{"id":1719,"date":"2013-12-04T11:50:58","date_gmt":"2013-12-04T02:50:58","guid":{"rendered":"https:\/\/www.taiyou-clinic.jp\/blog\/?p=1719"},"modified":"2013-12-04T11:50:58","modified_gmt":"2013-12-04T02:50:58","slug":"%e3%82%ac%e3%83%b3%e3%81%ae%ef%bd%84%ef%bd%8e%ef%bd%81%e3%82%92%e3%83%a1%e3%83%81%e3%83%ab%e5%8c%96%e3%81%99%e3%82%8b%e6%b2%bb%e7%99%82%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6","status":"publish","type":"post","link":"https:\/\/www.taiyou-clinic.jp\/blog\/archives\/1719","title":{"rendered":"\u30ac\u30f3\u306e\uff24\uff2e\uff21\u3092\u30e1\u30c1\u30eb\u5316\u3059\u308b\u6cbb\u7642\u306b\u3064\u3044\u3066"},"content":{"rendered":"<p>\u30ac\u30f3\u3068\u30e1\u30c1\u30eb\u5316\u6cbb\u7642\u306b\u3064\u3044\u3066<\/p>\n<p>\uff24\uff2e\uff21\u306e\u30e1\u30c1\u30eb\u5316\u3068\u306f\u3001\uff24\uff2e\uff21\u304c\u4e00\u90e8\u30e1\u30c1\u30eb\u5316\u3055\u308c\u308b\u3053\u3068\u306b\u3088\u308a\u3001\uff24\uff2e\uff21\u306e\u767a\u73fe\u306e\u8abf\u6574\u304c\u8d77\u3053\u308b\u3053\u3068\u3092\u8a00\u3046\u3002\u4ee5\u4e0b\u306e\u8ad6\u6587\u3067\u306f\u3001\u30ac\u30f3\u306e\u8840\u7ba1\u65b0\u751f\u304c\u30e1\u30c1\u30eb\u5316\u306b\u3088\u3063\u3066\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u308b\u3053\u3068\u3092\u884c\u3063\u3066\u3044\u308b\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a<\/p>\n<p>http:\/\/weeksmd.com\/2013\/11\/methylation-cancer\/<\/p>\n<p align=\"left\">\u30e1\u30c1\u30eb\u5316\u3068\u764c<\/p>\n<p align=\"left\">2013\u5e7411\u670830\u65e5\u306b\u30d6\u30e9\u30c3\u30c9\u30d5\u30a9\u30fc\u30c9S.\u9031\u535a\u58eb\u306b\u3088\u3063\u3066\u63b2\u793a\u3055\u308c\u308b<\/p>\n<p align=\"left\">\u9031\u535a\u58eb\u306e\u30b3\u30e1\u30f3\u30c8\uff1a\u30e1\u30c1\u30eb\u5316\u3068MTHFR\u8a66\u9a13\u306f\u3001\u5927\u90e8\u5206\u306e\u533b\u5e2b\u306b\u3088\u3063\u3066\u5341\u5206\u306b\u7406\u89e3\u3055\u308c\u306a\u304f\u3066\u3001\u305d\u308c\u3067\u3001\u300c\u30e1\u30c1\u30eb\u5316\u300d\u306b\u6ce8\u610f\u3092\u6255\u3046\u3002<\/p>\n<p align=\"left\">\u00a0<\/p>\n<p align=\"left\">\u30e1\u30c1\u30eb\u5316\u306e\u4fe1\u53f7\u306f\u30ac\u30f3\u306e\u6210\u9577\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3059\u308b<\/p>\n<p align=\"left\">2013\u5e7411\u670828\u65e5\u306b\uff0d\u30dc\u30b9\u30c8\u30f3\u533b\u79d1\u5927\u5b66\uff08BUSM\uff09\u306b\u7814\u7a76\u8005\u306b\u3088\u3063\u3066\u5c0e\u304b\u308c\u305f\u3042\u308b\u7814\u7a76\u306f\u3001\u65b0\u3057\u3044\u8840\u7ba1\u3068\u764c\u6210\u9577\u306e\u5f62\u6210\u3092\u59a8\u5bb3\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\u30fb\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u305d\u306e\u53d7\u5bb9\u4f53\u306e\u65b0\u3057\u3044\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u793a\u3057\u3066\u3044\u308b\u3002\u3053\u306e\u77e5\u898b\u306f\u3001Science Signaling\u306e\uff11\uff12\u6708\u53f7\u3067\u767a\u8868\u3055\u308c\u308b\u3002<\/p>\n<p align=\"left\">\u8840\u7ba1\u5f62\u6210\u306f\u3001\u3044\u304f\u3064\u304b\u306e\u75be\u60a3\uff08\u4f8b\u3048\u3070\u764c\u3068\u52a0\u9f62\u6027\u9ec4\u6591\u5909\u6027\uff09\u306e\u767a\u75c7\u3068\u9032\u884c\u306b\u3064\u306a\u304c\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u30d7\u30ed\u30bb\u30b9\u3067\u8d77\u3053\u308b\u3002<\/p>\n<p align=\"left\">\u8840\u7ba1\u5185\u76ae\u6210\u9577\u56e0\u5b50\uff08VEGF\uff09\u306f\u969c\u5bb3\u3092\u53d7\u3051\u305f\u7d30\u80de\u306b\u3088\u3063\u3066\u7523\u3055\u308c\u308b\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\u30fb\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308b\u3002\u305d\u3057\u3066\u3001\u305d\u308c\u306f\u8840\u7ba1\u7d30\u80de\u306e\u8868\u9762\u306b\u3042\u308b\u53d7\u5bb9\u4f53VEGFR-2\u306e\u3046\u3061\u306e1\u3064\u3068\u7d50\u5408\u3059\u308b\u3002\u4e00\u65e6VEGF\u304c\u305d\u306e\u53d7\u5bb9\u4f53\u306b\u5bc6\u63a5\u306b\u7d50\u3073\u3064\u304f\u306a\u3089\u3070\u3001\u305d\u308c\u306f\u6d3b\u6027\u5316\u3055\u308c\u3066\u3001\u8840\u7ba1\u5f62\u6210\u3092\u59cb\u3081\u308b\u305f\u3081\u306b\u8840\u7ba1\u7d30\u80de\u306e\u5185\u90e8\u306b\u751f\u5316\u5b66\u4fe1\u53f7\u3092\u9001\u308b\u3002\u3053\u306e\u30d7\u30ed\u30bb\u30b9\u3092\u76ee\u6a19\u3068\u3059\u308b\u73fe\u5728\u8907\u6570\u306e\uff26\uff24\uff21\u8a8d\u53ef\u306e\u85ac\u7269\u304c\u3001\u3042\u308b\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u3053\u308c\u3089\u306e\u85ac\u7269\u306f\u3001\u6709\u52b9\u6027\u304c\u4e0d\u5341\u5206\u3067\u3042\u308b\u3053\u3068\u3068\u85ac\u306b\u5bfe\u3059\u308b\u62b5\u6297\u6027\u304c\u767a\u9054\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u5236\u9650\u3055\u308c\u308b\u3002<\/p>\n<p align=\"left\">\u7814\u7a76\u8005\u306f\u307e\u305f\u3001\u30e1\u30c1\u30eb\u5316\uff08\u305d\u308c\u306f\u907a\u4f1d\u5b50\u767a\u73fe\u3092\u8abf\u6574\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\uff09\u3068\u547c\u3070\u308c\u3066\u3044\u308b\u751f\u5316\u5b66\u7684\u65b9\u6cd5\u304cVEGFR-2\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u3053\u3068\u3092\u8a3c\u660e\u3057\u305f\u3001\u305d\u3057\u3066\u3001\u3053\u308c\u306f\u8840\u7ba1\u5f62\u6210\u306b\u81f3\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002<\/p>\n<p align=\"left\">\u8907\u6570\u306e\u65b9\u6cd5\u3092\u4f7f\u7528\u3057\u3066\u3001\u7814\u7a76\u8005\u306fVEGFR-2\u306e\u30e1\u30c1\u30eb\u5316\u30d7\u30ed\u30bb\u30b9\u3092\u90aa\u9b54\u3057\u3066\u3001\u305d\u306e\u5f8c\u8840\u7ba1\u5f62\u6210\u3068\u816b\u760d\u6210\u9577\u3092\u59a8\u3052\u308b\u3053\u3068\u304c\u53ef\u80fd\u3060\u3063\u305f\u3002<\/p>\n<p align=\"left\">\u300c\u672c\u7814\u7a76\u306f\u764c\u3068\u773c\u6027\u8840\u7ba1\u5f62\u6210\u306e\u523a\u6fc0\u7684\u3067\u3042\u308b\u304c\u3001\u672a\u8e0f\u306e\u85ac\u76ee\u6a19\u3068\u3057\u3066VEGFR-2\u306e\u30e1\u30c1\u30eb\u5316\u3092\u793a\u3057\u3066\u3044\u308b\u3002\u305d\u3057\u3066\u3001\u6297\u8840\u7ba1\u5f62\u6210\u7642\u6cd5\u3067\u65b0\u3057\u3044\u30d1\u30e9\u30c0\u30a4\u30e0\u306e\u5230\u6765\u3092\u544a\u3052\u308b\u300d\u3068\u3001\u30cd\u30fc\u30c0\u30fcRahimi\u3001\u535a\u58eb\u3001\u75c5\u7406\u5b66\u306e\u6e96\u6559\u6388\u3067\u3042\u308a\u3053\u306e\u7814\u7a76\u306e\u4e0a\u7d1a\u7814\u7a76\u8005\u3067\u3042\u308b\u3001BUSM\u304c\u8a00\u3063\u305f\u3002<\/p>\n<p align=\"left\">\u00a0<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p align=\"left\">Methylation and Cancer<\/p>\n<p align=\"left\">Posted by <a title=\"Posts by Bradford S. Weeks, MD\" href=\"http:\/\/weeksmd.com\/author\/weeksmd\/\">Bradford S. Weeks, MD<\/a> on November 30, 2013<\/p>\n<p align=\"left\"><b><i>Dr. Weeks\u2019 Comment: \u00a0Methylation and MTHFR testing are poorly understood by most medical doctors, so pay attention to \u201cmethylation\u201d.\u00a0<\/i><\/b><\/p>\n<p align=\"left\">\u00a0<\/p>\n<p align=\"left\"><b>Methylation Signaling Controls Cancer Growth<\/b><\/p>\n<p align=\"left\">Nov. 28, 2013 \u2014 A study led by researchers at Boston University School of Medicine (BUSM) demonstrates <b><i>a new mechanism involving a signaling protein and its receptor that may block the formation of new blood vessels and cancer growth.<\/i><\/b><i> <\/i>The findings are published in the December issue of <i>Science Signaling<\/i>.<\/p>\n<p align=\"left\">Angiogenesis creates new blood vessels in a process that can lead to the onset and progression of several diseases such as cancer and age-related macular degeneration.<\/p>\n<p align=\"left\">Vascular endothelial growth factor (VEGF) is a signaling protein produced by damaged cells, which binds to one of its receptors VEGFR-2, located on the surface of blood vessel cells. Once VEGF is bound to its receptor, it is activated and sends a biochemical signal to the inside of the blood vessel cell to initiate angiogenesis. There are currently multiple Federal Drug Administration-approved medications that target this process. However these medications are limited by insufficient efficacy and the development of resistance.<\/p>\n<p align=\"left\">The researchers demonstrated that a biochemical process called methylation, which can regulate gene expression, also affects VEGFR-2, and this can lead to angiogenesis. <b><i>Using multiple methods, the researchers were able to interfere with the methylation process of VEGFR-2 and subsequently block angiogenesis and tumor growth.<\/i><\/b><\/p>\n<p align=\"left\">\u201cThe study points to the methylation of VEGFR-2 as an exciting, yet unexplored drug target for cancer and ocular angiogenesis, ushering in a new paradigm in anti-angiogenesis therapy,\u201d said Nader Rahimi, PhD, associate professor of pathology, BUSM, who served as the study\u2019s senior investigator.<\/p>\n<p>&nbsp;<\/p>\n<p align=\"left\">\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30ac\u30f3\u3068\u30e1\u30c1\u30eb\u5316\u6cbb\u7642\u306b\u3064\u3044\u3066 \uff24\uff2e\uff21\u306e\u30e1\u30c1\u30eb\u5316\u3068\u306f\u3001\uff24\uff2e\uff21\u304c\u4e00\u90e8\u30e1\u30c1\u30eb\u5316\u3055\u308c\u308b\u3053\u3068\u306b\u3088\u308a\u3001\uff24\uff2e\uff21\u306e\u767a\u73fe\u306e\u8abf\u6574\u304c\u8d77\u3053\u308b\u3053\u3068\u3092\u8a00\u3046\u3002\u4ee5\u4e0b\u306e\u8ad6\u6587\u3067\u306f\u3001\u30ac\u30f3\u306e\u8840\u7ba1\u65b0\u751f\u304c\u30e1\u30c1\u30eb\u5316\u306b\u3088\u3063\u3066\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3055\u308c\u308b\u3053\u3068\u3092\u884c\u3063\u3066\u3044\u308b\u3002 &#038;nbs [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts\/1719"}],"collection":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/comments?post=1719"}],"version-history":[{"count":0,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts\/1719\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/media?parent=1719"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/categories?post=1719"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/tags?post=1719"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}