\u00a0\u30a6\u30a4\u30fc\u30af\u30b9\u306eHP\u304b\u3089\u306e\u8ee2\u8f09\u3067\u3059\u3002<\/p>\n
\u304c\u3093\u7d30\u80de\u306f\u7cd6\u3092\u4ee3\u8b1d\u3059\u308b\u3053\u3068\u306f\u6709\u540d\u306a\u8a71\u3067\u3042\u308b\u3002\u3053\u306e\u6027\u8cea\u3092\u5229\u7528\u3057\u3066PET\u691c\u67fb\u304c\u51fa\u3066\u304d\u305f\u3002
\n\u3057\u304b\u3057\u3001\u4e16\u754c\u4e2d\u306e\u6a19\u6e96\u7642\u6cd5\u306e\u533b\u5e2b\u305f\u3061\u306f\u98df\u4e8b\u306b\u3064\u3044\u3066\u306f\u3001\u7cd6\u5206\u3092\u6442\u53d6\u3059\u308b\u3053\u3068\u306b\u5236\u9650\u3092\u3059\u308b\u6c17\u306f\u306a\u3044\u3089\u3057\u3044\u3002
\n\u65e5\u672c\u3067\u3082\u540c\u69d8\u3067\u3042\u308b\u304c\u3001\u30a6\u30a4\u30fc\u30af\u30b9\u306e\u4f4f\u3080\u30b7\u30a2\u30c8\u30eb\u3067\u3082\u540c\u3058\u3060\u305d\u3046\u3060\u3002<\/p>\n
\u7cd6\u306e\u4ee3\u8b1d\u7523\u7269\u306b\u4e73\u9178\u304c\u3042\u308a\u3001\u4e73\u9178\u304c\u304c\u3093\u7d30\u80de\u306e\u7d30\u80de\u5185\u306b\u3068\u3069\u307e\u308b\u3053\u3068\u3092\u9632\u3050\u305f\u3081\u306b\u3001\u304c\u3093\u7d30\u80de\u306f\u30ca\u30c8\u30ea\u30a6\u30e0\u3092\u4e73\u9178\u3068\u4ea4\u63db\u3057\u305f\u304c\u308b\u3002\u3060\u304b\u3089\u5869\u5206\u5236\u9650\u3082\u5fc5\u8981\u306b\u306a\u3063\u3066\u304f\u308b\u3002<\/p>\n
\u4eca\u56de\u306f\u3053\u306e\u4e73\u9178\u3092\u7523\u751f\u3057\u3066\u3057\u307e\u3046\u304c\u3093\u7d30\u80de\u306e\u6027\u8cea\u3092\u6d3b\u304b\u3057\u3066\u3001\u65b0\u3057\u3044\u691c\u67fb\u65b9\u6cd5\u304c\u958b\u767a\u3055\u308c\u3066\u3044\u308b\u3068\u3044\u3046\u8a71\u3067\u3042\u308b\u3002<\/p>\n
**************<\/p>\n
\u7cd6\u3068\u304c\u3093\uff0d\u305d\u3057\u3066\u65b0\u3057\u3044\u691c\u67fb\u65b9\u6cd5\u30fc\u4e73\u9178\u7523\u751f\u306b\u95a2\u3059\u308b\u691c\u67fb\u65b9\u6cd5<\/p>\n
2013\u5e743\u670817\u65e5\u306b\u30d6\u30e9\u30c3\u30c9\u30d5\u30a9\u30fc\u30c9S.\u9031\u535a\u58eb\u306b\u3088\u3063\u3066\u63b2\u793a\u3055\u308c\u308b<\/p>\n
\u30a6\u30a4\u30fc\u30af\u30b9\u533b\u5e2b\u306e\u30b3\u30e1\u30f3\u30c8\uff1a\u904e\u53bb12\u5e74\u306e\u9593\u3001\u6211\u3005\u306f\u764c\u7d30\u80de\u3092\u3088\u308a\u5f31\u304f\u3059\u308b\u751f\u7269\u5b66\u7684\u5f37\u5316\u3057\u3066\u3044\u308b\u85ac\u5264\u3068\u3057\u3066\u30a4\u30f3\u30b7\u30e5\u30ea\u30f3\u3092\u5229\u7528\u3059\u308bInsulin\u5f37\u5316\u7642\u6cd5\u3092\u63d0\u4f9b\u3057\u305f\u3002\u6211\u3005\u306f\u3001\u764c\u7d30\u80de\u304c\u7802\u7cd6\u2026\u3060\u3051\u3092\u98df\u3079\u308b\u3053\u3068\u3092\u77e5\u3063\u3066\u3044\u308b\u3002\u305d\u3057\u3066\u3001\u305d\u308c\u304cPETCT\u304cCT\u3088\u308a\u3082\u6709\u7528\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\u7406\u7531\u3067\u3042\u308b\u3002<\/em><\/strong><\/p>\n PET<\/em><\/strong>\u3067\u306f\u3069\u3053\u3067\u7cd6\u304c\u4ee3\u8b1d\u3055\u308c\u3066\u3044\u308b\u304b\u3092\u898b\u305b\u3066\u304f\u308c\u308b\u3002\u3057\u304b\u3057\u3044\u307e\u3060\u306b\u3001\u3042\u306a\u305f\u306e\u304c\u3093\u5c02\u9580\u533b\u306f\u3042\u306a\u305f\u306b\u6297\u764c\u5264\u6cbb\u7642\u5f8c\u306b\u30af\u30c3\u30ad\u30fc\uff1f\u30ad\u30e3\u30f3\u30c7\u30a3\uff1fSugar\u2026\u3092\u98df\u3079\u3066\u3082\u3044\u3044\u3068\u8a00\u3044\u307e\u305b\u3093\u304b\uff1f<\/em><\/strong><\/p>\n \u73fe\u5728\u3001\u7cd6\u8cea\u4ee3\u8b1d\u3092\u5229\u7528\u3057\u3066\u3044\u308b\u65b0\u3057\u3044\u8a3a\u65ad\u65b9\u6cd5\u304c\u63d0\u4f9b\u3055\u308c\u3066\u3044\u308b\uff01<\/em><\/strong><\/p>\n \u00a0<\/p>\n \u65b0\u3057\u3044\u764c\u8a3a\u65ad\u6280\u8853\u30c7\u30d3\u30e5\u30fc<\/strong><\/strong><\/p>\n 2013\u5e743\u670814\u65e5\uff0d\u304c\u3093\u7d30\u80de\u306f\u7cd6\u3092\u5206\u89e3\u3057\u3066\u3001\u6b63\u5e38\u306a\u7d30\u80de\u3088\u308a\u975e\u5e38\u306b\u9ad8\u3044\u7387\u3067\u3001\u4ee3\u8b1d\u7684\u306a\u9178\u6027\u4e73\u9178\u5869\u3092\u4f5c\u308a\u51fa\u3059\u3002\u3053\u306e\u73fe\u8c61\u306f\u3001\u764c\u304c\u305d\u3053\u306b\u3044\u308b\u3068\u3044\u3046\u9593\u9055\u3044\u306a\u3044\u8a3c\u62e0\u3092\u63d0\u4f9b\u3059\u308b\u3060\u308d\u3046\u3001\u305d\u3057\u3066\u305d\u308c\u306fPET\u30b9\u30ad\u30e3\u30f3\u306e\u3088\u3046\u306a\u8a3a\u65ad\u6cd5\u3092\u7d4c\u3066\u3001\u65b0\u3057\u3044\u764c\u6cbb\u7642\u65b9\u6cd5\u3092\u63d0\u4f9b\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3002 \u3053\u306e\u9032\u6b69\u306e\u4ee5\u524d\u306b\u306f\u3001\u4ed6\u306e\u3044\u304b\u306a\u308b\u6e2c\u5b9a\u65b9\u6cd5\u3082\u3001\u5358\u7d30\u80de\u30ec\u30d9\u30eb\u3067\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u306b\u4e73\u9178\u5869\u3092\u975e\u4fb5\u8972\u7684\u306b\u691c\u51fa\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u306a\u304b\u3063\u305f\u3002\u52b9\u679c\uff08\u958b\u3044\u305f\u30a2\u30af\u30bb\u30b9journalPLOS ONE<\/em>\u3067\u767a\u8868\u3055\u308c\u308b\uff09\u306f\u3001\u764c\u304c\u6253\u3064\u3068\u304d\u3001\u7570\u306a\u308b\u30bf\u30a4\u30d7\u306e\u7d30\u80de\u304c\u3069\u306e\u3088\u3046\u306b\u3086\u304c\u3093\u3067\u3044\u308b\u3088\u3046\u306b\u306a\u308b\u304b\u306b\u3064\u3044\u3066\u7406\u89e3\u3059\u308b\u3053\u3068\u306b\u3068\u3063\u3066\u306e\u5229\u76ca\u3067\u3042\u308b\u3002<\/p>\n \u300c\u6700\u5f8c\u306e10\u5e74\u306b\u308f\u305f\u3063\u3066\u3001\u30ab\u30fc\u30cd\u30ae\u30fc\u306e\u30d5\u30ed\u30fc\u30de\u30fc\u7814\u7a76\u5ba4\u306f\u3001\u30d5\u30a9\u30fc\u30b9\u30bf\u30fcResonance Energy Transfer\u307e\u305f\u306fFRET\uff08\u5358\u7d14\u306a\u86cd\u5149\u4f53\u8272\u5909\u5316\u3067\u500b\u3005\u306e\u7d30\u80de\u3067\u7cd6\u306e\u6fc3\u5ea6\u3068\u6d41\u308c\u3092\u5224\u65ad\u3059\u308b\u30bb\u30f3\u30b5\uff09\u306e\u4f7f\u7528\u3092\u5275\u59cb\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u7d30\u80de\u4ee3\u8b1d\u306e\u5206\u91ce\u306b\u9769\u547d\u3092\u3082\u305f\u3089\u3057\u59cb\u3081\u305f\u300d\u3068\u3001CECs\u7814\u7a76\u8005\u30a2\u30ec\u30cf\u30f3\u30c9\u30ed\u30fb\u30b5\u30f3\u30de\u30eb\u30c6\u30a3\u30f3\uff08\u8ad6\u6587\u306e\u7b46\u982d\u8457\u8005\uff09\u304c\u8aac\u660e\u3057\u305f\u3002\u300c\u540c\u3058\u57fa\u790e\u3092\u306a\u3059\u8eab\u4f53\u7684\u306a\u539f\u7406\u3092\u4f7f\u7528\u3057\u3066\u3001\u7802\u7cd6\u30bb\u30f3\u30b5\u306e\u5f71\u97ff\u3092\u53d7\u3051\u3066\u3001\u6211\u3005\u306f\u4eca\u306f\u3001\u8ee2\u5199\u56e0\u5b50\u306b\u57fa\u3065\u304f\u65b0\u578b\u306e\u30bb\u30f3\u30b5\u3092\u767a\u660e\u3057\u305f\u3002\u901a\u5e38\u30d0\u30af\u30c6\u30ea\u30a2\u304c\u305d\u306e\u74b0\u5883\u306b\u9069\u5fdc\u3059\u308b\u306e\u3092\u52a9\u3051\u308b\u5206\u5b50\u306f\u3001\u4eca\u306f\u3001\u6211\u3005\u306e\u305f\u3081\u306b\u4e73\u9178\u5869\u3092\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u3092\u3055\u305b\u3089\u308c\u305f\u3002\u300d<\/p>\n \u4e73\u9178\u5869\u306f\u3001\u6b63\u5e38\u306a\u4ee3\u8b1d\u904e\u7a0b\u306e\u4e00\u90e8\u3068\u3057\u3066\u7d30\u80de\u3068\u5185\u90e8\u306e\u7d30\u80de\u306e\u9593\u3092\u5f80\u5fa9\u3059\u308b\u3002\u3057\u304b\u3057\u3001\u764c\u306b\u52a0\u3048\u3066\u3001\u305d\u308c\u306f\u708e\u75c7\u3001\u7d30\u80de\u306b\u5bfe\u3059\u308b\u4e0d\u5341\u5206\u306a\u9178\u7d20\u4f9b\u7d66\u3001\u7d44\u7e54\u306b\u5bfe\u3059\u308b\u5236\u9650\u3055\u308c\u305f\u8840\u6db2\u4f9b\u7d66\u3068\u795e\u7d4c\u5b66\u7684\u4f4e\u4e0b\u3092\u542b\u3080\u75be\u60a3\u306b\u3082\u95a2\u4fc2\u3057\u3066\u3044\u308b\u3002<\/p>\n \u300c\u4e73\u9178\u5869\u3092\u6e2c\u5b9a\u3059\u308b\u6a19\u6e96\u65b9\u6cd5\u306f\u9175\u7d20\u306e\u9593\u3067\u53cd\u5fdc\u306b\u57fa\u3065\u304f\u3002\u305d\u3057\u3066\u3001\u305d\u308c\u306f\u8907\u96d1\u7d30\u80de\u6df7\u5408\u7269\u3067\u591a\u6570\u306e\u7d30\u80de\u3092\u5fc5\u8981\u3068\u3059\u308b\u300d\u3068\u3001\u30d5\u30a7\u30ea\u30da\u30fb\u30d0\u30ed\u30b7\u30e5\uff08\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u306e\u8171\uff09\u304c\u8aac\u660e\u3057\u305f\u3002\u300c\u3053\u308c\u306f\u3001\u30ac\u30f3\u3068\u304d\u3001\u7d30\u80de\u306e\u578b\u304c\u3069\u308c\u304f\u3089\u3044\u7570\u306a\u308b\u3075\u308a\u3092\u3057\u3066\u3044\u308b\u304b\u78ba\u8a8d\u3059\u308b\u3053\u3068\u3092\u96e3\u3057\u3044\u304b\u4e0d\u53ef\u80fd\u306b\u3055\u3048\u3059\u308b\u3002\u6211\u3005\u306e\u65b0\u3057\u3044\u6280\u8853\u306b\u3088\u3063\u3066\u6211\u3005\u306f\u500b\u3005\u306e\u7d30\u80de\u306e\u4ee3\u8b1d\u3092\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u305d\u3057\u3066\u3001\u7570\u306a\u308b\u764c\u304c\u3069\u306e\u3088\u3046\u306b\u4f5c\u52d5\u3059\u308b\u304b\u7406\u89e3\u3059\u308b\u305f\u3081\u306b\u6211\u3005\u306b\u65b0\u3057\u3044\u30a6\u30a4\u30f3\u30c9\u30a6\u3092\u4e0e\u3048\u308b\u3002\u3053\u306e\u6280\u8853\u306e\u91cd\u8981\u306a\u9577\u6240\u306f\u3001\u305d\u308c\u304c\u9ad8\u51e6\u7406\u306e\u30d5\u30a9\u30fc\u30de\u30c3\u30c8\u3067\u3001\u5fc5\u8981\u306b\u5fdc\u3058\u3066\u85ac\u5264\u958b\u767a\u306e\u305f\u3081\u306b\u4f7f\u308f\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u3067\u3042\u308b\u3002\u300d<\/p>\n \u672c\u7814\u7a76\u306f\u3001\u4e73\u9178\u5869\u30bb\u30f3\u30b5\u3092\u751f\u7523\u3057\u3066\u3001\u633f\u5165\u3059\u308b\u624b\u6bb5\u3068\u3057\u3066\u3001\u7d30\u83cc\u8ee2\u5199\u5236\u5fa1\u56e0\u5b50 \u2015 DNA\u304b\u3089mRNA\u307e\u3067\u907a\u4f1d\u60c5\u5831\u306e\u6d41\u308c\u3092\u5236\u5fa1\u3059\u308b\u305f\u3081\u306b\u7279\u7570\u7684DNA\u914d\u5217\u3068\u7d50\u5408\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea \u2015 \u3092\u4f7f\u7528\u3057\u305f\u3002\u5f7c\u3089\u306f\u30013\u3064\u306e\u7d30\u80de\u578b\u3067\u30bb\u30f3\u30b5\u3092\u30aa\u30f3\u306b\u3057\u305f\uff1a\u6b63\u5e38\u306a\u8133\u7d30\u80de\u3001\u816b\u760d\u8133\u7d30\u80de\u3068\u30d2\u30c8\u80da\u7d30\u80de\u3002\u30bb\u30f3\u30b5\u306f\u4e73\u9178\u5869\u306e\u975e\u5e38\u306b\u4f4e\u3044\u6fc3\u5ea6\u3092\u5b9a\u91cf\u5316\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u3060\u3063\u305f\u3002\u305d\u3057\u3066\u3001\u5148\u4f8b\u306e\u306a\u3044\u611f\u5ea6\u3068\u691c\u51fa\u306e\u7bc4\u56f2\u3092\u63d0\u4f9b\u3057\u305f\u3002<\/p>\n \u7814\u7a76\u8005\u306f\u3001\u816b\u760d\u7d30\u80de\u304c\u975e\u816b\u760d\u7d30\u80de\u3088\u308a3-5\u56de\u3059\u3070\u3084\u304f\u4e73\u9178\u5869\u3092\u751f\u7523\u3059\u308b\u3068\u308f\u304b\u3063\u305f\u3002\u300c\u764c\u7d30\u80de\u306e\u4e73\u9178\u5869\u7523\u751f\u306e\u9ad8\u3044\u7387\u306f\u3001\u764c\u4ee3\u8b1d\u306e\u7279\u8cea\u3067\u3042\u308b\u300d\u3068\u3001\u30d5\u30ed\u30fc\u30de\u30fc\u304c\u8ff0\u3079\u305f\u3002\u300c\u3053\u306e\u7d50\u679c\u306f\u3001\u764c\u306e\u7570\u306a\u308b\u578b\u3067\u3001\u305d\u3057\u3066\u3001\u3053\u306e\u707d\u3044\u3068\u6226\u3046\u3053\u3068\u306e\u65b0\u3057\u3044\u6280\u8853\u3092\u958b\u767a\u3059\u308b\u305f\u3081\u306b\u764c\u4ee3\u8b1d\u306e\u30cb\u30e5\u30a2\u30f3\u30b9\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u3078\u306e\u9053\u3092\u958b\u304f\u3002\u300d<\/em><\/strong><\/p>\n \u52a0\u3048\u3066\u3001\u30d0\u30a4\u30aa\u30bb\u30f3\u30b5\u30fc\u306f\u53e4\u3044\u8ad6\u4e89\u3092\u89e3\u6790\u3059\u308b\u3068\u7d04\u675f\u3059\u308b\u3002\u82e5\u5e72\u306e\u7814\u7a76\u304c\u30d6\u30c9\u30a6\u7cd6\u304c\u71c3\u6599\u3092\u8133\u306b\u63d0\u4f9b\u3059\u308b\u3053\u3068\u3092\u793a\u5506\u3059\u308b\u9593\u3001\u6700\u8fd1\u306e\u7814\u7a76\u306f\u4e73\u9178\u5869\u304c\u795e\u7d4c\u5358\u4f4d\u3067\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3092\u4f9b\u7d66\u3059\u308b\u3068\u3044\u3046\u8a3c\u62e0\u3092\u63d0\u4f9b\u3057\u305f\u3002\u4e73\u9178\u5869\u306e\u9178\u5316\u306f\u3001ATP \u2015 \u7d30\u80de\u3067\u30a8\u30cd\u30eb\u30ae\u30fc\u3092\u4f1d\u3048\u308b\u88dc\u9175\u7d20 \u2015 \u306e\u5927\u91cf\u3092\u751f\u3058\u308b\u306e\u306b\u7528\u3044\u3089\u308c\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u524d\u306b\u958b\u767a\u3055\u308c\u305f\u30d6\u30c9\u30a6\u7cd6\u30bb\u30f3\u30b5\u3068\u5171\u306b\u3001\u30c1\u30fc\u30e0\u304c\u305d\u3046\u3067\u3042\u308b\u30d0\u30ed\u30b7\u30e5\u3068\u30d5\u30ed\u30fc\u30de\u30fc\u306f\u3001\u305d\u308c\u3089\u306e\u65b0\u3057\u3044\u30bb\u30f3\u30b5\u3092\u7528\u3044\u3066\u89e3\u6790\u3059\u308b\u3053\u3068\u306b\u3064\u3044\u3066\u3001\u3053\u306e\u8b0e\u3092\u523a\u6fc0\u3057\u305f\u3002\u8fd1\u5e74\u3067\u306f\u30012\u3064\u306e\u7814\u7a76\u5ba4\u306e\u9593\u306e\u5354\u540c\u306f\u3001\u5358\u7d30\u80de\u3067\u30d6\u30c9\u30a6\u7cd6\u306e\u6d88\u8cbb\u306e\u7387\u3092\u6e2c\u5b9a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u7b2c1\u306e\u65b9\u6cd5\u306e\u7279\u8a31\u6a29\u3092\u3068\u308b\u3053\u3068\u306b\u3064\u306a\u304c\u3063\u305f\u3002<\/p>\n \u5b66\u8853\u8a8c\u53c2\u7167<\/strong>\uff1a<\/p>\n <\/p>\n <\/p>\n <\/p>\n <\/p>\n Sugar and Cancer \u2013 tell tale signs<\/p>\n Posted by Bradford S. Weeks, MD<\/a> on March 17, 2013<\/p>\n Dr. Weeks\u2019 Comment: For the past 12 years, we have offered Insulin potentiation therapy which utilizes insulin as a biologic potentiating agent to make cancer cells more vulnerable to cancer. \u00a0We all know that cancer cells eat exclusively sugar\u2026 \u00a0and that is why PET CT is more telling than just CT \u00a0since PET shows where sugar was\u00a0metabolized \u00a0yet what does your oncologist offer you after chemotherapy? Cookies? Candy? Sugar\u2026. \u00a0Now, new diagnostic cancer options utilizing sugar\u00a0metabolism are being offered!<\/em><\/strong><\/p>\n \u00a0<\/p>\n New Cancer Diagnostic Technique Debuts<\/strong><\/p>\n Mar. 14, 2013\u00a0\u2014 Cancer cells break down sugars and produce the metabolic acid lactate at a much higher rate than normal cells. This phenomenon provides a telltale sign that cancer is present, via diagnostics such as PET scans, and possibly offers an avenue for novel cancer therapies. Now a team of Chilean researchers at The Centro de Estudios Cient\u00edficos (CECs), with the collaboration of Carnegie\u2019s Wolf Frommer, has devised a molecular sensor that can detect levels of lactate<\/em><\/strong> in individual cells in real time.<\/p>\n Prior to this advance, no other measurement method could non-invasively detect lactate in real time at the single-cell level. The work, published in the open access journalPLOS ONE<\/em>, is a boon to understanding how different types of cells go awry when cancer hits.<\/p>\n \u201cOver the last decade, the Frommer lab at Carnegie has pioneered the use of F\u00f6rster Resonance Energy Transfer, or FRET, sensors to measure the concentration and flow of sugars in individual cells with a simple fluorescent color change. This has started to revolutionize the field of cell metabolism,\u201d explained CECs researcher Alejandro San Mart\u00edn, lead author of the article. \u201cUsing the same underlying physical principle and inspired by the sugar sensors, we have now invented a new type of sensor based on a transcriptional factor. A molecule that normally helps bacteria to adapt to its environment has now been tricked into measuring lactate for us.\u201d<\/p>\n Lactate shuttles between cells and inside cells as part of the normal metabolic process. But it is also involved in diseases that include inflammation, inadequate oxygen supply to cells, restricted blood supply to tissues, and neurological degradation, in addition to cancer.<\/p>\n \u201cStandard methods to measure lactate are based on reactions among enzymes, which require a large number of cells in complex cell mixtures,\u201d explained Felipe Barros, leader of the project. \u201cThis makes it difficult or even impossible to see how different types of cells are acting when cancerous. Our new technique lets us measure the metabolism of individual cells, giving us a new window for understanding how different cancers operate. An important advantage of this technique is that it may be used in high-throughput format, as required for drug development.\u201d<\/p>\n This work used a bacterial transcription factor \u2014 a protein that binds to specific DNA sequences to control the flow of genetic information from DNA to mRNA \u2014 as a means to produce and insert the lactate sensor. They turned the sensor on in three cell types: normal brain cells, tumor brain cells, and human embryonic cells. The sensor was able to quantify very low concentrations of lactate, providing an unprecedented sensitivity and range of detection.<\/p>\n The researchers found that the tumor cells produced lactate 3-5 times faster than the non-tumor cells. \u201cThe high rate of lactate production in the cancer cell is the hallmark of cancer metabolism,\u201d remarked Frommer. \u201cThis result paves the way for understanding the nuances of cancer metabolism in different types of cancer and for developing new techniques for combatting this scourge.\u201d<\/em><\/strong><\/p>\n In addition, the biosensors promise to solve an old controversy. While some studies have suggested the glucose provides the fuel for the brain, recent research has provided evidence that lactate feeds energy metabolism in neurons. Oxidation of lactate can be used to produce large amount of ATP \u2014 the coenzyme that carries energy in cells. The Barros and Frommer teams are excited about the solving this enigma with the use of their new sensors, together with the previously developed glucose sensors. Recently, a collaboration between the two labs led to the patenting of the first method capable of measuring the rate of glucose consumption in single cells.<\/p>\n Journal Reference<\/strong>:<\/p>\n <\/p>\n <\/p>\n <\/p>\n","protected":false},"excerpt":{"rendered":" \u00a0\u30a6\u30a4\u30fc\u30af\u30b9\u306eHP\u304b\u3089\u306e\u8ee2\u8f09\u3067\u3059\u3002 \u304c\u3093\u7d30\u80de\u306f\u7cd6\u3092\u4ee3\u8b1d\u3059\u308b\u3053\u3068\u306f\u6709\u540d\u306a\u8a71\u3067\u3042\u308b\u3002\u3053\u306e\u6027\u8cea\u3092\u5229\u7528\u3057\u3066PET\u691c\u67fb\u304c\u51fa\u3066\u304d\u305f\u3002 \u3057\u304b\u3057\u3001\u4e16\u754c\u4e2d\u306e\u6a19\u6e96\u7642\u6cd5\u306e\u533b\u5e2b\u305f\u3061\u306f\u98df\u4e8b\u306b\u3064\u3044\u3066\u306f\u3001\u7cd6\u5206\u3092\u6442\u53d6\u3059\u308b\u3053\u3068\u306b\u5236\u9650\u3092\u3059\u308b\u6c17\u306f\u306a\u3044\u3089\u3057\u3044\u3002 […]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts\/1333"}],"collection":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/comments?post=1333"}],"version-history":[{"count":0,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts\/1333\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/media?parent=1333"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/categories?post=1333"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/tags?post=1333"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\n\u4eca\u3001Centro\u30c7Estudios Cientificos\uff08CECs\uff09\u306e\u4e00\u9023\u306e\u30c1\u30ea\u306e\u7814\u7a76\u8005\u306f\u3001\u30ab\u30fc\u30cd\u30ae\u30fc\u306e\u30a6\u30eb\u30d5\u30fb\u30d5\u30ed\u30fc\u30de\u30fc\u3068\u5354\u540c\u3067\u3001\u30ea\u30a2\u30eb\u30bf\u30a4\u30e0\u306b\u500b\u3005\u306e\u7d30\u80de\u3067\u4e73\u9178\u5869\u306e\u6fc3\u5ea6\u3092\u691c\u51fa\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u5206\u5b50\u30bb\u30f3\u30b5\u30fc<\/em><\/strong>\u3092\u8003\u6848\u3057\u305f\u3002<\/p>\n
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