{"id":1417,"date":"2013-05-07T12:35:11","date_gmt":"2013-05-07T03:35:11","guid":{"rendered":"https:\/\/www.taiyou-clinic.jp\/blog\/?p=1417"},"modified":"2013-05-07T12:35:11","modified_gmt":"2013-05-07T03:35:11","slug":"%e7%b7%91%e8%8c%b6%e3%82%ab%e3%83%86%e3%82%ad%e3%83%b3%e3%81%a8%e4%b9%b3%e3%81%8c%e3%82%93%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6","status":"publish","type":"post","link":"https:\/\/www.taiyou-clinic.jp\/blog\/archives\/1417","title":{"rendered":"\u7dd1\u8336\u30ab\u30c6\u30ad\u30f3\u3068\u4e73\u304c\u3093\u306b\u3064\u3044\u3066"},"content":{"rendered":"

\u7dd1\u8336\u30ab\u30c6\u30ad\u30f3\u306e\u4e73\u304c\u3093\u306b\u5bfe\u3059\u308b\u6297\u304c\u3093\u4f5c\u7528\u30fb\u6297\u708e\u75c7\u4f5c\u7528<\/strong><\/strong><\/p>\n

\u7dd1\u8336\u306e\u529b\u306f\u3069\u306e\u7a0b\u5ea6\u5f37\u3044\u306e\u3060\u308d\u3046\u304b\uff1f\u304a\u305d\u3089\u304f\u306f\u3053\u3046\u3044\u3046\u6297\u708e\u75c7\u4f5c\u7528\u3001\u6297\u9178\u5316\u4f5c\u7528\u306f\u30ac\u30f3\u306b\u306a\u3089\u306a\u3044\u305f\u3081\u306b\u666e\u6bb5\u304b\u3089\u6442\u53d6\u3057\u305f\u307b\u3046\u304c\u3044\u3044\u3068\u3044\u3046\u3053\u3068\u3060\u308d\u3046\u3068\u601d\u308f\u308c\u308b\u3002<\/p>\n

\u6cbb\u7642\u52b9\u679c\u3068\u3057\u3066\u306f\u7de9\u5f90\u306b\u50cd\u304f\u305f\u3081\u306b\u6cbb\u7642\u671f\u9593\u304c\u9577\u3044\u3068\u3044\u3046\u6b20\u70b9\u3082\u3042\u308b\u3002<\/p>\n

\u306a\u3093\u306b\u3057\u308d\u666e\u6bb5\u304b\u3089\u3053\u3046\u3044\u3046\u3088\u3044\u3046\u3082\u306e\u306f\u751f\u6d3b\u306b\u53d6\u308a\u5165\u308c\u308b\u3079\u304d\u3067\u3042\u308b\u3002<\/p>\n

 <\/p>\n

***********************************<\/p>\n

http:\/\/www.dhcblog.com\/kamohara\/category_12\/<\/p>\n

\u4eca\u6708\u306e\u7d30\u80de\u751f\u7269\u5b66\u306e\u5c02\u9580\u30b8\u30e3\u30fc\u30ca\u30eb\u306b\u3001\u7dd1\u8336\u30ab\u30c6\u30ad\u30f3\u306b\u3088\u308b\u4e73\u304c\u3093\u306b\u5bfe\u3059\u308b\u6297\u304c\u3093\u4f5c\u7528\u3068\u6297\u708e\u75c7\u4f5c\u7528\u3092\u793a\u3057\u305f\u57fa\u790e\u7814\u7a76\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002(Vasc Cell. <\/em>2013 May 2;5(1):9.)<\/p>\n

\u7dd1\u8336\u306b\u306f\u3001\u7dd1\u8336\u30ab\u30c6\u30ad\u30f3\u304c\u542b\u307e\u308c\u3066\u304a\u308a\u3001\u591a\u304f\u306e\u57fa\u790e\u7814\u7a76\u3084\u75ab\u5b66\u8abf\u67fb\u306b\u3088\u3063\u3066\u3001\u6297\u304c\u3093\u4f5c\u7528\u3001\u304c\u3093\u30ea\u30b9\u30af\u4f4e\u6e1b\u4f5c\u7528\u304c\u793a\u3055\u308c\u3066\u304d\u307e\u3057\u305f\u3002
\n\u7279\u306b\u3001EGCG\u304c\u4e3b\u8981\u306a\u52b9\u679c\u3092\u793a\u3059\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u3055\u3066\u3001\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u4e73\u304c\u3093\u306b\u5bfe\u3059\u308b\u7dd1\u8336\u30ab\u30c6\u30ad\u30f3EGCG\u306e\u4f5c\u7528\u3068\u3057\u3066\u3001HIF-1alpha \u3068NFkappaB\u6d3b\u6027\u3078\u306e\u963b\u5bb3\u4f5c\u7528\u3001VEGF\u767a\u73fe\u3078\u306e\u963b\u5bb3\u4f5c\u7528\u304c\u691c\u8a3c\u3055\u308c\u307e\u3057\u305f\u3002
\n\u5177\u4f53\u7684\u306b\u306f\u3001
\n\u96ccC57BL\/6 J\u30de\u30a6\u30b9(8\u9031\u9f62\u3001n=16)\u306b\u30de\u30a6\u30b9\u4e73\u304c\u3093\u7d30\u80de\u304c\u64ad\u7a2e\u3055\u308c\u3001
\n\u30fbEGCG\u6295\u4e0e(50--100 mg\/kg\/d)\u7fa4(n=8)
\n\u30fb\u5bfe\u7167\u7fa4(n=8)\u306e2\u7fa4\u306b\u3064\u3044\u3066\u30014\u9031\u9593\u306e\u4ecb\u5165\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u89e3\u6790\u306e\u7d50\u679c\u3001\u5bfe\u7167\u7fa4\u306b\u6bd4\u3079\u3066\u3001EGCG\u6295\u4e0e\u7fa4\u3067\u306f\u3001\u816b\u760d\u7d44\u7e54\u91cd\u91cf\u306e\u6709\u610f\u306a\u6e1b\u5c11\u3001(0.37\u00b10.15 vs. 1.16\u00b10.30 g; P < 0.01),<\/p>\n

\u816b\u760d\u6bdb\u7d30\u8840\u7ba1\u5bc6\u5ea6\u306e\u6709\u610f\u306a\u6e1b\u5c11\u3001(109\u00b120 vs. 156\u00b112 capillary \/mm2; P < 0.01),<\/p>\n

\u816b\u760d\u7d44\u7e54\u3067\u306eVEGF\u767a\u73fe\u306e\u6709\u610f\u306a\u4f4e\u4e0b\u3001(45.72\u00b11.4 vs. 59.03\u00b13.8 pg\/mg; P < 0.01)
\n\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n

\u307e\u305f\u3001\u4e73\u304c\u3093\u7d44\u7e54\u306b\u304a\u3044\u3066\u3001\u5bfe\u7167\u7fa4\u306b\u6bd4\u3079\u3066\u3001EGCG\u6295\u4e0e\u306b\u3088\u308bHIF-1alpha \u3068NFkappaB\u6d3b\u6027\u306e\u6709\u610f\u306a\u6291\u5236\u3001VEGF\u767a\u73fe\u306e\u6709\u610f\u306a\u4f4e\u4e0b\u3082\u793a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

\u4e00\u65b9\u3001\u4f53\u91cd\u3084\u5fc3\u81d3\u91cd\u91cf\u3001\u5fc3\u81d3\u304a\u3088\u3073\u9aa8\u683c\u7b4b\u3067\u306e\u8840\u7ba1\u65b0\u751f\u3084VEGF\u767a\u73fe\u306b\u306fEGCG(50\u03bcg\/mL)\u306e\u7528\u91cf\u3067\u306f\u3001\u6709\u610f\u306a\u5909\u5316\u306f\u898b\u51fa\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n

\u4ee5\u4e0a\u306e\u30c7\u30fc\u30bf\u304b\u3089\u3001\u7dd1\u8336\u306b\u542b\u307e\u308c\u308b\u4e3b\u8981\u306a\u30ab\u30c6\u30ad\u30f3\u306eEGCG\u306b\u3088\u308b\u3001\u4e73\u304c\u3093\u7d30\u80de\u306e\u5897\u6b96\u6291\u5236\u4f5c\u7528\u304c\u793a\u5506\u3055\u308c\u307e\u3059\u3002<\/p>\n

\u4eca\u5f8c\u3001\u81e8\u5e8a\u7684\u610f\u7fa9\u306e\u691c\u8a3c\u304c\u671f\u5f85\u3055\u308c\u308b\u5206\u91ce\u3067\u3059\u3002
\n\u3053\u308c\u307e\u3067\u306e\u591a\u304f\u306e\u75ab\u5b66\u8abf\u67fb\u3067\u3001\u7dd1\u8336\u306e\u6442\u53d6\u3068\u3001\u80c3\u304c\u3093\u306a\u3069\u306e\u30ea\u30b9\u30af\u4f4e\u4e0b\u3068\u306e\u95a2\u9023\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002
\n\u307e\u305f\u3001\u57fa\u790e\u7814\u7a76\u3067\u306f\u3001\u7dd1\u8336\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\u306b\u3088\u308b\u6297\u304c\u3093\u4f5c\u7528\u3084\u6297\u9178\u5316\u4f5c\u7528\u304c\u898b\u51fa\u3055\u308c\u3066\u304a\u308a\u3001\u7dd1\u8336\u306b\u3088\u308b\u6297\u304c\u3093\u52b9\u679c\u304c\u78ba\u7acb\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

(\u305f\u3060\u3057\u3001\u7dd1\u8336\u30dd\u30ea\u30d5\u30a7\u30ce\u30fc\u30eb\/\u30ab\u30c6\u30ad\u30f3\u306b\u3088\u308b\u4ecb\u5165\u52b9\u679c\u306f\u7de9\u5f90\u3067\u3042\u308b\u305f\u3081\u3001\u305d\u306e\u6297\u304c\u3093\u4f5c\u7528\u3092\u898b\u51fa\u3059\u3053\u3068\u304c\u3067\u304d\u306a\u304b\u3063\u305f\u507d\u9670\u6027\u306e\u75ab\u5b66\u30c7\u30fc\u30bf\u3082\u6563\u898b\u3055\u308c\u3001\u30cd\u30ac\u30c6\u30a3\u30d6\u30c7\u30fc\u30bf\u3092\u597d\u3093\u3067\u53d6\u308a\u4e0a\u3052\u308b\u30e1\u30c7\u30a3\u30a2\u3067\u307f\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u3002)<\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

\u7dd1\u8336\u30ab\u30c6\u30ad\u30f3\u306e\u4e73\u304c\u3093\u306b\u5bfe\u3059\u308b\u6297\u304c\u3093\u4f5c\u7528\u30fb\u6297\u708e\u75c7\u4f5c\u7528 \u7dd1\u8336\u306e\u529b\u306f\u3069\u306e\u7a0b\u5ea6\u5f37\u3044\u306e\u3060\u308d\u3046\u304b\uff1f\u304a\u305d\u3089\u304f\u306f\u3053\u3046\u3044\u3046\u6297\u708e\u75c7\u4f5c\u7528\u3001\u6297\u9178\u5316\u4f5c\u7528\u306f\u30ac\u30f3\u306b\u306a\u3089\u306a\u3044\u305f\u3081\u306b\u666e\u6bb5\u304b\u3089\u6442\u53d6\u3057\u305f\u307b\u3046\u304c\u3044\u3044\u3068\u3044\u3046\u3053\u3068\u3060\u308d\u3046\u3068\u601d\u308f\u308c\u308b\u3002 \u6cbb\u7642\u52b9\u679c\u3068\u3057\u3066\u306f […]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[14],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts\/1417"}],"collection":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/comments?post=1417"}],"version-history":[{"count":0,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts\/1417\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/media?parent=1417"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/categories?post=1417"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/tags?post=1417"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}