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2013\u5e748\u670815\u65e5\u306b\uff0dCelery\u3001\u30a2\u30fc\u30c6\u30a3\u30c1\u30e7\u30fc\u30af\u3068\u85ac\u8349\uff08\u7279\u306b\u30e1\u30ad\u30b7\u30b3\u306e\u30aa\u30ec\u30ac\u30ce\uff09\u306f\u30012\u3064\u306e\u65b0\u3057\u3044\u30a4\u30ea\u30ce\u30a4\u5927\u5b66\u7814\u7a76\u306b\u3088\u3063\u3066\u3059\u3079\u3066\u3001\u30a2\u30d4\u30b2\u30cb\u30f3\u3068\u30eb\u30c6\u30aa\u30ea\u30f3\uff08\u91cd\u8981\u306a\u9175\u7d20\u3092\u963b\u5bb3\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u7814\u7a76\u5ba4\u3067\u4eba\u9593\u306e\u81b5\u81d3\u764c\u7d30\u80de\u3092\u6bba\u3059\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9<\/b>\uff09\u3092\u542b\u6709\u3059\u308b\u3002<\/p>\n 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Research<\/i>\u306e\u79d1\u5b66\u8005\u306e\u751f\u4f53\u5916\u7814\u7a76\u306f\u30a2\u30d4\u30b2\u30cb\u30f3\u6cbb\u7642\u304c\u81b5\u81d3\u7d30\u80de\u306717s\u3001\u30a4\u30f3\u30bf\u30fc\u30ed\u30a4\u30ad\u30f3\u306e\u5897\u52a0\u306b\u3064\u306a\u304c\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3053\u3068\u3092\u793a\u3059\u7b2c1\u3067\u3042\u308b\u3002\u305d\u3057\u3066\u3001\u6297\u81b5\u764c\u6d3b\u52d5\u3067\u305d\u306e\u6f5c\u5728\u7684\u95a2\u9023\u3092\u793a\u3059\u3002<\/p>\n \u81b5\u81d3\u304c\u3093\u60a3\u8005\u306f\u3001\u591a\u5206\u6709\u52b9\u306a\u30ec\u30d9\u30eb\u306b\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u306e\u8840\u6f3f\u6fc3\u5ea6\u3092\u4e0a\u3052\u308b\u306e\u306b\u5341\u5206\u306a\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u306e\u8c4a\u5bcc\u306a\u98df\u54c1\u3092\u98df\u3079\u308b\u3053\u3068\u304c\u53ef\u80fd\u3067\u306a\u3044\u3060\u308d\u3046\u3002\u3057\u304b\u3057\u3001\u79d1\u5b66\u8005\u306f\u305d\u308c\u3089\u306e\u96c6\u4e2d\u3092\u6210\u3057\u9042\u3052\u308b\u85ac\u3092\u8a2d\u8a08\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u305f\u3068\u3001\u30c7\u30fb\u30e1\u30d2\u30a2\u304c\u8a00\u3063\u305f\u3002<\/p>\n \u305d\u3057\u3066\u3001\u3053\u306e\u9a5a\u304f\u3079\u304d\u75be\u60a3\u306e\u4e88\u9632\u306f\u3001\u3082\u3046\u4e00\u3064\u306e\u8a18\u4e8b\u3067\u3042\u308b\u3002\u300c\u3042\u306a\u305f\u304c\u3042\u306a\u305f\u306e\u4eba\u751f\u3092\u901a\u3058\u3066\u591a\u304f\u306e\u679c\u7269\u3068\u91ce\u83dc\u3092\u98df\u3079\u308b\u5834\u5408\u3001\u3042\u306a\u305f\u306b\u306f\u3053\u308c\u3089\u306e\u751f\u7406\u6d3b\u6027\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u306b\u9577\u671f\u88ab\u66dd\u304c\u3042\u308b\u3002\u305d\u3057\u3066\u3001\u305d\u308c\u306f\u78ba\u5b9f\u306b\u764c\u306e\u30ea\u30b9\u30af\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u306e\u3092\u52a9\u3051\u308b\u300d\u3068\u3001\u5f7c\u5973\u304c\u6ce8\u610f\u3057\u305f\u3002<\/p>\n \u5b66\u8853\u8a8c\u53c2\u8003\u6587\u732e<\/b>\uff1a<\/p>\n <\/p>\n Salad fixings to fight pancreatic cancer<\/p>\n Posted by Bradford S. Weeks, MD<\/a> on August 19, 2013<\/p>\n Dr. Weeks\u2019 Comment: \u00a0I am on record for the past 2 decades for asserting that ALL plants have anti-cancer properties which will be discovered in due course. \u00a0Practically speaking, a plant wouldn\u2019t be able to adapt and survive without the capacity to fight cancer. \u00a0Now we learn that common vegetables in your salad (ahem\u2026 that you never eat !) can fight pancreatic cancer!<\/i><\/b><\/p>\n \u00a0<\/p>\n \u00a0<\/p>\n Celery, Artichokes Contain Flavonoids That Kill Human Pancreatic Cancer Cells<\/b><\/p>\n \u00a0<\/p>\n Aug. 15, 2013\u00a0\u2014 Celery, artichokes, and herbs, especially Mexican oregano, all contain apigenin and luteolin, flavonoids that kill human pancreatic cancer cells<\/b> in the lab by inhibiting an important enzyme, according to two new University of Illinois studies.<\/p>\n \u201cApigenin alone induced cell death in two aggressive human pancreatic cancer cell lines. But we received the best results when we pre-treated cancer cells with apigenin for 24 hours, then applied the chemotherapeutic drug gemcitabine for 36 hours,\u201d said Elvira de Mejia, a U of I professor of food chemistry and food toxicology.<\/p>\n The trick seemed to be using the flavonoids as a pre-treatment instead of applying them and the chemotherapeutic drug simultaneously, said Jodee Johnson, a doctoral student in de Mejia\u2019s lab who has since graduated.<\/p>\n \u201cEven though the topic is still controversial, our study indicated that taking antioxidant supplements on the same day as chemotherapeutic drugs may negate the effect of those drugs,\u201d she said.<\/p>\n \u201cThat happens because flavonoids can act as antioxidants. One of the ways that chemotherapeutic drugs kill cells is based on their pro-oxidant activity, meaning that flavonoids and chemotherapeutic drugs may compete with each other when they\u2019re introduced at the same time,\u201d she explained.<\/p>\n Pancreatic cancer is a very aggressive cancer, and there are few early symptoms, meaning that the disease is often not found before it has spread. Ultimately the goal is to develop a cure, but prolonging the lives of patients would be a significant development, Johnson added.<\/p>\n It is the fourth leading cause of cancer-related deaths, with a five-year survival rate of only 6 percent, she said.<\/p>\n The scientists found that apigenin inhibited an enzyme called glycogen synthase kinase-3\u03b2 (GSK-3\u03b2), which led to a decrease in the production of anti-apoptotic genes in the pancreatic cancer cells. Apoptosis means that the cancer cell self-destructs because its DNA has been damaged.<\/p>\n In one of the cancer cell lines, the percentage of cells undergoing apoptosis went from 8.4 percent in cells that had not been treated with the flavonoid to 43.8 percent in cells that had been treated with a 50-micromolar dose. In this case, no chemotherapy drug had been added.<\/p>\n Treatment with the flavonoid also modified gene expression. \u201cCertain genes associated with pro-inflammatory cytokines were highly upregulated,\u201d de Mejia said.<\/p>\n According to Johnson, the scientists\u2019 in vitro study in\u00a0Molecular Nutrition and Food Research<\/i>\u00a0is the first to show that apigenin treatment can lead to an increase in interleukin 17s in pancreatic cells, showing its potential relevance in anti-pancreatic cancer activity.<\/p>\n Pancreatic cancer patients would probably not be able to eat enough flavonoid-rich foods to raise blood plasma levels of the flavonoid to an effective level. But scientists could design drugs that would achieve those concentrations, de Mejia said.<\/p>\n And prevention of this frightening disease is another story. \u201cIf you eat a lot of fruits and vegetables throughout your life, you\u2019ll have chronic exposure to these bioactive flavonoids, which would certainly help to reduce the risk of cancer,\u201d she noted.<\/p>\n Journal References<\/b>:<\/p>\n <\/p>\n <\/p>\n","protected":false},"excerpt":{"rendered":" \u00a0\u30b5\u30e9\u30c0\u304c\u6297\u764c\u4f5c\u7528\u3092\u6301\u3063\u3066\u3044\u308b\u3068\u805e\u3044\u3066\u610f\u5916\u306b\u601d\u3046\u304b\u3082\u3057\u308c\u306a\u3044\u3002 \u79c1\u306f\u4eca\u307e\u3067\u306e\u7d4c\u9a13\u304b\u3089\u306a\u308b\u307b\u3069\u3068\u611f\u3058\u3066\u3044\u308b\u304c\u3001\u7686\u3055\u3093\u306f\u305d\u3046\u3067\u306f\u306a\u3044\u304b\u3082\u3057\u308c\u306a\u3044\u3002 \u30d1\u30af\u30ea\u30bf\u30ad\u30bb\u30eb (paclitaxel, TXL, TAX, PTX, PA […]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[12,3],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts\/1591"}],"collection":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/comments?post=1591"}],"version-history":[{"count":0,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts\/1591\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/media?parent=1591"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/categories?post=1591"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/tags?post=1591"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\n\u5b9f\u969b\u306e\u8a71\u3001\u690d\u7269\u306f\u764c\u3068\u6226\u3046\u80fd\u529b\u306a\u3057\u3067\u306f\u74b0\u5883\u306b\u9069\u5fdc\u3057\u3066\u751f\u304d\u306e\u3073\u308b\u3053\u3068\u306f\u3067\u304d\u306a\u3044\u306e\u3067\u3042\u308b\u3002
\n\u3055\u3066\u3001\u3042\u306a\u305f\u306e\u30b5\u30e9\u30c0\uff08\u3042\u306a\u305f\u304c\u6c7a\u3057\u3066\u98df\u3079\u306a\u3044\u3082\u306e\u304b\u3082\u2026\uff01\uff09\u3001\u91ce\u83dc\u306f\u81b5\u764c\u3068\u6226\u3046\u3053\u3068\u304c\u3067\u304d\u308b\u306e\u3060\uff01<\/i><\/b><\/p>\n
\n\u306f\u4eba\u9593\u306e\u81b5\u81d3\u764c\u7d30\u80de\u3092\u6bba\u3059\u30d5\u30e9\u30dc\u30ce\u30a4\u30c9\u3092\u542b\u6709\u3059\u308b<\/b><\/p>\n\n
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