{"id":1322,"date":"2013-03-21T14:14:25","date_gmt":"2013-03-21T05:14:25","guid":{"rendered":"https:\/\/www.taiyou-clinic.jp\/blog\/?p=1322"},"modified":"2013-03-21T14:14:25","modified_gmt":"2013-03-21T05:14:25","slug":"%e3%82%af%e3%83%ab%e3%82%af%e3%83%9f%e3%83%b3%e3%80%81%e3%82%a6%e3%82%b3%e3%83%b3%e3%81%ae%e8%a9%b1","status":"publish","type":"post","link":"https:\/\/www.taiyou-clinic.jp\/blog\/archives\/1322","title":{"rendered":"\u30af\u30eb\u30af\u30df\u30f3\u3001\u30a6\u30b3\u30f3\u306e\u8a71"},"content":{"rendered":"

\u30af\u30eb\u30af\u30df\u30f3\u306b\u3088\u308b\u6297\u9178\u5316\u80fd\u4ea2\u9032\u4f5c\u7528\uff20\u80a5\u6e80\u8005\u3000<\/strong>[2013<\/strong>\u5e74<\/strong>03<\/strong>\u6708<\/strong>18<\/strong>\u65e5<\/strong>(<\/strong>\u6708<\/strong>)]<\/strong><\/p>\n

\u30af\u30eb\u30af\u30df\u30f3\u3001\u30a6\u30b3\u30f3\u3067\u3042\u308b\u3002<\/p>\n

\u304b\u306a\u308a\u5927\u91cf\u306b\u6442\u53d6\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u304c\u3001\u52b9\u679c\u306f\u78ba\u5b9f\u306b\u3042\u308b\u3002\u304a\u307e\u3051\u306b\u304b\u306a\u308a\u5927\u91cf\u306b\u6442\u53d6\u3057\u3066\u3082\u5b89\u5168\u3067\u3042\u308b\u3002<\/p>\n

 <\/p>\n

\u3053\u3046\u3044\u3063\u305f\u5929\u7136\u306e\u6210\u5206\u3067\u85ac\u52b9\u304c\u3042\u308b\u3082\u306e\u306b\u306f\u6f22\u65b9\u85ac\u3082\u3042\u308b\u304c\u3001\u30cf\u30fc\u30d6\u306e\u65b9\u304c\u512a\u3057\u3044\u3082\u306e\u304c\u591a\u3044\u3002<\/p>\n

\u3057\u304b\u3057\u3001\u6bce\u65e5\u9152\u3092\u98f2\u3093\u3067\u3093\u3044\u308b\u79c1\u306a\u3069\u3001\u30a6\u30b3\u30f3\u3092\u3069\u308c\u307b\u3069\u5927\u91cf\u306b\u53d6\u3089\u306d\u3070\u306a\u3089\u306a\u3044\u306e\u304b\u3068\u8003\u3048\u308b\u3068\u3001\u76f8\u5f53\u306e\u91cf\u304c\u5fc5\u8981\u3060\u308d\u3046\u3068\u601d\u3046\u3002<\/p>\n

\u307e\u305a\u306f\u6bce\u65e5\u306e\u98f2\u9152\u3092\u3084\u3081\u3066\u9031\u672b\u3060\u3051\u98f2\u3080\u3068\u3044\u3046\u4ee5\u524d\u306e\u7fd2\u6163\u306b\u623b\u308a\u305f\u3044\u3068\u601d\u3063\u3066\u3044\u308b\u3002<\/p>\n

 <\/p>\n

\u4f11\u809d\u65e5\u304c\u3042\u308b\u3068\u306f\u8a00\u3048\u3001\u30d3\u30fc\u30eb\uff15\uff10\uff10ml\u306f\u7fd2\u6163\u306b\u306a\u3063\u3066\u3057\u307e\u3063\u3066\u306a\u305c\u98f2\u3080\u306e\u304b\u308f\u304b\u3089\u306a\u3044\u65e5\u3082\u3042\u308b\u306e\u3060\u3002<\/p>\n

\u307e\u305a\u306f\u6e1b\u91cf\u3057\u3066\u3001\u30a6\u30b3\u30f3\u3067\u7652\u3055\u306d\u3070\u306a\u3089\u306a\u3044\u3002<\/p>\n

\n

 <\/p>\n<\/div>\n

http:\/\/www.dhcblog.com\/kamohara\/<\/p>\n

\u4eca\u6708\u306e\u690d\u7269\u7642\u6cd5\u306e\u5c02\u9580\u30b8\u30e3\u30fc\u30ca\u30eb(\u96fb\u5b50\u7248)\u306b\u3001\u80a5\u6e80\u8005\u306b\u304a\u3044\u3066\u3001\u30af\u30eb\u30af\u30df\u30f3(\u30a6\u30b3\u30f3)\u306b\u3088\u308b\u6297\u9178\u5316\u80fd\u4ea2\u9032\u4f5c\u7528\u3092\u793a\u3057\u305f\u81e8\u5e8a\u7814\u7a76\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002(Phytother Res. <\/em>2013 Mar 15.)<\/p>\n

\u30a6\u30b3\u30f3\u306b\u306f\u6709\u52b9\u6210\u5206\u3068\u3057\u3066\u30af\u30eb\u30af\u30df\u30f3\u304c\u5b58\u5728\u3057\u3001\u6297\u708e\u75c7\u4f5c\u7528\u3092\u793a\u3057\u307e\u3059\u3002
\n\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u3001NF-\u03baB\u6291\u5236\u3092\u4ecb\u3057\u305f\u6297\u708e\u75c7\u4f5c\u7528\u3067\u3059\u3002
\n\u30af\u30eb\u30af\u30df\u30f3\/\u30a6\u30b3\u30f3\u306f\u3001\u65e5\u672c\u3067\u306f\u3001\u98f2\u9152\u6642\u306e\u809d\u81d3\u4fdd\u8b77\u3068\u3044\u3046\u30a4\u30e1\u30fc\u30b8\u3067\u3059\u304c\u3001\u6d77\u5916\u306e\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u3001\u6297\u708e\u75c7\u4f5c\u7528\u3001\u6297\u304c\u3093\u4f5c\u7528\u3001\u8a8d\u77e5\u75c7\u6291\u5236\u306a\u3069\u591a\u5f69\u306a\u4f5c\u7528\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u3055\u3066\u3001\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u80a5\u6e80\u8005\u306b\u304a\u3051\u308b\u30af\u30eb\u30af\u30df\u30f3\u306e\u6297\u9178\u5316\u80fd\u3078\u306e\u5f71\u97ff\u304c\u8abf\u3079\u3089\u308c\u307e\u3057\u305f\u3002
\n\u5177\u4f53\u7684\u306b\u306f\u3001\u80a5\u6e80\u800530\u540d\u3092\u5bfe\u8c61\u306b\u30011\u65e5\u3042\u305f\u308a1g\u306e\u30af\u30eb\u30af\u30df\u30f3\u3042\u308b\u3044\u306f\u507d\u85ac\u309230\u65e5\u9593\u6295\u4e0e\u3057\u3001
\n\u9178\u5316\u30fb\u6297\u9178\u5316\u306e\u30d0\u30e9\u30f3\u30b9\u304a\u3088\u3073Hsp27\u6297\u4f53\u3001\u9178\u5316LDL\u6297\u4f53\u3078\u306e\u5f71\u97ff\u304c\u6e2c\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002
\n(\u30e9\u30f3\u30c0\u30e0\u5316\u4e8c\u91cd\u76f2\u691c\u507d\u85ac\u5bfe\u7167\u30af\u30ed\u30b9\u30aa\u30fc\u30d0\u30fc\u6cd5)<\/p>\n

\u89e3\u6790\u306e\u7d50\u679c\u3001\u30af\u30eb\u30af\u30df\u30f3\u7b49\u306b\u3088\u3063\u3066\u3001\u8840\u6f3f\u306e\u9178\u5316\u30fb\u6297\u9178\u5316\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u3001\u6297\u9178\u5316\u306b\u6709\u610f\u306b\u5909\u5316\u3057\u305f\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002(PAB; pro-oxidant-antioxidant balance \u304c\u6709\u610f\u306b\u4f4e\u4e0b\u3002p&#8201;=&#8201;0.044)
\n\u3053\u306e\u6642\u3001Hsp27\u6297\u4f53\u3068\u9178\u5316LDL\u6297\u4f53\u306b\u306f\u6709\u610f\u306a\u5909\u5316\u306f\u898b\u51fa\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n

\u4ee5\u4e0a\u306e\u30c7\u30fc\u30bf\u304b\u3089\u3001\u30af\u30eb\u30af\u30df\u30f3(1g\/\u65e5)\u306e\u6295\u4e0e\u306b\u3088\u3063\u3066\u3001\u80a5\u6e80\u8005\u306b\u304a\u3051\u308b\u6297\u9178\u5316\u80fd\u306e\u4ea2\u9032\u4f5c\u7528\u304c\u793a\u5506\u3055\u308c\u307e\u3059\u3002
\n\u4eca\u5f8c\u3001\u81e8\u5e8a\u7684\u610f\u7fa9\u306e\u691c\u8a3c\u304c\u671f\u5f85\u3055\u308c\u308b\u5206\u91ce\u3067\u3059\u3002<\/p>\n

\u30af\u30eb\u30af\u30df\u30f3\uff08\u30a6\u30b3\u30f3\uff09\u306b\u3064\u3044\u3066\u7c21\u5358\u306b\u307e\u3068\u3081\u3066\u307f\u307e\u3057\u305f\u3002
\n\u25a0\u30af\u30eb\u30af\u30df\u30f3\u3068\u306f\u30fb\u30af\u30eb\u30af\u30df\u30f3\u306f\uff0c\u30a6\u30b3\u30f3\uff08\u5b66\u540dCurcuma longa\uff09\u306e\u6709\u52b9\u6210\u5206\u3002
\n\u30fb\u975e\u81e8\u5e8a\u7814\u7a76\uff1b\u6297\u708e\u75c7\u4f5c\u7528\uff0c\u6297\u9178\u5316\u4f5c\u7528\uff0c\u7d30\u80de\u5897\u6b96\u6291\u5236\u3002
\n\u30fb\u81e8\u5e8a\u7814\u7a76\u3067\u306f\uff0c\u9032\u884c\u304c\u3093\uff0c\u591a\u767a\u6027\u9aa8\u9ac4\u816b\uff0c\u5927\u8178\u817a\u816b\u7b49\u3078\u6295\u4e0e\u3002
\n\u25a0\u30af\u30eb\u30af\u30df\u30f3\u3000\u7b2c1\u76f8\u81e8\u5e8a\u8a66\u9a13\u3000
\n\u30fb\u30af\u30eb\u30af\u30df\u30f3\u3092\u7528\u3044\u305f\u7528\u91cf\u6f38\u5897\u8a66\u9a13(Dose Escalation Study)
\n\u3000\u5065\u5e38\u800524\u540d\u3092\u5bfe\u8c61\u306b\uff0c\u30af\u30eb\u30af\u30df\u30f3\u3092500\uff0c1,000\uff0c2,000\uff0c4,000\uff0c6,000\uff0c8,000 mg\u306e\u7528\u91cf\u306b\u3066\u5358\u56de\u6295\u4e0e\u3057\u305f\u7d50\u679c\uff0c\u8a8d\u5bb9\u6027\u304c\u793a\u3055\u308c\u305f\u3002(BMC Complement Altern Med. 2006 Mar 17)
\n\u30fbPhase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance.
\n\u3000\u5927\u8178\u304c\u3093\u60a3\u800515\u540d\u3092\u5bfe\u8c61\u306b\uff0c3,600mg\/\u65e5\u306e\u30af\u30eb\u30af\u30df\u30f3\u30924\u30f6\u6708\u9593\u6295\u4e0e\u3002(Clin Cancer Res. 2004)<\/p>\n

\u25a0\u30af\u30eb\u30af\u30df\u30f3\u3000\u7b2c2\u76f8\u81e8\u5e8a\u8a66\u9a13
\n\u30fb\u30af\u30eb\u30af\u30df\u30f3\u306b\u3088\u308b\u81e8\u5e8a\u8a66\u9a13\u7b2c\uff12\u76f8\uff1a\u9032\u884c\u81b5\u304c\u3093
\n\u3000\u81b5\u81d3\u304c\u3093\u60a3\u800525\u540d\u3092\u5bfe\u8c61\u306b\u30018,000mg\/\u65e5\u306e\u30af\u30eb\u30af\u30df\u30f3\u3092\u6295\u4e0e\u3002\u9ad8\u3044\u8a8d\u5bb9\u6027\u3002\u4e00\u90e8\u306e\u60a3\u8005\u3067\u306f\u6709\u52b9\u6027\u3082\u3002(Clin Cancer Res. 2008)
\n\u25a0\u7d30\u7c92\u5316\u30af\u30eb\u30af\u30df\u30f3\uff1a\u5438\u53ce\u7387\u306e\u98db\u8e8d\u7684\u5411\u4e0a\u3068\u30d2\u30c8\u81e8\u5e8a\u8a66\u9a13
\n\u30fbNanoparticle curcumin for improved oral bioavailability\u3000(Biol Pharm Bull. 2011;34(5):660-5)
\n\u30fbNanoparticle curcumin can safely increase plasma curcumin levels in a dose-dependent manner at least up to 210 mg without saturating the absorption. (Cancer Chemother Pharmacol. 2011 May 21.)<\/p>\n

DHC\u3067\u306f\u3059\u3067\u306b\u3001\u9ad8\u5438\u53ce\u30bf\u30a4\u30d7\u306e\u30af\u30eb\u30af\u30df\u30f3\u3092\u533b\u7642\u6a5f\u95a2\u5411\u3051\u306b\u88fd\u54c1\u5316\u3057\u3066\u3044\u307e\u3059\u3002
\n\u5177\u4f53\u7684\u306b\u306f\u3001
\n\u533b\u7642\u6a5f\u95a2\u5c02\u7528\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3010DHC FOR MEDIC\u3011\uff08DHC\u30d5\u30a9\u30fc\u30e1\u30c7\u30a3\u30c3\u30af\uff09<\/a>\u306e\u30e9\u30a4\u30f3\u30a2\u30c3\u30d7\u3067\u3001\u9ad8\u5438\u53ce\u30fb\u9ad8\u7528\u91cf\u30bf\u30a4\u30d7\u306e\u30af\u30eb\u30af\u30df\u30f3\u3092\u6271\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n

DHC\u306e\u30a6\u30b3\u30f3\u88fd\u54c1\u3067\u306f\u3001
\n\u6fc3\u7e2e\u30a6\u30b3\u30f3\u306e\u4ed6\u3001<\/a>\u9ad8\u5438\u53ce\u30bf\u30a4\u30d7\u30fb\u5373\u52b9\u6027<\/a>\u306e\u3082\u306e\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"

\u30af\u30eb\u30af\u30df\u30f3\u306b\u3088\u308b\u6297\u9178\u5316\u80fd\u4ea2\u9032\u4f5c\u7528\uff20\u80a5\u6e80\u8005\u3000[2013\u5e7403\u670818\u65e5(\u6708)] \u30af\u30eb\u30af\u30df\u30f3\u3001\u30a6\u30b3\u30f3\u3067\u3042\u308b\u3002 \u304b\u306a\u308a\u5927\u91cf\u306b\u6442\u53d6\u3059\u308b\u5fc5\u8981\u304c\u3042\u308b\u304c\u3001\u52b9\u679c\u306f\u78ba\u5b9f\u306b\u3042\u308b\u3002\u304a\u307e\u3051\u306b\u304b\u306a\u308a\u5927\u91cf\u306b\u6442\u53d6\u3057\u3066\u3082\u5b89\u5168\u3067\u3042\u308b\u3002   \u3053\u3046\u3044 […]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[4],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts\/1322"}],"collection":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/comments?post=1322"}],"version-history":[{"count":0,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts\/1322\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/media?parent=1322"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/categories?post=1322"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/tags?post=1322"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}