{"id":1665,"date":"2013-10-05T12:09:27","date_gmt":"2013-10-05T03:09:27","guid":{"rendered":"https:\/\/www.taiyou-clinic.jp\/blog\/?p=1665"},"modified":"2013-10-05T12:09:27","modified_gmt":"2013-10-05T03:09:27","slug":"%e3%82%bb%e3%83%b3%e3%83%88%e3%82%b8%e3%83%a7%e3%83%bc%e3%83%b3%e3%82%ba%e3%83%af%e3%83%bc%e3%83%88%e3%81%a8%e3%83%89%e3%82%bb%e3%82%bf%e3%82%ad%e3%82%bb%e3%83%ab%e6%8a%97%e3%81%8c%e3%82%93%e5%89%a4","status":"publish","type":"post","link":"https:\/\/www.taiyou-clinic.jp\/blog\/archives\/1665","title":{"rendered":"\u30bb\u30f3\u30c8\u30b8\u30e7\u30fc\u30f3\u30ba\u30ef\u30fc\u30c8\u3068\u30c9\u30bb\u30bf\u30ad\u30bb\u30eb(\u6297\u304c\u3093\u5264)\u3068\u306e\u76f8\u4e92\u4f5c\u7528"},"content":{"rendered":"

\u6297\u304c\u3093\u5264\u3068\u306e\u4f75\u7528\u304c\u554f\u984c\u3068\u306a\u308b\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306f\u3044\u304f\u3064\u304b\u3042\u308b\u3002<\/p>\n

\u3053\u306e\u30bb\u30f3\u30c8\u30b8\u30e7\u30fc\u30f3\u30ba\u30ef\u30fc\u30c8\u3082\u305d\u306e\u4e00\u3064\u3060\u304c\u3001\u30d3\u30bf\u30df\u30f3\uff23\u3082\u30e1\u30bd\u30c8\u30ec\u30ad\u30bb\u30fc\u30c8\u3068\u306e\u4f75\u7528\u306f\u7981\u5fcc\u3068\u3044\u3048\u308b\u3002\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u304c\u300d\u7121\u5bb3\u3068\u3044\u3046\u308f\u3051\u3067\u306f\u306a\u304f\u3001\u4f55\u304b\u3057\u3089\u4f53\u306b\u5f71\u97ff\u3059\u308b\u85ac\u5264\u3082\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3082\u305d\u308c\u305e\u308c\u4f5c\u7528\u6a5f\u5e8f\u304c\u3042\u308a\u3001\u305d\u306e\u4f5c\u7528\u304c\u62ee\u6297\u3059\u308b\u5834\u5408\u306b\u306f\u4f75\u7528\u3057\u306a\u3044\u3053\u3068\u3060\u3002<\/p>\n

\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a<\/p>\n

http:\/\/www.dhcblog.com\/kamohara\/<\/p>\n

\u81e8\u5e8a\u85ac\u7406\u5b66\u306e\u5c02\u9580\u30b8\u30e3\u30fc\u30ca\u30eb(\u96fb\u5b50\u7248)\u306b\u3001\u30bb\u30f3\u30c8\u30b8\u30e7\u30fc\u30f3\u30ba\u30ef\u30fc\u30c8\u3068\u30c9\u30bb\u30bf\u30ad\u30bb\u30eb(\u6297\u304c\u3093\u5264)\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u793a\u3057\u305f\u81e8\u5e8a\u7814\u7a76\u304c\u3001\u30aa\u30e9\u30f3\u30c0\u306e\u30b0\u30eb\u30fc\u30d7(Utrecht University)\u304b\u3089\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002
\n(Clin Pharmacokinet.<\/i> 2013 Sep 26)<\/p>\n

\u30bb\u30f3\u30c8\u30b8\u30e7\u30fc\u30f3\u30ba\u30ef\u30fc\u30c8(\u548c\u540d\u30bb\u30a4\u30e8\u30a6\u30aa\u30c8\u30ae\u30ea\u30bd\u30a6)\u306f\u3001\u8efd\u75c7\u304b\u3089\u4e2d\u7b49\u5ea6\u306e\u3046\u3064\u75c5\u306b\u5bfe\u3057\u3066\u6709\u52b9\u306a\u30cf\u30fc\u30d6\u3067\u3059\u3002SSRI\u306a\u3069\u306e\u533b\u85ac\u54c1\u3068\u540c\u7b49\u306e\u52b9\u679c\u3092\u6709\u3057\u3001\u304b\u3064\u3001\u526f\u4f5c\u7528\u306f\u533b\u85ac\u54c1\u3088\u308a\u3082\u5c11\u306a\u3044\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002
\n\u30bb\u30f3\u30c8\u30b8\u30e7\u30fc\u30f3\u30ba\u30ef\u30fc\u30c8\u306f\u3001\u5358\u72ec\u306e\u6295\u4e0e\u3067\u306f\u3001\u5b89\u5168\u6027\u3068\u6709\u52b9\u6027\u306e\u78ba\u7acb\u3055\u308c\u305f\u30cf\u30fc\u30d6\u3067\u3059\u3002<\/p>\n

\u4e00\u65b9\u3001\u533b\u85ac\u54c1\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u304c\u3042\u308a\u307e\u3059\u306e\u3067\u3001\u533b\u85ac\u54c1(CYP3A4\u3067\u4ee3\u8b1d\u3055\u308c\u308b\u533b\u85ac\u54c1)\u3068\u306e\u4f75\u7528\u6295\u4e0e\u306f\u907f\u3051\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059
\n\u30c9\u30bb\u30bf\u30ad\u30bb\u30eb\uff08docetaxel\u3001\u30bf\u30ad\u30bd\u30c6\u30fc\u30eb\uff09\u306f\u3001\u30bf\u30ad\u30b5\u30f3\u7cfb\u306e\u6297\u304c\u3093\u5264\u3067\u3001\u8ee2\u79fb\u30fb\u518d\u767a\u4e73\u304c\u3093\u3001\u5375\u5de3\u304c\u3093\u3001\u975e\u5c0f\u7d30\u80de\u80ba\u304c\u3093\u306e\u6cbb\u7642\u306b\u7528\u3044\u3089\u308c\u307e\u3059\u3002<\/p>\n

\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u30bb\u30f3\u30c8\u30b8\u30e7\u30fc\u30f3\u30ba\u30ef\u30fc\u30c8\u3068\u30c9\u30bb\u30bf\u30ad\u30bb\u30eb\u306e\u76f8\u4e92\u4f5c\u7528\u306b\u95a2\u3059\u308b\u691c\u8a3c\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u3002
\n(\u30bb\u30f3\u30c8\u30b8\u30e7\u30fc\u30f3\u30ba\u30ef\u30fc\u30c8\u3068\u30c9\u30bb\u30bf\u30ad\u30bb\u30eb\u306f\u3001\u3044\u305a\u308c\u3082\u809d\u81d3\u306e\u85ac\u5264\u4ee3\u8b1d\u9175\u7d20\u3067\u3042\u308b\u30c1\u30c8\u30af\u30ed\u30fc\u30e0CYP\u306e3A4\u306e\u57fa\u8cea\u3067\u3042\u308b\u3053\u3068\u304b\u3089\u3001\u4f75\u7528\u6642\u306b\u76f8\u4e92\u4f5c\u7528\u304c\u63a8\u6e2c\u3055\u308c\u307e\u3059\u3002)<\/p>\n

\u5177\u4f53\u7684\u306b\u306f\u3001\u304c\u3093\u60a3\u800510\u540d\u3092\u5bfe\u8c61\u306b\u3001\u30bb\u30f3\u30c8\u30b8\u30e7\u30fc\u30f3\u30ba\u30ef\u30fc\u30c8(900mg\u3001\u52063)\u309214\u65e5\u9593\u6442\u53d6\u3055\u305b\u3001\u305d\u306e\u524d\u5f8c\u3067\u3001\u30c9\u30bb\u30bf\u30ad\u30bb\u30eb(135mg\u309260\u5206\u3067\u70b9\u6ef4\u9759\u6ce8)\u6295\u4e0e\u3092\u884c\u3044\u3001\u85ac\u7269\u52d5\u614b\u304c\u6e2c\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u89e3\u6790\u306e\u7d50\u679c\u3001\u30bb\u30f3\u30c8\u30b8\u30e7\u30fc\u30f3\u30ba\u30ef\u30fc\u30c8(SJW)\u306e\u6295\u4e0e\u306b\u3088\u3063\u3066\u3001\u30c9\u30bb\u30bf\u30ad\u30bb\u30eb\u306e\u8840\u4e2d\u6fc3\u5ea6\uff08AUC\uff09\u306f\u6709\u610f\u306b\u4f4e\u4e0b\u3057\u307e\u3057\u305f\u3002<\/p>\n

(AUC\u221e\u3000SJW\u6295\u4e0e\u524d3,035 \u00b1 756\u3001SJW\u6295\u4e0e\u5f8c2,682 \u00b1 717 ng &#8226; h\/mL\u3001P = 0.045)<\/p>\n

\u307e\u305f\u3001\u30c9\u30bb\u30bf\u30ad\u30bb\u30eb\u306e\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u306f\u3001SJW\u6295\u4e0e\u5f8c\u306b\u6709\u610f\u306b\u5897\u52a0\u3057\u307e\u3057\u305f\u3002
\n(47.2 to 53.7 L\/h, P = 0.045)<\/p>\n

\u305d\u306e\u4ed6\u3001\u30c9\u30bb\u30bf\u30ad\u30bb\u30eb\u306e\u6700\u5927\u8840\u4e2d\u6fc3\u5ea6\u3068\u3001\u8840\u4e2d\u534a\u6e1b\u671f\u306f\u3001SJW\u6295\u4e0e\u5f8c\u306b\u4f4e\u4e0b\u50be\u5411\u3092\u793a\u3057\u307e\u3057\u305f(\u6709\u610f\u5dee\u306a\u3057)\u3002<\/p>\n

\u306a\u304a\u3001\u30c9\u30bb\u30bf\u30ad\u30bb\u30eb\u6295\u4e0e\u6642\u306b\u751f\u3058\u308b\u526f\u4f5c\u7528\u30fb\u6bd2\u6027\u306f\u3001SJW\u6295\u4e0e\u5f8c\u306b\u6e1b\u5c11\u3057\u305f\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002
\n\u4ee5\u4e0a\u306e\u30c7\u30fc\u30bf\u304b\u3089\u3001\u30bb\u30f3\u30c8\u30b8\u30e7\u30fc\u30f3\u30ba\u30ef\u30fc\u30c8\u306f\u3001CYP3A4\u6d3b\u6027\u8a98\u5c0e\u3092\u4ecb\u3057\u3066\u3001\u30c9\u30bb\u30bf\u30ad\u30bb\u30eb\u306e\u85ac\u52b9\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n

\u3057\u305f\u304c\u3063\u3066\u3001\u30c9\u30bb\u30bf\u30ad\u30bb\u30eb\u6295\u4e0e\u4e2d\u306e\u304c\u3093\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30bb\u30f3\u30c8\u30b8\u30e7\u30fc\u30f3\u30ba\u30ef\u30fc\u30c8\u306e\u6295\u4e0e\u306f\u7981\u5fcc\u3068\u306a\u308a\u307e\u3059\u3002
\n\u3053\u308c\u307e\u3067\u306e\u591a\u304f\u306e\u7814\u7a76\u306b\u3088\u3063\u3066\u3001\u30bb\u30f3\u30c8\u30b8\u30e7\u30fc\u30f3\u30ba\u30ef\u30fc\u30c8\u306f\u3001\u5358\u72ec\u306e\u6295\u4e0e\u3067\u306f\u3001\u5b89\u5168\u6027\u3068\u6709\u52b9\u6027\u306e\u78ba\u7acb\u3055\u308c\u305f\u30cf\u30fc\u30d6\u3067\u3059\u3002<\/p>\n

\u305f\u3060\u3057\u3001\u4e00\u90e8\u306e\u533b\u85ac\u54c1\u3068\u306e\u76f8\u4e92\u4f5c\u7528\u304c\u3042\u308a\u307e\u3059\u306e\u3067\u3001\u533b\u85ac\u54c1\u3068\u306e\u4f75\u7528\u6295\u4e0e\u306f\u907f\u3051\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002
\nDHC\u3067\u306f\u3001\u30bb\u30f3\u30c8\u30b8\u30e7\u30fc\u30f3\u30ba\u30ef\u30fc\u30c8<\/a>\u3092\u4e3b\u6210\u5206\u3068\u3059\u308b\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3084\u3001\u8907\u5408\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8<\/a>\u3092\u53d6\u308a\u6271\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u3046\u3064\u75c5\u306b\u3064\u3044\u3066\u306e\u7814\u7a76\u3068\u3057\u3066\u3001\u6b21\u306e\u3088\u3046\u306a\u5831\u544a\u304c\u3042\u308a\u307e\u3059\u3002
\nDHA\u306b\u3088\u308b\u91cd\u75c7\u3046\u3064\u75c5\u6539\u5584\u4f5c\u7528<\/a>
\n\u3046\u3064\u75c5\u306b\u5bfe\u3059\u308bEPA\u306e\u52b9\u679c<\/a>
\n\u6297\u3046\u3064\u4f5c\u7528\u306e\u3042\u308b\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u30ec\u30d3\u30e5\u30fc<\/a>
\n\u30bb\u30f3\u30c8\u30b8\u30e7\u30fc\u30f3\u30ba\u30ef\u30fc\u30c8\u306fSSRI\u3068\u540c\u7b49\u306e\u6297\u3046\u3064\u4f5c\u7528\u3092\u793a\u3059<\/a>
\n\u3046\u3064\u75c5\u6cbb\u7642\u306b\u304a\u3051\u308b\u30bb\u30f3\u30c8\u30b8\u30e7\u30fc\u30f3\u30ba\u30ef\u30fc\u30c8\u306e\u8cbb\u7528\u5bfe\u52b9\u679c<\/a>
\n\u3046\u3064\u75c5\u3078\u306e\u30d3\u30bf\u30df\u30f3D\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u6295\u4e0e<\/a>
\n\u7dd1\u8336\u306b\u3088\u308b\u5831\u916c\u5b66\u7fd2\u306e\u6539\u5584\u3068\u6297\u3046\u3064\u4f5c\u7528<\/a>
\n\u91ce\u83dc\u3068\u679c\u7269\u306e\u6442\u53d6\u304c\u591a\u3044\u9ad8\u9f62\u8005\u306f\u3046\u3064\u75c5\u30ea\u30b9\u30af\u304c\u4f4e\u3044<\/a>
\n\u82e5\u5e74\u5973\u6027\u306b\u304a\u3051\u308b\u8449\u9178\u306e\u6297\u3046\u3064\u4f5c\u7528<\/a>
\n\u3046\u3064\u75c5\u3067\u306f\u30d3\u30bf\u30df\u30f3D\u304c\u4f4e\u5024<\/a>
\n\u30b3\u30fc\u30d2\u30fc\u306e\u6442\u53d6\u304c\u5973\u6027\u306e\u3046\u3064\u75c5\u30ea\u30b9\u30af\u3092\u6291\u5236<\/a>
\n\u30d3\u30bf\u30df\u30f3B\u7fa4\u304c\u8133\u5352\u4e2d\u5f8c\u306e\u3046\u3064\u75c5\u3092\u4e88\u9632<\/a><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u6297\u304c\u3093\u5264\u3068\u306e\u4f75\u7528\u304c\u554f\u984c\u3068\u306a\u308b\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306f\u3044\u304f\u3064\u304b\u3042\u308b\u3002 \u3053\u306e\u30bb\u30f3\u30c8\u30b8\u30e7\u30fc\u30f3\u30ba\u30ef\u30fc\u30c8\u3082\u305d\u306e\u4e00\u3064\u3060\u304c\u3001\u30d3\u30bf\u30df\u30f3\uff23\u3082\u30e1\u30bd\u30c8\u30ec\u30ad\u30bb\u30fc\u30c8\u3068\u306e\u4f75\u7528\u306f\u7981\u5fcc\u3068\u3044\u3048\u308b\u3002\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u304c\u300d\u7121\u5bb3\u3068\u3044\u3046\u308f\u3051\u3067\u306f\u306a\u304f\u3001\u4f55\u304b\u3057\u3089\u4f53\u306b\u5f71\u97ff\u3059\u308b\u85ac\u5264\u3082\u30b5 […]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[14,3],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts\/1665"}],"collection":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/comments?post=1665"}],"version-history":[{"count":0,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts\/1665\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/media?parent=1665"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/categories?post=1665"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/tags?post=1665"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}