\u30c7\u30fc\u30bf\u304b\u3089\u3001\u8102\u8cea\u7570\u5e38\u75c7\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30a2\u30f3\u30c8\u30b7\u30a2\u30cb\u30f3\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u6295\u4e0e\u306f\u3001
\nHDL- PON1\u6d3b\u6027\u4ea2\u9032\u3092\u4ecb\u3057\u3066\u3001HDL\u306e\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u5f15\u304d\u629c\u304d\u80fd\u306e\u5897\u5927\u306b\u3088\u308a\u3001\u8102\u8cea\u4ee3\u8b1d\u6539\u5584\u4f5c\u7528\u3092\u3082\u305f\u3089\u3059\u3001\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n

\u8102\u8cea\u7570\u5e38\u75c7\u30fb\u9ad8\u8102\u8840\u75c7\u5bfe\u7b56\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u5b9a\u756a\u306f\u3001\u7d05\u9eb9<\/a>\u3067\u3059\u3002
\n\u6700\u8fd1\u3067\u306f\u3001\u30b9\u30bf\u30c1\u30f3\u4e0d\u8010\u75c7\u306e\u8102\u8cea\u7570\u5e38\u75c7\u60a3\u8005\u306b\u5bfe\u3057\u3066\u3001\u7d05\u9eb9\u6295\u4e0e\u306b\u3088\u308b\u8102\u8cea\u4ee3\u8b1d\u6539\u5584\u4f5c\u7528\u3092\u793a\u3057\u305f\u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a13\u3082\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

\u7d05\u9eb9\u306b\u95a2\u3059\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u3067\u306f\u3001
\n\u30fb\u30b9\u30bf\u30c1\u30f3\u4e0d\u8010\u75c7\u306b\u5bfe\u3059\u308b\u7d05\u9eb9\u6295\u4e0e\u306b\u3088\u308b\u8102\u8cea\u7570\u5e38\u75c7\u306e\u6539\u5584\u52b9\u679c
\n\u30fb\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u767a\u751f\u306e\u6291\u5236\u52b9\u679c
\n\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u7d05\u9eb9\u306f\u3001\u30b9\u30bf\u30c1\u30f3\u3068\u6bd4\u3079\u3066\u3001\u5b89\u5168\u6027\u30fb\u6709\u52b9\u6027\u30fb\u7d4c\u6e08\u6027\u306b\u512a\u308c\u305f\u30cf\u30fc\u30d6\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3067\u3059\u3002
\n\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u7d4c\u6e08\u6027\uff08\u8cbb\u7528\u5bfe\u52b9\u679c\uff09\uff1a\u533b\u85ac\u54c1\u3068\u306e\u6bd4\u8f03<\/a>
\n\uff08\u306a\u304a\u3001\u30b9\u30bf\u30c1\u30f3\u304a\u3088\u3073\u7d05\u9eb9\u306e\u3044\u305a\u308c\u3082\u3001\u30b3\u30a8\u30f3\u30b6\u30a4\u30e0Q10<\/a>\u3068\u306e\u4f75\u7528\u304c\u5fc5\u8981\u3068\u8003\u3048\u307e\u3059\u3002\uff09<\/p>\n

\u30b3\u30a8\u30f3\u30b6\u30a4\u30e0Q10<\/a>\u306b\u306f\u3001\u9178\u5316\u578b(=\u30e6\u30d3\u30ad\u30ce\u30f3\uff0cubiquinone)\u3068\u9084\u5143\u578b(=\u30e6\u30d3\u30ad\u30ce\u30fc\u30eb\uff0cubiquinol)\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

\u9084\u5143\u578bCoQ10\u306e\u307b\u3046\u304c\u3001\u9178\u5316\u578bCoQ10\u3088\u308a\u3082\u4f53\u5185\u3067\u5229\u7528\u3055\u308c\u3084\u3059\u3044\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002
\n\uff08\u9178\u5316\u578bCoQ10\u306f\u3001\u4f53\u5185\u306b\u5438\u53ce\u3055\u308c\u305f\u5f8c\u3001\u3044\u3063\u305f\u3093\u9084\u5143\u3055\u308c\u3066\u304b\u3089\u3001\u5229\u7528\u3055\u308c\u307e\u3059\u3002\uff09
\n\u30b3\u30a8\u30f3\u30b6\u30a4\u30e0Q10\u306b\u95a2\u3059\u308b\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u306e\u591a\u304f\u306f\u3001\u9178\u5316\u578b(=\u30e6\u30d3\u30ad\u30ce\u30f3\uff0cubiquinone)\u3092\u7528\u3044\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u3057\u305f\u304c\u3063\u3066\u3001\u4e00\u822c\u7684\u306b\u306f\u3001\u751f\u6d3b\u7fd2\u6163\u75c5\u306e\u4e88\u9632\u3084\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u76ee\u7684\u306b\u95a2\u3057\u3066\u3001\u9178\u5316\u578bCoQ10<\/a>\u306e\u30e6\u30d3\u30ad\u30ce\u30f3\u306e\u6442\u53d6\u3067\u5341\u5206\u306a\u52b9\u679c\u304c\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/p>\n

\u4e00\u65b9\u3001\u7279\u5b9a\u306e\u75be\u60a3\u306b\u5bfe\u3057\u3066\u7528\u3044\u308b\u5834\u5408\u3001\u3042\u308b\u3044\u306f\u3001\u4f53\u5185\u306e\u751f\u7406\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u308b\u9ad8\u9f62\u8005\u306e\u5834\u5408\u306b\u306f\u3001\u9084\u5143\u578bCoQ10<\/a>\u306e\u5229\u7528\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

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