{"id":1366,"date":"2013-04-13T13:21:13","date_gmt":"2013-04-13T04:21:13","guid":{"rendered":"https:\/\/www.taiyou-clinic.jp\/blog\/?p=1366"},"modified":"2013-04-13T13:21:13","modified_gmt":"2013-04-13T04:21:13","slug":"%e3%82%af%e3%83%ab%e3%82%af%e3%83%9f%e3%83%b3%e3%82%a6%e3%82%b3%e3%83%b3%e3%81%ab%e3%82%88%e3%82%8b%e3%82%a2%e3%82%bb%e3%83%88%e3%82%a2%e3%83%9f%e3%83%8e%e3%83%95%e3%82%a7%e3%83%b3%e3%82%bf","status":"publish","type":"post","link":"https:\/\/www.taiyou-clinic.jp\/blog\/archives\/1366","title":{"rendered":"\u30af\u30eb\u30af\u30df\u30f3(\u30a6\u30b3\u30f3)\u306b\u3088\u308b\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3(\u30bf\u30a4\u30ec\u30ce\u30fc\u30eb)\u8a98\u5c0e\u6027\u809d\u969c\u5bb3\u6291\u5236\u4f5c\u7528\u3000"},"content":{"rendered":"<p><strong>\u30af\u30eb\u30af\u30df\u30f3<\/strong><strong>(<\/strong><strong>\u30a6\u30b3\u30f3<\/strong><strong>)<\/strong><strong>\u306b\u3088\u308b\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3<\/strong><strong>(<\/strong><strong>\u30bf\u30a4\u30ec\u30ce\u30fc\u30eb<\/strong><strong>)<\/strong><strong>\u8a98\u5c0e\u6027\u809d\u969c\u5bb3\u6291\u5236\u4f5c\u7528\u3000<\/strong><\/p>\n<p>\u5185\u670d\u85ac\u306e\u526f\u4f5c\u7528\u3082\u6291\u5236\u3059\u308b\u52b9\u679c\u304c\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u305f\u3002\u3057\u3070\u3057\u3070\u3001\u983b\u56de\u306bNSIDs\u3092\u4f7f\u7528\u3059\u308b\u969b\u306b\u306f\u4f75\u7528\u3059\u308c\u3070\u3044\u3044\u3060\u308d\u3046\u3002<\/p>\n<p>********************<\/p>\n<p>http:\/\/www.dhcblog.com\/kamohara\/<\/p>\n<p>\u6d88\u5316\u5668\u75c5\u5b66\u306e\u5c02\u9580\u30b8\u30e3\u30fc\u30ca\u30eb\u306b\u3001\u30af\u30eb\u30af\u30df\u30f3(\u30a6\u30b3\u30f3)\u306b\u3088\u308b\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3(\u30bf\u30a4\u30ec\u30ce\u30fc\u30eb)\u8a98\u5c0e\u6027\u809d\u969c\u5bb3\u6291\u5236\u4f5c\u7528\u3092\u793a\u3057\u305f\u57fa\u790e\u7814\u7a76\u304c\u3001\u30bf\u30a4\u306e\u30b0\u30eb\u30fc\u30d7(Chulalongkorn University)\u304b\u3089\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002<br \/>\n(<em>World J Gastroenterol. <\/em>2013 Mar 28;19(12):1962-7.)<\/p>\n<p>\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3(\u30bf\u30a4\u30ec\u30ce\u30fc\u30eb)\u306f\u3001\u65e5\u672c\u3092\u542b\u3081\u3066\u5e83\u304f\u4e16\u754c\u4e2d\u3067\u7528\u3044\u3089\u308c\u3066\u3044\u308b\u93ae\u75db\u85ac\u3067\u3059\u3002<br \/>\n\u305f\u3060\u3057\u3001\u904e\u5270\u6295\u4e0e\u3084\u98f2\u9152\u3068\u306e\u4f75\u7528\u306b\u3088\u308b\u91cd\u7be4\u306a\u809d\u969c\u5bb3\u3092\u751f\u3058\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3055\u3066\u3001\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u30a6\u30b3\u30f3\u306b\u542b\u307e\u308c\u308b\u6a5f\u80fd\u6027\u6210\u5206\u306e\u30af\u30eb\u30af\u30df\u30f3\u306b\u3088\u308b\u3001\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3\u904e\u5270\u6295\u4e0e\u6642\u306e\u809d\u969c\u5bb3\u3078\u306e\u4f5c\u7528\u304c\u8abf\u3079\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u5177\u4f53\u7684\u306b\u306f\u96c4\u30de\u30a6\u30b9\u3092\u7528\u3044\u3066\u3001\u30fb\u5bfe\u7167\u7fa4(n=8)<br \/>\n\u30fb\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3\u6295\u4e0e\u7fa4(n=8)\uff1a400mg\/kg\u306e\u5358\u56de\u6295\u4e0e<br \/>\n\u30fb\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3+\u4f4e\u7528\u91cf\u30af\u30eb\u30af\u30df\u30f3\u306e\u4f75\u7528\u6295\u4e0e(n=8)\uff1a\u30af\u30eb\u30af\u30df\u30f3\u306f200mg\/kg<br \/>\n\u30fb\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3+\u9ad8\u7528\u91cf\u30af\u30eb\u30af\u30df\u30f3\u306e\u4f75\u7528\u6295\u4e0e(n=8)\uff1a\u30af\u30eb\u30af\u30df\u30f3\u306f600mg\/kg<br \/>\n\u306e4\u7fa4\u306b\u3064\u3044\u3066\u3001\u809d\u81d3\u7d44\u7e54\u5b66\u7684\u691c\u67fb\u3001\u9178\u5316\u969c\u5bb3\u3001\u809d\u6a5f\u80fd\u95a2\u9023\u6307\u6a19\u304c\u6e2c\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u89e3\u6790\u306e\u7d50\u679c\u5bfe\u7167\u7fa4\u306b\u6bd4\u3079\u3066\u3001\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3\u6295\u4e0e\u7fa4\u3067\u306f\u3001\u809d\u9038\u8131\u9175\u7d20\u306e\u5897\u52a0\u3001\u809dMDA\u5024\u306e\u5897\u52a0\u3001\u708e\u75c7\u60f9\u8d77\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u985e\u306e\u5897\u52a0\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u30af\u30eb\u30af\u30df\u30f3\u306e\u4f75\u7528\u7fa4\u3067\u306f\u3001\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3\u6295\u4e0e\u7fa4\u306b\u6bd4\u3079\u3066\u3001\u3053\u308c\u3089\u306e\u6307\u6a19(\u306e\u5897\u52a0)\u304c\u6709\u610f\u306b\u6291\u5236\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002<br \/>\nGSH(\u6297\u9178\u5316\u80fd\u306e\u6307\u6a19)\u306f\u3001\u5bfe\u7167\u7fa4\u306b\u6bd4\u3079\u3066\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3\u6295\u4e0e\u7fa4\u3067\u306f\u6709\u610f\u306b\u4f4e\u4e0b\u3057\u3066\u3044\u307e\u3059\u3002<br \/>\n\u3053\u308c\u306b\u5bfe\u3057\u3066\u3001\u30af\u30eb\u30af\u30df\u30f3\u306e\u4f75\u7528\u3067\u306f\u6709\u610f\u306a\u5897\u52a0\u3092\u793a\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u809d\u81d3\u306e\u7d44\u7e54\u5b66\u7684\u6240\u898b\u3067\u306f\u3001\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3\u6295\u4e0e\u7fa4\u3067\u306f\u3001\u51fa\u8840\u6027\u58ca\u6b7b\u7d44\u7e54\u304c\u8a8d\u3081\u3089\u308c\u305f\u306e\u306b\u5bfe\u3057\u3066\u3001<br \/>\n\u30af\u30eb\u30af\u30df\u30f3\u4f75\u7528\u7fa4\u3067\u306f\u3001\u3053\u308c\u3089\u306e\u6240\u898b\u306e\u6539\u5584\u304c\u898b\u51fa\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n\u4ee5\u4e0a\u306e\u30c7\u30fc\u30bf\u304b\u3089\u3001<\/p>\n<p>\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3\u306e(\u904e\u5270)\u6295\u4e0e\u6642\u306b\u304a\u3051\u308b\u809d\u969c\u5bb3\u3084\u9178\u5316\u969c\u5bb3\u306e\u30ea\u30b9\u30af\u6291\u5236\u306b\u5bfe\u3057\u3066\u3001<br \/>\n\u30a6\u30b3\u30f3\/\u30af\u30eb\u30af\u30df\u30f3\u306e\u4f75\u7528\u6295\u4e0e\u304c\u6709\u7528\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<br \/>\n\u4eca\u5f8c\u3001\u81e8\u5e8a\u7684\u610f\u7fa9\u306e\u691c\u8a3c\u304c\u671f\u5f85\u3055\u308c\u308b\u5206\u91ce\u3067\u3059\u3002<\/p>\n<p>\u30a6\u30b3\u30f3\u306b\u306f\u6709\u52b9\u6210\u5206\u3068\u3057\u3066\u30af\u30eb\u30af\u30df\u30f3\u304c\u5b58\u5728\u3057\u3001\u6297\u708e\u75c7\u4f5c\u7528\u3092\u793a\u3057\u307e\u3059\u3002<br \/>\n\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u3001NF-\u03baB\u6291\u5236\u3092\u4ecb\u3057\u305f\u6297\u708e\u75c7\u4f5c\u7528\u3067\u3059\u3002<br \/>\n\u30af\u30eb\u30af\u30df\u30f3\/\u30a6\u30b3\u30f3\u306f\u3001\u65e5\u672c\u3067\u306f\u3001\u98f2\u9152\u6642\u306e\u809d\u81d3\u4fdd\u8b77\u3068\u3044\u3046\u30a4\u30e1\u30fc\u30b8\u3067\u3059\u304c\u3001\u6d77\u5916\u306e\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u3001\u6297\u708e\u75c7\u4f5c\u7528\u3001\u6297\u304c\u3093\u4f5c\u7528\u3001\u8a8d\u77e5\u75c7\u6291\u5236\u306a\u3069\u591a\u5f69\u306a\u4f5c\u7528\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u30af\u30eb\u30af\u30df\u30f3\uff08\u30a6\u30b3\u30f3\uff09\u306b\u3064\u3044\u3066\u7c21\u5358\u306b\u307e\u3068\u3081\u3066\u307f\u307e\u3057\u305f\u3002<\/p>\n<p>\u25a0\u30af\u30eb\u30af\u30df\u30f3\u3068\u306f<br \/>\n\u30fb\u30af\u30eb\u30af\u30df\u30f3\u306f\uff0c\u30a6\u30b3\u30f3\uff08\u5b66\u540dCurcuma longa\uff09\u306e\u6709\u52b9\u6210\u5206\u3002<br \/>\n\u30fb\u975e\u81e8\u5e8a\u7814\u7a76\uff1b\u6297\u708e\u75c7\u4f5c\u7528\uff0c\u6297\u9178\u5316\u4f5c\u7528\uff0c\u7d30\u80de\u5897\u6b96\u6291\u5236\u3002<br \/>\n\u30fb\u81e8\u5e8a\u7814\u7a76\u3067\u306f\uff0c\u9032\u884c\u304c\u3093\uff0c\u591a\u767a\u6027\u9aa8\u9ac4\u816b\uff0c\u5927\u8178\u817a\u816b\u7b49\u3078\u6295\u4e0e\u3002<\/p>\n<p>\u25a0\u30af\u30eb\u30af\u30df\u30f3\u3000\u7b2c1\u76f8\u81e8\u5e8a\u8a66\u9a13\u3000<br \/>\n\u30fb\u30af\u30eb\u30af\u30df\u30f3\u3092\u7528\u3044\u305f\u7528\u91cf\u6f38\u5897\u8a66\u9a13(Dose Escalation Study)<br \/>\n\u3000\u5065\u5e38\u800524\u540d\u3092\u5bfe\u8c61\u306b\uff0c\u30af\u30eb\u30af\u30df\u30f3\u3092500\uff0c1,000\uff0c2,000\uff0c4,000\uff0c6,000\uff0c8,000 mg\u306e\u7528\u91cf\u306b\u3066\u5358\u56de\u6295\u4e0e\u3057\u305f\u7d50\u679c\uff0c\u8a8d\u5bb9\u6027\u304c\u793a\u3055\u308c\u305f\u3002(BMC Complement Altern Med. 2006 Mar 17)<\/p>\n<p>\u30fbPhase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance.<br \/>\n\u3000\u5927\u8178\u304c\u3093\u60a3\u800515\u540d\u3092\u5bfe\u8c61\u306b\uff0c3,600mg\/\u65e5\u306e\u30af\u30eb\u30af\u30df\u30f3\u30924\u30f6\u6708\u9593\u6295\u4e0e\u3002<br \/>\n(Clin Cancer Res. 2004)<\/p>\n<p>\u25a0\u30af\u30eb\u30af\u30df\u30f3\u3000\u7b2c2\u76f8\u81e8\u5e8a\u8a66\u9a13<br \/>\n\u30fb\u30af\u30eb\u30af\u30df\u30f3\u306b\u3088\u308b\u81e8\u5e8a\u8a66\u9a13\u7b2c\uff12\u76f8\uff1a\u9032\u884c\u81b5\u304c\u3093<br \/>\n\u3000\u81b5\u81d3\u304c\u3093\u60a3\u800525\u540d\u3092\u5bfe\u8c61\u306b\u30018,000mg\/\u65e5\u306e\u30af\u30eb\u30af\u30df\u30f3\u3092\u6295\u4e0e\u3002\u9ad8\u3044\u8a8d\u5bb9\u6027\u3002\u4e00\u90e8\u306e\u60a3\u8005\u3067\u306f\u6709\u52b9\u6027\u3082\u3002(Clin Cancer Res. 2008)<\/p>\n<p>\u25a0\u7d30\u7c92\u5316\u30af\u30eb\u30af\u30df\u30f3\uff1a\u5438\u53ce\u7387\u306e\u98db\u8e8d\u7684\u5411\u4e0a\u3068\u30d2\u30c8\u81e8\u5e8a\u8a66\u9a13<br \/>\n\u30fbNanoparticle curcumin for improved oral bioavailability\u3000(Biol Pharm Bull. 2011;34(5):660-5)<br \/>\n\u30fbNanoparticle curcumin can safely increase plasma curcumin levels in a dose-dependent manner at least up to 210 mg without saturating the absorption. (Cancer Chemother Pharmacol. 2011 May 21.)<\/p>\n<p><a href=\"http:\/\/formedic.dhc.co.jp\/\" target=\"_blank\" class=\"broken_link\" rel=\"nofollow\">\u533b\u7642\u6a5f\u95a2\u5c02\u7528\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3010DHC FOR MEDIC\u3011\uff08DHC\u30d5\u30a9\u30fc\u30e1\u30c7\u30a3\u30c3\u30af\uff09<\/a>\u306e\u30e9\u30a4\u30f3\u30a2\u30c3\u30d7\u3067\u3001\u9ad8\u5438\u53ce\u30fb\u9ad8\u7528\u91cf\u30bf\u30a4\u30d7\u306e\u30af\u30eb\u30af\u30df\u30f3\u3092\u6271\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30af\u30eb\u30af\u30df\u30f3(\u30a6\u30b3\u30f3)\u306b\u3088\u308b\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3(\u30bf\u30a4\u30ec\u30ce\u30fc\u30eb)\u8a98\u5c0e\u6027\u809d\u969c\u5bb3\u6291\u5236\u4f5c\u7528\u3000 \u5185\u670d\u85ac\u306e\u526f\u4f5c\u7528\u3082\u6291\u5236\u3059\u308b\u52b9\u679c\u304c\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u305f\u3002\u3057\u3070\u3057\u3070\u3001\u983b\u56de\u306bNSIDs\u3092\u4f7f\u7528\u3059\u308b\u969b\u306b\u306f\u4f75\u7528\u3059\u308c\u3070\u3044\u3044\u3060\u308d\u3046\u3002 ********** [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[4],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts\/1366"}],"collection":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/comments?post=1366"}],"version-history":[{"count":0,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts\/1366\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/media?parent=1366"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/categories?post=1366"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/tags?post=1366"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}