{"id":1679,"date":"2013-10-21T16:59:00","date_gmt":"2013-10-21T07:59:00","guid":{"rendered":"https:\/\/www.taiyou-clinic.jp\/blog\/?p=1679"},"modified":"2013-10-21T16:59:00","modified_gmt":"2013-10-21T07:59:00","slug":"%e3%83%93%e3%82%bf%e3%83%9f%e3%83%b3d3%e3%82%b5%e3%83%97%e3%83%aa%e3%83%a1%e3%83%b3%e3%83%88%e3%81%ae%e9%aa%a8%e6%a0%bc%e7%ad%8b%e3%81%b8%e3%81%ae%e4%bd%9c%e7%94%a8","status":"publish","type":"post","link":"https:\/\/www.taiyou-clinic.jp\/blog\/archives\/1679","title":{"rendered":"\u30d3\u30bf\u30df\u30f3D3\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u9aa8\u683c\u7b4b\u3078\u306e\u4f5c\u7528"},"content":{"rendered":"

\u30d3\u30bf\u30df\u30f3\uff24\uff13\u306f\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u4e2d\u3067\u3082\u30d3\u30bf\u30df\u30f3\uff23\u306b\u3064\u3044\u3067\u30de\u30eb\u30c1\u306a\u529b\u3092\u767a\u63ee\u3059\u308b\u30d3\u30bf\u30df\u30f3\u3067\u3042\u308b\u3002\u9ad8\u9f62\u8005\u306e\u7b4b\u65ad\u9762\u7a4d\u306e\u5897\u52a0\u304c\u898b\u3089\u308c\u308b\u306e\u3060\u304b\u3089\u76f8\u5f53\u306e\u52b9\u679c\u3060\u3068\u601d\u308f\u308c\u308b\u3002<\/p>\n

 <\/p>\n

\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a<\/p>\n

http:\/\/www.dhcblog.com\/kamohara\/<\/p>\n

\u4eca\u6708\u306e\u81e8\u5e8a\u5185\u5206\u6ccc\u4ee3\u8b1d\u5b66\u306e\u5c02\u9580\u30b8\u30e3\u30fc\u30ca\u30eb(\u96fb\u5b50\u7248)\u306b\u3001\u30d3\u30bf\u30df\u30f3D3\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306b\u3088\u308b\u7b4b\u8089\u7d44\u7e54\u3078\u306e\u5f71\u97ff\u3092\u8abf\u3079\u305f\u81e8\u5e8a\u7814\u7a76\u304c\u3001\u7c73\u56fd\u306e\u30b0\u30eb\u30fc\u30d7(Tufts Medical Center)\u304b\u3089\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002
\n(J Clin Endocrinol Metab.<\/i> 2013 Oct 9.)<\/p>\n

\u30d3\u30bf\u30df\u30f3D\u306f\u3001\u9aa8\u306e\u5065\u5eb7\u7dad\u6301\u306b\u95a2\u4fc2\u3059\u308b\u8102\u6eb6\u6027\u30d3\u30bf\u30df\u30f3\u3068\u3057\u3066\u5e83\u304f\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002
\n\u8fd1\u5e74\u306e\u7814\u7a76\u3067\u306f\u3001\u514d\u75ab\u8abf\u7bc0\u4f5c\u7528\u3084\u6297\u304c\u3093\u4f5c\u7528\u3082\u898b\u51fa\u3055\u308c\u3066\u304a\u308a\u3001\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u5206\u91ce\u3067\u306f\u30d9\u30fc\u30b7\u30c3\u30af\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3068\u3057\u3066\u6442\u53d6\u304c\u63a8\u5968\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n

\u307e\u305f\u3001\u30d3\u30bf\u30df\u30f3D\u306f\u3001\u9aa8\u306e\u5065\u5eb7\u7dad\u6301\u306b\u52a0\u3048\u3066\u3001\u7b4b\u8089\u7d44\u7e54\u3078\u306e\u4f5c\u7528\u3082\u793a\u5506\u3055\u308c\u3066\u304a\u308a\u3001\u8ee2\u5012\u4e88\u9632\u3001\u9aa8\u6298\u4e88\u9632\u306e\u70b9\u304b\u3089\u3001\u30ed\u30b3\u30e2\u30c6\u30a3\u30d6\u75c7\u5019\u7fa4\u5bfe\u7b56\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3067\u3082\u3042\u308a\u307e\u3059\u3002
\n\u305f\u3060\u3057\u3001\u73fe\u6642\u70b9\u3067\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u6295\u4e0e\u306b\u3088\u308b\u7b4b\u8089\u91cf\u306e\u5897\u52a0\u3084\u7b4b\u7279\u7570\u7684\u306a\u30d3\u30bf\u30df\u30f3D\u53d7\u5bb9\u4f53\u306e\u5897\u52a0\u3068\u3044\u3063\u305f\u4f5c\u7528\u306b\u306f\u8b70\u8ad6\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

\u305d\u3053\u3067\u3001\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u30d3\u30bf\u30df\u30f3D3\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306b\u3088\u308b\u9aa8\u683c\u7b4b\u3078\u306e\u4f5c\u7528\u304c\u691c\u8a3c\u3055\u308c\u307e\u3057\u305f\u3002
\n\u5177\u4f53\u7684\u306b\u306f\u30014\u304b\u6708\u9593\u306e\u30e9\u30f3\u30c0\u30e0\u5316\u4e8c\u91cd\u76f2\u691c\u507d\u85ac\u5bfe\u7167\u8a66\u9a13\u3068\u3057\u3066\u300165\u6b73\u4ee5\u4e0a\u3067\u904b\u52d5\u80fd\u304c\u969c\u5bb3\u3055\u308c\u305f\u5973\u602721\u540d\u3092\u5bfe\u8c61\u306b\u30011\u65e5\u3042\u305f\u308a4000 IU\u306e\u30d3\u30bf\u30df\u30f3D3\u6295\u4e0e\u306b\u3088\u308b\u3001
\n\u7b4b\u7dda\u7dad\u6a2a\u65ad\u9762\u7a4d(FCSA, muscle fiber cross-sectional area)\u304a\u3088\u3073\u7b4b\u8089\u5185\u306e\u30d3\u30bf\u30df\u30f3D\u53d7\u5bb9\u4f53\u6fc3\u5ea6\u3078\u306e\u5f71\u97ff\u304c\u8abf\u3079\u3089\u308c\u307e\u3057\u305f\u3002
\n(\u88ab\u9a13\u8005\u306e25OHD\u5024\u306f22.5-60 nmol\/L)<\/p>\n

\u4e3b\u30a2\u30a6\u30c8\u30ab\u30e0\u306f\u30014\u304b\u6708\u5f8c\u306eFCSA\u3068\u7b4b\u8089\u4e2dVDR\u3067\u3059\u3002(\u5916\u5074\u5e83\u7b4b\u306b\u3066\u6e2c\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7b4b\u7e4a\u7dad\u30bf\u30a4\u30d7\u306fI\/IIa\/IIx)<\/p>\n

\u89e3\u6790\u306e\u7d50\u679c\u3001\u307e\u305a\u3001\u6295\u4e0e\u958b\u59cb\u6642\u306e\u30c7\u30fc\u30bf\u306f\u3001
\n\u5e73\u5747\u5e74\u9f6278\u00b15\u6b73\u3001
\nBMI 27\u00b15 kg\/m2\u3001
\n25OHD; 46.3\u00b19.5 nmol\/L\u3001
\n\u8eab\u4f53\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9\u30b9\u30b3\u30a2;\uff08\u516812\u30b9\u30b3\u30a2\u4e2d\u306e\uff097.95\u00b11.57
\n\u3067\u3057\u305f\u3002<\/p>\n

\u6b21\u306b\u30014\u304b\u6708\u5f8c\u306e\u30c7\u30fc\u30bf\u306f\u3001
\n25OHD\u5024\u306f\u507d\u85ac\u7fa4\u306e52.5\u00b117.1\u306b\u5bfe\u3057\u3066\u3001
\n\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u6295\u4e0e\u7fa4\u3067\u306f 80.0\u00b111.5 nmol\/L (VD; P<0.01) \u3067\u3042\u308a\u3001
\n25OHD\u5024\u306e\u5909\u5316\u306f\u3001\u7b4b\u8089\u4e2d\u306eVDR\u3068\u6709\u610f\u306b\u76f8\u95a2\u3057\u3066\u3044\u307e\u3057\u305f\u3002
\n(r=0.87, P<0.001)<\/p>\n

\u30d3\u30bf\u30df\u30f3D3\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u6295\u4e0e\u306b\u3088\u308b\u7b4b\u8089\u4e2d\u306eVDR\u306e\u5909\u5316\u306f\u300129.7\u00b111.7%\u3067\u3042\u308a\u3001
\n\u507d\u85ac\u7fa4\u3067\u306f7.8\u00b118.2%\u3067\u3057\u305f\u3002
\nFCSA\u306f\u3001\u507d\u85ac\u7fa4\u3067\u306f-7.4\u00b118.9%\u306b\u5bfe\u3057\u3066\u3001\u30d3\u30bf\u30df\u30f3D3\u6295\u4e0e\u7fa4\u3067\u306f10.6\u00b120.0%\u3067\u3057\u305f\u3002<\/p>\n

\u4ee5\u4e0a\u306e\u30c7\u30fc\u30bf\u304b\u3089\u3001\u904b\u52d5\u8eab\u4f53\u6a5f\u80fd\u306b\u969c\u5bb3\u306e\u3042\u308b\u9ad8\u9f62\u8005\u306b\u304a\u3044\u3066\u3001
\n\u30d3\u30bf\u30df\u30f3D3\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u6295\u4e0e\u306f\u3001\u9aa8\u683c\u7b4b\u306b\u304a\u3051\u308b\u30d3\u30bf\u30df\u30f3D\u53d7\u5bb9\u4f53\u309230\uff05\u5897\u52a0\u3055\u305b\u3001
\n\u9aa8\u683c\u7b4b\u7e4a\u7dad\u306e\u30b5\u30a4\u30ba\u309210\uff05\u5927\u304d\u304f\u3059\u308b\u3053\u3068\u304c\u793a\u5506\u3055\u308c\u307e\u3059\u3002<\/p>\n

\u4eca\u5f8c\u3001\u9ad8\u9f62\u8005\u306b\u304a\u3051\u308b\u8ee2\u5012\u4e88\u9632\u3084\u30ed\u30b3\u30e2\u30c6\u30a3\u30d6\u75c7\u5019\u7fa4\u4e88\u9632\u306e\u898b\u5730\u304b\u3089\u3001\u30d3\u30bf\u30df\u30f3D3\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u6295\u4e0e\u306e\u81e8\u5e8a\u7684\u610f\u7fa9\u306e\u691c\u8a3c\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<\/p>\n

\u8fd1\u5e74\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u6a5f\u80fd\u6027\u3068\u3057\u3066\u3001\u514d\u75ab\u8abf\u7bc0\u4f5c\u7528\u3084\u6297\u304c\u3093\u4f5c\u7528\u3001\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u4e88\u9632\u4f5c\u7528\u306a\u3069\u3082\u898b\u51fa\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n

\u65e5\u672c\u304b\u3089\u306e\u5831\u544a\u3067\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u4e88\u9632\u52b9\u679c<\/a>
\n\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u307e\u305f\u3001\u3055\u307e\u3056\u307e\u306a\u751f\u6d3b\u7fd2\u6163\u75c5\u3067\u306f\u3001\u8840\u4e2d\u30d3\u30bf\u30df\u30f3D\u5024\u304c\u4f4e\u3044\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u304a\u308a\u3001\u5065\u5eb7\u4fdd\u6301\u3084\u75be\u75c5\u4e88\u9632\u306e\u305f\u3081\u306b\u3001\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u6442\u53d6\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002
\n\uff08\u6b20\u4e4f\u75c7\u306e\u4e88\u9632\u3068\u3044\u3046\u3053\u3068\u3067\u306f\u901a\u5e38\u306e\u98df\u4e8b\u304b\u3089\u3067\u3082\u88dc\u3048\u307e\u3059\u304c\u3001\u75be\u75c5\u4e88\u9632\u3068\u3044\u3046\u76ee\u7684\u3067\u306f\u30011\u65e5\u3042\u305f\u308a1,000\uff5e2,000IU\u306e\u6442\u53d6\u304c\u5fc5\u8981\u3067\u3042\u308a\u3001\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u5229\u7528\u3059\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002\uff09<\/p>\n

\u4eca\u65e5\u3067\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u75c7\u306e\u5178\u578b\u4f8b\u306e\u3088\u3046\u306a\u75be\u60a3\u306f\u5c11\u306a\u3044\u4e00\u65b9\u3001\u8840\u4e2d\u30d3\u30bf\u30df\u30f3D\u306e\u4f4e\u5024\u304c\u5e83\u304f\u8a8d\u3081\u3089\u308c\u308b\u3053\u3068\u304b\u3089\u3001\u751f\u6d3b\u7fd2\u6163\u75c5\u306e\u4e88\u9632\u3084\u30a2\u30f3\u30c1\u30a8\u30a4\u30b8\u30f3\u30b0\u3092\u76ee\u7684\u3068\u3057\u305f\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u5229\u7528\u304c\u63a8\u5968\u3055\u308c\u307e\u3059\u3002
\n\u65e5\u672c\u4eba\u306e\u9593\u3067\u3082\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u6f5c\u5728\u7684\u4e0d\u8db3\/\u6b20\u4e4f\u304c\u9855\u8457<\/a>\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u305f\u3068\u3048\u3070\u3001
\n\u65e5\u672c\u4eba\u598a\u5a66\u306e90\uff05\u304c\u30d3\u30bf\u30df\u30f3D\u4e0d\u8db3<\/a>\u3001
\n\u8840\u4e2d\u30d3\u30bf\u30df\u30f3D\u5024\u304c\u9ad8\u3044\u3068\u5927\u8178\u817a\u816b\u30ea\u30b9\u30af\u304c\u4f4e\u3044<\/a>
\n\u3068\u3044\u3046\u30c7\u30fc\u30bf\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

DHC\u3067\u306f\u3001\u30d3\u30bf\u30df\u30f3D3\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8<\/a>\u3092\u88fd\u54c1\u5316\u3057\u3066\u3044\u307e\u3059\u3002
\n\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306b\u5bfe\u3059\u308b\u52b9\u679c\u306b\u306f\u500b\u4eba\u5dee\u304c\u3042\u308a\u307e\u3059\u304c\u3001
\n\u81e8\u5e8a\u7684\u306b\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\uff11\uff0c\uff10\uff10\uff10IU\/\u65e5\u306e\u7528\u91cf\u3067\u6295\u4e0e\u3059\u308b\u3068\u3001\u8840\u4e2d25\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D\u5024\u304c10ng\/ml\u5897\u52a0\u3059\u308b\u3001\u3068\u3044\u3046\u5831\u544a\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n

\u30de\u30eb\u30c1\u30d3\u30bf\u30df\u30f3\u306e\u30d3\u30bf\u30df\u30f3D\u306fRDA\u306e\u305f\u3081\u306e\u8a2d\u5b9a\u3067\u3059\u306e\u3067\u3001\u5225\u9014\u3001\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306e\u5229\u7528\u3068\u306a\u308a\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

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