{"id":1231,"date":"2013-02-20T23:26:36","date_gmt":"2013-02-20T14:26:36","guid":{"rendered":"https:\/\/www.taiyou-clinic.jp\/blog\/?p=1231"},"modified":"2013-02-20T23:26:36","modified_gmt":"2013-02-20T14:26:36","slug":"brca1%e3%81%a8brca2%ef%bc%9a%e4%b9%b3%e7%99%8c%e3%83%aa%e3%82%b9%e3%82%af%e3%81%a8%e9%81%ba%e4%bc%9d%e5%ad%90%e6%a4%9c%e6%9f%bb","status":"publish","type":"post","link":"https:\/\/www.taiyou-clinic.jp\/blog\/archives\/1231","title":{"rendered":"BRCA1\u3068BRCA2\uff1a\u4e73\u764c\u30ea\u30b9\u30af\u3068\u907a\u4f1d\u5b50\u691c\u67fb"},"content":{"rendered":"

\u4e73\u304c\u3093\u30ea\u30b9\u30af\u306e\u907a\u4f1d\u5b50\u691c\u67fb\u306f\uff22\uff32\uff23\uff21\uff11\u3001\uff12\u304c\u6709\u540d\u3067\u3042\u308b\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306b\u3064\u3044\u3066\u306f\u5b66\u3076\u3053\u3068\u304c\u591a\u3044\u3002<\/p>\n

\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a<\/p>\n

\u30ad\u30fc\u30dd\u30a4\u30f3\u30c8<\/strong><\/p>\n

\u30fbBRCA1<\/a><\/em>\u304a\u3088\u3073BRCA2<\/em>\u306f\u816b\u760d\u6291\u5236\u907a\u4f1d\u5b50\u3068\u3057\u3066\u77e5\u3089\u308c\u308b\u907a\u4f1d\u5b50\u306e\u30af\u30e9\u30b9\u306b\u5c5e\u3059\u308b\u30d2\u30c8\u907a\u4f1d\u5b50\u3067\u3059\u3002\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306f\u3001\u907a\u4f1d\u6027\u4e73\u764c\u304a\u3088\u3073\u5375\u5de3\u764c\u3068\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\uff08Question 1<\/strong><\/a>\u53c2\u7167\uff09\u3002<\/p>\n

\u30fb\u60aa\u5f71\u97ff\u3092\u53ca\u307c\u3059(\u6709\u5bb3\u306a)BRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u907a\u4f1d\u5b50\u5909\u7570\u3092\u53d7\u3051\u7d99\u3050\u3068\u3001\u5973\u6027\u304c\u4e73\u764c\u307e\u305f\u306f\u5375\u5de3\u764c\u3001\u3042\u308b\u3044\u306f\u305d\u306e\u4e21\u65b9\u3092\u767a\u75c7\u3059\u308b\u30ea\u30b9\u30af\u304c\u8457\u3057\u304f\u5897\u52a0\u3057\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u5909\u7570\u3092\u6301\u3064\u7537\u6027\u3082\u4e73\u764c\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u306a\u308a\u307e\u3059\u3002\u6709\u5bb3\u306aBRCA1<\/a><\/em>\u307e\u305f\u306fBRCA2<\/em>\u5909\u7570\u3092\u6301\u3064\u7537\u5973\u3068\u3082\u306b\u4ed6\u306e\u764c\u30ea\u30b9\u30af\u3082\u5897\u52a0\u3057\u307e\u3059\uff08Question 2<\/strong><\/a>\u53c2\u7167\uff09\u3002<\/p>\n

\u30fb\u907a\u4f1d\u5b50\u691c\u67fb\u3067BRCA1<\/a><\/em>\u304a\u3088\u3073BRCA2<\/em>\u5909\u7570\u3092\u8abf\u3079\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u691c\u67fb\u306b\u306f\u8840\u6db2\u30b5\u30f3\u30d7\u30eb\u304c\u5fc5\u8981\u3067\u3001\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3092\u691c\u67fb\u524d\u5f8c\u306b\u53d7\u3051\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u307e\u3059\uff08Question 5<\/strong><\/a>\u53c2\u7167\uff09\u3002<\/p>\n

\u30fb\u6709\u5bb3\u306aBRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u5909\u7570\u304c\u691c\u51fa\u3055\u308c\u305f\u5834\u5408\u3001\u764c\u30ea\u30b9\u30af\u306e\u7ba1\u7406\u3092\u652f\u63f4\u3059\u308b\u9078\u629e\u80a2\u306f\u3044\u304f\u3064\u304b\u3042\u308a\u307e\u3059\uff08Question 11<\/strong><\/a>\u53c2\u7167\uff09\u3002<\/p>\n

\u30fb\u9023\u90a6\u6cd5\u304a\u3088\u3073\u5dde\u6cd5\u3067\u500b\u4eba\u306e\u907a\u4f1d\u60c5\u5831\u306e\u30d7\u30e9\u30a4\u30d0\u30b7\u30fc\u3092\u5b88\u308a\u3001\u5065\u5eb7\u4fdd\u967a\u3084\u96c7\u7528\u6163\u884c\u3067\u306e\u5dee\u5225\u306b\u5bfe\u3059\u308b\u4fdd\u8b77\u3092\u884c\u3044\u307e\u3059\uff08Question 14<\/strong><\/a>\u3001Question 15<\/strong><\/a>\u53c2\u7167\uff09\u3002<\/p>\n

\u30fbBRCA1<\/em>\u304a\u3088\u3073BRCA2<\/em>\u5909\u7570\u4fdd\u56e0\u8005\u306b\u304a\u3051\u308b\u764c\u306e\u767a\u898b\u3001\u6cbb\u7642\u3001\u4e88\u9632\u306e\u6700\u65b0\u3067\u3088\u308a\u826f\u3044\u65b9\u6cd5\u3092\u898b\u51fa\u3059\u305f\u3081\u306e\u591a\u304f\u306e\u8abf\u67fb\u7814\u7a76\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u8ffd\u52a0\u7684\u306a\u7814\u7a76\u3067\u306f\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u306e\u65b9\u6cd5\u3084\u6210\u679c\u306e\u6539\u5584\u306b\u91cd\u70b9\u3092\u7f6e\u3044\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u5206\u91ce\u3067\u306e\u77e5\u8b58\u306f\u6025\u901f\u306b\u9032\u5316\u3057\u3066\u3044\u307e\u3059\uff08Question 18<\/strong><\/a>\u53c2\u7167\uff09\u3002<\/p>\n

 <\/p>\n

<\/a>\uff11.BRCA1<\/a><\/em>\u3068BRCA2<\/em>\u3068\u306f\u4f55\u3067\u3059\u304b\uff1f<\/strong><\/p>\n

BRCA1<\/a><\/em>\u304a\u3088\u3073BRCA2<\/em>\u306f\u816b\u760d\u6291\u5236\u907a\u4f1d\u5b50\u3068\u3057\u3066\u77e5\u3089\u308c\u308b\u907a\u4f1d\u5b50\u306e\u30af\u30e9\u30b9\u306b\u5c5e\u3059\u308b\u30d2\u30c8\u907a\u4f1d\u5b50\u3067\u3059\u3002<\/p>\n

\u6b63\u5e38\u7d30\u80de\u3067\u306f\u3001BRCA1<\/a><\/em>\u304a\u3088\u3073BRCA2<\/em>\u306f\u7d30\u80de\u306e\u907a\u4f1d\u7269\u8cea\uff08DNA\uff09\u306e\u5b89\u5b9a\u6027\u3092\u78ba\u4fdd\u3059\u308b\u5f79\u5272\u3092\u3057\u3001\u5236\u5fa1\u3055\u308c\u306a\u3044\u7d30\u80de\u5897\u6b96\u3092\u963b\u6b62\u3057\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306f\u3001\u907a\u4f1d\u6027\u4e73\u764c\u304a\u3088\u3073\u5375\u5de3\u764c\u306e\u767a\u75c7\u3068\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002 BRCA1<\/a><\/em>\u304a\u3088\u3073BRCA2<\/em>\u306e\u540d\u524d\u306f\u3001\u305d\u308c\u305e\u308c\u4e73\u764c\u611f\u53d7\u6027\u907a\u4f1d\u5b501\uff08br<\/strong>east ca<\/strong>ncer susceptibility gene 1<\/strong>\uff09\u3068\u4e73\u764c\u611f\u53d7\u6027\u907a\u4f1d\u5b502\uff08br<\/strong>east ca<\/strong>ncer susceptibility gene 2<\/strong>\uff09\u3092\u8868\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n

 <\/p>\n

<\/a>\uff12.BRCA1<\/em>\u3068BRCA2<\/em>\u306e\u907a\u4f1d\u5b50\u5909\u7570\u306f\u764c\u30ea\u30b9\u30af\u306b\u3069\u306e\u3088\u3046\u306a\u5f71\u97ff\u3092\u53ca\u307c\u3057\u307e\u3059\u304b\uff1f<\/strong><\/p>\n

\u3059\u3079\u3066\u306e\u907a\u4f1d\u5b50\u304c\u5909\u5316\u307e\u305f\u306f\u5909\u7570\u3057\u305f\u308a\u3001\u60aa\u5f71\u97ff\u3092\u53ca\u307c\u3057\u305f\u308a\u3059\u308b\uff08\u6709\u5bb3\uff09\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u6709\u76ca\u306a\u5909\u7570\u3082\u3042\u308b\u4e00\u65b9\u3067\u3001\u306f\u3063\u304d\u308a\u3057\u305f\u5f71\u97ff\u3092\u53ca\u307c\u3055\u306a\u3044\u5909\u7570\uff08\u4e2d\u7acb\uff09\u3082\u3042\u308a\u307e\u3059\u3002\u6709\u5bb3\u306a\u5909\u7570\u306b\u3088\u3063\u3066\u764c\u306a\u3069\u306e\u75be\u60a3\u3092\u767a\u75c7\u3059\u308b\u30ea\u30b9\u30af\u304c\u5897\u52a0\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

BRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u306e\u6709\u5bb3\u306a\u5909\u7570\u3092\u53d7\u3051\u7d99\u3050\u3068\u3001\u4e73\u764c\u307e\u305f\u306f\u5375\u5de3\u764c\u3001\u3042\u308b\u3044\u306f\u305d\u306e\u4e21\u65b9\u3092\u767a\u75c7\u3059\u308b\u751f\u6daf\u30ea\u30b9\u30af\u304c\u8457\u3057\u304f\u5897\u52a0\u3057\u307e\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u5973\u6027\u306f\u3001\u82e5\u5e74\uff08\u9589\u7d4c\u524d)\u3067\u306e\u4e73\u764c\u307e\u305f\u306f\u5375\u5de3\u764c\u3001\u3042\u308b\u3044\u306f\u305d\u306e\u4e21\u65b9\u306e\u767a\u75c7\u30ea\u30b9\u30af\u304c\u5897\u52a0\u3057\u3001\u3053\u308c\u3089\u306e\u75be\u60a3\u3068\u8a3a\u65ad\u3055\u308c\u305f\u8fd1\u89aa\u8005\u304c\u8907\u6570\u3044\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u3002\u6709\u5bb3\u306aBRCA1<\/em>\u5909\u7570\u306b\u3088\u3063\u3066\u5973\u6027\u306e\u5b50\u5bae\u9838\u764c\u3001\u5b50\u5bae\u764c\u3001\u81b5\u81d3\u764c\u3001\u5927\u8178\u764c\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3082\u5897\u52a0\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\uff081,2\uff09\u3002\u307e\u305f\u3001\u6709\u5bb3\u306aBRCA2<\/em>\u5909\u7570\u306b\u3088\u308a\u3001\u81b5\u81d3\u764c\u3001\u80c3\u764c\u3001\u80c6\u56a2\u764c\u3001\u80c6\u7ba1\u764c\u306e\u60aa\u6027\u9ed2\u8272\u816b\u306e\u30ea\u30b9\u30af\u304c\u5897\u52a0\u3059\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\uff083\uff09\u3002<\/p>\n

\u6709\u5bb3\u306aBRCA1<\/em>\u5909\u7570\u3092\u6709\u3059\u308b\u7537\u6027\u3082\u4e73\u764c\u3001\u5834\u5408\u306b\u3088\u3063\u3066\u306f\u3001\u81b5\u81d3\u764c\u3001\u7cbe\u5de3\u764c\u3001\u521d\u671f\u306e\u524d\u7acb\u817a\u764c\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u306a\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u7537\u6027\u4e73\u764c\u3001\u81b5\u81d3\u764c\u3001\u524d\u7acb\u817a\u764c\u306fBRCA2<\/em>\u907a\u4f1d\u5b50\u5909\u7570\u3068\u3088\u308a\u5f37\u304f\u95a2\u9023\u3057\u3066\u3044\u308b\u3088\u3046\u3067\u3059\uff082-4\uff09\u3002 \u4e73\u764c\u307e\u305f\u306f\u5375\u5de3\u764c\u3001\u3042\u308b\u3044\u306f\u305d\u306e\u4e21\u65b9\u304cBRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u306e\u6709\u5bb3\u306a\u5909\u7570\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u306f\u3001\u8907\u6570\u306e\u4e73\u764c\u306e\u75c5\u6b74\u3001\u4e73\u764c\u304a\u3088\u3073\u5375\u5de3\u764c\u306e\u4e21\u65b9\u306e\u75c5\u6b74\u3092\u6709\u3059\u308b\u5bb6\u65cf\u30011\u4eba\u3042\u308b\u3044\u306f\u8907\u6570\u306e\u5bb6\u65cf\u304c2\u3064\u306e\u539f\u767a\u764c\uff08\u7570\u306a\u308b\u90e8\u4f4d\u3067\u6700\u521d\u306b\u767a\u73fe\u3057\u305f\u816b\u760d\uff09\u3092\u6709\u3059\u308b\u5bb6\u65cf\u3001\u307e\u305f\u306f\u30a2\u30b7\u30e5\u30b1\u30ca\u30fc\u30b8\uff08\u6771\u30e8\u30fc\u30ed\u30c3\u30d1\u306e\uff09\u7cfb\u30e6\u30c0\u30e4\u4eba\u306e\u7d4c\u6b74\u3092\u6709\u3059\u308b\u5bb6\u65cf\u3067\u6700\u3082\u9ad8\u304f\u306a\u3063\u3066\u3044\u307e\u3059\uff08\u8cea\u554f6\u53c2\u7167\uff09\u3002\u3057\u304b\u3057\u3001\u305d\u306e\u3088\u3046\u306a\u5bb6\u65cf\u306e\u3059\u3079\u3066\u306e<\/strong>\u5973\u6027\u304c\u6709\u5bb3\u306aBRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u5909\u7570\u3092\u6301\u3064\u308f\u3051\u3067\u306f\u306a\u304f<\/strong>\u3001\u305d\u306e\u3088\u3046\u306a\u5bb6\u65cf\u304c\u767a\u75c7\u3059\u308b\u3059\u3079\u3066\u306e<\/strong>\u764c\u304c\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306e1\u3064\u306b\u304a\u3051\u308b\u6709\u5bb3\u306a\u5909\u7570\u3068\u95a2\u9023\u304c\u3042\u308b\u3068\u3044\u3046\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093<\/strong>\u3002\u3055\u3089\u306b\u3001\u6709\u5bb3\u306aBRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u5909\u7570\u3092\u6301\u3064\u3059\u3079\u3066\u306e<\/strong>\u5973\u6027\u304c\u4e73\u764c\u307e\u305f\u306f\u5375\u5de3\u764c\u3001\u3042\u308b\u3044\u306f\u305d\u306e\u4e21\u65b9\u3092\u767a\u75c7\u3059\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093<\/strong>\u3002<\/p>\n

\u751f\u6daf\u30ea\u30b9\u30af\u306e\u63a8\u5b9a\u306b\u3088\u308b\u3068\u3001\u6bcd\u96c6\u56e3\u306e\u5973\u6027\u306e\u7d0412\uff05\uff081,000\u4eba\u4e2d120\u4eba\uff09\u304c\u751f\u6daf\u306e\u3042\u308b\u6642\u671f\u306b\u4e73\u764c\u3092\u767a\u75c7\u3059\u308b\u306e\u306b\u5bfe\u3057\u3001BRCA1\u307e\u305f\u306fBRCA2\u306e\u6709\u5bb3\u306a\u5909\u7570\u3092\u53d7\u3051\u7d99\u3044\u3060\u5973\u6027\u3067\u306f\u7d0460\uff05\uff081,000\u4eba\u4e2d600\u4eba\uff09\u3067\u3059\u3002\u8a00\u3044\u63db\u3048\u308b\u3068\u3001BRCA1\u307e\u305f\u306fBRCA2\u306e\u6709\u5bb3\u306a\u5909\u7570\u3092\u53d7\u3051\u7d99\u3044\u3060\u5973\u6027\u306f\u3001\u305d\u308c\u3089\u306e\u5909\u7570\u3092\u6301\u305f\u306a\u3044\u5973\u6027\u3088\u308a\u4e73\u764c\u767a\u75c7\u7387\u304c\u7d045\u500d\u9ad8\u304f\u306a\u308a\u307e\u3059\u3002<\/p>\n

\u6bcd\u96c6\u56e3\u306e\u5973\u6027\u306e\u5375\u5de3\u764c\u306e\u751f\u6daf\u30ea\u30b9\u30af\u967a\u63a8\u5b9a\u3067\u306f\u30011.4\uff05\uff081,000\u4eba\u4e2d14\u4eba\uff09\u304c\u5375\u5de3\u764c\u3068\u8a3a\u65ad\u3055\u308c\u308b\u306e\u306b\u5bfe\u3057\u3001\u6709\u5bb3\u306aBRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u5909\u7570\u3092\u6301\u3064\u5973\u6027\u3067\u306f15\uff5e40\uff05\uff081,000\u4eba\u4e2d150\uff5e400\u4eba\uff09\u3067\u3042\u308b\u3068\u793a\u3057\u3066\u3044\u307e\u3059\uff084,5\uff09\u3002<\/p>\n

\u3057\u304b\u3057\u3001\u6ce8\u610f\u3057\u306a\u3051\u308c\u3070\u3044\u3051\u306a\u3044\u306e\u306f\u3001BRCA1<\/em>\u304a\u3088\u3073BRCA2<\/em>\u306b\u95a2\u9023\u3057\u305f\u7814\u7a76\u306e\u5927\u534a\u306f\u3001\u591a\u304f\u306e\u764c\u60a3\u8005\u304c\u3044\u308b\u5927\u5bb6\u65cf\u306b\u3064\u3044\u3066\u884c\u308f\u308c\u305f\u3068\u3044\u3046\u3053\u3068\u3067\u3059\u3002BRCA1<\/em>\u304a\u3088\u3073BRCA2<\/em>\u306e\u5909\u7570\u3068\u95a2\u9023\u3059\u308b\u4e73\u764c\u304a\u3088\u3073\u5375\u5de3\u764c\u306e\u63a8\u5b9a\u30ea\u30b9\u30af\u306f\u3001\u3053\u308c\u3089\u306e\u5bb6\u65cf\u306b\u95a2\u3059\u308b\u7814\u7a76\u304b\u3089\u7b97\u51fa\u3055\u308c\u307e\u3057\u305f\u3002\u5bb6\u65cf\u306f\u907a\u4f1d\u5b50\u3084\u3001\u591a\u304f\u306e\u5834\u5408\u74b0\u5883\u306e\u4e00\u90e8\u3092\u5171\u6709\u3057\u3066\u3044\u308b\u305f\u3081\u3001\u3053\u306e\u3088\u3046\u306a\u5bb6\u65cf\u306b\u307f\u3089\u308c\u308b\u591a\u6570\u306e\u764c\u75c7\u4f8b\u306f\u3042\u308b\u7a0b\u5ea6\u306f\u4ed6\u306e\u907a\u4f1d\u56e0\u5b50\u3042\u308b\u3044\u306f\u74b0\u5883\u56e0\u5b50\u304c\u539f\u56e0\u3067\u3042\u308b\u53ef\u80fd\u6027\u3082\u3042\u308a\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u591a\u304f\u306e\u7f79\u60a3\u8005\u304c\u3044\u308b\u5bb6\u65cf\u306b\u57fa\u3065\u3044\u305f\u30ea\u30b9\u30af\u63a8\u5b9a\u306f\u3001\u6bcd\u96c6\u56e3\u306eBRCA1<\/em>\u304a\u3088\u3073BRCA2<\/em>\u5909\u7570\u4fdd\u56e0\u8005\u306e\u30ea\u30b9\u30af\u30ec\u30d9\u30eb\u3092\u6b63\u78ba\u306b\u53cd\u6620\u3057\u3066\u3044\u306a\u3044\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u305d\u308c\u306b\u52a0\u3048\u3066\u3001\u6709\u5bb3\u306aBRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u5909\u7570\u3092\u6301\u3064\u5973\u6027\u3068\u6301\u305f\u306a\u3044\u5973\u6027\u306e\u764c\u30ea\u30b9\u30af\u3092\u6bd4\u8f03\u3057\u305f\u6bcd\u96c6\u56e3\u306e\u9577\u671f\u7684\u306a\u7814\u7a76\u30c7\u30fc\u30bf\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u305d\u306e\u305f\u3081\u3001\u3055\u3089\u306b\u30c7\u30fc\u30bf\u304c\u5f97\u3089\u308c\u308b\u3088\u3046\u306b\u306a\u308c\u3070\u3001\u4e0a\u8a18\u306e\u5272\u5408\u306f\u3001\u5909\u308f\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

 <\/p>\n

\uff13.\u4ed6\u306e\u907a\u4f1d\u5b50\u306e\u907a\u4f1d\u6027\u5909\u7570\u3067\u4e73\u764c\u307e\u305f\u306f\u5375\u5de3\u764c\u3001\u3042\u308b\u3044\u306f\u305d\u306e\u4e21\u65b9\u306e\u30ea\u30b9\u30af\u306f\u5897\u52a0\u3057\u307e\u3059\u304b\uff1f<\/strong><\/p>\n

\u306f\u3044\u3001\u5897\u52a0\u3057\u307e\u3059\u3002TP53\u3001PTEN\u3001STK11\uff0fLKB1\u3001CDH1\u3001CHEK2\u3001ATM\u3001MLH1\u3001MSH2<\/em>\u306a\u3069\u306e\u3044\u304f\u3064\u304b\u306e\u4ed6\u306e\u907a\u4f1d\u5b50\u306e\u5909\u7570\u306f\u907a\u4f1d\u6027\u4e73\u764c\u307e\u305f\u306f\u5375\u5de3\u764c\u3001\u3042\u308b\u3044\u306f\u305d\u306e\u4e21\u65b9\u3068\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\uff084,6,7\uff09\u3002\u3057\u304b\u3057\u3001\u907a\u4f1d\u6027\u4e73\u764c\u306e\u5927\u90e8\u5206\u306fBRCA1<\/em>\u304a\u3088\u3073BRCA2<\/em>\u306e\u907a\u4f1d\u6027\u5909\u7570\u3068\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\uff088\uff09\u3002\u5168\u4f53\u7684\u306b\u306f\u3001BRCA1<\/em>\u304a\u3088\u3073BRCA2<\/em>\u306e\u907a\u4f1d\u6027\u5909\u7570\u306f\u7c73\u56fd\u306e\u767d\u4eba\u5973\u6027\u3067\u3001\u4e73\u764c\u306e5\uff5e10\uff05\u3001\u5375\u5de3\u764c\u306e10\uff5e15\uff05\u306e\u539f\u56e0\u3068\u306a\u3063\u3066\u3044\u308b\u3068\u63a8\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\uff086\uff09\u3002<\/p>\n

 <\/p>\n

\uff14.BRCA1<\/em>\u3068BRCA2<\/em>\u306e\u7279\u7570\u7684\u5909\u7570\u306f\u3001\u7279\u5b9a\u306e\u6bcd\u96c6\u56e3\u3067\u3088\u308a\u591a\u304f\u307f\u3089\u308c\u307e\u3059\u304b\uff1f<\/strong><\/p>\n

\u306f\u3044\u3002\u305f\u3068\u3048\u3070\u3001BRCA1<\/em>\u907a\u4f1d\u5b50\u306b2\u3064\u3001BRCA2<\/em>\u907a\u4f1d\u5b50\u306b1\u3064\u3042\u308b3\u3064\u306e\u7279\u7570\u7684\u5909\u7570\u306f\u30a2\u30b7\u30e5\u30b1\u30ca\u30fc\u30b8\u7cfb\u30e6\u30c0\u30e4\u4eba\u306e\u6bcd\u96c6\u56e3\u306e\u907a\u4f1d\u5b50\u3067\u691c\u51fa\u3055\u308c\u308b\u6700\u3082\u591a\u3044\u5909\u7570\u3067\u3059\u3002\u3042\u308b\u7814\u7a76\u3067\u306f\u3001\u53c2\u52a0\u8005\u306e2.3\uff05\uff085,318\u4eba\u4e2d120\u4eba\uff09\u304c\u3053\u308c\u30893\u3064\u306e\u5909\u7570\u306e\u3046\u3061\u306e1\u3064\u3092\u4fdd\u56e0\u3057\u3066\u3044\u307e\u3057\u305f\uff089\uff09\u3002\u3053\u308c\u306f\u4e00\u822c\u7684\u6bcd\u96c6\u56e3\u3068\u6bd4\u8f03\u3059\u308b\u3068\u7d045\u500d\u9ad8\u3044\u983b\u5ea6\u306b\u306a\u308a\u307e\u3059\uff0e\u975e\u30e6\u30c0\u30e4\u4eba\u306e\u6bcd\u96c6\u56e3\u3068\u6bd4\u8f03\u3057\u3066\u3001\u3053\u308c\u3089\u306e\u5909\u7570\u306e\u983b\u5ea6\u304c\u9ad8\u3044\u305f\u3081\u306b\u30e6\u30c0\u30e4\u4eba\u306e\u6bcd\u96c6\u56e3\u3067\u4e73\u764c\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u306e\u304b\u3069\u3046\u304b\u306f\u308f\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n

\u30ce\u30eb\u30a6\u30a7\u30fc\u4eba\u3001\u30aa\u30e9\u30f3\u30c0\u4eba\u3001\u30a2\u30a4\u30b9\u30e9\u30f3\u30c9\u4eba\u306a\u3069\u306e\u4ed6\u306e\u4eba\u7a2e\u7684\u96c6\u56e3\u3084\u5730\u7406\u7684\u96c6\u56e3\u3067\u3082\u3001BRCA1<\/em>\u304a\u3088\u3073BRCA2<\/em>\u306e\u7279\u7570\u7684\u5909\u7570\u306e\u983b\u5ea6\u304c\u9ad8\u304f\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n

\u307e\u305f\u3001BRCA1<\/em>\u304a\u3088\u3073BRCA2<\/em>\u306e\u7279\u7570\u7684\u5909\u7570\u306e\u983b\u5ea6\u306f\u30a2\u30d5\u30ea\u30ab\u7cfb\u30a2\u30e1\u30ea\u30ab\u4eba\u3001\u30d2\u30b9\u30d1\u30cb\u30c3\u30af\u3001\u30a2\u30b8\u30a2\u7cfb\u30a2\u30e1\u30ea\u30ab\u4eba\u3001\u975e\u30d2\u30b9\u30d1\u30cb\u30c3\u30af\u7cfb\u767d\u4eba\u306a\u3069\u7c73\u56fd\u306e\u5404\u4eba\u7a2e\u304a\u3088\u3073\u6c11\u65cf\u96c6\u56e3\u3067\u7570\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u9650\u3089\u308c\u305f\u30c7\u30fc\u30bf\u3067\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059\uff0811-13\uff09\u3002 \u4eba\u7a2e\u304a\u3088\u3073\u6c11\u65cf\u96c6\u56e3\u9593\u306e\u907a\u4f1d\u5b50\u306e\u5dee\u7570\u306b\u95a2\u3059\u308b\u3053\u306e\u60c5\u5831\u306f\u3001\u533b\u7642\u5f93\u4e8b\u8005\u304c\u6700\u3082\u9069\u5207\u306a\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u9078\u629e\u3059\u308b\u306e\u306b\u5f79\u7acb\u3064\u304b\u3082\u3057\u308c\u307e\u305b\u3093\uff08\u8cea\u554f5\u53c2\u7167\uff09\u3002<\/p>\n

 <\/p>\n

<\/a>\uff15.BRCA1<\/em>\u3068BRCA2<\/em>\u306e\u5909\u7570\u3092\u691c\u51fa\u3059\u308b\u907a\u4f1d\u5b50\u691c\u67fb\u306f\u3042\u308a\u307e\u3059\u304b\uff1f\u307e\u305f\u3001\u305d\u306e\u691c\u67fb\u306f\u3069\u306e\u3088\u3046\u306b\u884c\u308f\u308c\u307e\u3059\u304b\uff1f<\/strong><\/p>\n

\u3042\u308a\u307e\u3059\u3002BRCA1<\/em>\u304a\u3088\u3073BRCA2<\/em>\u5909\u7570\u306e\u691c\u67fb\u306b\u306f\u3044\u304f\u3064\u304b\u306e\u65b9\u6cd5\u304c\u3042\u308a\u307e\u3059\uff0814\uff09\u3002\u307b\u3068\u3093\u3069\u306e\u65b9\u6cd5\u3067\u3001BRCA1<\/em>\u304a\u3088\u3073BRCA2<\/em>\uff24\uff2e\uff21\u306e\u5909\u5316\u3092\u8abf\u3079\u307e\u3059\u3002\u5c11\u306a\u304f\u3068\u30821\u3064\u306e\u65b9\u6cd5\u3067\u3001\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u304c\u751f\u6210\u3059\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u5909\u5316\u3092\u8abf\u3079\u307e\u3059\u3002\u8907\u6570\u306e\u65b9\u6cd5\u3092\u7d44\u307f\u5408\u308f\u305b\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u3002<\/p>\n

\u3053\u308c\u3089\u306e\u691c\u67fb\u306b\u306f\u8840\u6db2\u30b5\u30f3\u30d7\u30eb\u304c\u5fc5\u8981\u3067\u3059\u3002\u7814\u7a76\u5ba4\u3001\u8a3a\u7642\u6240\u3001\u75c5\u9662\u307e\u305f\u306f\u30af\u30ea\u30cb\u30c3\u30af\u3067\u63a1\u8840\u3055\u308c\u3001\u691c\u67fb\u5c02\u9580\u306e\u7814\u7a76\u5ba4\u306b\u9001\u3089\u308c\u307e\u3059\u3002\u691c\u67fb\u7d50\u679c\u304c\u308f\u304b\u308b\u307e\u3067\u306b\u306f\u901a\u5e38\u6570\u9031\u9593\u4ee5\u4e0a\u304b\u304b\u308a\u307e\u3059\u3002\u691c\u67fb\u3092\u53d7\u3051\u308b\u3068\u6c7a\u3081\u305f\u4eba\u306f\u3001\u691c\u67fb\u7d50\u679c\u304c\u3044\u3064\u308f\u304b\u308b\u306e\u304b\u3092\u533b\u7642\u6a5f\u95a2\u306b\u78ba\u8a8d\u3057\u306a\u304f\u3066\u306f\u3044\u3051\u307e\u305b\u3093\u3002<\/p>\n

\u4e00\u822c\u7684\u306b\u3001\u691c\u67fb\u524d\u5f8c\u306b\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3092\u53d7\u3051\u308b\u3053\u3068\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u306f\u764c\u907a\u4f1d\u5b50\u306b\u7fd2\u719f\u3057\u3066\u3044\u308b\u533b\u7642\u306e\u5c02\u9580\u5bb6\u304c\u884c\u308f\u306a\u3051\u308c\u3070\u3044\u3051\u307e\u305b\u3093\uff08\u8cea\u554f17\u53c2\u7167\uff09\u3002\u901a\u5e38\u3001\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u306b\u306f\u3001\u500b\u4eba\u3084\u5bb6\u65cf\u306e\u75c5\u6b74\u306b\u57fa\u3065\u304f\u30ea\u30b9\u30af\u8a55\u4fa1\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u59a5\u5f53\u6027\u306b\u95a2\u3059\u308b\u8a71\u3057\u5408\u3044\u3001\u7528\u3044\u308b\u3053\u3068\u306b\u306a\u308b\u7279\u5b9a\u306e\u691c\u67fb\u3068\u305d\u306e\u691c\u67fb\u306e\u6280\u8853\u7684\u7cbe\u5ea6\u3001\u967d\u6027\u307e\u305f\u306f\u9670\u6027\u306e\u691c\u67fb\u7d50\u679c\u306e\u533b\u5b66\u7684\u610f\u5473\u3001\u691c\u67fb\u7d50\u679c\u304c\u6709\u76ca\u3067\u306f\u306a\u3044\uff08\u66d6\u6627\u306a\u7d50\u679c\uff09\u53ef\u80fd\u6027\uff08\u4e0b\u8a18\u53c2\u7167\uff09\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u7d50\u679c\u306e\u5fc3\u7406\u7684\u30ea\u30b9\u30af\u3068\u5229\u70b9\u3001\u5909\u7570\u304c\u5b50\u4f9b\u306b\u53d7\u3051\u7d99\u304c\u308c\u308b\u30ea\u30b9\u30af\u304c\u542b\u307e\u308c\u307e\u3059\u3002<\/p>\n

 <\/p>\n

\uff16.BRCA1<\/em>\u3068BRCA2<\/em>\u5909\u7570\u306e\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u691c\u8a0e\u3059\u3079\u304d\u304b\u3069\u3046\u304b\u306f\u3069\u306e\u3088\u3046\u306b\u5206\u304b\u308b\u306e\u3067\u3059\u304b\uff1f<\/strong><\/p>\n

\u73fe\u5728\u306e\u3068\u3053\u308d\u3001BRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u5909\u7570\u691c\u67fb\u3092\u63a8\u5968\u3057\u305f\u308a\u52e7\u3081\u305f\u308a\u3059\u308b\u6a19\u6e96\u7684\u306a\u57fa\u6e96\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n

\u4e73\u764c\u307e\u305f\u306f\u5375\u5de3\u764c\u3001\u3042\u308b\u3044\u306f\u305d\u306e\u4e21\u65b9\u306e\u5bb6\u65cf\u6b74\u304c\u3042\u308b\u5834\u5408\u3001\u4e73\u764c\u307e\u305f\u306f\u5375\u5de3\u764c\u306b\u7f79\u60a3\u3057\u3066\u3044\u308b\u5bb6\u65cf\u304c\u307e\u305a\u691c\u67fb\u3092\u53d7\u3051\u308b\u306e\u304c\u6700\u3082\u6709\u76ca\u3067\u3057\u3087\u3046\u3002\u305d\u306e\u5bb6\u65cf\u304c\u6709\u5bb3\u306aBRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u5909\u7570\u3092\u6301\u3063\u3066\u3044\u308b\u3068\u5224\u660e\u3059\u308c\u3070\u3001\u4ed6\u306e\u5bb6\u65cf\u3082\u691c\u67fb\u3092\u53d7\u3051\u3001\u305d\u306e\u5909\u7570\u3092\u6301\u3063\u3066\u3044\u308b\u304b\u3069\u3046\u304b\u8abf\u3079\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n

\u3068\u306b\u304b\u304f\u3001\u6709\u5bb3\u306aBRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u5909\u7570\u3092\u6301\u3064\u8fd1\u89aa\u8005\u304c\u3044\u308b\u5973\u6027\u304a\u3088\u3073\u5bb6\u65cf\u6b74\u304c\u3042\u308b\u305f\u3081\u4e73\u764c\u307e\u305f\u306f\u5375\u5de3\u764c\u3001\u3042\u308b\u3044\u306f\u305d\u306e\u4e21\u65b9\u306e\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3068\u601d\u308f\u308c\u308b\u5973\u6027\u306f\u3001\u6f5c\u5728\u7684\u30ea\u30b9\u30af\u3068BRCA1<\/em>\u304a\u3088\u3073BRCA2<\/em>\u306e\u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u77e5\u308b\u305f\u3081\u306b\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u3092\u691c\u8a0e\u3059\u3079\u304d\u3067\u3059\u3002<\/p>\n

BRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u306e\u6709\u5bb3\u306a\u5909\u7570\u3092\u6301\u3064\u53ef\u80fd\u6027\u306f\u3001\u764c\u306e\u7279\u5b9a\u306e\u5bb6\u65cf\u30d1\u30bf\u30fc\u30f3\u3067\u5897\u52a0\u3057\u307e\u3059\u3002\u30d1\u30bf\u30fc\u30f3\u306b\u306f\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u3082\u306e\u304c\u3042\u308a\u307e\u3059\uff0815\uff09\u3002<\/p>\n

\u30fb\u30a2\u30b7\u30e5\u30b1\u30ca\u30fc\u30b8\u7cfb\u30e6\u30c0\u30e4\u4eba\u3067\u306f\u306a\u3044\u5973\u6027\uff1a<\/p>\n

    \n
  1. \u4e73\u764c\u3068\u8a3a\u65ad\u3055\u308c\u305f2\u4eba\u306e\u7b2c\u4e00\u5ea6\u8fd1\u89aa\u8005\uff08\u6bcd\u89aa\u3001\u5a18\u3001\u307e\u305f\u306f\u59c9\u59b9\uff09\u304c\u304a\u308a\u3001\u305d\u306e\u3046\u3061\u306e1\u4eba\u304c50\u6b73\u4ee5\u4e0b\u3067\u7f79\u60a3\u3057\u3066\u3044\u308b<\/li>\n
  2. 3\u4eba\u4ee5\u4e0a\u306e\u7b2c\u4e00\u5ea6\u307e\u305f\u306f\u7b2c\u4e8c\u5ea6\u8fd1\u89aa\u8005\uff08\u7956\u6bcd\u307e\u305f\u306f\u53d4\u6bcd\uff09\u304c\u8a3a\u65ad\u6642\u306e\u5e74\u9f62\u306b\u95a2\u4fc2\u306a\u304f\u4e73\u764c\u3068\u8a3a\u65ad\u3055\u308c\u3066\u3044\u308b<\/li>\n
  3. \u7b2c\u4e00\u5ea6\u304a\u3088\u3073\u7b2c\u4e8c\u5ea6\u8fd1\u89aa\u8005\u306e\u4e21\u65b9\u304c\u4e73\u764c\u304a\u3088\u3073\u5375\u5de3\u764c\u3068\u8a3a\u65ad\u3055\u308c\u3066\u3044\u308b\uff08\u4e00\u4eba\u306b\u3064\u304d1\u7a2e\u985e\u306e\u764c\uff09<\/li>\n
  4. \u7b2c\u4e00\u5ea6\u8fd1\u89aa\u8005\u304c\u4e21\u4e73\u623f\u306b\u304a\u3044\u3066\u764c\u3068\u8a3a\u65ad\u3055\u308c\u3066\u3044\u308b\uff08\u4e21\u5074\u4e73\u764c\uff09<\/li>\n
  5. 2\u4eba\u4ee5\u4e0a\u306e\u7b2c\u4e00\u5ea6\u304a\u3088\u3073\u7b2c\u4e8c\u5ea6\u8fd1\u89aa\u8005\u304c\u8a3a\u65ad\u6642\u306e\u5e74\u9f62\u306b\u95a2\u4fc2\u306a\u304f\u5375\u5de3\u764c\u3068\u8a3a\u65ad\u3055\u308c\u3066\u3044\u308b<\/li>\n
  6. \u7b2c\u4e00\u5ea6\u307e\u305f\u306f\u7b2c\u4e8c\u5ea6\u8fd1\u89aa\u8005\u304c\u8a3a\u65ad\u6642\u306e\u5e74\u9f62\u306b\u95a2\u4fc2\u306a\u304f\u4e73\u764c\u304a\u3088\u3073\u5375\u5de3\u764c\u306e\u4e21\u65b9\u3068\u8a3a\u65ad\u3055\u308c\u3066\u3044\u308b<\/li>\n
  7. \u7537\u6027\u306e\u8fd1\u89aa\u8005\u304c\u4e73\u764c\u3068\u8a3a\u65ad\u3055\u308c\u3066\u3044\u308b<\/li>\n<\/ol>\n

    \u30fb\u30a2\u30b7\u30e5\u30b1\u30ca\u30fc\u30b8\u7cfb\u30e6\u30c0\u30e4\u4eba\u306e\u5973\u6027\uff1a<\/p>\n

      \n
    1. \u7b2c\u4e00\u5ea6\u8fd1\u89aa\u8005\u304c\u4e73\u764c\u307e\u305f\u306f\u5375\u5de3\u764c\u3068\u8a3a\u65ad\u3055\u308c\u3066\u3044\u308b<\/li>\n
    2. \u540c\u7cfb\u306e2\u4eba\u306e\u7b2c\u4e8c\u5ea6\u8fd1\u89aa\u8005\u304c\u4e73\u764c\u307e\u305f\u306f\u5375\u5de3\u764c\u3068\u8a3a\u65ad\u3055\u308c\u3066\u3044\u308b<\/li>\n<\/ol>\n

      \u3053\u308c\u3089\u306e\u5bb6\u65cf\u6b74\u30d1\u30bf\u30fc\u30f3\u306f\u6bcd\u96c6\u56e3\u306e\u7d042\uff05\u306e\u6210\u4eba\u5973\u6027\u306b\u5f53\u3066\u306f\u307e\u308a\u307e\u3059\u3002\u3053\u308c\u3089\u306e\u5bb6\u65cf\u6b74\u30d1\u30bf\u30fc\u30f3\u306b\u8a72\u5f53\u3057\u306a\u3044\u5973\u6027\u306f\u6709\u5bb3\u306aBRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u5909\u7570\u3092\u6301\u3064\u53ef\u80fd\u6027\u304c\u4f4e\u3044\u3067\u3059\u3002<\/p>\n

       <\/p>\n

      \uff17.BRCA1<\/em>\u3068BRCA2<\/em>\u306e\u5909\u7570\u691c\u67fb\u306b\u306f\u3069\u306e\u304f\u3089\u3044\u306e\u8cbb\u7528\u304c\u304b\u304b\u308a\u307e\u3059\u304b\uff1f<\/strong><\/p>\n

      BRCA1<\/em>\u304a\u3088\u3073BRCA2<\/em>\u5909\u7570\u691c\u67fb\u306e\u8cbb\u7528\u306f\u3001\u901a\u5e38\u6570\u767e\u304b\u3089\u6570\u5343\u30c9\u30eb\u307e\u3067\u3055\u307e\u3056\u307e\u3067\u3059\u3002\u691c\u67fb\u8cbb\u7528\u304c\u4fdd\u969c\u5bfe\u8c61\u306b\u306a\u308b\u304b\u3069\u3046\u306f\u4fdd\u967a\u5951\u7d04\u306b\u3088\u3063\u3066\u7570\u306a\u308a\u307e\u3059\u3002BRCA1<\/em>\u304a\u3088\u3073BRCA2<\/em>\u5909\u7570\u691c\u67fb\u3092\u691c\u8a0e\u3057\u3066\u3044\u308b\u4eba\u306f\u907a\u4f1d\u5b50\u691c\u67fb\u306b\u95a2\u3059\u308b\u4fdd\u967a\u5951\u7d04\u306b\u3064\u3044\u3066\u8abf\u3079\u3066\u307f\u308b\u3068\u3088\u3044\u3067\u3057\u3087\u3046\u3002<\/p>\n

       <\/p>\n

      \uff18.BRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u967d\u6027\u306e\u691c\u67fb\u7d50\u679c\u306f\u4f55\u3092\u610f\u5473\u3057\u307e\u3059\u304b\uff1f<\/strong><\/p>\n

      \u4e00\u822c\u7684\u306b\u3001\u967d\u6027\u306e\u691c\u67fb\u7d50\u679c\u306fBRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u306e\u65e2\u77e5\u306e\u6709\u5bb3\u306a\u5909\u7570\u3092\u53d7\u3051\u7d99\u3044\u3067\u304a\u308a\u3001\u305d\u306e\u305f\u3081\u3001\u524d\u8ff0\u306e\u3088\u3046\u306b\u7279\u5b9a\u306e\u764c\u306e\u767a\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u3053\u3068\u3092\u793a\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u967d\u6027\u306e\u691c\u67fb\u7d50\u679c\u306f\u3001\u764c\u767a\u75c7\u30ea\u30b9\u30af<\/strong>\u306b\u95a2\u3059\u308b\u60c5\u5831\u306e\u307f\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002\u5b9f\u969b\u306b\u764c\u3092\u767a\u75c7\u3059\u308b\u306e\u304b\u3084\u3001\u3044\u3064\u767a\u75c7\u3059\u308b\u306e\u304b\u306f\u5206\u304b\u308a\u307e\u305b\u3093\u3002\u6709\u5bb3\u306aBRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u5909\u7570\u3092\u53d7\u3051\u7d99\u3044\u3060\u3059\u3079\u3066\u306e<\/strong>\u5973\u6027\u304c\u3001\u4e73\u764c\u307e\u305f\u306f\u5375\u5de3\u764c\u3092\u767a\u75c7\u3059\u308b\u308f\u3051\u3067\u3042\u308a\u307e\u305b\u3093<\/strong>\u3002<\/p>\n

      \u967d\u6027\u306e\u907a\u4f1d\u5b50\u691c\u67fb\u7d50\u679c\u306f\u3001\u5c06\u6765\u306e\u4e16\u4ee3\u3092\u542b\u3080\u5bb6\u65cf\u306b\u3068\u3063\u3066\u3001\u5065\u5eb7\u4e0a\u304a\u3088\u3073\u793e\u4f1a\u7684\u306b\u91cd\u8981\u306a\u610f\u5473\u304c\u3042\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u5927\u90e8\u5206\u306e\u4ed6\u306e\u533b\u5b66\u691c\u67fb\u3068\u306f\u7570\u306a\u308a\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3067\u306f\u691c\u67fb\u3092\u53d7\u3051\u308b\u4eba\u306b\u3064\u3044\u3066\u3060\u3051\u3067\u306a\u304f\u3001\u305d\u306e\u4eba\u306e\u8fd1\u89aa\u8005\u306b\u3064\u3044\u3066\u306e\u60c5\u5831\u3082\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3059\u3002\u764c\u3092\u767a\u75c7\u3057\u3066\u3044\u308b\u304b\u5426\u304b\u306b\u304b\u304b\u308f\u3089\u305a\u3001\u6709\u5bb3\u306aBRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u5909\u7570\u3092\u53d7\u3051\u7d99\u3044\u3067\u3044\u308b\u7537\u5973\u5171\u306b\u3001\u305d\u306e\u5909\u7570\u3092\u606f\u5b50\u3084\u5a18\u306b\u4f1d\u3048\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u6709\u5bb3\u306a\u5909\u7570\u3092\u6301\u3064\u4eba\u3005\u306e\u5b50\u4f9b\u3059\u3079\u3066\u304c<\/strong>\u3001\u5909\u7570\u3092\u53d7\u3051\u7d99\u3050\u3068\u3044\u3046\u308f\u3051\u3067\u3042\u308a\u307e\u305b\u3093<\/strong>\u3002<\/p>\n

       <\/p>\n

      \uff19.BRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u9670\u6027\u306e\u691c\u67fb\u7d50\u679c\u306f\u4f55\u3092\u610f\u5473\u3057\u307e\u3059\u304b\uff1f<\/strong><\/p>\n

      \u9670\u6027\u306e\u691c\u67fb\u7d50\u679c\u306f\u3001\u691c\u67fb\u3092\u53d7\u3051\u305f\u4eba\u306e\u5bb6\u65cf\u304c\u6709\u5bb3\u306aBRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u5909\u7570\u3092\u4fdd\u56e0\u3057\u3066\u3044\u308b\u3068\u78ba\u8a8d\u3055\u308c\u3066\u3044\u308b\u304b\u3069\u3046\u304b\u3067\u89e3\u91c8\u304c\u7570\u306a\u308a\u307e\u3059\u3002\u5bb6\u65cf\u306e\u8ab0\u304b\u304c\u65e2\u77e5\u306e\u5909\u7570\u3092\u6301\u3063\u3066\u3044\u308c\u3070\u3001\u4ed6\u306e\u5bb6\u65cf\u304c\u540c\u4e00\u306e\u5909\u7570\u306b\u5bfe\u3059\u308b\u691c\u67fb\u3092\u3059\u308b\u3053\u3068\u3067\u5f7c\u3089\u306e\u764c\u30ea\u30b9\u30af\u306b\u95a2\u3059\u308b\u60c5\u5831\u304c\u5f97\u3089\u308c\u307e\u3059\u3002\u305d\u306e\u5bb6\u65cf\u306e\u65e2\u77e5\u306e\u5909\u7570\u306b\u5bfe\u3057\u3066\u9670\u6027\u306a\u3089\u3070\u3001BRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u306b\u95a2\u9023\u3057\u305f\u907a\u4f1d\u7684\u306a\u764c\u611f\u53d7\u6027\u3092\u6301\u3064\u53ef\u80fd\u6027\u306f\u4f4e\u3044\u3067\u3059\u3002\u3053\u306e\u3088\u3046\u306a\u691c\u67fb\u7d50\u679c\u306f\u3001\u300c\u771f\u306e\u9670\u6027\u300d\u3068\u547c\u3070\u308c\u3066\u3044\u307e\u3059\u3002\u771f\u306e\u9670\u6027\u306e\u691c\u67fb\u7d50\u679c\u306f\u3001\u305d\u306e\u4eba\u304c\u764c\u3092\u767a\u75c7\u3057\u306a\u3044\u3053\u3068\u3092\u610f\u5473\u3059\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u764c\u30ea\u30b9\u30af\u304c\u6bcd\u96c6\u56e3\u306e\u30ea\u30b9\u30af\u3068\u304a\u305d\u3089\u304f\u540c\u3058\u3067\u3042\u308b\u3053\u3068\u3092\u610f\u5473\u3057\u307e\u3059\u3002<\/p>\n

      \u5bb6\u65cf\u306b\u4e73\u764c\u307e\u305f\u306f\u5375\u5de3\u764c\u3042\u308b\u3044\u306f\u305d\u306e\u4e21\u65b9\u306e\u75c5\u6b74\u304c\u3042\u308a\u3001BRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u306e\u65e2\u77e5\u306e\u5909\u7570\u304c\u3053\u308c\u307e\u3067\u306b\u78ba\u8a8d\u3055\u308c\u3066\u3044\u306a\u3044\u5834\u5408\u306f\u3001\u9670\u6027\u306e\u691c\u67fb\u7d50\u679c\u306f\u6709\u76ca\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u691c\u67fb\uff08\u300c\u507d\u9670\u6027\u300d\uff09\u3067\u691c\u51fa\u3055\u308c\u306a\u304b\u3063\u305f\u6709\u5bb3\u306aBRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u306e\u5909\u7570\u3092\u6301\u3063\u3066\u3044\u308b\u304b\u3069\u3046\u304b\u3001\u307e\u305f\u306f\u7d50\u679c\u304c\u771f\u306e\u9670\u6027\u3067\u3042\u308b\u304b\u3069\u3046\u304b\u898b\u5206\u3051\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002\u307e\u305f\u3001BRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u4ee5\u5916\u306e\u764c\u30ea\u30b9\u30af\u3092\u5897\u52a0\u3055\u305b\u308b\u907a\u4f1d\u5b50\u306b\u5909\u7570\u3092\u6301\u3063\u3066\u3044\u308b\u53ef\u80fd\u6027\u3082\u3042\u308a\u307e\u3059\u304c\u3001\u3053\u306e\u691c\u67fb\u3067\u306f\u691c\u51fa\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n

       <\/p>\n

      \uff11\uff10.\u66d6\u6627\u306aBRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u306e\u691c\u67fb\u7d50\u679c\u306f\u4f55\u3092\u610f\u5473\u3057\u307e\u3059\u304b\uff1f<\/strong><\/p>\n

      \u4ed6\u306e\u4eba\u3005\u306b\u304a\u3044\u3066\u3053\u308c\u307e\u3067\u764c\u3068\u95a2\u9023\u306e\u306a\u3044BRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u306e\u5909\u5316\u304c\u691c\u67fb\u3067\u793a\u3055\u308c\u308b\u5834\u5408\u3001\u305d\u306e\u691c\u67fb\u7d50\u679c\u306f\u300c\u66d6\u6627\u300d\uff08\u4e0d\u78ba\u5b9f\uff09\u3068\u89e3\u91c8\u3055\u308c\u308b\u5834\u5408\u304c\u3042\u308a\u307e\u3059\u3002\u3042\u308b\u7814\u7a76\u3067\u3001BRCA1<\/em>\u304a\u3088\u3073BRCA2<\/em>\u306e\u5909\u7570\u691c\u67fb\u3092\u53d7\u3051\u305f\u5973\u6027\u306e10\uff05\u304c\u3053\u306e\u7a2e\u306e\u66d6\u6627\u306a\u7d50\u679c\u3092\u6709\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f(16)\u3002<\/p>\n

      \u75c5\u6c17\u306e\u30ea\u30b9\u30af\u5897\u52a0\u3068\u95a2\u9023\u3057\u3066\u3044\u306a\u3044\u907a\u4f1d\u5b50\u306e\u5dee\u7570\u306f\u8ab0\u3067\u3082\u6301\u3063\u3066\u3044\u308b\u306e\u3067\u3001\u7279\u5b9a\u306eDNA\u306e\u5909\u5316\u304c\u764c\u767a\u75c7\u30ea\u30b9\u30af\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u304b\u3069\u3046\u304b\u308f\u304b\u3089\u306a\u3044\u5834\u5408\u3082\u3042\u308a\u307e\u3059\u3002\u3088\u308a\u591a\u304f\u306e\u7814\u7a76\u304c\u884c\u308f\u308c\u3001\u3088\u308a\u591a\u304f\u306e\u4eba\u3005\u304cBRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u306e\u5909\u5316\u306b\u5bfe\u3059\u308b\u691c\u67fb\u3092\u53d7\u3051\u308c\u3070\u3001\u79d1\u5b66\u8005\u3089\u306f\u3053\u308c\u3089\u306e\u5909\u5316\u3068\u764c\u306e\u30ea\u30b9\u30af\u306b\u3064\u3044\u3066\u3055\u3089\u306b\u5206\u304b\u308b\u3067\u3057\u3087\u3046\u3002<\/p>\n

       <\/p>\n

      <\/a>\uff11\uff11.\u967d\u6027\u53cd\u5fdc\u3092\u793a\u3059\u4eba\u306e\u305f\u3081\u306e\u9078\u629e\u80a2\u306b\u306f\u3069\u306e\u3088\u3046\u306a\u3082\u306e\u304c\u3042\u308a\u307e\u3059\u304b\uff1f<\/strong><\/p>\n

      \u6709\u5bb3\u306aBRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u5909\u7570\u306e\u3042\u308b\u4eba\u306b\u304a\u3044\u3066\u764c\u30ea\u30b9\u30af\u306e\u7ba1\u7406\u3092\u884c\u3046\u9078\u629e\u80a2\u306f\u3044\u304f\u3064\u304b\u3042\u308a\u307e\u3059\u304c\u3001\u3053\u308c\u3089\u306e\u9078\u629e\u80a2\u306e\u6709\u52b9\u6027\u3092\u793a\u3059\u8cea\u306e\u9ad8\u3044\u30c7\u30fc\u30bf\u306f\u9650\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

      \u691c\u67fb<\/strong>\u30b5\u30fc\u30d9\u30a4\u30e9\u30f3\u30b9<\/strong>\u2015\u30b5\u30fc\u30d9\u30a4\u30e9\u30f3\u30b9\u3068\u306f\u764c\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u307e\u305f\u306f\u75c5\u6c17\u3092\u65e9\u671f\u767a\u898b\u3059\u308b\u65b9\u6cd5\u306e\u3053\u3068\u3067\u3059\u304c\u3001\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u3092\u884c\u3063\u3066\u3082\u764c\u767a\u75c7\u306e\u30ea\u30b9\u30af\u306f\u5909\u308f\u308a\u307e\u305b\u3093\u3002\u764c\u3092\u6700\u3082\u6cbb\u7642\u3067\u304d\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u65e9\u671f\u306b\u767a\u898b\u3059\u308b\u3053\u3068\u304c\u76ee\u6a19\u3067\u3059\u3002 \u4e73\u764c\u306e\u30b5\u30fc\u30d9\u30a4\u30e9\u30f3\u30b9\u65b9\u6cd5\u306b\u306f\u3001\u30de\u30f3\u30e2\u30b0\u30e9\u30d5\u30a3\u30fc\u3084\u81e8\u5e8a\u4e73\u623f\u691c\u67fb\u306a\u3069\u304c\u3042\u308a\u307e\u3059\u3002BRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u5909\u7570\u3092\u6301\u3064\u5973\u6027\u306b\u304a\u3051\u308b\u78c1\u6c17\u5171\u9cf4\u753b\u50cf\u6cd5\uff08MRI\uff09\u306a\u3069\u306e\u4ed6\u306e\u4e73\u764c\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u65b9\u6cd5\u306e\u6709\u52b9\u6027\u3092\u691c\u8a3c\u3059\u308b\u7814\u7a76\u304c\u73fe\u5728\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u614e\u91cd\u306a\u30b5\u30fc\u30d9\u30a4\u30e9\u30f3\u30b9\u3092\u884c\u3048\u3070\u3001\u4e73\u764c\u306e\u591a\u304f\u306f\u3001\u5341\u5206\u65e9\u3044\u6642\u671f\u306b\u8a3a\u65ad\u3055\u308c\u3001\u6cbb\u7642\u304c\u53ef\u80fd\u3067\u3059\u3002 \u5375\u5de3\u764c\u306e\u30b5\u30fc\u30d9\u30a4\u30e9\u30f3\u30b9\u65b9\u6cd5\u306b\u306f\u3001\u7d4c\u81a3\u8d85\u97f3\u6ce2\u691c\u67fb\u3001CA-125\u6297\u539f\u8840\u6db2\u691c\u67fb\u3001\u81e8\u5e8a\u691c\u67fb\u306a\u3069\u304c\u3042\u308a\u307e\u3059\u3002\u30b5\u30fc\u30d9\u30a4\u30e9\u30f3\u30b9\u306b\u3088\u308a\u764c\u3092\u65e9\u671f\u306b\u767a\u898b\u3067\u304d\u308b\u3053\u3068\u3082\u3042\u308a\u307e\u3059\u304c\u3001\u3053\u308c\u3089\u306e\u65b9\u6cd5\u304c\u5375\u5de3\u764c\u306b\u3088\u308b\u6b7b\u4ea1\u7387\u3092\u6e1b\u5c11\u3067\u304d\u308b\u304b\u3069\u3046\u304b\u306f\u4e0d\u78ba\u5b9a\u3067\u3059\u3002<\/p>\n

      \u4e88\u9632\u7684\u624b\u8853<\/strong>\u2015\u3053\u306e\u7a2e\u306e\u624b\u8853\u3067\u306f\u3001\u764c\u3092\u767a\u75c7\u3059\u308b\u53ef\u80fd\u6027\u3092\u6e1b\u3089\u3059\u305f\u3081\u306b\u300c\u30ea\u30b9\u30af\u306e\u3042\u308b\u300d\u7d44\u7e54\u3092\u3067\u304d\u308b\u3060\u3051\u591a\u304f\u5207\u9664\u3057\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u4e88\u9632\u7684\u4e21\u5074\u6027\u4e73\u623f\u5207\u9664\u8853\uff08\u5065\u5eb7\u306a\u4e73\u623f\u306e\u5207\u9664\uff09\u304a\u3088\u3073\u4e88\u9632\u7684\u4e21\u5074\u5375\u7ba1\u5375\u5de3\u6458\u51fa\u8853\uff08\u5065\u5eb7\u306a\u5375\u7ba1\u3068\u5375\u5de3\u306e\u6458\u51fa\uff09\u306f\u3001\u764c\u3092\u767a\u75c7\u3057\u306a\u3044\u3053\u3068\u3092\u4fdd\u8a3c\u3059\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u30ea\u30b9\u30af\u306e\u3042\u308b\u7d44\u7e54\u3059\u3079\u3066\u304c\u3053\u308c\u3089\u306e\u624b\u8853\u3067\u5207\u9664\u3055\u308c\u308b\u308f\u3051\u3067\u306f\u306a\u3044\u306e\u3067\u3001\u4e88\u9632\u7684\u624b\u8853\u306e\u5f8c\u3067\u3082\u4e73\u764c\u3001\u5375\u5de3\u764c\u3001\u307e\u305f\u306f\u539f\u767a\u6027\u8179\u819c\u764c\uff08\u5375\u5de3\u764c\u306b\u985e\u4f3c\u3057\u305f\u764c\u306e\u4e00\u7a2e\uff09\u3092\u767a\u75c7\u3059\u308b\u5973\u6027\u3082\u3044\u307e\u3059\u3002\u307e\u305f\u3001\u5375\u7ba1\u5375\u5de3\u6458\u51fa\u8853\u304c\u4e73\u764c\u304a\u3088\u3073\u5375\u5de3\u764c\u306e\u767a\u75c7\u306b\u5bfe\u3057\u3066\u3082\u305f\u3089\u3059\u4fdd\u8b77\u4f5c\u7528\u306e\u7a0b\u5ea6\u306fBRCA1<\/em>\u304a\u3088\u3073BRCA2<\/em>\u5909\u7570\u306e\u4fdd\u56e0\u8005\u9593\u3067\u7570\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u793a\u5506\u3059\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u3082\u3042\u308a\u307e\u3059\uff0817\uff09\u3002<\/p>\n

      \u30ea\u30b9\u30af\u56de\u907f<\/strong>\u2015\u7279\u5b9a\u306e\u884c\u52d5\u304c\u6bcd\u96c6\u56e3\u306b\u304a\u3044\u3066\u4e73\u764c\u304a\u3088\u3073\u5375\u5de3\u764c\u306e\u30ea\u30b9\u30af\u3068\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\uff08\u8cea\u554f16\u53c2\u7167\uff09\u3002BRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u5909\u7570\u4fdd\u56e0\u8005\u306b\u304a\u3044\u3066\u3001\u500b\u4eba\u306e\u884c\u52d5\u3092\u4fee\u6b63\u3057\u3066\u764c\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3092\u6e1b\u5c11\u3055\u305b\u308b\u5229\u70b9\u306b\u95a2\u3059\u308b\u7814\u7a76\u7d50\u679c\u306f\u9650\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n

      \u5316\u5b66\u4e88\u9632<\/strong>\u2015\u3053\u306e\u65b9\u6cd5\u3067\u306f\u3001\u5929\u7136\u7269\u8cea\u307e\u305f\u306f\u5408\u6210\u7269\u8cea\u306e\u4f7f\u7528\u3067\u3001\u764c\u306e\u767a\u75c7\u30ea\u30b9\u30af\u3084\u518d\u767a\u7387\u3092\u6e1b\u3089\u3057\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001\u85ac\u5264\u30bf\u30e2\u30ad\u30b7\u30d5\u30a7\u30f3\u304c\u9ad8\u30ea\u30b9\u30af\u5973\u6027\u306e\u4e73\u764c\u767a\u75c7\u30ea\u30b9\u30af\u3092\u7d0450\uff05\u6e1b\u3089\u3057\u3001\u904e\u53bb\u306b\u4e73\u764c\u3068\u8a3a\u65ad\u3055\u308c\u3001\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308b\u5973\u6027\u306e\u4e73\u764c\u518d\u767a\u7387\u3092\u6e1b\u5c11\u3055\u305b\u308b\u3068\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u305d\u308c\u3092\u53d7\u3051\u3066\u3001\u30bf\u30e2\u30ad\u30b7\u30d5\u30a7\u30f3\u306f\u4e73\u764c\u6cbb\u7642\u85ac\u3068\u3057\u3066\u7c73\u56fd\u98df\u54c1\u533b\u85ac\u54c1\u5c40\uff08FDA\uff09\u306b\u627f\u8a8d\u3055\u308c\u3001\u9589\u7d4c\u524d\u304a\u3088\u3073\u9589\u7d4c\u5f8c\u306e\u9ad8\u30ea\u30b9\u30af\u306e\u5973\u6027\u306e\u4e73\u764c\u767a\u75c7\u30ea\u30b9\u30af\u3092\u6e1b\u5c11\u3055\u305b\u3066\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u3001BRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u5909\u7570\u3092\u6301\u3064\u5973\u6027\u306b\u304a\u3051\u308b\u30bf\u30e2\u30ad\u30b7\u30d5\u30a7\u30f3\u306e\u6709\u52b9\u6027\u3092\u8a55\u4fa1\u3059\u308b\u7814\u7a76\u306f\u307b\u3068\u3093\u3069\u3042\u308a\u307e\u305b\u3093\u3002\u30bf\u30e2\u30ad\u30b7\u30d5\u30a7\u30f3\u304cBRCA1<\/em>\u304a\u3088\u3073BRCA2<\/em>\u5909\u7570\u4fdd\u56e0\u8005\u306b\u304a\u3051\u308b\u4e73\u764c\u30ea\u30b9\u30af\u3092\u4e0b\u3052\u308b\u306e\u306b\u6709\u7528\u3067\u3042\u308b\u30683\u3064\u306e\u7814\u7a76\u306b\u3088\u308b\u30c7\u30fc\u30bf\u3067\u793a\u3055\u308c\u3066\u3044\u307e\u3059\uff0818-20\uff09\u3002\u3053\u308c\u3089\u306e\u7814\u7a76\u306e\u3046\u3061\u306e2\u3064\u3067\u306f\u3001\u521d\u56de\u306e\u4e73\u764c\u6cbb\u7642\u3092\u53d7\u3051\u3066\u3044\u308b\u5973\u6027\u306e\u5bfe\u5074\u4e73\u623f\u306e\u764c\u767a\u75c7\u3092\u6e1b\u5c11\u3055\u305b\u308b\u4e0a\u3067\u306e\u30bf\u30e2\u30ad\u30b7\u30d5\u30a7\u30f3\u306e\u6709\u52b9\u6027\u3092\u8abf\u3079\u307e\u3057\u305f\uff0819,20\uff09\u3002 \u3082\u3046\u4e00\u3064\u306e\u85ac\u5264\u3001\u30e9\u30ed\u30ad\u30b7\u30d5\u30a7\u30f3\u306f\u7c73\u56fd\u56fd\u7acb\u764c\u7814\u7a76\u6240\uff08NCI\uff09\u306e\u8cc7\u91d1\u63d0\u4f9b\u306b\u3088\u308b\u5927\u898f\u6a21\u306a\u81e8\u5e8a\u8a66\u9a13\u3067\u3001\u9ad8\u30ea\u30b9\u30af\u306e\u9589\u7d4c\u5f8c\u5973\u6027\u306e\u6d78\u6f64\u6027\u4e73\u764c\u767a\u75c7\u30ea\u30b9\u30af\u3092\u30bf\u30e2\u30ad\u30b7\u30d5\u30a7\u30f3\u3068\u307b\u307c\u540c\u7a0b\u5ea6\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u304c\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u30e9\u30ed\u30ad\u30b7\u30d5\u30a7\u30f3\u306f\u9589\u7d4c\u5f8c\u5973\u6027\u306b\u304a\u3051\u308b\u4e73\u764c\u30ea\u30b9\u30af\u6e1b\u5c11\u306e\u305f\u3081FDA\u306b\u627f\u8a8d\u3055\u308c\u307e\u3057\u305f\u3002\u30bf\u30e2\u30ad\u30b7\u30d5\u30a7\u30f3\u3068\u30e9\u30ed\u30ad\u30b7\u30d5\u30a7\u30f3\u306f\u540c\u69d8\u306e\u65b9\u6cd5\u3067\u4e73\u764c\u7d30\u80de\u306e\u5897\u6b96\u3092\u963b\u5bb3\u3059\u308b\u305f\u3081\u3001\u30e9\u30ed\u30ad\u30b7\u30d5\u30a7\u30f3\u306f\u9589\u7d4c\u5f8c\u306eBRCA1<\/em>\u304a\u3088\u3073BRCA2<\/em>\u5909\u7570\u4fdd\u56e0\u8005\u306e\u4e73\u764c\u30ea\u30b9\u30af\u3092\u6e1b\u5c11\u3055\u305b\u308b\u306e\u306b\u6709\u7528\u3067\u3057\u3087\u3046\u3002\u3057\u304b\u3057\u3001\u3053\u308c\u306f\u76f4\u63a5\u7814\u7a76\u304c\u884c\u308f\u308c\u305f\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n

       <\/p>\n

      \uff11\uff12.\u4e73\u764c\u304a\u3088\u3073\u5375\u5de3\u764c\u30ea\u30b9\u30af\u306b\u5bfe\u3059\u308b\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u5229\u70b9\u306b\u306f\u3069\u306e\u3088\u3046\u306a\u3082\u306e\u304c\u3042\u308a\u307e\u3059\u304b\uff1f<\/strong><\/p>\n

      \u691c\u67fb\u7d50\u679c\u304c\u967d\u6027\u304b\u9670\u6027\u304b\u306b\u95a2\u4fc2\u306a\u304f\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3088\u308b\u5229\u70b9\u304c\u3042\u308a\u307e\u3059\u3002\u7d50\u679c\u304c\u9670\u6027\u306e\u5834\u5408\u306e\u8003\u3048\u3089\u308c\u308b\u5229\u70b9\u306b\u306f\u3001\u5b89\u5835\u611f\u3001\u304a\u3088\u3073\u7279\u5225\u306e\u4e88\u9632\u7684\u306a\u691c\u67fb\u3001\u691c\u67fb\u3001\u307e\u305f\u306f\u624b\u8853\u306e\u5fc5\u8981\u6027\u304c\u306a\u3044\u3067\u3042\u308d\u3046\u3068\u3044\u3046\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u691c\u67fb\u7d50\u679c\u304c\u967d\u6027\u306e\u5834\u5408\u3001\u4e0d\u78ba\u5b9f\u3055\u3092\u7de9\u548c\u3057\u3001\u764c\u30ea\u30b9\u30af\u3092\u6e1b\u3089\u3059\u305f\u3081\u306b\u5bfe\u7b56\u3092\u8b1b\u3058\u308b\u306a\u3069\u3001\u60c5\u5831\u3092\u5f97\u305f\u4e0a\u3067\u5c06\u6765\u306b\u3064\u3044\u3066\u306e\u6c7a\u5b9a\u304c\u3067\u304d\u307e\u3059\u3002\u305d\u306e\u3046\u3048\u3001\u691c\u67fb\u7d50\u679c\u304c\u967d\u6027\u306e\u4eba\u306e\u591a\u304f\u306f\u3001\u9577\u671f\u7684\u306b\u306f\u4e73\u764c\u306b\u3088\u308b\u6b7b\u4ea1\u3092\u6e1b\u5c11\u3055\u305b\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u533b\u5b66\u7814\u7a76\u306b\u53c2\u52a0\u3067\u304d\u307e\u3059\u3002<\/p>\n

       <\/p>\n

      \uff11\uff13.\u4e73\u764c\u304a\u3088\u3073\u5375\u5de3\u764c\u30ea\u30b9\u30af\u306b\u5bfe\u3059\u308b\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u30ea\u30b9\u30af\u306b\u306f\u3069\u306e\u3088\u3046\u306a\u3082\u306e\u304c\u3042\u308a\u307e\u3059\u304b\uff1f<\/strong><\/p>\n

      \u907a\u4f1d\u5b50\u691c\u67fb\u306e\u76f4\u63a5\u7684\u306a\u533b\u5b66\u7684\u30ea\u30b9\u30af\u3001\u307e\u305f\u306f\u5bb3\u306f\u975e\u5e38\u306b\u5c0f\u3055\u3044\u3067\u3059\u304c\u3001\u8a66\u9a13\u7d50\u679c\u306f\u611f\u60c5\u3001\u793e\u4f1a\u7684\u95a2\u4fc2\u3001\u8cc7\u91d1\u9762\u3001\u533b\u7642\u306e\u9078\u629e\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002 \u8a66\u9a13\u7d50\u679c\u304c\u967d\u6027\u306e\u4eba\u3005\u306f\u3001\u5fc3\u914d\u3057\u305f\u308a\u3001\u843d\u80c6\u3057\u305f\u308a\u3001\u61a4\u6168\u3057\u305f\u308a\u3059\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u5f7c\u3089\u306f\u3001\u91cd\u5927\u3067\u9577\u671f\u7684\u306a\u5f71\u97ff\u304c\u3042\u308a\u3001\u6709\u52b9\u6027\u304c\u4e0d\u78ba\u304b\u3067\u3042\u308b\u4e88\u9632\u7684\u624b\u8853\u306a\u3069\u306e\u4e88\u9632\u65b9\u6cd5\u3092\u884c\u3046\u3053\u3068\u3092\u9078\u3076\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002 \u8a66\u9a13\u7d50\u679c\u304c\u9670\u6027\u306e\u4eba\u3005\u306f\u30011\u4eba\u307e\u305f\u306f\u8907\u6570\u306e\u5927\u5207\u306a\u4eba\u306b\u5f71\u97ff\u3059\u308b\u75c5\u6c17\u306e\u767a\u75c7\u30ea\u30b9\u30af\u304c\u304a\u305d\u3089\u304f\u9ad8\u304f\u306a\u3044\u3053\u3068\u3092\u77e5\u308a\u3001\u300c\u751f\u5b58\u8005\u306e\u7f6a\u60aa\u611f\u300d\u3092\u7d4c\u9a13\u3059\u308b\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002 \u907a\u4f1d\u5b50\u691c\u67fb\u3067\u306f\u8907\u6570\u306e\u5bb6\u65cf\u306b\u95a2\u3059\u308b\u60c5\u5831\u304c\u660e\u3089\u304b\u306b\u306a\u308b\u306e\u3067\u3001\u691c\u67fb\u7d50\u679c\u306b\u3088\u308b\u611f\u60c5\u3067\u5bb6\u65cf\u5185\u306b\u7dca\u5f35\u3092\u3082\u305f\u3089\u3059\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u691c\u67fb\u7d50\u679c\u306f\u3001\u7d50\u5a5a\u3084\u51fa\u7523\u306e\u3088\u3046\u306a\u500b\u4eba\u306e\u9078\u629e\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3059\u5834\u5408\u3082\u3042\u308a\u307e\u3059\u3002\u907a\u4f1d\u5b50\u691c\u67fb\u7d50\u679c\u306e\u30d7\u30e9\u30a4\u30d0\u30b7\u30fc\u3068\u5b88\u79d8\u7fa9\u52d9\u306b\u95a2\u3059\u308b\u554f\u984c\u306f\u3001\u3055\u3089\u306a\u308b\u6f5c\u5728\u7684\u30ea\u30b9\u30af\u3067\u3059\uff08\u4e0b\u8a18\u53c2\u7167\uff09\u3002<\/p>\n

       <\/p>\n

      <\/a>\uff11\uff14.\u907a\u4f1d\u5b50\u691c\u67fb\u7d50\u679c\u304c\u533b\u7642\u8a18\u9332\u306b\u8a18\u8f09\u3055\u308c\u308b\u3068\u3069\u3046\u306a\u308a\u307e\u3059\u304b\uff1f<\/strong><\/p>\n

      \u81e8\u5e8a\u691c\u67fb\u7d50\u679c\u306f\u901a\u5e38\u500b\u4eba\u306e\u533b\u7642\u8a18\u9332\u306b\u8a18\u8f09\u3055\u308c\u307e\u3059\u3002\u3057\u305f\u304c\u3063\u3066\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u691c\u8a0e\u3057\u3066\u3044\u308b\u4eba\u306f\u3001\u7d50\u679c\u304c\u6a5f\u5bc6\u6271\u3044\u306b\u306a\u3089\u306a\u3044\u53ef\u80fd\u6027\u3092\u7406\u89e3\u3057\u306a\u304f\u3066\u306f\u3044\u3051\u307e\u305b\u3093\u3002<\/p>\n

      \u500b\u4eba\u306e\u907a\u4f1d\u60c5\u5831\u306f\u5065\u5eb7\u60c5\u5831\u3068\u307f\u306a\u3055\u308c\u308b\u305f\u3081\u30011996\u5e74\u306e\u533b\u7642\u4fdd\u967a\u306e\u76f8\u4e92\u904b\u7528\u6027\u3068\u8aac\u660e\u8cac\u4efb\u306b\u95a2\u3059\u308b\u6cd5\u5f8b\uff08HIPAA\uff09\u306e\u30d7\u30e9\u30a4\u30d0\u30b7\u30fc\u898f\u5247\u304c\u9069\u7528\u3055\u308c\u307e\u3059\uff0821\uff09\u3002\u30d7\u30e9\u30a4\u30d0\u30b7\u30fc\u898f\u5247\u306f\u533b\u7642\u5f93\u4e8b\u8005\u306a\u3069\u304c\u5065\u5eb7\u60c5\u5831\u306e\u30d7\u30e9\u30a4\u30d0\u30b7\u30fc\u3092\u4fdd\u8b77\u3059\u308b\u3088\u3046\u6c42\u3081\u3001\u5065\u5eb7\u8a18\u9332\u306e\u4f7f\u7528\u3068\u516c\u958b\u306b\u9650\u5ea6\u3092\u8a2d\u3051\u3001\u5065\u5eb7\u95a2\u9023\u60c5\u5831\u306e\u7279\u5b9a\u306e\u4f7f\u7528\u3068\u958b\u793a\u3092\u7ba1\u7406\u3059\u308b\u6a29\u9650\u3092\u500b\u4eba\u306b\u4e0e\u3048\u308b\u3082\u306e\u3067\u3059\u3002\u307e\u305f\u3001\u591a\u304f\u306e\u5dde\u3067\u30d7\u30e9\u30a4\u30d0\u30b7\u30fc\u3092\u4fdd\u8b77\u3057\u3001\u907a\u4f1d\u304a\u3088\u3073\u4ed6\u306e\u5065\u5eb7\u60c5\u5831\u306e\u958b\u793a\u3092\u5236\u9650\u3059\u308b\u6cd5\u5f8b\u3092\u8a2d\u3051\u3066\u3044\u307e\u3059\u3002 2008\u5e74\u3001\u907a\u4f1d\u60c5\u5831\u5dee\u5225\u7981\u6b62\u6cd5\uff08GINA\uff09\u306f\u9023\u90a6\u6cd5\u3068\u306a\u308a\u307e\u3057\u305f\uff08\u8cea\u554f15\u53c2\u7167\uff09\u3002GINA\u306f\u5065\u5eb7\u4fdd\u967a\u3084\u96c7\u7528\u306b\u95a2\u3057\u3066\u907a\u4f1d\u60c5\u5831\u306b\u57fa\u3065\u3044\u305f\u5dee\u5225\u3092\u7981\u3058\u3066\u3044\u307e\u3059\u304c\u3001\u3053\u306e\u6cd5\u5f8b\u306f\u751f\u547d\u4fdd\u967a\u3001\u8eab\u4f53\u969c\u5bb3\u8005\u4fdd\u967a\u3001\u4ecb\u8b77\u4fdd\u967a\u306f\u9069\u7528\u5bfe\u8c61\u5916\u3067\u3059\u3002\u3053\u308c\u3089\u306e\u30bf\u30a4\u30d7\u306e\u4fdd\u967a\u306b\u7533\u3057\u8fbc\u3080\u969b\u306b\u306f\u3001\u4fdd\u967a\u4f1a\u793e\u306e\u5065\u5eb7\u8a18\u9332\u306e\u5165\u624b\u3092\u8a31\u53ef\u3059\u308b\u7528\u7d19\u306b\u7f72\u540d\u3059\u308b\u3088\u3046\u6c42\u3081\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u4fdd\u967a\u4f1a\u793e\u306f\u88dc\u511f\u7bc4\u56f2\u3092\u6c7a\u5b9a\u3059\u308b\u306b\u3042\u305f\u308a\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u7d50\u679c\u3092\u8003\u616e\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002 \u4e00\u90e8\u306e\u533b\u5e2b\u306f\u907a\u4f1d\u5b50\u691c\u67fb\u7d50\u679c\u3092\u533b\u7642\u8a18\u9332\u306b\u8a18\u8f09\u3057\u307e\u305b\u3093\u3002\u3057\u304b\u3057\u3001\u305f\u3068\u3048\u7d50\u679c\u304c\u533b\u7642\u8a18\u9332\u306b\u8a18\u8f09\u3055\u308c\u306a\u3044\u3068\u3057\u3066\u3082\u3001\u907a\u4f1d\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306b\u95a2\u3059\u308b\u60c5\u5831\u306f\u3001\u305d\u306e\u4eba\u306e\u5bb6\u65cf\u306e\u75c5\u6b74\u304b\u3089\u96c6\u3081\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

      <\/a>\uff11\uff15.\u907a\u4f1d\u5b50\u5dee\u5225\u3068\u306f\u4f55\u3067\u3059\u304b\uff1f\u3053\u306e\u7a2e\u306e\u5dee\u5225\u304b\u3089\u4eba\u3005\u3092\u4fdd\u8b77\u3059\u308b\u6cd5\u5f8b\u306f\u3042\u308a\u307e\u3059\u304b\uff1f<\/strong><\/p>\n

      \u764c\u306a\u3069\u306e\u75c5\u6c17\u306b\u306a\u308b\u30ea\u30b9\u30af\u3092\u5897\u52a0\u3055\u305b\u308b\u907a\u4f1d\u5b50\u5909\u7570\u3092\u6301\u3064\u305f\u3081\u306b\u4fdd\u967a\u4f1a\u793e\u307e\u305f\u306f\u96c7\u7528\u4e3b\u306b\u7570\u306a\u308b\u6271\u3044\u3092\u53d7\u3051\u308b\u3068\u304d\u3001\u907a\u4f1d\u5b50\u5dee\u5225\u306f\u8d77\u3053\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u30012008\u5e74GINA\u304c\u6210\u7acb\u3057\u3001\u5065\u5eb7\u4fdd\u967a\u3084\u96c7\u7528\u306b\u95a2\u3059\u308b\u907a\u4f1d\u60c5\u5831\u306b\u57fa\u3065\u304f\u5dee\u5225\u304b\u3089\u7c73\u56fd\u6c11\u3092\u4fdd\u8b77\u3057\u3066\u3044\u307e\u3059\uff0822,23\uff09\u3002\u5065\u5eb7\u4fdd\u967a\u4f1a\u793e\u306b\u95a2\u3059\u308b\u3053\u306e\u6cd5\u5f8b\u306e\u4e00\u90e8\u306f2009\u5e745\u6708\u304b\u30892010\u5e745\u6708\u306e\u9593\u306b\u767a\u52b9\u3057\u3001\u96c7\u7528\u4e3b\u306b\u95a2\u3059\u308b\u6cd5\u5f8b\u306f2009\u5e7411\u6708\u307e\u3067\u306b\u767a\u52b9\u3057\u307e\u3059\u3002\u3053\u306e\u6cd5\u5f8b\u306f\u751f\u547d\u4fdd\u967a\u3001\u8eab\u4f53\u969c\u5bb3\u8005\u4fdd\u967a\u3001\u4ecb\u8b77\u4fdd\u967a\u306f\u9069\u7528\u5bfe\u8c61\u5916\u3067\u3059\u3002\u307e\u305f\u3001\u8ecd\u4eba\u3082\u9069\u7528\u5916\u3067\u3059\u3002 \u5065\u5eb7\u4fdd\u967a\u306b\u95a2\u3059\u308bGINA\u306b\u3088\u308b\u4fdd\u8b77\u306b\u306f\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u3082\u306e\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

        \n
      1. \u56e3\u4f53\u533b\u7642\u4fdd\u967a\u306e\u4fdd\u967a\u6599\u3084\u5206\u62c5\u91d1\u306f\u3001\u4fdd\u967a\u306b\u52a0\u5165\u3059\u308b\u500b\u4eba\u306e\u907a\u4f1d\u60c5\u5831\u306b\u57fa\u3065\u3044\u3066\u5f15\u304d\u4e0a\u3052\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/li>\n
      2. \u4fdd\u967a\u4f1a\u793e\u306f\u3001\u56e3\u4f53\u533b\u7642\u4fdd\u967a\u52a0\u5165\u524d\u306b\u500b\u4eba\u307e\u305f\u306f\u305d\u306e\u5bb6\u65cf\u306b\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u53d7\u3051\u308b\u3088\u3046\u306b\u8981\u6c42\u3067\u304d\u307e\u305b\u3093\u3002<\/li>\n
      3. \u4fdd\u967a\u4f1a\u793e\u306f\u3001\u500b\u4eba\u304c\u56e3\u4f53\u533b\u7642\u4fdd\u967a\u306b\u52a0\u5165\u3059\u308b\u524d\u306b\u3001\u307e\u305f\u306f\u4fdd\u967a\u3078\u306e\u52a0\u5165\u306b\u95a2\u3057\u3066\u3001\u500b\u4eba\u306b\u3064\u3044\u3066\u306e\u907a\u4f1d\u60c5\u5831\u3092\u8981\u8acb\u3001\u8981\u6c42\u3001\u307e\u305f\u306f\u8cfc\u5165\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/li>\n
      4. \u5065\u5eb7\u4fdd\u967a\u4f1a\u793e\u306f\u907a\u4f1d\u60c5\u5831\u3092\u552f\u4e00\u306e\u6839\u62e0\u3068\u3057\u3066\u3001\u65e2\u5f80\u75c7\u306e\u5b58\u5728\u3092\u4e3b\u5f35\u3057\u3001\u305d\u306e\u305f\u3081\u306b\u4fdd\u967a\u9069\u7528\u3092\u62d2\u3080\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/li>\n<\/ol>\n

        \u96c7\u7528\u306b\u95a2\u3059\u308bGINA\u306b\u3088\u308b\u4fdd\u8b77\u306b\u306f\u4ee5\u4e0b\u306e\u3088\u3046\u306a\u3082\u306e\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n

          \n
        1. \u96c7\u7528\u4e3b\u306f\u907a\u4f1d\u60c5\u5831\u306b\u57fa\u3065\u3044\u3066\u63a1\u7528\u3092\u62d2\u5426\u3057\u305f\u308a\u3001\u89e3\u96c7\u3057\u305f\u308a\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/li>\n
        2. \u96c7\u7528\u4e3b\u306f\u907a\u4f1d\u60c5\u5831\u306b\u3088\u3063\u3066\u3001\u7d66\u4e0e\u3001\u96c7\u7528\u6761\u4ef6\u3001\u7279\u6a29\u3001\u4eca\u5f8c\u306e\u6a5f\u4f1a\u306b\u95a2\u3057\u3066\u5f93\u696d\u54e1\u3092\u5dee\u5225\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/li>\n
        3. \u96c7\u7528\u4e3b\u306f\u7279\u6b8a\u306a\u72b6\u6cc1\u3092\u9664\u3044\u3066\u3001\u5f93\u696d\u54e1\u306e\u907a\u4f1d\u60c5\u5831\u3092\u8981\u8acb\u3001\u8981\u6c42\u3001\u307e\u305f\u306f\u8cfc\u5165\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/li>\n
        4. \u96c7\u7528\u4e3b\u306f\u7279\u6b8a\u306a\u72b6\u6cc1\u3092\u9664\u3044\u3066\u3001\u5f93\u696d\u54e1\u306e\u907a\u4f1d\u60c5\u5831\u3092\u958b\u793a\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/li>\n<\/ol>\n

          GINA\u306e\u6210\u7acb\u524d\u3001\u591a\u304f\u306e\u5dde\u3067\u907a\u4f1d\u5b50\u5dee\u5225\u306b\u5bfe\u3059\u308b\u6cd5\u5f8b\u304c\u5236\u5b9a\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u6cd5\u5f8b\u306b\u3088\u308b\u4fdd\u8b77\u7bc4\u56f2\u306f\u5dde\u306b\u3088\u3063\u3066\u5927\u304d\u304f\u7570\u306a\u308a\u307e\u3059\u3002GINA\u306f\u3059\u3079\u3066\u306e\u5dde\u304c\u6e80\u305f\u3059\u3079\u304d\u6700\u4f4e\u4fdd\u8b77\u57fa\u6e96\u3092\u5b9a\u3081\u3066\u304a\u308a\u3001\u3044\u304b\u306a\u308b\u5dde\u6cd5\u306b\u3088\u308b\u4fdd\u8b77\u3092\u3082\u5f31\u4f53\u5316\u3055\u305b\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n

          \uff11\uff16.\u4e00\u822c\u306b\u3001\u3069\u306e\u3088\u3046\u306a\u8981\u56e0\u304c\u4e73\u764c\u3084\u5375\u5de3\u764c\u306e\u767a\u75c7\u3092\u5897\u52a0\u307e\u305f\u306f\u6e1b\u5c11\u3055\u305b\u307e\u3059\u304b\uff1f<\/strong><\/p>\n

          \u4ee5\u4e0b\u306e\u8981\u56e0\u306f\u3001\u6bcd\u96c6\u56e3\u306b\u304a\u3044\u3066\u4e73\u764c\u307e\u305f\u306f\u5375\u5de3\u764c\u3001\u3042\u308b\u3044\u306f\u305d\u306e\u4e21\u65b9\u306e\u767a\u75c7\u30ea\u30b9\u30af\u5897\u52a0\u307e\u305f\u306f\u6e1b\u5c11\u306b\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u3053\u308c\u3089\u306e\u8981\u56e0\u304c\u3069\u306e\u3088\u3046\u306bBRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u5909\u7570\u3092\u6301\u3064\u4eba\u306e\u30ea\u30b9\u30af\u306b\u5f71\u97ff\u3059\u308b\u304b\u306f\u307e\u3060\u306f\u3063\u304d\u308a\u3068\u306f\u308f\u304b\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u307e\u305f\u3001\u907a\u4f1d\u6027\u4e73\u764c\u306e\u5927\u90e8\u5206\u306fBRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u5909\u7570\u3068\u306f\u95a2\u9023\u3057\u3066\u3044\u307e\u305b\u3093\uff088\uff09\u3002<\/p>\n

            \n
          1. \u5e74\u9f62<\/strong>\u2015\u4e73\u764c\u304a\u3088\u3073\u5375\u5de3\u764c\u306e\u30ea\u30b9\u30af\u306f\u3001\u5e74\u9f62\u3068\u5171\u306b\u5897\u52a0\u3057\u307e\u3059\u3002\u5927\u90e8\u5206\u306e\u4e73\u764c\u3068\u5375\u5de3\u764c\u306f\u300150\u6b73\u4ee5\u4e0a\u306e\u5973\u6027\u306b\u767a\u75c7\u3057\u307e\u3059\u3002\u6709\u5bb3\u306aBRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u5909\u7570\u3092\u6301\u3064\u5973\u6027\u306f\u300150\u6b73\u672a\u6e80<\/strong>\u3067\u4e73\u764c\u307e\u305f\u306f\u5375\u5de3\u764c\u3092\u767a\u75c7\u3059\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u3002<\/li>\n
          2. \u5bb6\u65cf\u6b74<\/strong>\u2015\u4e73\u764c\u307e\u305f\u306f\u5375\u5de3\u764c\u3001\u3042\u308b\u3044\u306f\u305d\u306e\u4e21\u65b9\u306e\u764c\u306b\u7f79\u60a3\u3057\u305f\u7b2c\u4e00\u5ea6\u8fd1\u89aa\u8005\uff08\u6bcd\u3001\u59c9\u59b9\u3001\u5a18\uff09\u307e\u305f\u306f\u4ed6\u306e\u8840\u7e01\u8005\u306e\u3044\u308b\u5973\u6027\u306f\u3001\u3053\u308c\u3089\u306e\u764c\u306e\u767a\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u3044\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u307e\u305f\u3001\u5927\u8178\u764c\u306e\u8fd1\u89aa\u8005\u3092\u6301\u3064\u5973\u6027\u306f\u3001\u5375\u5de3\u764c\u306e\u767a\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u306a\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/li>\n
          3. \u75c5\u6b74<\/strong>\u2015\u4e73\u764c\u306b\u306a\u3063\u305f\u5973\u6027\u306f\u3001\u4e73\u764c\u306e\u518d\u767a\u30ea\u30b9\u30af\u307e\u305f\u306f\u5375\u5de3\u764c\u306e\u767a\u75c7\u30ea\u30b9\u30af\u304c\u9ad8\u304f\u306a\u308a\u307e\u3059\u3002<\/li>\n
          4. \u30db\u30eb\u30e2\u30f3\u306e\u5f71\u97ff<\/strong>\u2015\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306f\u4f53\u5185\u3067\u81ea\u7136\u306b\u751f\u6210\u3055\u308c\u3001\u4e73\u623f\u7d44\u7e54\u306e\u6b63\u5e38\u306a\u6210\u9577\u3092\u4fc3\u9032\u3059\u308b\u30db\u30eb\u30e2\u30f3\u3067\u3059\u3002\u4e73\u623f\u7d44\u7e54\u306e\u6210\u9577\u3092\u4fc3\u9032\u3059\u308b\u3068\u3044\u3046\u305d\u306e\u672c\u6765\u306e\u5f79\u5272\u306e\u305f\u3081\u3001\u904e\u5270\u306a\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u304c\u4e73\u764c\u30ea\u30b9\u30af\u306e\u4e00\u56e0\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u521d\u6f6e\u304c12\u624d\u672a\u6e80\u307e\u305f\u306f\u9589\u7d4c\u304c55\u624d\u4ee5\u964d\u306e\u5973\u6027\u306f\u3001\u4e73\u764c\u30ea\u30b9\u30af\u304c\u308f\u305a\u304b\u306b\u9ad8\u304f\u300130\u6b73\u4ee5\u964d\u306b\u7b2c\u4e00\u5b50\u3092\u51fa\u7523\u3057\u305f\u5973\u6027\u3082\u540c\u69d8\u3067\u3059\u3002\u3053\u308c\u3089\u306e\u5404\u8981\u56e0\u306b\u3088\u3063\u3066\u3001\u5973\u6027\u306e\u4f53\u304c\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306b\u66b4\u9732\u3055\u308c\u308b\u671f\u9593\u304c\u5897\u52a0\u3057\u307e\u3059\u3002\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306e\u4e3b\u306a\u751f\u6210\u6e90\u3067\u3042\u308b\u5375\u5de3\u306e\u6458\u51fa\u306f\u3001\u4e73\u764c\u30ea\u30b9\u30af\u3092\u6e1b\u3089\u3057\u307e\u3059\u3002\u307e\u305f\u3001\u6388\u4e73\u3082\u4e73\u764c\u30ea\u30b9\u30af\u3092\u6e1b\u5c11\u3055\u305b\u3001\u30db\u30eb\u30e2\u30f3\u6a5f\u69cb\u306b\u3088\u3063\u3066\u4f5c\u7528\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\uff0824\uff09\u3002<\/li>\n
          5. \u7d4c\u53e3\u907f\u598a\u85ac\uff08\u7d4c\u53e3\u30d4\u30eb\uff09<\/strong>\u2015\u5927\u90e8\u5206\u306e\u7814\u7a76\u306b\u3088\u308a\u3001\u7d4c\u53e3\u907f\u598a\u85ac\u3092\u670d\u7528\u3057\u3066\u3044\u308b\u5973\u6027\u306e\u4e73\u764c\u30ea\u30b9\u30af\u5897\u52a0\u306f\u308f\u305a\u304b\u3067\u3042\u308b\u304b\u3001\u307e\u305f\u306f\u5909\u5316\u304c\u306a\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f(24)\u3002\u4e00\u65b9\u3001\u7d4c\u53e3\u907f\u598a\u85ac\u306e\u670d\u7528\u3067\u5375\u5de3\u764c\u30ea\u30b9\u30af\u304c\u6e1b\u5c11\u3059\u308b\u3068\u591a\u304f\u306e\u7814\u7a76\u304c\u793a\u5506\u3057\u3066\u3044\u307e\u3059\uff0825\uff09\u3002\u3053\u306e\u4e88\u9632\u52b9\u679c\u306f\u7d4c\u53e3\u30d4\u30eb\u306e\u670d\u7528\u671f\u9593\u306b\u3088\u3063\u3066\u5897\u52a0\u3057\u3001\u670d\u7528\u4e2d\u6b62\u5f8c\u6700\u957725\u5e74\u9593\u6301\u7d9a\u3059\u308b\u3088\u3046\u3067\u3059\u3002\u307e\u305f\u3001\u7d4c\u53e3\u907f\u598a\u85ac\u306e\u670d\u7528\u3067\u6709\u5bb3\u306aBRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u5909\u7570\u3092\u6301\u3064\u5973\u6027\u306e\u5375\u5de3\u764c\u30ea\u30b9\u30af\u3082\u6e1b\u5c11\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059\uff0826\uff09\u3002<\/li>\n
          6. \u30db\u30eb\u30e2\u30f3\u88dc\u5145\u7642\u6cd5<\/strong>\u2015\u533b\u5e2b\u304c\u3001\u4f53\u306e\u307b\u3066\u308a<\/a>\u306e\u306a\u3069\u306e\u7279\u5b9a\u306e\u66f4\u5e74\u671f\u75c7\u72b6\u306b\u3088\u308b\u4e0d\u5feb\u611f\u3092\u8efd\u6e1b\u3059\u308b\u305f\u3081\u306b\u3001\u30db\u30eb\u30e2\u30f3\u88dc\u5145\u7642\u6cd5\uff08HRT\uff09\u3092\u51e6\u65b9\u3059\u308b\u5834\u5408\u3082\u3042\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u56fd\u7acb\u885b\u751f\u7814\u7a76\u6240\uff08NIH\uff09\u306e\u4e00\u90e8\u3067\u3042\u308b\u56fd\u7acb\u5fc3\u80ba\u8840\u6db2\u7814\u7a76\u6240\u306b\u3088\u308b\u5927\u898f\u6a21\u306a\u81e8\u5e8a\u8a66\u9a13\u3067\u3042\u308b\u5973\u6027\u306e\u5065\u5eb7\u30a4\u30cb\u30b7\u30a2\u30c1\u30d6\uff08WHI\uff09\u306e\u7d50\u679c\u3067\u306f\u3001\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u3084\u30d7\u30ed\u30b2\u30b9\u30c1\u30f3\u306e\u30db\u30eb\u30e2\u30f3\u3092\u7528\u3044\u305fHRT\u306f\u3001\u4e73\u764c\u3001\u5fc3\u81d3\u767a\u4f5c\u3001\u8840\u6813\u3001\u8133\u5352\u4e2d\u306e\u30ea\u30b9\u30af\u5897\u52a0\u306a\u3069\u306e\u6709\u5bb3\u306a\u526f\u4f5c\u7528\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3068\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001WHI\u306f\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u306e\u307f\u3092\u7528\u3044\u308bHRT\u306f\u8840\u6813\u3084\u8133\u5352\u4e2d\u306e\u30ea\u30b9\u30af\u5897\u52a0\u3068\u95a2\u9023\u3057\u3066\u3044\u307e\u3057\u305f\u304c\u3001\u4e73\u764c\u30ea\u30b9\u30af\u3078\u306e\u5f71\u97ff\u306f\u4e0d\u78ba\u5b9a\u3067\u3042\u308b\u3068\u3057\u3066\u3044\u307e\u3059\uff0827\uff09\u3002\u3055\u3089\u306b\u3001WHI\u306f\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u3068\u30d7\u30ed\u30b2\u30b9\u30c1\u30f3\u3092\u7528\u3044\u305fHRT\u3092\u53d7\u3051\u305f\u5973\u6027\u306e\u5375\u5de3\u764c\u30ea\u30b9\u30af\u306e\u5897\u52a0\u3082\u793a\u5506\u3057\u307e\u3057\u305f\u304c\u3001\u3053\u306e\u7d50\u679c\u306f\u7d71\u8a08\u7684\u306b\u6709\u610f\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\uff0828\uff09\u3002\u3053\u308c\u3089\u306e\u8d77\u3053\u308a\u3046\u308b\u6709\u5bb3\u306a\u526f\u4f5c\u7528\u306e\u305f\u3081\u3001FDA\u306f\u3001HRT\u306f\u6cbb\u7642\u76ee\u6a19\u9054\u6210\u306b\u5fc5\u8981\u306a\u6700\u4f4e\u7528\u91cf\u3067\u6700\u77ed\u306e\u671f\u9593\u306e\u307f\u7528\u3044\u308b\u3053\u3068\u3092\u63a8\u5968\u3057\u307e\u3057\u305f\u3002<\/li>\n<\/ol>\n

            \u6709\u5bb3\u306aBRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u5909\u7570\u3092\u6301\u3064\u5973\u6027\u306e\u4e73\u764c\u30ea\u30b9\u30af\u3078\u306eHRT\u306e\u5f71\u97ff\u306b\u95a2\u3059\u308b\u30c7\u30fc\u30bf\u306f\u3053\u308c\u307e\u3067\u306e\u3068\u3053\u308d\u5831\u544a\u3055\u308c\u3066\u304a\u3089\u305a\u3001\u305d\u306e\u3088\u3046\u306a\u5973\u6027\u306b\u304a\u3051\u308bHRT\u306e\u4f7f\u7528\u3068\u5375\u5de3\u764c\u30ea\u30b9\u30af\u306b\u95a2\u3057\u3066\u306f\u9650\u3089\u308c\u305f\u30c7\u30fc\u30bf\u3057\u304b\u3042\u308a\u307e\u305b\u3093\u3002\u3042\u308b\u7814\u7a76\u3067\u306f\u3001HRT\u306e\u4f7f\u7528\u306fBRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u5909\u7570\u3092\u6301\u3064\u5973\u6027\u306e\u5375\u5de3\u764c\u30ea\u30b9\u30af\u306b\u5f71\u97ff\u3057\u306a\u3044\u3068\u8003\u3048\u3089\u308c\u307e\u3057\u305f\uff0829\uff09\u3002 HRT\u306e\u4f7f\u7528\u3092\u691c\u8a0e\u3059\u308b\u3068\u304d\u306f\u3001\u3053\u306e\u7a2e\u306e\u6cbb\u7642\u306e\u6f5c\u5728\u7684\u306a\u6709\u5bb3\u6027\u3068\u5229\u70b9\u306e\u4e21\u65b9\u306b\u3064\u3044\u3066\u60a3\u8005\u3068\u533b\u7642\u5f93\u4e8b\u8005\u304c\u614e\u91cd\u306b\u8a71\u3057\u5408\u308f\u306a\u304f\u3066\u306f\u3044\u3051\u307e\u305b\u3093\u3002<\/p>\n

              \n
            1. \u80a5\u6e80<\/strong>\uff0d\u80a5\u6e80\u306f\u3001\u7279\u306bHRT\u3092\u53d7\u3051\u3066\u3044\u306a\u3044\u9589\u7d4c\u5f8c\u306e\u5973\u6027\u306b\u304a\u3044\u3066\u3001\u4e73\u764c\u30ea\u30b9\u30af\u306e\u5897\u52a0\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3068\u5b9f\u8cea\u7684\u306a\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u793a\u5506\u3057\u3066\u3044\u307e\u3059\uff0824\uff09\u3002\u307e\u305f\u3001\u30a8\u30d3\u30c7\u30f3\u30b9\u3067\u306f\u80a5\u6e80\u306f\u5375\u5de3\u764c\u306b\u3088\u308b\u6b7b\u4ea1\u7387\uff08\u6b7b\u4ea1\uff09\u306e\u5897\u52a0\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3068\u793a\u3057\u3066\u3044\u307e\u3059\uff0830\uff09\u3002<\/li>\n
            2. \u904b\u52d5<\/strong>\u2015\u904b\u52d5\u3068\u4e73\u764c\u30ea\u30b9\u30af\u306e\u95a2\u4fc2\u304c\u591a\u304f\u306e\u7814\u7a76\u3067\u8abf\u67fb\u3055\u308c\u3001\u3053\u308c\u3089\u306e\u7814\u7a76\u306e\u307b\u3068\u3093\u3069\u304c\u904b\u52d5\u3001\u7279\u306b\u6fc0\u3057\u3044\u904b\u52d5\u304c\u3001\u30ea\u30b9\u30af\u6e1b\u5c11\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u3068\u793a\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u30ea\u30b9\u30af\u6e1b\u5c11\u306f\u9589\u7d4c\u524d\u5973\u6027\u304a\u3088\u3073\u6b63\u5e38\u4f53\u91cd\u3092\u4e0b\u56de\u308b\u5973\u6027\u3067\u3088\u308a\u9855\u8457\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u307e\u3059(24)\u3002<\/li>\n
            3. \u30a2\u30eb\u30b3\u30fc\u30eb<\/strong>\u30a2\u30eb\u30b3\u30fc\u30eb\u6442\u53d6\u306f\u4e73\u764c\u30ea\u30b9\u30af\u306e\u5897\u52a0\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u5b9f\u8cea\u7684\u306a\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u3042\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u6442\u53d6\u3092\u6e1b\u3089\u305b\u3070\u4e73\u764c\u30ea\u30b9\u30af\u304c\u6e1b\u5c11\u3059\u308b\u304b\u3069\u3046\u304b\u306f\u4e0d\u78ba\u5b9a\u3067\u3059\uff0824\uff09\u3002<\/li>\n
            4. \u98df\u4e8b\u8102\u80aa<\/strong>\u2015\u521d\u671f\u306e\u7814\u7a76\u306f\u9ad8\u8102\u80aa\u98df\u3068\u4e73\u764c\u30ea\u30b9\u30af\u5897\u52a0\u306e\u6f5c\u5728\u7684\u95a2\u4fc2\u6027\u3092\u793a\u5506\u3057\u307e\u3057\u305f\u304c\u3001\u6700\u8fd1\u306e\u7814\u7a76\u3067\u306f\u7d50\u8ad6\u306b\u5230\u9054\u3057\u307e\u305b\u3093\u3067\u3057\u305f\u3002WHI\u3067\u306f\u3001\u4f4e\u8102\u80aa\u98df\u306f\u4e73\u764c\u30ea\u30b9\u30af\u3092\u6e1b\u5c11\u3055\u305b\u307e\u305b\u3093\u3067\u3057\u305f\uff0831\uff09\u3002<\/li>\n<\/ol>\n

               <\/p>\n

              \uff11\uff17.\u764c\u30ea\u30b9\u30af\u306b\u5bfe\u3059\u308b\u907a\u4f1d\u5b50\u691c\u67fb\u306e\u8a73\u7d30\u306a\u60c5\u5831\u306f\u3069\u3053\u3067\u5f97\u3089\u308c\u307e\u3059\u304b\uff1f<\/strong><\/p>\n

              \u907a\u4f1d\u5b50\u691c\u67fb\u3092\u691c\u8a0e\u3057\u3066\u3044\u308b\u4eba\u306f\u3001\u691c\u67fb\u3092\u53d7\u3051\u308b\u304b\u3069\u3046\u304b\u6c7a\u3081\u308b\u524d\u306b\u907a\u4f1d\u5b66\u3092\u719f\u77e5\u3057\u305f\u5c02\u9580\u5bb6\u3068\u8a71\u3057\u5408\u3046\u3079\u304d\u3067\u3059\u3002\u3053\u308c\u3089\u306e\u5c02\u9580\u5bb6\u3068\u306f\u3001\u533b\u5e2b\u3001\u907a\u4f1d\u5b50\u30ab\u30a6\u30f3\u30bb\u30e9\u30fc\u3001\u907a\u4f1d\u5b66\u3092\u719f\u77e5\u3057\u305f\u305d\u306e\u4ed6\u306e\u533b\u7642\u5f93\u4e8b\u8005\uff08\u770b\u8b77\u5e2b\u3001\u5fc3\u7406\u5b66\u8005\u3001\u30bd\u30fc\u30b7\u30e3\u30eb\u30ef\u30fc\u30ab\u30fc\u306a\u3069\uff09\u3067\u3059\u3002\u907a\u4f1d\u5b66\u3092\u719f\u77e5\u3057\u305f\u533b\u7642\u5c02\u9580\u5bb6\u3092\u63a2\u3059\u652f\u63f4\u306b\u3064\u3044\u3066\u306f\u3001\u30a4\u30f3\u30bf\u30fc\u30cd\u30c3\u30c8\u3067NCI\u306eCancer Genetics Services Directory\uff08http:\/\/www.cancer.gov\/search\/geneticsservices<\/a>\uff09\u3092\u3054\u89a7\u304f\u3060\u3055\u3044\u3002\u3042\u308b\u3044\u306f\u3001NCI\u306e\u764c\u60c5\u5831\u30b5\u30fc\u30d3\u30b9\uff08CIS\uff09\u306b\u304a\u554f\u5408\u305b\u304f\u3060\u3055\u3044\uff08\u554f\u3044\u5408\u308f\u305b\u5148\u306f\u4e0b\u8a18\u53c2\u7167\uff09\u3002CIS\u3067\u306f\u907a\u4f1d\u5b50\u691c\u67fb\u306b\u3064\u3044\u3066\u306e\u8a73\u3057\u3044\u60c5\u5831\u3092\u63d0\u4f9b\u3057\u3001\u907a\u4f1d\u5b66\u3092\u719f\u77e5\u3057\u305f\u533b\u7642\u5c02\u9580\u5bb6\u3092\u63a2\u3059\u652f\u63f4\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n

              <\/a>\uff11\uff18.\u6709\u5bb3\u306aBRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u5909\u7570\u3092\u6301\u3064\u4eba\u306e\u652f\u63f4\u306e\u305f\u3081\u306b\u73fe\u5728\u3069\u306e\u3088\u3046\u306a\u7814\u7a76\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u304b\uff1f<\/strong><\/p>\n

              BRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u5909\u7570\u4fdd\u56e0\u8005\u306b\u304a\u3051\u308b\u764c\u306e\u767a\u898b\u3001\u6cbb\u7642\u3001\u4e88\u9632\u306e\u6700\u65b0\u3067\u3088\u308a\u826f\u3044\u65b9\u6cd5\u3092\u898b\u51fa\u3059\u305f\u3081\u306e\u8abf\u67fb\u7814\u7a76\u304c\u884c\u308f\u308c\u3066\u3044\u307e\u3059\u3002\u8ffd\u52a0\u7684\u306a\u7814\u7a76\u3067\u306f\u907a\u4f1d\u30ab\u30a6\u30f3\u30bb\u30ea\u30f3\u30b0\u306e\u65b9\u6cd5\u3084\u6210\u679c\u306e\u6539\u5584\u306b\u91cd\u70b9\u3092\u7f6e\u3044\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u5206\u91ce\u3067\u306e\u77e5\u8b58\u306f\u6025\u901f\u306b\u9032\u5316\u3057\u3066\u3044\u307e\u3059\u3002 BRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u5909\u7570\u4fdd\u56e0\u8005\u306e\u305f\u3081\u306e\u9032\u884c\u4e2d\u306e\u81e8\u5e8a\u8a66\u9a13\uff08\u4eba\u9593\u3067\u306e\u8abf\u67fb\u7814\u7a76\uff09\u306b\u95a2\u3059\u308b\u60c5\u5831\u306fNCI\u306e\u30a6\u30a7\u30d6\u30b5\u30a4\u30c8\u3067\u5165\u624b\u3067\u304d\u307e\u3059\u3002\u4e0b\u8a18\u306e\u30ea\u30f3\u30af\u3088\u308aNCI\u306e\u81e8\u5e8a\u8a66\u9a13\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3092\u691c\u7d22\u3057\u3001BRCA1<\/em>\u307e\u305f\u306fBRCA2<\/em>\u5909\u7570\u4fdd\u56e0\u8005\u304c\u53c2\u52a0\u3067\u304d\u308b\u8a66\u9a13\u306e\u4e00\u89a7\u3092\u8abf\u3079\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n

                \n
              1. BRCA1<\/em>\u5909\u7570\u4fdd\u56e0\u8005<\/li>\n
              2. BRCA2<\/em>\u5909\u7570\u4fdd\u56e0\u8005<\/li>\n<\/ol>\n

                \u307e\u305f\u3001NCI\u306eCIS\u306f\u81e8\u5e8a\u8a66\u9a13\u306b\u95a2\u3059\u308b\u60c5\u5831\u3092\u63d0\u4f9b\u3057\u3001\u81e8\u5e8a\u8a66\u9a13\u306e\u691c\u7d22\u3092\u652f\u63f4\u3057\u307e\u3059\uff08\u554f\u3044\u5408\u308f\u305b\u5148\u306f\u4e0b\u8a18\u53c2\u7167\uff09\u3002<\/p>\n

                \u53c2\u8003\u6587\u732e<\/strong><\/p>\n

                  \n
                1. Kadouri L, Hubert A, Rotenberg Y, et al. Cancer risks in carriers of the BRCA1\/2 Ashkenazi founder mutations. Journal of Medical Genetics<\/em> 2007; 44(7):467\u2013471.<\/li>\n
                2. Thompson D, Easton DF, the Breast Cancer Linkage Consortium. Cancer incidence in BRCA1 mutation carriers. Journal of the National Cancer Institute<\/em> 2002; 94(18):1358\u20131365.<\/li>\n
                3. The Breast Cancer Linkage Consortium. Cancer risks in BRCA2 mutation carriers. Journal of the National Cancer Institute<\/em> 1999; 91(15):1310\u20131316.<\/li>\n
                4. PDQ\u00ae Cancer Information Summary. National Cancer Institute; Bethesda, MD. Genetics of Breast and Ovarian Cancer (PDQ\u00ae) \u2013 Health Professional. Date last modified 04\/24\/2009. Available at: http:\/\/www.cancer.gov\/cancertopics\/pdq\/genetics\/breast-and-ovarian\/healthprofessional<\/a>. Accessed 05\/15\/2009.<\/li>\n
                5. National Cancer Institute. SEER Cancer Statistics Review<\/em>, 1975\u20132005. Retrieved April 20, 2009, from: http:\/\/seer.cancer.gov\/csr\/1975_2005\/index.html<\/a>.<\/li>\n
                6. Campeau PM, Foulkes WD, Tischkowitz MD. Hereditary breast cancer: New genetic developments, new therapeutic avenues. Human Genetics<\/em> 2008; 124(1):31\u201342.<\/li>\n
                7. Walsh T, Casadei S, Coats KH, et al. Spectrum of mutations in BRCA1, BRCA2, CHEK2, and TP53 in families at high risk of breast cancer. Journal of the American Medical Association<\/em> 2006; 295(12):1379\u20131388.<\/li>\n
                8. Lynch HT, Silva E, Snyder C, Lynch JF. Hereditary breast cancer: Part I. Diagnosing hereditary breast cancer syndromes. The Breast Journal<\/em> 2008; 14(1):3\u201313.<\/li>\n
                9. Struewing JP, Hartge P, Wacholder S, et al. The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews. New England<\/em> Journal of Medicine<\/em> 1997; 336(20):1401\u20131408.<\/li>\n
                10. Warner E, Foulkes W, Goodwin P, et al. Prevalence and penetrance of BRCA1 and BRCA2 gene mutations in unselected Ashkenazi Jewish women with breast cancer. Journal of the National Cancer Institute<\/em> 1999; 91(14):1241\u20131247.<\/li>\n
                11. John EM, Miron A, Gong G, et al. Prevalence of pathogenic BRCA1 mutation carriers in 5 U.S. racial\/ethnic groups. Journal of the American Medical Association<\/em> 2007; 298(24):2869\u20132876.<\/li>\n
                12. Vogel KJ, Atchley DP, Erlichman J, et al. BRCA1 and BRCA2 genetic testing in Hispanic patients: Mutation prevalence and evaluation of the BRCAPRO risk assessment model. Journal of Clinical Oncology<\/em> 2007; 25(29):4635\u20134641.<\/li>\n
                13. Malone KE, Daling JR, Doody DR, et al. Prevalence and predictors of BRCA1 and BRCA2 mutations in a population-based study of breast cancer in white and black American women ages 35 to 64 years. Cancer Research<\/em> 2006; 66(16):8297\u20138308.<\/li>\n
                14. Palma M, Ristori E, Ricevuto E, Giannini G, Gulino A. BRCA1 and BRCA2: The genetic testing and the current management options for mutation carriers. Critical Reviews in Oncology\/Hematology<\/em> 2006; 57(1):1\u201323.<\/li>\n
                15. U.S. Preventive Services Task Force. Genetic risk assessment and BRCA mutation testing for breast and ovarian cancer susceptibility. Retrieved April 20, 2009, from: http:\/\/www.ahrq.gov\/clinic\/uspstf05\/brcagen\/brcagenrs.htm<\/a>.<\/li>\n
                16. Peshkin BN, DeMarco TA, Brogan BM, Lerman C, Isaacs C. BRCA1\/2 testing: Complex themes in result interpretation. Journal of Clinical Oncology<\/em> 2001; 19(9):2555\u20132565.<\/li>\n
                17. Kauff ND, Domchek SM, Friebel TM, et al. Risk-reducing salpingo-oophorectomy for the prevention of BRCA1- and BRCA2-associated breast and gynecologic cancer: A multicenter, prospective study. Journal of Clinical Oncology<\/em> 2008; 26(8):1331\u20131337.<\/li>\n
                18. King MC, Wieand S, Hale K, et al. Tamoxifen and breast cancer incidence among women with inherited mutations in BRCA1 and BRCA2: National Surgical Adjuvant Breast and Bowel Project (NSABP\u2013P1) Breast Cancer Prevention Trial. Journal of the American Medical Association<\/em> 2001; 286(18):2251\u20132256.<\/li>\n
                19. Narod SA, Brunet JS, Ghadirian P, et al. Tamoxifen and risk of contralateral breast cancer in BRCA1 and BRCA2 mutation carriers: A case-control study. Lancet <\/em>2000; 356(9245):1876\u20131881.<\/li>\n
                20. Gronwald J, Tung N, Foulkes WD, et al. Tamoxifen and contralateral breast cancer in BRCA1 and BRCA2 carriers: An update. International Journal of Cancer<\/em> 2006; 118(9):2281\u20132284.<\/li>\n
                21. U.S. Department of Health and Human Services. HIPAA Frequent Questions: About the Privacy Rule FAQs. Retrieved April 20, 2009, from: http:\/\/www.hhs.gov\/hipaafaq\/about\/354.html<\/a>.<\/li>\n
                22. H.R. 493. The Genetic Information Nondiscrimination Act of 2008. Retrieved April 20, 2009, from: http:\/\/frwebgate.access.gpo.gov\/cgi-bin\/getdoc.cgi?dbname=110_cong_bills&docid=f:h493enr.txt.pdf<\/a>.<\/li>\n
                23. The National Human Genome Research Institute. GINA: The Genetic Information Nondiscrimination Act of 2008: Information for Researchers and Health Care Professionals. Retrieved April 30, 2009, from: http:\/\/www.genome.gov\/Pages\/PolicyEthics\/GeneticDiscrimination\/GINAInfoDoc.pdf<\/a>.<\/li>\n
                24. PDQ\u00ae Cancer Information Summary. National Cancer Institute; Bethesda, MD. Breast Cancer Prevention (PDQ\u00ae) \u2013 Health Professional. Date last modified 04\/30\/2009. Available at: http:\/\/www.cancer.gov\/cancertopics\/pdq\/prevention\/breast\/healthprofessional<\/a>. Accessed 05\/15\/2009.<\/li>\n
                25. PDQ\u00ae Cancer Information Summary. National Cancer Institute; Bethesda, MD. Ovarian Cancer Prevention (PDQ\u00ae) \u2013 Health Professional. Date last modified 04\/03\/2008. Available at: http:\/\/www.cancer.gov\/cancertopics\/pdq\/prevention\/ovarian\/healthprofessional<\/a>. Accessed 05\/15\/2009.<\/li>\n
                26. Whittemore AS, Balise RR, Pharoah PDP, et al. Oral contraceptive use and ovarian cancer risk among carriers of BRCA1 or BRCA2 mutations. British Journal of Cancer<\/em> 2004; 91(11):1911\u20131915.<\/li>\n
                27. National Heart, Lung, and Blood Institute. Women\u2019s Health Initiative. Retrieved April 20, 2009, from: http:\/\/www.nhlbi.nih.gov\/whi<\/a>.<\/li>\n
                28. Anderson GL, Judd HL, Kaunitz AM, et al. Effects of estrogen plus progestin on gynecologic cancers and associated diagnostic procedures: The Women\u2019s Health Initiative randomized trial. Journal of the American Medical Association<\/em> 2003; 290(13):1739\u20131748.<\/li>\n
                29. Kotsopoulos J, Lubinski J, Neuhausen SL, et al. Hormone replacement therapy and the risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers. Gynecologic Oncology<\/em> 2006; 100(1):83\u201388.<\/li>\n
                30. Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. New England<\/em> Journal of Medicine<\/em> 2003; 348(17):1625\u20131638.<\/li>\n
                31. Prentice RL, Caan B, Chlebowski RT, et al. Low-fat dietary pattern and risk of invasive breast cancer: The Women\u2019s Health Initiative Randomized Controlled Dietary Modification Trial. Journal of the American Medical Association<\/em> 2006; 295(6):629\u2013642.<\/li>\n<\/ol>\n<\/blockquote>\n","protected":false},"excerpt":{"rendered":"

                  \u4e73\u304c\u3093\u30ea\u30b9\u30af\u306e\u907a\u4f1d\u5b50\u691c\u67fb\u306f\uff22\uff32\uff23\uff21\uff11\u3001\uff12\u304c\u6709\u540d\u3067\u3042\u308b\u3002\u3053\u306e\u907a\u4f1d\u5b50\u306b\u3064\u3044\u3066\u306f\u5b66\u3076\u3053\u3068\u304c\u591a\u3044\u3002 \uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a\uff0a \u30ad\u30fc\u30dd\u30a4\u30f3\u30c8 \u30fbBRCA1\u304a\u3088\u3073BRCA2\u306f\u816b\u760d\u6291\u5236\u907a\u4f1d\u5b50\u3068\u3057 […]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts\/1231"}],"collection":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/comments?post=1231"}],"version-history":[{"count":0,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts\/1231\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/media?parent=1231"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/categories?post=1231"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/tags?post=1231"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}