{"id":1233,"date":"2013-02-22T08:53:14","date_gmt":"2013-02-21T23:53:14","guid":{"rendered":"https:\/\/www.taiyou-clinic.jp\/blog\/?p=1233"},"modified":"2013-02-22T08:53:14","modified_gmt":"2013-02-21T23:53:14","slug":"%ef%bb%bf%e9%ab%98%e6%bf%83%e5%ba%a6%e3%83%93%e3%82%bf%e3%83%9f%e3%83%b3c%e7%82%b9%e6%bb%b4%e7%99%82%e6%b3%95%e3%81%a8%e5%8c%96%e5%ad%a6%e7%99%82%e6%b3%95%e3%81%ae%e4%bd%b5%e7%94%a8%e3%81%a7%e8%86%b5","status":"publish","type":"post","link":"https:\/\/www.taiyou-clinic.jp\/blog\/archives\/1233","title":{"rendered":"\ufeff\u9ad8\u6fc3\u5ea6\u30d3\u30bf\u30df\u30f3C\u70b9\u6ef4\u7642\u6cd5\u3068\u5316\u5b66\u7642\u6cd5\u306e\u4f75\u7528\u3067\u81b5\u81d3\u764c\u306e\u751f\u5b58\u671f\u9593\u304c\uff12\u500d\u306b\u5ef6\u9577"},"content":{"rendered":"

\u6240\u5c5e\u3057\u3066\u3044\u308b\u7814\u7a76\u4f1a\u304b\u3089\u65b0\u3057\u3044\u60c5\u5831\u304c\u5c4a\u3044\u305f\u3002
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*********************<\/p>\n

\u6587\u732e\u60c5\u5831\u3011
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\n\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500\u2500<\/p>\n

2\u67085\u65e5\u306b\u30a2\u30a4\u30aa\u30ef\u5927\u5b66\u304b\u3089\u30b9\u30c6\u30fc\u30b8\uff14\u306e\u81b5\u81d3\u304c\u3093\u306bgemicitabin\u3068\u9ad8\u6fc3\u5ea6
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\n\u306b\u767a\u8868\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n

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http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23381814<\/a><\/p>\n

 <\/p>\n

The following popper user interface control may not be accessible. Tab to the next button to revert the control to an accessible version.<\/p>\n

Abstract<\/a><\/p>\n

Cancer Chemother Pharmacol.<\/a> 2013 Feb 5. [Epub ahead of print]<\/p>\n

Pharmacological ascorbate with gemcitabine for the control of metastatic and node-positive pancreatic cancer (PACMAN): results from a phase I clinical trial.<\/strong><\/p>\n

Welsh JL<\/a>, Wagner BA<\/a>, Van't Erve TJ<\/a>, Zehr PS<\/a>, Berg DJ<\/a>, Halfdanarson TR<\/a>, Yee NS<\/a>, Bodeker KL<\/a>, Du J<\/a>, Roberts LJ 2nd<\/a>, Drisko J<\/a>, Levine M<\/a>, Buettner GR<\/a>, Cullen JJ<\/a>.<\/p>\n

Source<\/strong><\/p>\n

Department of Surgery, 1528 JCP-UIHC, The University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.<\/p>\n

Abstract<\/strong><\/p>\n

BACKGROUND: <\/strong><\/p>\n

Treatment for pancreatic cancer with pharmacological ascorbate (ascorbic acid, vitamin C) decreases tumor progression in preclinical models. A phase I clinical trial was performed to establish safety and tolerability of pharmacological ascorbate combined with gemcitabine in patients with biopsy-proven stage IV pancreatic adenocarcinoma.<\/p>\n

DESIGN: <\/strong><\/p>\n

Nine subjects received twice-weekly intravenous ascorbate (15-125\u00a0g) employing Simon's accelerated titration design to achieve a targeted post-infusion plasma level of \u2265350\u00a0mg\/dL (\u226520\u00a0mM). Subjects received concurrent gemcitabine. Disease burden, weight, performance status, hematologic and metabolic laboratories, time to progression and overall survival were monitored.<\/p>\n

RESULTS: <\/strong><\/p>\n

Mean plasma ascorbate trough levels were significantly higher than baseline (1.46\u00a0\u00b1\u00a00.02 vs. 0.78\u00a0\u00b1\u00a00.09\u00a0mg\/dL, i.e., 83 vs. 44\u00a0\u03bcM, p\u00a0<\u00a00.001). Adverse events attributable to the drug combination were rare and included diarrhea (n\u00a0=\u00a04) and dry mouth (n\u00a0=\u00a06). Dose-limiting criteria were not met for this study. Mean survival of subjects completing at least two cycles (8\u00a0weeks) of therapy was 13\u00a0\u00b1\u00a02\u00a0months.<\/p>\n

CONCLUSIONS: <\/strong><\/p>\n

Data suggest pharmacologic ascorbate administered concurrently with gemcitabine is well tolerated. Initial data from this small sampling suggest some efficacy. Further studies powered to determine efficacy should be conducted.<\/p>\n

PMID:<\/p>\n

23381814<\/p>\n

[PubMed - as supplied by publisher]<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

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