{"id":1462,"date":"2013-06-04T15:32:11","date_gmt":"2013-06-04T06:32:11","guid":{"rendered":"https:\/\/www.taiyou-clinic.jp\/blog\/?p=1462"},"modified":"2013-06-04T15:32:11","modified_gmt":"2013-06-04T06:32:11","slug":"%e5%85%8d%e7%96%ab%e7%b3%bb%e3%82%92%e5%bc%b7%e5%8c%96%e3%81%99%e3%82%8b%e7%99%8c%e6%b2%bb%e7%99%82%e6%b3%95%e3%80%81%e8%a9%a6%e9%a8%93%e6%8b%a1%e5%a4%a7%e3%81%b8%ef%bc%8f%e3%82%b8%e3%83%a7%e3%83%b3","status":"publish","type":"post","link":"https:\/\/www.taiyou-clinic.jp\/blog\/archives\/1462","title":{"rendered":"\u514d\u75ab\u7cfb\u3092\u5f37\u5316\u3059\u308b\u764c\u6cbb\u7642\u6cd5\u3001\u8a66\u9a13\u62e1\u5927\u3078\uff0f\u30b8\u30e7\u30f3\u30ba\u30db\u30d7\u30ad\u30f3\u30b9\u5927\u5b66"},"content":{"rendered":"<h1><strong>\u514d\u75ab\u7cfb\u3092\u5f37\u5316\u3059\u308b\u764c\u6cbb\u7642\u6cd5\u3001\u8a66\u9a13\u62e1\u5927\u3078\uff0f\u30b8\u30e7\u30f3\u30ba\u30db\u30d7\u30ad\u30f3\u30b9\u5927\u5b66<\/strong><strong><\/strong><\/h1>\n<h1><strong>\u00a0<\/strong><\/h1>\n<p>******************************************<\/p>\n<p>\u6cbb\u7642\u306f\u5b89\u5168\u3067\u3001\u3042\u308b\u7a2e\u306e\u816b\u760d\u3092\u7e2e\u5c0f\u3057\u3001\u30de\u30fc\u30ab\u30fc\u306f\u6cbb\u7642\u52b9\u679c\u3092\u4e88\u6e2c\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u8a66\u9a13\u62c5\u5f53\u533b\u5e2b\u3089\u306f\u8ff0\u3079\u3066\u3044\u308b\u3002<\/p>\n<p>\u30b8\u30e7\u30f3\u30ba\u30db\u30d7\u30ad\u30f3\u30b9\u5927\u5b66\u30ad\u30f3\u30e1\u30eb\u304c\u3093\u30bb\u30f3\u30bf\u30fc\u306e\u7814\u7a76\u8005\u306e\u4e3b\u5c0e\u3067\u4ed6\u306e\u533b\u7642\u30bb\u30f3\u30bf\u30fc\u3068\u5171\u540c\u3067\u5b9f\u65bd\u3057\u305f2\u4ef6\u306e\u81e8\u5e8a\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u764c\u3092\u898b\u3064\u3051\u653b\u6483\u3059\u308b\u514d\u75ab\u7cfb\u306e\u80fd\u529b\u3092\u56de\u5fa9\u3055\u305b\u308b\u3053\u3068\u3092\u76ee\u7684\u3068\u3057\u305f\u88ab\u9a13\u85ac\u306e\u8a66\u9a13\u3092\u884c\u3063\u305f\u7d50\u679c\u3001\u9032\u884c\u6027\u975e\u5c0f\u7d30\u80de\u6027\u80ba\u764c\u60a3\u8005\u3001\u30e1\u30e9\u30ce\u30fc\u30de\u60a3\u8005\u3001\u814e\u764c\u60a3\u8005\u306b\u304a\u3044\u3066\u6709\u671b\u306a\u65e9\u671f\u7d50\u679c\u304c\u793a\u3055\u308c\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u540c\u3058\u514d\u75ab\u6291\u5236\u7d4c\u8def\u3092\u6a19\u7684\u3068\u3059\u308b\uff12\u3064\u306e\u85ac\u5264\u306e\u8a66\u9a13\u306b\u304a\u3044\u3066500\u4eba\u4ee5\u4e0a\u306e\u60a3\u8005\u304c\u6cbb\u7642\u3092\u53d7\u3051\u3001\u8a66\u9a13\u62c5\u5f53\u533b\u5e2b\u3089\u306b\u3088\u308b\u3068\u3055\u3089\u306b\u5927\u898f\u6a21\u306e\u60a3\u8005\u3067\u8a66\u9a13\u3092\u62e1\u5927\u3059\u308b\u305f\u3081\u306b\u5341\u5206\u306a\u8a3c\u62e0\u304c\u5f97\u3089\u308c\u305f\u3068\u3044\u3046\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u7b2c1\u76f8\u81e8\u5e8a\u8a66\u9a13\u306e\u7d50\u679c\u306f6\u67082\u65e5\u306bNew England Journal of Medicine\u306b\u304a\u3044\u3066\u30aa\u30f3\u30e9\u30a4\u30f3\u3067\u767a\u8868\u3055\u308c\u30012012\u5e74\u7c73\u56fd\u81e8\u5e8a\u816b\u760d\u5b66\u4f1a\u5e74\u6b21\u96c6\u4f1a\uff082012 American Society of Clinical Oncology Annual Meeting\u3000\u6284\u9332 #2509 and #2510)\u306b\u304a\u3044\u3066\u3082\u767a\u8868\u3055\u308c\u308b\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u300c\u3053\u308c\u3089\u306e\u85ac\u5264\u306b\u5bfe\u3059\u308b\u826f\u597d\u306a\u594f\u52b9\u7387\u3084\u305d\u306e\u52b9\u679c\u304c\u9577\u304f\u6301\u7d9a\u3059\u308b\u5834\u5408\u304c\u591a\u3044\u3053\u3068\u304b\u3089\u3001\u65b0\u305f\u306a\u81e8\u5e8a\u8a66\u9a13\u3092\u9032\u3081\u308b\u3079\u304d\u3060\u3068\u6211\u3005\u306f\u8003\u3048\u3066\u3044\u307e\u3059\u300d\u3068\u30b8\u30e7\u30f3\u30ba\u30db\u30d7\u30ad\u30f3\u30b9\u5927\u5b66\u306e\u5916\u79d1\u30fb\u816b\u760d\u5b66\u6559\u6388\u3067\u3042\u308bSuzanne 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death-1\uff09\u3068\u3001\u764c\u7d30\u80de\u306b\u767a\u73fe\u3059\u308bPD-L1\uff08programmed death ligand-1\uff09\u3068\u547c\u3070\u308c\u308b2\u3064\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3002PD-1\u3068PD-L1\u304c\u7d50\u5408\u3059\u308b\u3068\u3001\u514d\u75ab\u7cfb\u306b\u3088\u308b\u7834\u58ca\u304b\u3089\u816b\u760d\u7d30\u80de\u3092\u4fdd\u8b77\u3059\u308b\u751f\u5316\u5b66\u7684\u306a\u201c\u30b7\u30fc\u30eb\u30c9\u201d\u3092\u5f62\u6210\u3059\u308b\u3002\u672c\u7d4c\u8def\u306b\u95a2\u4e0e\u3057\u3001\u514d\u75ab\u7cfb\u306e\u7d30\u80de\u306b\u767a\u73fe\u3059\u308b\u3082\u30461\u3064\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3001PD-L2\uff08programmed death ligand-2\uff09\u306f\u30b8\u30e7\u30f3\u30ba\u30db\u30d7\u30ad\u30f3\u30b9\u5927\u5b66\u306e\u7814\u7a76\u8005\u3089\u304c\u6700\u521d\u306b\u767a\u898b\u3057\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u764c\u7d30\u80de\u3092\u514d\u75ab\u7cfb\u306b\u3088\u308a\u653b\u6483\u3055\u308c\u3084\u3059\u304f\u3059\u308b\u305f\u3081\u306b\u3001\u8a66\u9a13\u62c5\u5f53\u533b\u5e2b\u3089\u306f2\u3064\u306e\u85ac\u5264\u3001PD-1\u3092\u963b\u5bb3\u3059\u308bBMS-936558\u3068PD-L1\u3092\u963b\u5bb3\u3059\u308bBMS-936559\u3092\u8907\u6570\u306e\u7c73\u56fd\u306e\u75c5\u9662\u3067\u5b9f\u65bd\u3055\u308c\u308b\u5225\u3005\u306e\u81e8\u5e8a\u8a66\u9a13\u3067\u305d\u308c\u305e\u308c\u8a66\u9a13\u3057\u305f\u3002\u85ac\u5264\u306f2\u9031\u9593\u304a\u304d\u306b\u5916\u6765\u30af\u30ea\u30cb\u30c3\u30af\u3067\u9759\u8108\u5185\u6295\u4e0e\u3055\u308c\u3001\u60a3\u8005\u306f\u6700\u95772\u5e74\u9593\u6cbb\u7642\u3092\u7d99\u7d9a\u3067\u304d\u308b\u3053\u3068\u3068\u3057\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>PD-1\u963b\u5bb3\u85ac\u306e\u8a66\u9a13\u306f\u6a19\u6e96\u7642\u6cd5\u306b\u53cd\u5fdc\u3057\u306a\u304b\u3063\u305f\u69d8\u3005\u306a\u9032\u884c\u764c\u306e\u60a3\u8005296\u4eba\u3092\u5bfe\u8c61\u306b\u884c\u308f\u308c\u305f\u3002\u6297PD-1\u7642\u6cd5\u3092\u53d7\u3051\u305f\u60a3\u8005\u306e\u3046\u3061\u30012011\u5e747\u6708\u307e\u3067\u306b\u6cbb\u7642\u3092\u958b\u59cb\u3057\u305f240\u4eba\u306b\u3064\u3044\u3066\u816b\u760d\u53cd\u5fdc\u306e\u89e3\u6790\u3092\u884c\u3063\u305f\u3002\u6709\u610f\u306a\u816b\u760d\u306e\u7e2e\u5c0f\u304c\u307f\u3089\u308c\u305f\u306e\u306f\u3001\u975e\u5c0f\u7d30\u80de\u6027\u80ba\u764c\u60a3\u800576\u4eba\u4e2d14\u4eba\uff0818\uff05\uff09\u3001\u30e1\u30e9\u30ce\u30fc\u30de\u60a3\u800594\u4eba\u4e2d26\u4eba\uff0828\uff05\uff09\u3001\u814e\u764c\u60a3\u800533\u4eba\u4e2d9\u4eba\uff0827\uff05\uff09\u3067\u3042\u3063\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u672c\u8a66\u9a13\u306b\u304a\u3044\u3066\u3001\u80ba\u764c\u60a3\u800576\u4eba\u4e2d5\u4eba\uff087\uff05\uff09\u3001\u30e1\u30e9\u30ce\u30fc\u30de\u60a3\u800594\u4eba\u4e2d6\u4eba\uff086\uff05\uff09\u3001\u814e\u764c\u60a3\u800533\u4eba\u4e2d9\u4eba\uff0827\uff05\uff09\u306f6\u30ab\u6708\u4ee5\u4e0a\u75c5\u72b6\u304c\u5b89\u5b9a\u3057\u3066\u3044\u305f\u3002\u85ac\u5264\u304c\u751f\u5b58\u671f\u9593\u306b\u4e0e\u3048\u308b\u5f71\u97ff\u3092\u8abf\u67fb\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u3055\u3089\u306a\u308b\u81e8\u5e8a\u8a66\u9a13\u304c\u5fc5\u8981\u3067\u3042\u308b\u3068\u8a66\u9a13\u62c5\u5f53\u533b\u5e2b\u3089\u306f\u8ff0\u3079\u3066\u3044\u308b\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u300c\u514d\u75ab\u7642\u6cd5\u306b\u901a\u5e38\u306f\u53cd\u5fdc\u6027\u306e\u306a\u3044\u9032\u884c\u6027\u306e\u80ba\u764c\u306e\u60a3\u8005\u3067\u306e\u3053\u306e\u30ec\u30d9\u30eb\u306e\u53cd\u5fdc\u304c\u5f97\u3089\u308c\u305f\u3053\u3068\u306f\u4e88\u60f3\u5916\u3067\u3042\u308a\u3001\u6ce8\u76ee\u3059\u3079\u304d\u3053\u3068\u3067\u3057\u305f\u300d\u3068\u30b8\u30e7\u30f3\u30ba\u30db\u30d7\u30ad\u30f3\u30b9\u5927\u5b66\u306e\u816b\u760d\u5b66\u306e\u51c6\u6559\u6388\u3067\u3042\u308bJulie Brahmer\u533b\u5e2b\u306f\u8ff0\u3079\u3066\u3044\u308b\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u6297PD-L1\u7642\u6cd5\u306b\u3088\u308a\u6cbb\u7642\u3092\u53d7\u3051\u305f207\u4eba\u306e\u60a3\u8005\u306b\u304a\u3044\u3066\u3082\u53cd\u5fdc\u304c\u307f\u3089\u308c\u305f\u3002\u53cd\u5fdc\u304c\u307f\u3089\u308c\u305f\u306e\u306f\u3001\u975e\u5c0f\u7d30\u80de\u6027\u80ba\u764c\u60a3\u800549\u4eba\u4e2d5\u4eba\uff0810\uff05\uff09\u3001\u30e1\u30e9\u30ce\u30fc\u30de\u60a3\u800552\u4eba\u4e2d9\u4eba\uff0817\uff05\uff09\u3001\u814e\u764c\u60a3\u800517\u4eba\u4e2d2\u4eba\uff0812\uff05\uff09\u3067\u3042\u3063\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u300c\u4e21\u85ac\u5264\u3067\u597d\u307e\u3057\u3044\u7d50\u679c\u304c\u5f97\u3089\u308c\u305f\u3053\u3068\u306f\u3001PD-L1\/PD-1\u7d4c\u8def\u304c\u764c\u6cbb\u7642\u306e\u91cd\u8981\u306a\u6a19\u7684\u3067\u3042\u308b\u3068\u3044\u3046\u826f\u3044\u5146\u5019\u3067\u3059\u300d\u3068Topalian\u6c0f\u306f\u8ff0\u3079\u3066\u3044\u308b\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u6297PD-1\u7642\u6cd5\u306f296\u4eba\u4e2d41\u4eba\uff0814\uff05\uff09\u306e\u60a3\u8005\u306b\u304a\u3044\u3066\u91cd\u7be4\u306a\u6bd2\u6027\u3092\u5f15\u304d\u8d77\u3053\u3057\u305f\u3002\u6bd2\u6027\u306e\u591a\u304f\u306f\u3001\u7d50\u8178\u708e\u3001\u7532\u72b6\u817a\u7570\u5e38\u3001\u80ba\u81d3\u708e\u306b\u3088\u308b\u6b7b\u4ea1\uff083\u4eba\uff09\u306a\u3069\u514d\u75ab\u73fe\u8c61\u306b\u95a2\u9023\u3059\u308b\u3082\u306e\u3067\u3042\u3063\u305f\u3002\u8a66\u9a13\u62c5\u5f53\u533b\u5e2b\u3089\u306f\u5168\u56fd\u306e\u5171\u540c\u7814\u7a76\u8005\u3068\u5171\u306b\u3001\u80ba\u81d3\u708e\u306e\u65e9\u671f\u767a\u898b\u3068\u52b9\u679c\u7684\u306a\u6cbb\u7642\u306e\u305f\u3081\u306e\u3088\u308a\u826f\u3044\u65b9\u6cd5\u3092\u958b\u767a\u3059\u308b\u305f\u3081\u306b\u7814\u7a76\u3092\u884c\u3063\u3066\u3044\u308b\u3002\u305d\u306e\u4ed6\u306e\u91cd\u5ea6\u306e\u4f4e\u3044\u6bd2\u6027\u306f\u3001\u75b2\u52b4\u3001\u75d2\u307f\u3001\u767a\u75b9\u306a\u3069\u3067\u3042\u3063\u305f\u3002\u6297PD-L1\u7642\u6cd5\u306f9\uff05\u306e\u60a3\u8005\u306b\u91cd\u7be4\u306a\u6bd2\u6027\u3092\u5f15\u304d\u8d77\u3053\u3057\u305f\u304c\u3001\u6b7b\u4ea1\u3057\u305f\u60a3\u8005\u306f\u3044\u306a\u304b\u3063\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u6297PD-1\u7642\u6cd5\u3092\u53d7\u3051\u308b\u60a3\u8005\u306e\u3046\u3061\u300142\u4eba\u306e\u60a3\u8005\u304b\u3089\u8a66\u9a13\u85ac\u6295\u4e0e\u3092\u53d7\u3051\u308b\u524d\u306b\u816b\u760d\u306e\u691c\u4f53\u3092\u63a1\u53d6\u3057\u3001\u30b8\u30e7\u30f3\u30ba\u30db\u30d7\u30ad\u30f3\u30b9\u30e1\u30c7\u30a3\u30b9\u30f3\u3067\u81e8\u5e8a\u53cd\u5fdc\u306b\u95a2\u4e0e\u3059\u308b\u5206\u5b50\u30de\u30fc\u30ab\u30fc\u3092\u8a55\u4fa1\u3057\u305f\u3002\u8a66\u9a13\u62c5\u5f53\u533b\u5e2b\u3089\u306f42\u691c\u4f53\u4e2d25\u691c\u4f53\u306b\u304a\u3044\u3066PD-1\u306e\u30d1\u30fc\u30c8\u30ca\u30fc\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308bPD-L1\u304c\u767a\u73fe\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u305f\u3002PD-L1\u967d\u6027\u816b\u760d\u3092\u6709\u3059\u308b25\u4eba\u306e\u60a3\u8005\u306e\u3046\u30619\u4eba\u3067\u816b\u760d\u306e\u7e2e\u5c0f\u304c\u307f\u3089\u308c\u305f\u304c\u3001PD-L1\u9670\u6027\u816b\u760d\u3092\u6709\u3059\u308b\u60a3\u8005\u3067\u306f\u816b\u760d\u306e\u7e2e\u5c0f\u306f\u307f\u3089\u308c\u306a\u304b\u3063\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u300c\u6cbb\u7642\u524d\u306e\u816b\u760d\u751f\u691c\u3067\u306ePD-L1\u306e\u767a\u73fe\u304c\u6297PD-1\u7642\u6cd5\u306b\u5bfe\u3059\u308b\u81e8\u5e8a\u53cd\u5fdc\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u3092\u3053\u308c\u3089\u306e\u65e9\u671f\u7d50\u679c\u306f\u793a\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u3053\u306e\u3053\u3068\u3092\u78ba\u5b9f\u306b\u3059\u308b\u306b\u306f\u3055\u3089\u306a\u308b\u7814\u7a76\u304c\u5fc5\u8981\u3068\u306a\u308a\u307e\u3059\u300d\u3068Brahmer\u6c0f\u306f\u8ff0\u3079\u3066\u3044\u308b\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>PD-1\/PD-L1\u7d4c\u8def\u3092\u6a19\u7684\u3068\u3059\u308b2\u3064\u306e\u6cbb\u7642\u6cd5\u306f\u3001\u3044\u308f\u3086\u308b\u300c\u6297\u4f53\u7642\u6cd5\u300d\u3068\u3044\u308f\u308c\u308b\u540c\u30af\u30e9\u30b9\u306e\u6cbb\u7642\u6cd5\u3067\u3042\u308b\u3002\u300c\u6297\u4f53\u7642\u6cd5\u300d\u306f\u7d30\u80de\u8868\u9762\u306e\u7279\u5b9a\u306e\u5206\u5b50\u3092\u6a19\u7684\u3068\u3057\u7d50\u5408\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3088\u308a\u306a\u308b\u3002\u4ed6\u306e\u6297\u4f53\u7642\u6cd5\u3068\u3057\u3066\u3001\u30a2\u30fc\u30d3\u30bf\u30c3\u30af\u30b9\u3001\u30cf\u30fc\u30bb\u30d7\u30c1\u30f3\u3001\u30ea\u30c4\u30ad\u30b5\u30f3\u306a\u3069\u306e\u85ac\u5264\u304c\u3042\u308b\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u300c\u6211\u3005\u306f\u3053\u308c\u3089\u306e\u85ac\u5264\u306e\u975e\u81e8\u5e8a\u7814\u7a76\u304a\u3088\u3073\u81e8\u5e8a\u7814\u7a76\u306e\u4e0a\u3063\u9762\u3092\u306a\u3067\u305f\u306b\u3059\u304e\u306a\u3044\u306e\u3067\u3059\u300d\u3068Topalian\u6c0f\u306f\u8ff0\u3079\u3066\u3044\u308b\u3002<\/p>\n<p>\u6700\u7d42\u7684\u306b\u306f\u3001\u672c\u6cbb\u7642\u6cd5\u3068\u764c\u30ef\u30af\u30c1\u30f3\u306a\u3069\u306e\u6297\u764c\u5264\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u672c\u6cbb\u7642\u6cd5\u306e\u6709\u52b9\u6027\u3092\u5897\u5927\u3055\u305b\u308b\u3053\u3068\u3092\u8a66\u9a13\u62c5\u5f53\u533b\u5e2b\u3089\u306f\u8003\u3048\u3066\u3044\u308b\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u672c\u81e8\u5e8a\u8a66\u9a13\u306f\u30d6\u30ea\u30b9\u30c8\u30eb\u30fb\u30de\u30a4\u30e4\u30fc\u30ba\u30b9\u30af\u30a4\u30d6\u793e\u304a\u3088\u3073\u5c0f\u91ce\u85ac\u54c1\u5de5\u696d\u682a\u5f0f\u4f1a\u793e\u304b\u3089\u8cc7\u91d1\u63d0\u4f9b\u3092\u53d7\u3051\u3066\u3044\u308b\u3002\u7814\u7a76\u52a9\u6210\u306f\u7c73\u56fd\u56fd\u7acb\u885b\u751f\u7814\u7a76\u6240\uff08NIH\uff09\u306e\u7c73\u56fd\u56fd\u7acb\u764c\u7814\u7a76\u6240\uff08NCI\uff09\u304a\u3088\u3073Melanoma Research Alliance\u304b\u3089\u306e\u30b0\u30e9\u30f3\u30c8\uff08CA142779\u3001CA006973\uff09\u306b\u3088\u308b\u3002<\/p>\n<p>Topalian\u6c0f\u3001Brahmer\u6c0f\u4ee5\u5916\u306b2\u4ef6\u306e\u8a66\u9a13\u306b\u95a2\u4e0e\u3057\u305f\u8a66\u9a13\u62c5\u5f53\u533b\u5e2b\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3042\u308b\u3002<br \/>\nCharles G. Drake, M.D., Drew M. Pardoll, M.D., Ph.D., William H. Sharfman, M.D., Robert A. Anders, M.D., Ph.D., Janis M. Taube, M.D., Tracee L. McMiller, M.S., Haiying Xu, B.A., Shuming Chen, Ph.D., and Theresa M. Salay, B.S., from Johns Hopkins; Stephen Hodi, M.D., from the Dana Farber Cancer Center; Scott N. Gettinger, M.D., Lieping Chen, M.D., Ph.D., and Mario Sznol, M.D. from Yale University; David C. Smith, M.D., from the University of Michigan; David F. McDermott, M.D., and Michael B. Atkins, M.D., from Beth Israel Deaconess Medical Center; John D. Powderly, M.D., from the Carolina BioOncology Institute; Richard D. Carvajal, M.D., from Memorial Sloan Kettering Cancer Center; Jeffrey A. Sosman, M.D., and Leora Horn, M.D., from Vanderbilt University; Philip D. Leming, M.D., from Cincinnati Hematology-Oncology Inc.; David R. Spigel, M.D., from the Sara Cannon Research Institute\/Tennessee Oncology; Scott J. Antonia, M.D., Ph.D., from the H. Lee Moffitt Cancer Center; Alan J. Korman, Ph.D., Maria Jure-Kunkel, Ph.D., Shruti Agrawal, Ph.D., Dan McDonald, M.B.A., Georgia D. Kollia, Ph.D., Ashok Gupta, M.D., Ph.D., Suresh Alaparthy, Ph.D., Joseph F. Grosso, Ph.D., Susan M. Parker, Ph.D., Stacie M. Goldberg, Ph.D., and Jon M. Wigginton, M.D., from Bristol-Myers Squibb; Scott S. Tykodi, M.D., Ph.D., Laura Q. M. Chow, M.D., Shailender Bhatia, M.D., Renato Martins, M.D., M.P.H., Keith Eaton, M.D., Ph.D., from the University of Washington and Fred Hutchinson Cancer Research Center; Wen-Jen Hwu, M.D., Ph.D., and Patrick Hwu, M.D., from the MD Anderson Cancer Center; Luis H. Camacho, M.D., M.P.H., from the St. Luke\u2019s Episcopal Hospital Cancer Center; John Kauh, M.D., from the Winship Cancer Institute of Emory University; Kunle Odunsi, M.D., Ph.D., from the Roswell Park Cancer Institute; Henry C. Pitot, M.D., from the Mayo Clinic; Omid Hamid, M.D., from the Angeles Clinic<\/p>\n<p>Brahmer\u6c0f\u3001Topalian\u6c0f\u3001Drake\u6c0f\u3001Pardoll\u6c0f\u306f\u30d6\u30ea\u30b9\u30c8\u30eb\u30fb\u30de\u30a4\u30e4\u30fc\u30ba\u30b9\u30af\u30a4\u30d6\u793e\u306e\u76f8\u8ac7\u5f79\u3067\u3042\u3063\u305f\u3002Topalian\u6c0f\u306fMelanoma Research Alliance\u306eChief Scientific Officer\u3067\u3042\u308b\u3002\u3053\u308c\u3089\u306e\u53d6\u308a\u6c7a\u3081\u306e\u7528\u8a9e\u306f\u5229\u5bb3\u95a2\u4fc2\u306e\u65b9\u91dd\u306b\u5f93\u3044\u30b8\u30e7\u30f3\u30ba\u30db\u30d7\u30ad\u30f3\u30b9\u5927\u5b66\u306b\u3088\u308a\u7ba1\u7406\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n<p>\u95a2\u9023\u3059\u308b\u30cb\u30e5\u30fc\u30b9\u30ea\u30ea\u30fc\u30b9\uff1aSome Melanomas Use Cloaking Protein to Hide from Immune Cells<\/p>\n<p>\u30e1\u30c7\u30a3\u30a2\u9023\u7d61\u5148\uff1a<br \/>\nJohns Hopkins Kimmel Cancer Center<br \/>\nOffice of Public Affairs<br \/>\nVanessa Wasta<br \/>\n410-614-2916, wasta@jhmi.edu<\/p>\n<p>******<br \/>\n\u5f35\u77e5\u5b50 \u8a33<br \/>\n\u7530\u4e2d\u8b19\u592a\u90ce\uff08\u547c\u5438\u5668\u30fb\u816b\u760d\u5185\u79d1\u3001\u514d\u75ab\uff0f\u30c6\u30ad\u30b5\u30b9\u5927\u5b66MD\u30a2\u30f3\u30c0\u30fc\u30bd\u30f3\u304c\u3093\u30bb\u30f3\u30bf\u30fc\uff09\u76e3\u4fee<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u514d\u75ab\u7cfb\u3092\u5f37\u5316\u3059\u308b\u764c\u6cbb\u7642\u6cd5\u3001\u8a66\u9a13\u62e1\u5927\u3078\uff0f\u30b8\u30e7\u30f3\u30ba\u30db\u30d7\u30ad\u30f3\u30b9\u5927\u5b66 \u00a0 ****************************************** \u6cbb\u7642\u306f\u5b89\u5168\u3067\u3001\u3042\u308b\u7a2e\u306e\u816b\u760d\u3092\u7e2e\u5c0f\u3057\u3001\u30de\u30fc\u30ab\u30fc\u306f\u6cbb\u7642\u52b9\u679c\u3092\u4e88\u6e2c\u3067\u304d\u308b\u53ef [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts\/1462"}],"collection":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/comments?post=1462"}],"version-history":[{"count":0,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts\/1462\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/media?parent=1462"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/categories?post=1462"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/tags?post=1462"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}