{"id":1305,"date":"2013-03-15T19:13:47","date_gmt":"2013-03-15T10:13:47","guid":{"rendered":"https:\/\/www.taiyou-clinic.jp\/blog\/?p=1305"},"modified":"2013-03-15T19:13:47","modified_gmt":"2013-03-15T10:13:47","slug":"%e3%82%b0%e3%83%ab%e3%82%b3%e3%82%b5%e3%83%9f%e3%83%b3%e3%81%ab%e3%82%88%e3%82%8b%e5%a4%89%e5%bd%a2%e6%80%a7%e9%96%a2%e7%af%80%e7%97%87%e3%81%a7%e3%81%ae%e6%9c%80%e7%b5%82%e7%b3%96%e5%8c%96%e7%94%a3","status":"publish","type":"post","link":"https:\/\/www.taiyou-clinic.jp\/blog\/archives\/1305","title":{"rendered":"\u30b0\u30eb\u30b3\u30b5\u30df\u30f3\u306b\u3088\u308b\u5909\u5f62\u6027\u95a2\u7bc0\u75c7\u3067\u306e\u6700\u7d42\u7cd6\u5316\u7523\u7269\u53d7\u5bb9\u4f53\uff08RAGE\uff09\u767a\u73fe\u6291\u5236\u52b9\u679c"},"content":{"rendered":"<p><strong>\u30b0\u30eb\u30b3\u30b5\u30df\u30f3\u306b\u3088\u308b\u5909\u5f62\u6027\u95a2\u7bc0\u75c7\u3067\u306e\u6700\u7d42\u7cd6\u5316\u7523\u7269\u53d7\u5bb9\u4f53\uff08<\/strong><strong>RAGE<\/strong><strong>\uff09\u767a\u73fe\u6291\u5236\u52b9\u679c<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p>\u30b0\u30eb\u30b3\u30b5\u30df\u30f3\u306f\u8edf\u9aa8\u3092\u4f5c\u308b\u306e\u3067\u306f\u306a\u304f\u3066\u3001\u95a2\u7bc0\u8edf\u9aa8\u306e\u6ed1\u819c\u708e\u3001\u9aa8\u9ac4\u708e\u3092\u6291\u5236\u3059\u308b\u4f5c\u7528\u304c\u3042\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u305f\u3002<\/p>\n<p>\u30c6\u30ec\u30d3\u306a\u3069\u3067\u306f\u8edf\u9aa8\u304c\u518d\u751f\u3059\u308b\u304b\u306e\u3088\u3046\u306b\u5ba3\u4f1d\u3055\u308c\u3001\u8fd1\u6240\u306e\u982d\u306e\u56fa\u3044\u533b\u5e2b\u304b\u3089\u306f\u306a\u3093\u306e\u52b9\u679c\u3082\u306a\u3044\u3068\u7121\u77e5\u3086\u3048\u306e\u65ad\u8a00\u3092\u3055\u308c\u3066\u60a3\u8005\u3055\u3093\u306f\u56f0\u3063\u3066\u3044\u308b\u3053\u3068\u3060\u308d\u3046\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>\u771f\u5b9f\u306f\u610f\u5916\u306a\u5834\u6240\u306b\u3042\u308b\u3002<\/p>\n<p>*****************<\/p>\n<p>http:\/\/www.dhcblog.com\/kamohara\/<\/p>\n<p>\u30ea\u30a6\u30de\u30c1\u5b66\u306e\u5c02\u9580\u30b8\u30e3\u30fc\u30ca\u30eb(\u96fb\u5b50\u7248)\u306b\u3001\u30b0\u30eb\u30b3\u30b5\u30df\u30f3\u6295\u4e0e\u306b\u3088\u308b\u5909\u5f62\u6027\u95a2\u7bc0\u75c7\u3067\u306e\u6700\u7d42\u7cd6\u5316\u7523\u7269\u53d7\u5bb9\u4f53\uff08RAGE\uff09\u6291\u5236\u304a\u3088\u3073\u6ed1\u819c\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u3078\u306e\u50cd\u304d\u3092\u793a\u3057\u305f\u81e8\u5e8a\u7814\u7a76\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002(<em>Rheumatol Int.<\/em> 2013 Feb 27.)<\/p>\n<p>\u30b0\u30eb\u30b3\u30b5\u30df\u30f3(\u5869\u9178\u5869\u30fb\u786b\u9178\u5869)\u306f\u3001\u5909\u5f62\u6027\u819d\u95a2\u7bc0\u75c7\u306e\u4e88\u9632\u3084\u75c7\u72b6\u6539\u5584\u52b9\u679c\u3001\u819d\u95a2\u7bc0\u7f6e\u63db\u8853\u30ea\u30b9\u30af\u4f4e\u6e1b\u52b9\u679c\u304c\u793a\u3055\u308c\u3066\u304a\u308a\u3001\u5341\u5206\u306a\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u69cb\u7bc9\u3055\u308c\u3001\u95a2\u7bc0\u5bfe\u7b56\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3068\u3057\u3066\u5e83\u304f\u5229\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n(\u65e5\u672c\u3067\u306f\u3001GAIT1\u306e\u30cd\u30ac\u30c6\u30a3\u30d6\u30c7\u30fc\u30bf\u304c\u77ed\u7d61\u7684\u306b\u5f15\u7528\u3055\u308c\u308b\u3053\u3068\u304c\u591a\u304f\u3001\u6df7\u4e71\u3057\u3066\u3044\u307e\u3059\u304c\u3002)<\/p>\n<p>\u4f5c\u7528\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u3001\u7d4c\u53e3\u6442\u53d6\u3055\u308c\u305f\u30b0\u30eb\u30b3\u30b5\u30df\u30f3\u304c\u3001\u7d30\u80de\u5185\u5916\u306e\u60c5\u5831\u4f1d\u9054\u7269\u8cea\u3068\u3057\u3066\u4f5c\u7528\u3057\u3001\u95a2\u7bc0\u8edf\u9aa8\u306b\u8d77\u56e0\u3059\u308b\u75c7\u72b6\u306e\u6539\u5584(\u6ed1\u819c\u708e\u304a\u3088\u3073\u9aa8\u9ac4\u708e\u306e\u6291\u5236\u3068\u6539\u5584)\u306b\u50cd\u304f\u3001\u3068\u7406\u89e3\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n(\u521d\u671f\u306e\u7814\u7a76\u3067\u30a4\u30e1\u30fc\u30b8\u3055\u308c\u3066\u3044\u305f\u3088\u3046\u306a\u3001\u95a2\u7bc0\u8edf\u9aa8\u306e\u6210\u5206\u3092\u7d4c\u53e3\u6442\u53d6\u3059\u308b\u3053\u3068\u3067\u3001\u305d\u306e\u6210\u5206\u304c\u95a2\u7bc0\u306e\u4fee\u5fa9\u306b\u50cd\u304f\u3001\u3068\u3044\u3046\u6a5f\u5e8f\u3068\u306f\u7570\u306a\u3063\u3066\u304d\u3066\u3044\u307e\u3059\u3002)<\/p>\n<p>\u3055\u3066\u3001\u4eca\u56de\u306e\u7814\u7a76\u3067\u306f\u3001\u5909\u5f62\u6027\u819d\u95a2\u7bc0\u75c7\u60a3\u8005\u306b\u304a\u3044\u306612\u9031\u9593\u306e\u30ec\u30b8\u30b9\u30bf\u30f3\u30b9\u904b\u52d5\u306b\u3088\u3063\u3066\u751f\u3058\u308b\u9aa8\u683c\u7b4b\u3067\u306e\u30b3\u30e9\u30fc\u30b2\u30f3\u3084RAGE\u3078\u306e\u5909\u5316\u306b\u5bfe\u3057\u3066\u3001\u6d88\u708e\u93ae\u75db\u5264(NSAID)\u3068\u30b0\u30eb\u30b3\u30b5\u30df\u30f3\u306e\u50cd\u304d\u304c\u8abf\u3079\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>AGEs(\u7d42\u672b\u7cd6\u5316\u7523\u7269\u3001advanced glycation end-products)\u3068\u3044\u3046\u306e\u306f\u3001<br \/>\n\u30d6\u30c9\u30a6\u7cd6\uff08\u30b0\u30eb\u30b3\u30fc\u30b9\uff09\u306a\u3069\u306e\u9084\u5143\u7cd6\u3068\u30bf\u30f3\u30d1\u30af\u8cea\u3001\u8102\u8cea\u3001\u6838\u9178\u3068\u3044\u3063\u305f\u751f\u4f53\u306e\u5206\u5b50\u3068\u306e\u9593\u306e\u975e\u9175\u7d20\u7684\u7cd6\u5316\u53cd\u5fdc\u3067\u751f\u6210\u3055\u308c\u3001\u6162\u6027\u708e\u75c7\u3084\u7cd6\u5c3f\u75c5\u3068\u3044\u3063\u305f\u75be\u60a3\u3084\u8001\u5316\u306b\u4f34\u3044\u84c4\u7a4d\u3057\u307e\u3059\u3002<br \/>\nRAGE\uff08receptor for advanced glycation\u3000endproducts\uff09\u306f\u3001\u6700\u7d42\u7cd6\u5316\u7523\u7269\uff08AGEs\uff09\u306e\u53d7\u5bb9\u4f53\u3068\u3057\u3066\u540c\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u6162\u6027\u708e\u75c7\u3084\u7cd6\u5c3f\u75c5\u3067\u306f\u3001RAGE\u306e\u767a\u73fe\u4ea2\u9032\u304c\u898b\u51fa\u3055\u308c\u3066\u3044\u307e\u3059\u3002<br \/>\n\u5177\u4f53\u7684\u306b\u306f\u300155-69\u6b73\u306e\u5909\u5f62\u6027\u819d\u95a2\u7bc0\u75c7\u60a3\u8005\u3092\u5bfe\u8c61\u306b\u3001<br \/>\n\u30fbNSAID\u6295\u4e0e\u7fa4\u3001<br \/>\n\u30fb\u30b0\u30eb\u30b3\u30b5\u30df\u30f3\u6295\u4e0e\u7fa4\u3001<br \/>\n\u30fb\u507d\u85ac\u6295\u4e0e\u7fa4\u306e3\u7fa4\u306b\u3064\u3044\u3066\u300112\u9031\u9593\u306e\u30ec\u30b8\u30b9\u30bf\u30f3\u30b9\u904b\u52d5\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u306e\u524d\u5f8c\u3067\u3001\u7b4b\u8089(\u5916\u5074\u5e83\u7b4b)\u306e\u30d0\u30a4\u30aa\u30d7\u30b7\u30fc\u304c\u884c\u308f\u308c\u3001\u7b4b\u8089\u4e2d\u306e\u30b3\u30e9\u30fc\u30b2\u30f3\u3068RAGE\u306e\u8a55\u4fa1\u304c\u884c\u308f\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u89e3\u6790\u306e\u7d50\u679c\u3001\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u524d\u3068\u6bd4\u8f03\u3057\u3066\u3001\u5404\u7fa4\u3068\u3082\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u2163\u578b\u306e\u5897\u52a0\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002<br \/>\n\u30b0\u30eb\u30b3\u30b5\u30df\u30f3\u6295\u4e0e\u7fa4\u3067\u306f\u3001\u30b3\u30e9\u30fc\u30b2\u30f3\u2160\u578b\u306e\u6e1b\u5c11\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002<br \/>\n\u507d\u85ac\u7fa4\u306b\u304a\u3044\u3066\u306e\u307f\u3001\u30c8\u30ec\u30fc\u30cb\u30f3\u30b0\u5f8c\u306b\u3001RAGE\u91cf\u306e\u6709\u610f\u306a\u5897\u52a0\u304c\u898b\u51fa\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u30b0\u30eb\u30b3\u30b5\u30df\u30f3\u7fa4\u3068\u507d\u85ac\u7fa4\u306e\u6bd4\u8f03\u3067\u3082\u3001\u507d\u85ac\u7fa4\u306b\u304a\u3051\u308b\u6709\u610f\u306a\u5897\u52a0\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002<br \/>\n\u4ee5\u4e0a\u306e\u30c7\u30fc\u30bf\u304b\u3089\u3001\u5909\u5f62\u6027\u819d\u95a2\u7bc0\u75c7\u60a3\u8005\u306b\u304a\u3044\u3066\u3001\u30b0\u30eb\u30b3\u30b5\u30df\u30f3\u306e\u6295\u4e0e\u306f\u3001\u30ec\u30b8\u30b9\u30bf\u30f3\u30b9\u904b\u52d5\u6642\u306b\u751f\u3058\u308b\u7b4b\u8089\u4e2d\u3067\u306eRAGE\u84c4\u7a4d\u3092\u6291\u5236\u3057\u3001\u6162\u6027\u708e\u75c7\u306b\u4f34\u3046\u75c5\u614b\u3092\u6291\u3048\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/p>\n<p>\u5909\u5f62\u6027\u95a2\u7bc0\u75c7\u306b\u5bfe\u3057\u3066\u306f\u3001\u30b0\u30eb\u30b3\u30b5\u30df\u30f3\u3084\u30b3\u30f3\u30c9\u30ed\u30a4\u30c1\u30f3\u3068\u3044\u3063\u305f\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306b\u52a0\u3048\u3066\u3001<br \/>\n\u9069\u6b63\u4f53\u91cd\u306e\u7dad\u6301\u3084\u904b\u52d5\u7fd2\u6163\u3082\u5927\u5207\u3067\u3059\u3002<\/p>\n<p>\u307e\u305f\u3001\u6297\u708e\u75c7\u4f5c\u7528\u3092\u6709\u3059\u308b\u30a6\u30b3\u30f3(\u30af\u30eb\u30af\u30df\u30f3)\u3084\u30d4\u30af\u30ce\u30b8\u30a7\u30ce\u30fc\u30eb\u306b\u3088\u308b\u52b9\u679c\u3082\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u4eca\u56de\u306e\u7814\u7a76\u304b\u3089\u3001\u30b0\u30eb\u30b3\u30b5\u30df\u30f3\u306f\u3001OA\u60a3\u8005\u3067\u306e\u904b\u52d5\u6642\u306b\u3082\u30b7\u30ca\u30b8\u30fc\u304c\u671f\u5f85\u3055\u308c\u307e\u3059\u3002<br \/>\n<a href=\"http:\/\/www.dhc.co.jp\/goods\/goodsdetail.jsp?gCode=4392\" 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\/>\n\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3067\u306f\u3001<a href=\"http:\/\/www.dhc.co.jp\/goods\/cagoods.jsp?cCode=10266003\" target=\"_blank\">\u30b0\u30eb\u30b3\u30b5\u30df\u30f3\u3084\u30b3\u30f3\u30c9\u30ed\u30a4\u30c1\u30f3\u304c\u6700\u3082\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u8c4a\u5bcc<\/a>\u3067\u3042\u308a\u3001\u6b27\u5dde\u306e\u5b66\u8853\u56e3\u4f53EULAR\u3067\u306f\u30b0\u30ec\u30fc\u30c9A\u306e\u63a8\u5968\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30b0\u30eb\u30b3\u30b5\u30df\u30f3\u306b\u3088\u308b\u5909\u5f62\u6027\u95a2\u7bc0\u75c7\u3067\u306e\u6700\u7d42\u7cd6\u5316\u7523\u7269\u53d7\u5bb9\u4f53\uff08RAGE\uff09\u767a\u73fe\u6291\u5236\u52b9\u679c &nbsp; 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