{"id":1221,"date":"2013-02-17T14:24:58","date_gmt":"2013-02-17T05:24:58","guid":{"rendered":"https:\/\/www.taiyou-clinic.jp\/blog\/?p=1221"},"modified":"2013-02-17T14:24:58","modified_gmt":"2013-02-17T05:24:58","slug":"%e3%80%8c%e3%83%93%e3%82%bf%e3%83%9f%e3%83%b3d%e3%81%af%e7%8f%be%e5%9c%a8%e3%80%81%e6%9c%80%e3%82%82%e6%b3%a8%e7%9b%ae%e3%81%95%e3%82%8c%e3%81%a6%e3%81%84%e3%82%8b%e3%83%93%e3%82%bf%e3%83%9f%e3%83%b3","status":"publish","type":"post","link":"https:\/\/www.taiyou-clinic.jp\/blog\/archives\/1221","title":{"rendered":"\u300c\u30d3\u30bf\u30df\u30f3D\u306f\u73fe\u5728\u3001\u6700\u3082\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u30d3\u30bf\u30df\u30f3\u3067\u3042\u308b\u300d"},"content":{"rendered":"
\n

\u6240\u5c5e\u3057\u3066\u3044\u308b\u5b66\u4f1a\u304b\u3089\u30e1\u30eb\u30de\u30ac\u304c\u6765\u3066\u3044\u305f\u306e\u3067\u7d39\u4ecb\u3057\u305f\u3044\u3002
\n\u79c1\u306e\u30d6\u30ed\u30b0\u3067\u3082\u4f55\u5ea6\u3082\u53d6\u308a\u4e0a\u3052\u3066\u3044\u308b\u304c\u30d3\u30bf\u30df\u30f3D\u3067\u3042\u308b\u3002<\/p>\n

\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u306e\u4e88\u9632\u52b9\u679c\u3001\u304c\u3093\u306e\u4e88\u9632\u52b9\u679c\u3001\u30ac\u30f3\u5e79\u7d30\u80de\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u52b9\u679c\u3001\u306a\u3069\u306a\u3069\u3067\u3042\u308b\u3002
\n\u8272\u3005\u306a\u610f\u5473\u3067\u6709\u7528\u306a\u3053\u306e\u30d3\u30bf\u30df\u30f3\u3092\u7d39\u4ecb\u3059\u308b\u8ad6\u6587\u304c\u591a\u304f\u51fa\u3066\u3044\u308b\u306e\u3067\u53c2\u8003\u306b\u3057\u3066\u6b32\u3057\u3044\u3002
\n*********************************
\n\uff08http:\/\/www.iv-therapy.jp\/omns\/<\/a>\uff09<\/p>\n

\uff08English\u7248\u306f\u3053\u3061\u3089\uff09<\/a><\/p>\n

\u300c\u30d3\u30bf\u30df\u30f3D\u306f\u73fe\u5728\u3001\u6700\u3082\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u30d3\u30bf\u30df\u30f3\u3067\u3042\u308b\u300d<\/h2>\n

\u57f7\u7b46\u8005\uff1aWilliam B. Grant, Ph.D.<\/p>\n

\uff08OMNS\u30012013\u5e741\u670817\u65e5\uff09\u3000\u3000PubMed.gov\uff08\u8a33\u8a3b\uff1a\u533b\u5b66\u6587\u732e\u306e\u691c\u7d22\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\uff09\u306b\u3088\u308b\u3068\u3001\u8868\u984c\u3084\u6284\u9332\u306b\u300c\u30d3\u30bf\u30df\u30f3D\u300d\u3068\u3044\u3046\u8a9e\u304c\u5165\u3063\u3066\u3044\u308b\u516c\u8868\u6587\u732e\u306f\u30012012\u5e74\u4e2d\u306b\u7d043,600\u672c\u3042\u3063\u305f\u3002PubMed\u306b\u63b2\u8f09\u3055\u308c\u305f\u30d3\u30bf\u30df\u30f3D\u95a2\u9023\u306e\u516c\u8868\u6587\u732e\u3092\u5408\u8a08\u3059\u308b\u3068\u3001\u3053\u308c\u3067\u7d0433,800\u672c\u3068\u306a\u308b\uff08http:\/\/www.ncbi.nlm.nih.gov\/pubmed<\/a>\uff09\u3002\u5408\u8a08\u3067\u6bd4\u8f03\u3059\u308b\u3068\u3001\u30d3\u30bf\u30df\u30f3C\uff08\u30a2\u30b9\u30b3\u30eb\u30d3\u30f3\u9178\uff09\u95a2\u9023\u306e\u516c\u8868\u6587\u732e\u306f\u7d0435,100\u672c\u3001\u30d3\u30bf\u30df\u30f3E\u95a2\u9023\u306f\u7d0421,700\u672c\u3001\u30d3\u30bf\u30df\u30f3A\u95a2\u9023\u306f\u7d0419,100\u672c\u3001\u8449\u9178\u95a2\u9023\u306f\u7d0417,600\u672c\u3001\u30d3\u30bf\u30df\u30f3B12\u95a2\u9023\u306f\u7d0412,000\u672c\u3068\u306a\u3063\u3066\u3044\u308b\u3002\u3057\u304b\u3057\u30012000\u5e74\u306e\u982d\u304b\u3089\u6570\u3048\u308b\u3068\u3001\u30d3\u30bf\u30df\u30f3D\u306b\u95a2\u3059\u308b\u516c\u8868\u6587\u732e\u306f\u7d0420,500\u672c\u3042\u308b\u304c\u3001\u30d3\u30bf\u30df\u30f3C\uff08\u30a2\u30b9\u30b3\u30eb\u30d3\u30f3\u9178\uff09\u306b\u95a2\u3059\u308b\u3082\u306e\u306f\u7d0416,300\u672c\u306b\u3059\u304e\u306a\u3044\u3002\u3053\u306e\u3088\u3046\u306b\u3001\u30d3\u30bf\u30df\u30f3D\u306f\u3001\u6700\u3082\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u30d3\u30bf\u30df\u30f3\u3067\u3042\u308b\u3002\u305f\u3060\u3001\u53b3\u5bc6\u306b\u8a00\u3048\u3070\u3001\u30d3\u30bf\u30df\u30f3\u3067\u306f\u306a\u3044\u3002\u7d2b\u5916\u7ddaB\u6ce2\uff08UVB\uff09\u306e\u4f5c\u7528\u306b\u3088\u3063\u3066\u4f53\u5185\u3067\u4f5c\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3001\u5fc5\u8981\u306a\u30db\u30eb\u30e2\u30f3\u306e\u4e00\u3064\u3067\u3042\u308b\u3002\u3057\u304b\u3057\u3001\u3053\u308c\u306f\u98df\u4e8b\u3084\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3067\u7d4c\u53e3\u6442\u53d6\u3059\u308b\u3053\u3068\u3082\u3067\u304d\u308b\u3002<\/p>\n

2012\u5e74\u306e\u30c8\u30c3\u30d716\u306b\u5165\u308b\u30d3\u30bf\u30df\u30f3D\u95a2\u9023\u8ad6\u6587<\/h4>\n

2012\u5e74\u5ea6\u672b\u306bPubMed.gov\u3067\u691c\u7d22\u3057\u3066\u9078\u3093\u3060\u30012012\u5e74\u5ea6\u306e\u4e0a\u4f4d\u306b\u5165\u308b\u30d3\u30bf\u30df\u30f3D\u95a2\u9023\u8ad6\u6587\u3092\u4ee5\u4e0b\u306b\u6319\u3052\u308b\u3002\u3053\u308c\u3092\u6319\u3052\u308b\u306b\u3042\u305f\u308a\u3001\u307e\u305a\u306f\u5019\u88dc\u3068\u306a\u308b\u8ad6\u658760\u672c\u3092\u9078\u3093\u3060\u3002\u6b21\u306b\u3001\u305d\u306e\u30ea\u30b9\u30c8\u3092\u30d3\u30bf\u30df\u30f3D\u306e\u7814\u7a76\u8005\u3068\u652f\u6301\u8005\u304b\u3089\u6210\u308b\u5be9\u67fb\u54e1\u56e3\u306b\u9001\u308a\u3001\u305d\u3053\u3067\u6570\u672c\u306e\u8ad6\u6587\u304c\u8ffd\u52a0\u3055\u308c\u305f\u4e0a\u3067\u3001\u5168\u30ea\u30b9\u30c8\u3092\u5bfe\u8c61\u306b\u63a1\u6c7a\u304c\u884c\u308f\u308c\u305f\u3002\u6700\u7d42\u7684\u306a\u30ea\u30b9\u30c8\u306b\u306f\u3001\u69d8\u3005\u306a\u5065\u5eb7\u52b9\u679c\u306b\u3088\u308b\u8ad6\u6587\u304c\u542b\u307e\u308c\u3066\u3044\u305f\u3002\u4ed6\u306b\u3082\u3059\u3070\u3089\u3057\u3044\u8ad6\u6587\u304c\u591a\u304f\u3042\u3063\u305f\u304c\u3001\u30b9\u30da\u30fc\u30b9\u306b\u9650\u308a\u304c\u3042\u308b\u305f\u3081\u3001\u63b2\u8f09\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u306a\u304b\u3063\u305f\u3002<\/p>\n

\u598a\u5a20\u671f\u9593\u4e2d\u306e4,000 IU\u306e\u30d3\u30bf\u30df\u30f3D3\u6442\u53d6\u306b\u3088\u308b\u591a\u5927\u306a\u52b9\u679c<\/h4>\n

\u4eca\u5e74\u304b\u306a\u308a\u306e\u95a2\u5fc3\u3092\u751f\u3093\u3060\u8a71\u984c\u306e\u4e00\u3064\u306b\u3001\u300c\u598a\u5a20\u671f\u9593\u4e2d\u306e\u30d3\u30bf\u30df\u30f3D\u306e\u5f79\u5272\u300d\u304c\u3042\u3063\u305f\u3002\u30b5\u30a6\u30b9\u30ab\u30ed\u30e9\u30a4\u30ca\u533b\u5b66\u5927\u5b66\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u4e00\u7d44\u306e\u8ad6\u6587\u306b\u3066\u3001\u598a\u5a20\u671f\u9593\u4e2d\u306e\u30d3\u30bf\u30df\u30f3D\u88dc\u7d66\u306b\u95a2\u3059\u308b\u7121\u4f5c\u70ba\u5316\u6bd4\u8f03\u8a66\u9a13\u306e\u7d50\u679c\u3068\u793a\u5506\u306b\u3064\u3044\u3066\u8003\u5bdf\u3057\u3066\u3044\u308b [Hollis et al., 2012\u3001Wagner et al., 2012]\u3002\u3053\u306e\u8a66\u9a13\u306b\u306f300\u4eba\u4ee5\u4e0a\u306e\u5973\u6027\u304c\u53c2\u52a0\u3057\u30011\u65e5\u5f53\u305f\u308a400 IU\u30012,000 IU\u307e\u305f\u306f4,000 IU\u306e\u30d3\u30bf\u30df\u30f3D3\u304c\u542b\u307e\u308c\u3066\u3044\u308b\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3001\u3082\u3057\u304f\u306f\u30d7\u30e9\u30bb\u30dc\u306e\u3044\u305a\u308c\u304b\u3092\u6442\u308b\u3088\u3046\u5272\u308a\u5f53\u3066\u3089\u308c\u305f\u3002\u9ad8\u30ab\u30eb\u30b7\u30a6\u30e0\u8840\u75c7\u3084\u9ad8\u30ab\u30eb\u30b7\u30a6\u30e0\u5c3f\u75c7\u306a\u3069\u306e\u526f\u4f5c\u7528\u306f\u4e00\u5207\u898b\u3089\u308c\u306a\u304b\u3063\u305f\u3002\u3053\u306e\u8a66\u9a13\u306b\u3088\u308a\u3001\u8840\u6e0525-\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D [25(OH)D]\u5024\u3092\u3001\u307b\u307c\u6700\u9069\u306a1,25-\u30b8\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D\u5024\u3067\u3042\u308b\u7d0440 ng\/mL\u307e\u3067\u9ad8\u3081\u308b\u306b\u306f\uff08nmol\/L\u5358\u4f4d\u306b\u63db\u7b97\u3059\u308b\u306b\u306f\u3001ng\/mL\u306e\u5024\u306b2.5\u3092\u639b\u3051\u308b\uff09\u30014,000 IU\/\u65e5\u3068\u3044\u3046\u91cf\u304c\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u305f\u30021,25-\u30b8\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u6d3b\u6027\u4ee3\u8b1d\u7523\u7269\u307e\u305f\u306f\u30db\u30eb\u30e2\u30f3\u4ee3\u8b1d\u7523\u7269\u3067\u3042\u308a\u3001\u3068\u304f\u306b\u3001\u6570\u767e\u306e\u907a\u4f1d\u5b50\u306e\u767a\u73fe\u3092\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u3059\u308b\u3002\uff08\u80ce\u5150\u306e\u767a\u9054\u306b\u5bfe\u3059\u308b\u30d3\u30bf\u30df\u30f3D\u306e\u5f71\u97ff\u306e\u6982\u8981\u306b\u3064\u3044\u3066\u306f\u3001Hossein-nezhad and Holick [2012] \u3092\u53c2\u7167\u3002\uff09\u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u7528\u91cf\u304c\u591a\u304b\u3063\u305f\u30b0\u30eb\u30fc\u30d7\u307b\u3069\u3001\u521d\u56de\u5e1d\u738b\u5207\u958b\u5206\u5a29\u304a\u3088\u3073\u598a\u5a20\u9ad8\u8840\u5727\u814e\u75c7\u306e\u30ea\u30b9\u30af\u306b\u6709\u610f\u306a\u4f4e\u4e0b\u304c\u898b\u3089\u308c\u305f\u3002\u65e9\u7523\u3084\u4f4e\u51fa\u751f\u4f53\u91cd\u306a\u3069\u3001\u6709\u5bb3\u306a\u4ed6\u306e\u598a\u5a20\u8ee2\u5e30\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u306b\u3088\u3063\u3066\u751f\u3058\u308b\u304c\u3001\u3053\u3046\u3057\u305f\u6761\u4ef6\u4e0b\u3067\u7d71\u8a08\u7684\u306b\u6709\u610f\u306a\u7d50\u679c\u3092\u5f97\u308b\u306b\u306f\u3001\u8a66\u9a13\u306e\u53c2\u52a0\u8005\u6570\u304c\u5c11\u306a\u3059\u304e\u305f\u3002<\/p>\n

\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u306f\u81ea\u9589\u75c7\u306e\u91cd\u8981\u306a\u5371\u967a\u56e0\u5b50\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3059\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u5897\u52a0<\/h4>\n

\u30b5\u30a6\u30b8\u30a2\u30e9\u30d3\u30a2\u3067\u884c\u308f\u308c\u305f\u7814\u7a76\u3067\u306f\u30018\u6b73\u524d\u5f8c\u306e\u81ea\u9589\u75c7\u5150\u306b\u304a\u3051\u308b\u8840\u6e0525(OH)D\u5024\u3068\u6297\u30df\u30a8\u30ea\u30f3\u95a2\u9023\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\uff08\u6297MAG\uff09\u81ea\u5df1\u6297\u4f53\u3068\u306e\u95a2\u4fc2\u304c\u8abf\u3079\u3089\u308c\u305f [Mostafa and Al-Ayadhi, 2012]\u3002\u3053\u306e2\u3064\u306e\u6570\u5024\u306b\u306f\u3001\u304d\u308f\u3081\u3066\u5f37\u3044\u9006\u76f8\u95a2\u304c\u898b\u3089\u308c\u305f\uff08r = -0.86, p<0.001\uff09\u3002\u5065\u5e38\u5150\u306e\u5e73\u5747\u8840\u6e0525(OH)D\u5024\u306f33 ng\/mL\u3067\u3042\u3063\u305f\u306e\u306b\u5bfe\u3057\u3001\u81ea\u9589\u75c7\u5150\u306e\u5e73\u5747\u306f19 ng\/mL\u3067\u3042\u3063\u305f\u3002\u81ea\u9589\u75c7\u5150\u3082\u5065\u5e38\u5150\u3082\u30011\u9031\u5f53\u305f\u308a\u306e\u65e5\u5149\u66b4\u9732\u6642\u9593\u306f\u7d046\u6642\u9593\u3067\u3042\u3063\u305f\u3002\u30df\u30a8\u30ea\u30f3\u95a2\u9023\u7cd6\u30bf\u30f3\u30d1\u30af\u8cea\uff08MAG\uff09\u304c\u81ea\u9589\u75c7\u5150\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u7406\u7531\u306f\u3001MAG\u304c\u82e5\u3044\u30cb\u30e5\u30fc\u30ed\u30f3\u306e\u518d\u751f\u3092\u4fc3\u9032\u3059\u308b\u5316\u5408\u7269\u3060\u304b\u3089\u3067\u3042\u308b\u3002\u6297MAG\u81ea\u5df1\u6297\u4f53\u306f\u3001\u5065\u5e38\u306a\u795e\u7d4c\u7cfb\u3092\u7dad\u6301\u3059\u308b\u7d30\u80de\u3092\u653b\u6483\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u30cb\u30e5\u30fc\u30ed\u30f3\u306b\u95a2\u4fc2\u3057\u3066\u3044\u308b\u4e00\u90e8\u306e\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306b\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3068\u601d\u308f\u308c\u308b\u3002\u8840\u6e05\u4e2d\u306e\u6297MAG\u81ea\u5df1\u6297\u4f53\u306e\u5024\u306b\u306f\u3001\u5c0f\u5150\u81ea\u9589\u75c7\u8a55\u5b9a\u5c3a\u5ea6\u306b\u3088\u308b\u81ea\u9589\u75c7\u6e2c\u5b9a\u5024\u3068\u5f37\u3044\u95a2\u9023\u304c\u898b\u3089\u308c\u3066\u3044\u308b\u3002\u3053\u308c\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u304c\u4f55\u3089\u304b\u306e\u5f62\u3067\u81ea\u9589\u75c7\u3068\u95a2\u9023\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u793a\u3059\u3001\u975e\u5e38\u306b\u5f37\u529b\u306a\u30a8\u30d3\u30c7\u30f3\u30b9\u3067\u3042\u308b\u3002\u81ea\u9589\u75c7\u304c\u3042\u308b\u4eba\u306e\u8840\u6e0525(OH)D\u5024\u3092\u4e0a\u3052\u308c\u3070\u81ea\u9589\u75c7\u306e\u75c7\u72b6\u304c\u8efd\u6e1b\u3055\u308c\u308b\u304b\u3069\u3046\u304b\u306f\u3001\u307e\u3060\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u306a\u3044\u3002<\/p>\n

\u598a\u5a20\u671f\u9593\u4e2d\u306e\u30d3\u30bf\u30df\u30f3D\u4f4e\u5024\u306f\u3001\u5c0f\u5150\u671f\u306e\u8a00\u8a9e\u6a5f\u80fd\u969c\u5bb3\u306b\u95a2\u9023\u304c\u3042\u308b<\/h4>\n

\u30aa\u30fc\u30b9\u30c8\u30e9\u30ea\u30a2\u306e\u30d1\u30fc\u30b9\u3067\u884c\u308f\u308c\u305f\u7814\u7a76\u3067\u306f\u3001\u598a\u5a2018\u9031\u306e\u6642\u70b9\u3067\u598a\u5a66\u306e\u8840\u6e0525(OH)D\u5024\u3092\u6e2c\u5b9a\u3057\u3001\u305d\u306e\u5f8c\u3001\u751f\u307e\u308c\u305f\u5b50\u304c5\u6b73\u306810\u6b73\u306e\u3068\u304d\u306b\u3001\u5b50\u306e\u8a00\u8a9e\u6a5f\u80fd\u969c\u5bb3\u306e\u6e2c\u5b9a\u3092\u884c\u3063\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u8840\u6e0525(OH)D\u5024\u304c18 ng\/mL\u672a\u6e80\u3067\u3042\u3063\u305f\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u300125(OH)D\u5024\u304c28ng\/mL\u3092\u8d85\u3048\u3066\u3044\u305f\u30b0\u30eb\u30fc\u30d7\u3068\u6bd4\u8f03\u3057\u3066\u3001\u5b50\u304c\u81e8\u5e8a\u7684\u306b\u91cd\u5927\u306a\u8a00\u8a9e\u969c\u5bb3\u3092\u6709\u3059\u308b\u30ea\u30b9\u30af\u304c2\u500d\u306b\u306a\u3063\u3066\u3044\u305f\u3002\u305d\u306e\u6b63\u78ba\u306a\u539f\u56e0\u306f\u307e\u3060\u308f\u304b\u3063\u3066\u3044\u306a\u3044\u304c\u3001\u591a\u304f\u306e\u53ef\u80fd\u6027\u304c\u3042\u308b\u30022000\u5e74\u4ee3\u59cb\u3081\u306b\u7c73\u56fd\u3067\u884c\u308f\u308c\u305f\u7814\u7a76\u306b\u3088\u308b\u3068\u3001\u51fa\u7523\u53ef\u80fd\u5e74\u9f62\u306e\u767d\u4eba\u5973\u6027\u306e\u5e73\u574725(OH)D\u5024\u306f26 ng\/mL\u3067\u3042\u3063\u305f\u306e\u306b\u5bfe\u3057\u3001\u51fa\u7523\u53ef\u80fd\u5e74\u9f62\u306e\u9ed2\u4eba\u5973\u6027\u306e\u5e73\u574725(OH)D\u5024\u306f14 ng\/mL\u3067\u3042\u3063\u305f\u3002\u73fe\u884c\u306e\u57fa\u6e96\u3067\u306f\u3001\u3069\u3061\u3089\u306e\u6570\u5024\u3082\u4f4e\u3044\u3002\u4ee5\u4e0b\u3067\u8aac\u660e\u3059\u308b\u3068\u304a\u308a\u3001\u76ae\u819a\u306e\u8272\u306f\u3001\u65e5\u5149\u66b4\u9732\u306b\u3088\u3063\u3066\u751f\u6210\u3055\u308c\u308b\u30d3\u30bf\u30df\u30f3D\u306e\u8840\u6e05\u5024\u306b\u76f4\u63a5\u95a2\u9023\u3057\u3066\u3044\u308b\u3002<\/p>\n

\u30d3\u30bf\u30df\u30f3D\u5024\u304c\u9ad8\u3044\u307b\u3069\u3001\u7dcf\u6b7b\u4ea1\u7387\u304c\u4f4e\u4e0b<\/h4>\n

\u5c0f\u5150\u671f\u3068\u306f\u5bfe\u6975\u306b\u3042\u308b\u4eba\u751f\u306e\u5c40\u9762\u3067\u306e\u8208\u5473\u6df1\u3044\u8a71\u984c\u3068\u3057\u3066\u3001\u6b7b\u4ea1\u7387\u3068\u8840\u6e0525(OH)D\u5024\u3068\u306e\u95a2\u4fc2\u304c\u3042\u3063\u305f\u300211\u306e\u89b3\u5bdf\u7814\u7a76\u3068\u7d0460,000\u4eba\u306e\u88ab\u9a13\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30e1\u30bf\u5206\u6790\u306b\u3066\u300125(OH)D\u5024\u304c\u6700\u3082\u9ad8\u3044\u90e8\u985e\u3067\u306f\u3001\u6700\u3082\u4f4e\u3044\u90e8\u985e\u3068\u6bd4\u8f03\u3057\u3066\u3001\u7d0410\u5e74\u9593\u306e\u6b7b\u4ea1\u30ea\u30b9\u30af\u304c29\uff05\u4f4e\u3044\u3053\u3068\u304c\u308f\u304b\u3063\u305f [Zittermann et al., 2012]\u3002\u6442\u53d6\u91cf\u306e\u6bb5\u968e\u7684\u6bd4\u8f03\u3067\u306f\u3001\u8840\u6f3f25(OH)D \u5024\u306b\u3064\u3044\u3066\u3001\u7d0411 ng\/mL\u3068\u3044\u3046\u4e2d\u592e\u5024\u304b\u3089\u59cb\u307e\u3063\u3066\u30015 ng\/mL\u5897\u3048\u308b\u306814\uff05\u300110 ng\/mL\u5897\u3048\u308b\u3068 23%\u300120 ng\/mL\u5897\u3048\u308b\u306839%\u3001\u6b7b\u4ea1\u30ea\u30b9\u30af\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u305f\u3002\u958b\u59cb\u6642\u306e\u8840\u6e0525(OH)D\u5024\u304c\u6700\u3082\u4f4e\u304b\u3063\u305f\u30b0\u30eb\u30fc\u30d7\u306b\u3066\u3001\u6700\u5927\u306e\u52b9\u679c\u304c\u898b\u3089\u308c\u305f\u3002\u958b\u59cb\u6642\u306e\u8840\u6e0525(OH)D\u5024\u304c\u305d\u308c\u3088\u308a\u9ad8\u304f\u3001\u6700\u9069\u5024\uff0830\uff5e40 ng\/mL\uff09\u306b\u8fd1\u304b\u3063\u305f\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u3092\u8ffd\u52a0\u6442\u53d6\u3057\u3066\u3082\u305d\u308c\u307b\u3069\u306e\u52b9\u679c\u306f\u898b\u3089\u308c\u306a\u304b\u3063\u305f\u3002\u958b\u59cb\u6642\u306e\u8840\u6e0525(OH)D\u5024\u3068\u5065\u5eb7\u8ee2\u5e30\u3068\u306e\u3053\u3046\u3057\u305f\u95a2\u4fc2\u306b\u3064\u3044\u3066\u306f\u3001\u5065\u5eb7\u95a2\u9023\u306e\u4ed6\u306e\u591a\u304f\u306e\u7814\u7a76\u7d50\u679c\u3068\u985e\u4f3c\u3057\u3066\u3044\u308b\u305f\u3081\u3001\u9a5a\u304f\u306b\u306f\u3042\u305f\u3089\u306a\u3044\u3002\u8a66\u9a13\u671f\u9593\u4e2d\u306b25(OH)D\u5024\u304c\u5909\u5316\u3057\u305f\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u307e\u305f\u3001\u3053\u308c\u3068\u306f\u7121\u95a2\u4fc2\u306e\u539f\u56e0\u3067\u6b7b\u4ea1\u3057\u305f\u88ab\u9a13\u8005\u3082\u3044\u308b\u305f\u3081\u3001\u6b7b\u4ea1\u7387\u306b\u5bfe\u3059\u308b\u8840\u6e0525(OH)D\u5024\u306e\u5b9f\u969b\u306e\u5f71\u97ff\u306f\u3001\u4e0a\u8a18\u306e\u63a8\u5b9a\u5024\u3088\u308a\u3082\u5927\u304d\u3044\u3002<\/p>\n

\u307e\u305f\u3001\u5faa\u74b0\u5668\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3082\u4f4e\u4e0b<\/h4>\n

\u5faa\u74b0\u5668\u75be\u60a3\u306f\u3001\u6b7b\u4ea1\u7387\u306b\u5bfe\u3059\u308b\u91cd\u8981\u306a\u5bc4\u4e0e\u56e0\u5b50\u306e\u4e00\u3064\u3067\u3042\u308b\u3002\u30ab\u30f3\u30b6\u30b9\u5dde\u306e\u7d0411,000\u4eba\u306e\u60a3\u8005\u306b\u95a2\u3059\u308b\u7814\u7a76\u7d50\u679c\u304c\u5831\u544a\u3055\u308c\u305f\u3002\u3053\u306e\u60a3\u8005\u306e\u5e73\u5747\u5e74\u9f62\u306f58\u00b115\u6b73\u3001\u4f53\u683c\u6307\u6570\u306f30\u00b18 kg\/m2\u3001\u5e73\u5747\u8840\u6e0525(OH)D\u5024\u306f24\u00b114 ng\/mL\u3067\u3042\u3063\u305f [Vacek et al., 2012]\u3002\u8840\u6e0525(OH)D\u5024\u304c30 ng\/mL\u672a\u6e80\u3067\u3042\u308b\u5834\u5408\u306b\u3001\u9ad8\u8840\u5727\u75c7\u3001\u51a0\u52d5\u8108\u75be\u60a3\u3001\u5fc3\u7b4b\u75c7\u3001\u7cd6\u5c3f\u75c5\u3092\u542b\u3080\u3001\u3044\u304f\u3064\u304b\u306e\u5fc3\u8840\u7ba1\u95a2\u9023\u75be\u60a3\u3068\u306e\u6709\u610f\u306a\u95a2\u9023\u304c\u898b\u3089\u308c\u305f\u3002\u8840\u6e0525(OH)D\u5024\u304c30 ng\/mL\u672a\u6e80\u3067\u3042\u3063\u305f\u30b0\u30eb\u30fc\u30d7\u306f\u30015.5\u5e74\u5f8c\u306e\u6642\u70b9\u3067\u300125(OH)D\u5024\u304c\u305d\u308c\u4ee5\u4e0a\u3067\u3042\u3063\u305f\u30b0\u30eb\u30fc\u30d7\u3068\u6bd4\u8f03\u3057\u3066\u3001\u6b7b\u4ea1\u7387\u304c2\u500d\u306b\u306a\u3063\u3066\u3044\u305f\u3002<\/p>\n

\u307e\u305f\u30012\u578b\u7cd6\u5c3f\u75c5\u306e\u30ea\u30b9\u30af\u3082\u4f4e\u4e0b<\/h4>\n

\u7d042,000\u4eba\u306e\u524d\u7cd6\u5c3f\u75c5\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f2.7\u5e74\u9593\u306e\u8a66\u9a13\u306b\u3088\u308b\u3068\u300125(OH)D\u5024\u304c\u4e0a\u4f4d3\u5206\u306e1\u306b\u5165\u3063\u3066\u3044\u305f\u30b0\u30eb\u30fc\u30d7\uff08\u4e2d\u592e\u502430.1 ng\/mL\uff09\u306f\u3001\u4e0b\u4f4d3\u5206\u306e1\u306b\u5165\u3063\u3066\u3044\u305f\u30b0\u30eb\u30fc\u30d7\uff08\u4e2d\u592e\u502412.8 ng\/mL\uff09\u3068\u6bd4\u8f03\u3057\u3066\u30012\u578b\u7cd6\u5c3f\u75c5\u306e\u767a\u75c7\u30ea\u30b9\u30af\u304c28\uff05\u4f4e\u304f\u306a\u3063\u3066\u3044\u305f [Pittas, 2012]\u3002<\/p>\n

\u305d\u3057\u3066\u30011\u578b\u7cd6\u5c3f\u75c5\uff08T1DM\uff09\u306e\u30ea\u30b9\u30af\u3082\u4f4e\u4e0b<\/h4>\n

2002\u5e74\u304b\u30892011\u5e74\u306e\u9593\u306b\u30a4\u30f3\u30b9\u30ea\u30f3\u4f9d\u5b58\u6027\u7cd6\u5c3f\u75c5\uff08T1DM\uff09\u3092\u767a\u75c7\u3057\u305f\u7c73\u56fd\u8ecd\u4eba1,000\u4eba\u306e\u30c7\u30fc\u30bf\u306b\u3082\u3068\u3065\u304d\u3001\u3053\u306e\u75c5\u6c17\u306b\u95a2\u3059\u308b\u89b3\u5bdf\u7814\u7a76\u304c\u884c\u308f\u308c\u305f [Gorham et al., 2012]\u3002\u3053\u306e\u88ab\u9a13\u8005\u306f\u3001T1DM\u3092\u767a\u75c7\u3059\u308b1\uff5e10\u5e74\u524d\u306b\u3001\u8840\u6db2\u30b5\u30f3\u30d7\u30eb\u3092\u63d0\u4f9b\u3057\u3066\u3044\u305f\u3002\u88ab\u9a13\u8005\u306f\u3001T1DM\u3092\u767a\u75c7\u3057\u3066\u3044\u306a\u3044\u5225\u306e\u8ecd\u4eba1,000\u4eba\u3068\u5165\u5ff5\u306b\u30de\u30c3\u30c1\u30f3\u30b0\u3055\u305b\u305f\u3002\u8840\u6e0525(OH)D\u5024\u304c24 ng\/mL\u3092\u8d85\u3048\u3066\u3044\u305f\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u300124 ng\/mL\u672a\u6e80\u3067\u3042\u3063\u305f\u30b0\u30eb\u30fc\u30d7\u3068\u6bd4\u8f03\u3057\u3066\u3001T1DM\u306e\u767a\u75c7\u30ea\u30b9\u30af\u304c78\uff05\u4f4e\u304f\u306a\u3063\u3066\u3044\u305f\u3002\u3053\u306e\u7814\u7a76\u7d50\u679c\u306f\u3001\u7d71\u8a08\u7684\u306b\u304d\u308f\u3081\u3066\u6709\u610f\u3067\u3042\u308a\u3001\u305d\u306e\u578b\u306b\u95a2\u3059\u308b\u6700\u5f37\u306e\u7814\u7a76\u306e\u4e00\u3064\u3067\u3042\u308b\u3002<\/p>\n

\u7d30\u83cc\u611f\u67d3\u3068\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u306e\u6e1b\u5c11<\/h4>\n

\u30d3\u30bf\u30df\u30f3D\u306b\u3088\u308b\u611f\u67d3\u30ea\u30b9\u30af\u4f4e\u6e1b\u52b9\u679c\u306f\u3001\u95a2\u5fc3\u304c\u9ad8\u307e\u3063\u3066\u3044\u308b\u8a71\u984c\u306e\u4e00\u3064\u3067\u3042\u308b\u3002\u30d3\u30bf\u30df\u30f3D\u306f\u3001\u4e3b\u3068\u3057\u3066\u3001\u6297\u5fae\u751f\u7269\u6027\u3068\u6297\u5185\u6bd2\u7d20\u7279\u6027\u304c\u3042\u308b\u30dd\u30ea\u30da\u30d7\u30c1\u30c9\u306e\u4e00\u7a2e\u3067\u3042\u308b\u30ab\u30c6\u30ea\u30b7\u30b8\u30f3\u306e\u751f\u6210\u3092\u8a98\u767a\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u4e3b\u306b\u81ea\u7136\u514d\u75ab\u7cfb\u3092\u5f37\u5316\u3057\u3066\u3001\u611f\u67d3\u30ea\u30b9\u30af\u3092\u4e0b\u3052\u308b\u3002\u307e\u305f\u3001\u30d3\u30bf\u30df\u30f3D\u306f\u3001\u7d30\u80de\u306e\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\u5206\u5b50\u306e\u4e00\u7a2e\u3067\u3042\u308b\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u306e\u751f\u6210\u3092\u3001\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u907f\u3051\u308b\u3088\u3046\u306b\u5207\u308a\u66ff\u3048\u3001\u4ed6\u306b\u3082\u3001\u81ea\u7136\u514d\u75ab\u7cf8\u3068\u9069\u5fdc\u514d\u75ab\u7cfb\u306e\u4e21\u65b9\u306b\u6570\u3005\u306e\u4f5c\u7528\u3092\u3082\u305f\u3089\u3059 [Lang et al., 2012]\u3002\u3053\u308c\u307e\u3067\u306b\u898b\u3064\u304b\u3063\u3066\u3044\u308b\u30d3\u30bf\u30df\u30f3D\u306e\u52b9\u679c\u306f\u3001\u307b\u3068\u3093\u3069\u7d30\u83cc\u611f\u67d3\u306b\u5bfe\u3059\u308b\u3082\u306e\u3067\u3042\u308b\u304c\u3001\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u3001HIV\u3001C\u578b\u809d\u708e\u306a\u3069\u306e\u30a6\u30a4\u30eb\u30b9\u611f\u67d3\u3078\u306e\u52b9\u679c\u3082\u4e00\u90e8\u5831\u544a\u3055\u308c\u3066\u3044\u308b [Lang et al., 2012]\u3002\u547c\u5438\u5668\u611f\u67d3\u75c7\u3092\u983b\u767a\u3057\u3066\u3044\u305f\u60a3\u8005140\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30b9\u30a6\u30a7\u30fc\u30c7\u30f3\u3067\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u6442\u53d6\u7814\u7a76\u3067\u30014,000 IU\/\u65e5\u306e\u30d3\u30bf\u30df\u30f3D3\u3092\u4f7f\u7528\u3057\u305f\u3068\u3053\u308d\u3001\u8840\u6e0525(OH)D\u5024\u306f\u30d7\u30e9\u30bb\u30dc\u30b0\u30eb\u30fc\u30d7\u306727 ng\/mL\u524d\u5f8c\u3067\u3042\u3063\u305f\u306e\u306b\u5bfe\u3057\u3001\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3092\u6442\u53d6\u3057\u305f\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u300153 ng\/mL\u307e\u3067\u5897\u52a0\u3057\u305f [Bergman et al., 2012]\u3002\u30d3\u30bf\u30df\u30f3D3\u3092\u6442\u3063\u3066\u3044\u305f\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001\u547c\u5438\u5668\u611f\u67d3\u75c7\u306b23\uff05\u3001\u6297\u751f\u7269\u8cea\u306e\u4f7f\u7528\u65e5\u6570\u306b50\uff05\u306e\u4f4e\u4e0b\u304c\u898b\u3089\u308c\u305f\u3002<\/p>\n

\u30d3\u30bf\u30df\u30f3D\u306b\u3088\u308b\u30ac\u30f3\u306e\u30ea\u30b9\u30af\u4f4e\u6e1b\u52b9\u679c<\/h4>\n

\u6587\u66f8\u306b\u3088\u308b\u5341\u5206\u306a\u88cf\u4ed8\u3051\u304c\u3042\u308b\u30d3\u30bf\u30df\u30f3D\u306e\u91cd\u8981\u306a\u52b9\u679c\u306e\u4e2d\u306b\u3001\u30ac\u30f3\u306e\u30ea\u30b9\u30af\u4f4e\u4e0b\u3068\u3001\u30ac\u30f3\u8a3a\u65ad\u5f8c\u306e\u751f\u5b58\u7387\u306e\u5897\u52a0\u304c\u3042\u308b\u3002PubMed.gov \u306b\u3088\u308b\u3068\u30012012\u5e74\u306b\u306f\u3001\u30d3\u30bf\u30df\u30f3D\u3068\u30ac\u30f3\u3068\u306e\u95a2\u4fc2\u306b\u95a2\u3059\u308b\u516c\u8868\u6587\u732e\u304c\u7d04400\u672c\u3042\u3063\u305f\u3002\u5730\u57df\u76f8\u95a2\u7814\u7a76\u3001\u89b3\u5bdf\u7814\u7a76\u304a\u3088\u3073\u57fa\u790e\u7814\u7a76\u306b\u3088\u308b\u30a8\u30d3\u30c7\u30f3\u30b9\u3067\u306f\u300115\u7a2e\u985e\u3092\u8d85\u3048\u308b\u30ac\u30f3\u306b\u3064\u3044\u3066\u3001\u592a\u967d\u7d2b\u5916\u7ddaB\u6ce2\u306e\u5024\u3084\u8840\u6e0525(OH)D\u5024\u304c\u9ad8\u3044\u307b\u3069\u30ea\u30b9\u30af\u304c\u4f4e\u304f\u306a\u308b\u95a2\u9023\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u308b\u3002\u305d\u306e\u4e2d\u3067\u30822\u3064\u306e\u8ad6\u6587\u306f\u3068\u304f\u306b\u6ce8\u76ee\u306b\u5024\u3059\u308b\u3002\u305d\u306e1\u3064\u306f\u3001\u4e73\u30ac\u30f3\u3001\u7d50\u8178\u30ac\u30f3\u3001\u80ba\u30ac\u30f3\u3001\u30ea\u30f3\u30d1\u816b\u306e\u3044\u305a\u308c\u304b\u306e\u60a3\u8005658\u4eba\u306e\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30ce\u30eb\u30a6\u30a7\u30fc\u3067\u306e\u7814\u7a76\u3067\u3001\u3053\u3053\u3067\u306f\u3001\u30ac\u30f3\u8a3a\u65ad\u5f8c90\u65e5\u4ee5\u5185\u306b\u8840\u6e0525(OH)D\u5024\u3092\u6e2c\u5b9a\u3057\u3001\u6700\u9ad89\u5e74\u307e\u3067\u8ffd\u8de1\u3057\u305f [Tretli et al., 2012]\u3002\uff11\uff18ng\uff0fml\u4ee5\u4e0b\u306e\u65b9\u3068\u6bd4\u8f03\u3057\u3066\u3001\u8840\u6e0525(OH)D\u5024\u304c32 ng\/mL\u3067\u3042\u3063\u305f\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001\u30ac\u30f3\u306b\u3088\u308b\u6b7b\u4ea1\u30ea\u30b9\u30af\u304c66\uff05\u4f4e\u304f\u306a\u3063\u3066\u3044\u305f\u3002\u30ac\u30f3\u60a3\u8005\u306b\u3068\u3063\u3066\u3001\u3053\u308c\u306f\u547d\u7db1\u3068\u306a\u308b\u3060\u308d\u3046\u3002
\n\u3082\u30461\u3064\u306e\u30ac\u30f3\u95a2\u9023\u8ad6\u6587\u306f\u3001\u751f\u691c\u306b\u3066\u60aa\u6027\u5ea6\u304c\u4f4e\u3044\u3068\u8a55\u4fa1\u3055\u308c\u305f\u524d\u7acb\u817a\u30ac\u30f3\u306e\u60a3\u8005\u306b4,000 IU\/\u65e5\u306e\u30d3\u30bf\u30df\u30f3D3\u3092\u88dc\u7d66\u3057\u305f\u7d50\u679c\u306b\u3064\u3044\u3066\u5831\u544a\u3057\u305f\u3082\u306e\u3067\u3042\u308b [Marshall et al., 2012]\u300244\u4eba\u306e\u60a3\u8005\u304c1\u5e74\u9593\u306e\u8a66\u9a13\u3092\u6700\u5f8c\u307e\u3067\u7d42\u3048\u3001\u305d\u306e\u3046\u306124\u4eba\uff0855\uff05\uff09\u306b\u30ac\u30f3\u306e\u91cf\u306e\u6e1b\u5c11\u304c\u898b\u3089\u308c\u305f\u30025\u4eba\uff0811\uff05\uff09\u306b\u306f\u4f55\u306e\u5909\u5316\u3082\u898b\u3089\u308c\u305a\u300115\u4eba\uff0834\uff05\uff09\u306b\u306f\u5897\u52a0\u304c\u898b\u3089\u308c\u305f\u3002\u3053\u308c\u3068\u6bd4\u8f03\u3057\u3066\u300119\u4eba\u306e\u60a3\u8005\u304b\u3089\u6210\u308b\u5f93\u6765\u7684\u306a\u30b0\u30eb\u30fc\u30d7\u3067\u306f\u3001\u30ac\u30f3\u306e\u91cf\u306e\u6e1b\u5c11\u304c\u898b\u3089\u308c\u305f\u306e\u306f\u308f\u305a\u304b4\u4eba\uff0821\uff05\uff09\u3067\u30013\u4eba\uff0816\uff05\uff09\u306b\u306f\u4f55\u306e\u5909\u5316\u3082\u898b\u3089\u308c\u305a\u300112\u4eba\uff0863\uff05\uff09\u306b\u30ac\u30f3\u306e\u5897\u52a0\u304c\u898b\u3089\u308c\u305f\u3002\u5f93\u3063\u3066\u3001\u6700\u9069\u306a\u30d3\u30bf\u30df\u30f3D\u88dc\u7d66\u306f\u3001\u30ac\u30f3\u60a3\u8005\u306e\u6cbb\u7642\u306b\u5f79\u7acb\u3064\u3068\u601d\u308f\u308c\u308b\u3002<\/p>\n

\u8ee2\u5012\u3068\u9aa8\u6298<\/h4>\n

\u6614\u304b\u3089\u77e5\u3089\u308c\u3066\u3044\u308b\u30d3\u30bf\u30df\u30f3D\u306e\u5f79\u5272\u306f\u3001\u30ab\u30eb\u30b7\u30a6\u30e0\u3068\u30ea\u30f3\u9178\u5869\u306e\u5438\u53ce\u304a\u3088\u3073\u4ee3\u8b1d\u3092\u8abf\u7bc0\u3059\u308b\u3053\u3068\u3067\u3001\u3053\u308c\u306f\u9aa8\u306e\u5f37\u5316\u306b\u3064\u306a\u304c\u308b\u3002\u30d3\u30bf\u30df\u30f3D\u88dc\u7d66\u306b\u95a2\u3059\u308b\u7121\u4f5c\u70ba\u5316\u6bd4\u8f03\u8a66\u9a13\u306b\u53c2\u52a0\u3057\u305f\u88ab\u9a13\u8005\u7d0431,000\u4eba\uff08\u5e73\u5747\u5e74\u9f6276\u6b73\u3001\u5973\u602791\uff05\uff09\u306e\u30d7\u30fc\u30eb\u89e3\u6790\u3067\u306f\u3001\u3053\u306e\u88ab\u9a13\u8005\u306e\u4e2d\u3067\u3001\u80a1\u95a2\u7bc0\u90e8\u9aa8\u6298\u304c\u7d041,000\u4ef6\u3001\u975e\u810a\u690e\u9aa8\u6298\u304c\u7d043,800\u4ef6\u898b\u3089\u308c\u305f\u304c\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u6442\u53d6\u91cf\u304c\u6700\u3082\u591a\u304b\u3063\u305f\u30b0\u30eb\u30fc\u30d7\uff08\u4e2d\u592e\u5024800 IU\/\u65e5\u3001\u5024\u57df792\uff5e2000\uff09\u3067\u306f\u3001\u80a1\u95a2\u7bc0\u90e8\u9aa8\u6298\u306e\u30ea\u30b9\u30af\u304c30%\u3001\u975e\u810a\u690e\u9aa8\u6298\u306e\u30ea\u30b9\u30af\u304c14\uff05\u4f4e\u304f\u306a\u3063\u3066\u3044\u305f [Bischoff-Ferrari et al., 2012]\u3002\u795e\u7d4c\u7b4b\u5236\u5fa1\u306b\u304a\u3051\u308b\u30d3\u30bf\u30df\u30f3D\u306e\u5f79\u5272\u306f\u3001\u8ee2\u5012\u3068\u9aa8\u6298\u306e\u30ea\u30b9\u30af\u4f4e\u4e0b\u306b\u304a\u3044\u3066\u3082\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3057\u3066\u3044\u308b\u3002<\/p>\n

\u7d2b\u5916\u7dda\u74b0\u5883\u306e\u5909\u5316\u306b\u5bfe\u3059\u308b\u76ae\u819a\u8272\u7d20\u306e\u9069\u5408\u901f\u5ea6\u306f\u9045\u3044<\/h4>\n

Jablonski\u3068Chaplin\u306f\u3001\u4eba\u9593\u306e\u76ae\u819a\u8272\u7d20\u6c88\u7740\u304a\u3088\u3073\u305d\u308c\u3068\u592a\u967d\u7d2b\u5916\u7dda\u3068\u306e\u95a2\u4fc2\u3092\u793a\u3057\u305f\u4e00\u9023\u306e\u8ad6\u6587\u3092\u516c\u8868\u3057\u3066\u3044\u308b [Jablonski and Chaplin, 2012]\u3002\u5f7c\u3089\u306f\u547d\u984c\u3068\u3057\u3066\u3001\u300c\u4eba\u9593\u306e\u76ae\u819a\u8272\u7d20\u6c88\u7740\u306f\u3001\u4eba\u306e\u96c6\u56e3\u304c50\u4e16\u4ee3\u3064\u307e\u308a\u7d041,000\u5e74\u306b\u308f\u305f\u3063\u3066\u4f4f\u3093\u3067\u3044\u308b\u5834\u6240\u306e\u7d2b\u5916\u7dda\u72b6\u614b\u306b\u9069\u5408\u3057\u3066\u304d\u305f\u300d\u3053\u3068\u3092\u6319\u3052\u3066\u3044\u308b\u3002\u771f\u663c\u306e\u65e5\u5149\u304b\u3089\u53d7\u3051\u308b\u7d2b\u5916\u7dda\u306b\u3088\u3063\u3066\u30d3\u30bf\u30df\u30f3D\u304c\u751f\u6210\u3055\u308c\u3001\u3053\u308c\u304c\u591a\u304f\u306e\u75be\u60a3\u306b\u5bfe\u3059\u308b\u91cd\u8981\u306a\u4fdd\u8b77\u4f5c\u7528\u3092\u3082\u305f\u3089\u3059\u304c\u3001\u65e5\u5149\u306f\u76ae\u819a\u30ac\u30f3\u3084\u8449\u9178\u306e\u7834\u58ca\u306e\u539f\u56e0\u306b\u3082\u306a\u308b\u3002\u76ae\u819a\u306e\u8272\u304c\u6fc3\u3044\u3068\u3001\u30d5\u30ea\u30fc\u30e9\u30b8\u30ab\u30eb\u306e\u767a\u751f\u3001DNA\u306e\u640d\u50b7\u3001\u30ac\u30f3\u3001\u306a\u3089\u3073\u306b\u8449\u9178\u306e\u640d\u5931\u304b\u3089\u4fdd\u8b77\u3055\u308c\u308b\u3002\u3053\u306e\u305f\u3081\u3001\u6fc3\u3044\u8272\u306e\u76ae\u819a\u306f\u3001\u71b1\u5e2f\u5730\u65b9\u306b\u306f\u6700\u9069\u3067\u3042\u308a\u3001\u4e00\u65b9\u3001\u7def\u5ea6\u306e\u9ad8\u3044\u5730\u57df\u3067\u306f\u3001\u8584\u3044\u8272\u306e\u76ae\u819a\u304c\u6700\u9069\u3067\u3042\u308b\u300223\u00b0\uff5e46\u00b0\u306e\u7def\u5ea6\u5730\u57df\u306b\u304a\u3051\u308b\u7d2b\u5916\u7ddaB\u6ce2\u306b\u9069\u5408\u3057\u305f\u76ae\u819a\u3092\u6301\u3064\u4eba\u306f\u3001\u65e5\u713c\u3051\u3059\u308b\u529b\u304c\u5099\u308f\u3063\u3066\u3044\u308b\u3002\u65e5\u713c\u3051\u306f\u3001\u592a\u967d\u7d2b\u5916\u7ddaB\u6ce2\u306e\u91cf\u306e\u5b63\u7bc0\u7684\u5909\u5316\u306b\u5bfe\u3059\u308b\u9069\u5fdc\u624b\u6bb5\u306e\u4e00\u3064\u3067\u3042\u308b\u3002\u3057\u304b\u3057\u73fe\u4ee3\u3067\u306f\u3001\u4eba\u306f\u79fb\u4f4f\u3084\u65c5\u884c\u3092\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u81ea\u5206\u306e\u76ae\u819a\u8272\u7d20\u6c88\u7740\u304c\u9069\u3057\u3066\u3044\u306a\u3044\u7d2b\u5916\u7dda\u72b6\u614b\u3067\u3042\u308b\u5730\u57df\u306b\u884c\u304f\u3088\u3046\u306b\u306a\u3063\u305f\u3002\u3053\u306e\u8ad6\u6587\u3067\u306f\u3001\u6804\u990a\u6027\u304f\u308b\u75c5\u3001\u591a\u767a\u6027\u786c\u5316\u75c7\u3001\u9ed2\u8272\u816b\u3068\u3044\u30463\u3064\u306e\u4f8b\u306b\u3064\u3044\u3066\u8003\u5bdf\u3057\u3066\u3044\u308b\u3002\u305d\u306e\u6284\u9332\u306f\u3001\u300c\u5834\u6240\u3084\u751f\u6d3b\u7fd2\u6163\u306e\u5909\u5316\u306b\u3088\u3063\u3066\u751f\u3058\u308b\u7d2b\u5916\u7ddaB\u6ce2\u4f4e\u5024\u3084\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u304c\u300121\u4e16\u7d00\u306b\u304a\u3051\u308b\u6700\u5927\u7d1a\u306e\u91cd\u75c7\u75be\u60a3\u306e\u4e00\u90e8\u3092\u3082\u305f\u3089\u3057\u3066\u3044\u308b\u300d\u3068\u3044\u3046\u6240\u898b\u3067\u7de0\u3081\u304f\u304f\u3089\u308c\u3066\u3044\u308b\u3002<\/p>\n

\u6614\u304b\u3089\u4f4f\u3093\u3067\u3044\u308b\u30a2\u30d5\u30ea\u30ab\u4eba\u306e\u30d3\u30bf\u30df\u30f3D\u5024<\/h4>\n

\u8d64\u9053\u8fd1\u304f\u306b\u6614\u304b\u3089\u4f4f\u3093\u3067\u3044\u308b\u30a2\u30d5\u30ea\u30ab\u4eba\u3092\u8abf\u3079\u305f\u7814\u7a76\u306b\u3088\u308a\u3001\u300c\u6b63\u5e38\u306a\u300d25(OH)D\u5024\u306b\u95a2\u3059\u308b\u60c5\u5831\u304c\u5f97\u3089\u308c\u3066\u3044\u308b\u3002\u30bf\u30f3\u30b6\u30cb\u30a2\u306e\u5357\u7def4\u5ea6\u4ed8\u8fd1\u306b\u4f4f\u3093\u3067\u3044\u308b\u30de\u30b5\u30a4\u65cf\u304a\u3088\u3073\u30cf\u30c3\u30b6\u65cf\u306e\u8840\u6e0525(OH)D\u5024\u306b\u95a2\u3059\u308b\u8ad6\u6587\u304c\u516c\u8868\u3055\u308c\u305f [Luxwolda et al., 2012]\u3002\u3053\u308c\u3089\u306e\u6c11\u65cf\u306f\u3001\u76ae\u819a\u30bf\u30a4\u30d7\u304cVI\uff08\u975e\u5e38\u306b\u6fc3\u3044\u8272\uff09\u3067\u3001\u4e2d\u7a0b\u5ea6\u306e\u91cf\u306e\u8863\u985e\u3092\u8eab\u306b\u4ed8\u3051\u30011\u65e5\u306e\u5927\u534a\u3092\u6238\u5916\u3067\u904e\u3054\u3057\u3066\u3044\u308b\u304c\u3001\u53ef\u80fd\u306a\u5834\u5408\u306f\u65e5\u5149\u306b\u76f4\u63a5\u5f53\u305f\u3089\u306a\u3044\u3088\u3046\u306b\u3057\u3066\u3044\u308b\u3002\u5e73\u5747\u8840\u6e0525(OH)D\u5024\u306f\u3001\u30de\u30b5\u30a4\u65cf\u304c48 ng\/mL\uff08\u5024\u57df23\uff5e67 ng\/mL\uff09\u3001\u30cf\u30c3\u30b6\u65cf\u304c44 ng\/mL \uff08\u5024\u57df28\uff5e68 ng\/mL\uff09\u3067\u3042\u3063\u305f\u3002\u3053\u3046\u3057\u305f\u7d50\u679c\u304b\u3089\u3001\u4eba\u9593\u306e\u5065\u5eb7\u306b\u3068\u3063\u3066\u300140\uff5e50 ng\/mL\u3068\u3044\u3046\u7bc4\u56f2\u306e\u5e73\u5747\u8840\u6e0525(OH)D\u5024\u304c\u6700\u9069\u3067\u3042\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u308b\u3002\u3053\u308c\u306f\u3001\u6982\u3057\u3066\u3001\u3044\u304f\u3064\u304b\u306e\u5065\u5eb7\u8ee2\u5e30\u306b\u95a2\u3059\u308b\u89b3\u5bdf\u7814\u7a76\u3068\u4e00\u81f4\u3057\u3066\u3044\u308b\u3002
\n\u30d3\u30bf\u30df\u30f3D\u306f\u3001\u304b\u306a\u308a\u306e\u7a0b\u5ea6\u3001\u65e5\u5149\u306b\u5f53\u305f\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u751f\u6210\u3055\u308c\u308b\u304c\u3001\u3053\u308c\u306f\u592a\u967d\u304c\u5730\u5e73\u7dda\u304b\u308945\u5ea6\u4ee5\u4e0a\u6607\u3063\u3066\u3044\u308b\u9593\u306b\u9650\u3089\u308c\u308b\u3002\u3053\u308c\u306f\u3001\u5317\u7c73\u3084\u6b27\u5dde\u3068\u3044\u3046\u7def\u5ea6\u5730\u57df\u3067\u306f\u3001\u590f\u671f\u306e\u5348\u524d11\u6642\u304b\u3089\u5348\u5f8c3\u6642\u307e\u3067\u306e\u771f\u663c\u306e\u65e5\u5149\u306b\u76f8\u5f53\u3059\u308b\u3002\u65e9\u671d\u3084\u5348\u5f8c\u9045\u3044\u6642\u9593\u3067\u306f\u3001\u76ae\u819a\u306e\u767d\u3044\u4eba\u306f\u65e5\u713c\u3051\u3092\u3059\u308b\u3053\u3068\u304c\u3042\u308b\u304c\u3001\u65e5\u5149\u304b\u3089\u30d3\u30bf\u30df\u30f3D\u306f\u307b\u3068\u3093\u3069\u5f97\u3089\u308c\u306a\u3044\u3002\u307e\u305f\u3001\u51ac\u671f\u306f\u3069\u3093\u306a\u4eba\u3082\u3001\u65e5\u5149\u304b\u3089\u591a\u304f\u306e\u30d3\u30bf\u30df\u30f3D\u306f\u5f97\u3089\u308c\u306a\u3044\u3002\u3053\u306e\u3053\u3068\u304b\u3089\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u6442\u53d6\u304c\u5065\u5eb7\u306b\u5f79\u7acb\u3064\u3053\u3068\u306f\u660e\u3089\u304b\u3067\u3042\u308b\u3002<\/p>\n

\u307e\u3068\u3081\u3068\u7d50\u8ad6<\/h4>\n

\u6700\u9069\u306a\u5065\u5eb7\u72b6\u614b\u306e\u305f\u3081\u306b\u306f30\uff5e40 ng\/mL\u3092\u8d85\u3048\u308b\u8840\u6e0525(OH)D\u5024\u304c\u5fc5\u8981\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3059\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u3001\u3053\u306e\u3088\u3046\u306b\u5897\u3048\u7d9a\u3051\u3066\u3044\u308b\u3002\u7d2b\u5916\u7ddaB\u6ce2\u306e\u304b\u306a\u308a\u306e\u66b4\u9732\u304c\u306a\u3044\u5834\u5408\u3001\u3053\u3046\u3057\u305f\u5024\u306b\u9054\u3059\u308b\u305f\u3081\u306b\u306f\u30011,000\uff5e4,000 IU\/\u65e5\u306e\u30d3\u30bf\u30df\u30f3D3\u304c\u5fc5\u8981\u3068\u306a\u308b\u3002\u3053\u3046\u3057\u305f\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u3001\u89b3\u5bdf\u7814\u7a76\u3001\u57fa\u790e\u7814\u7a76\u3001\u7121\u4f5c\u70ba\u5316\u6bd4\u8f03\u8a66\u9a13\u3092\u542b\u3080\u7a2e\u3005\u306e\u7814\u7a76\u306b\u3088\u3063\u3066\u5f97\u3089\u308c\u3066\u3044\u308b\u3002\u660e\u3089\u304b\u306b\u4eba\u5de5\u5316\u5408\u7269\u3067\u3042\u308b\u8abf\u5408\u85ac\u306e\u5834\u5408\u3001\u305d\u306e\u52b9\u679c\u3068\u7121\u5bb3\u6027\u3092\u5b9f\u8a3c\u3059\u308b\u305f\u3081\u306b\u7121\u4f5c\u70ba\u5316\u6bd4\u8f03\u8a66\u9a13\u304c\u5fc5\u8981\u3067\u3042\u308b\u304c\u3001\u30d3\u30bf\u30df\u30f3D\u306b\u3064\u3044\u3066\u306f\u3001\u4eba\u9593\u3092\u542b\u3080\u3059\u3079\u3066\u306e\u52d5\u7269\u306e\u547d\u306b\u3068\u3063\u3066\u91cd\u8981\u306a\u5929\u7136\u306e\u5316\u5408\u7269\u3067\u3042\u308b\u305f\u3081\u3001\u7121\u4f5c\u70ba\u5316\u6bd4\u8f03\u8a66\u9a13\u306f\u5fc5\u8981\u306a\u3044\u306f\u305a\u3067\u3042\u308b\u3002\u307e\u305f\u3001\u30d3\u30bf\u30df\u30f3D\u306e\u6442\u53d6\u6e90\u306f\u4ed6\u306b\u3082\u3042\u308b\u3053\u3068\u3084\u3001\u8840\u6e05\u5024\u304c\u9ad8\u3044\u307b\u306925(OH)D\u5024\u3078\u306e\u30d3\u30bf\u30df\u30f3D\u306e\u63db\u7b97\u5024\u304c\u4f4e\u304f\u306a\u308b\u3053\u3068\u304b\u3089\u3001\u30d3\u30bf\u30df\u30f3D\u306b\u95a2\u3059\u308b\u7121\u4f5c\u70ba\u5316\u6bd4\u8f03\u8a66\u9a13\u306f\u5b9f\u65bd\u3059\u308b\u306e\u304c\u96e3\u3057\u3044\u3002\u30d3\u30bf\u30df\u30f3D\u306e\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u306b\u3064\u3044\u3066\u8abf\u3079\u308b\u5927\u898f\u6a21\u306a\u7121\u4f5c\u70ba\u5316\u6bd4\u8f03\u8a66\u9a13\u3092\u5b8c\u4e86\u3057\u5831\u544a\u3059\u308b\u307e\u3067\u306b\u306f\u30015\u5e74\u4ee5\u4e0a\u304b\u304b\u308b\u3053\u3068\u306b\u306a\u308b\u30024,000 IU\/\u65e5\u307e\u3067\u306e\u30d3\u30bf\u30df\u30f3D3\u306e\u7d4c\u53e3\u6442\u53d6\u3001\u306a\u3089\u3073\u306b100 ng\/mL\u307e\u3067\u306e\u8840\u6e0525(OH)D\u5024\u306b\u3088\u308b\u60aa\u5f71\u97ff\u306f\u3001\u9ad8\u30ab\u30eb\u30b7\u30a6\u30e0\u8840\u75c7\u3092\u5f15\u304d\u8d77\u3053\u3059\u53ef\u80fd\u6027\u304c\u3042\u308b\u75c5\u6c17\u306e\u3042\u308b\u4eba\u3092\u9664\u304d\u3001\u4e8b\u5b9f\u4e0a\u5b58\u5728\u3057\u306a\u3044\u3002\u305f\u3060\u3057\u3001\u7528\u91cf\u304c4,000 IU\/\u65e5\u3092\u8d85\u3048\u305f\u5834\u5408\u3001\u4e00\u90e8\u306e\u4eba\u306b\u3001\u9ad8\u8840\u5727\u75c7\u3001\u523a\u6fc0\u3001\u983b\u8108\u304c\u898b\u3089\u308c\u3066\u3044\u308b\u3002\u3053\u3046\u3057\u305f\u3053\u3068\u304b\u3089\u3001\u7d4c\u53e3\u6442\u53d6\u91cf\u3092\u5897\u3084\u3059\u3001\u9069\u5ea6\u306b\u7d2b\u5916\u7ddaB\u6ce2\u306b\u5f53\u305f\u308b\u3001\u9069\u5ea6\u306a\u8840\u6e0525(OH)D\u5024\u3092\u4fdd\u3064\u3001\u3068\u3044\u3046\u30d3\u30bf\u30df\u30f3D\u30dd\u30ea\u30b7\u30fc\u3092\u5b9f\u65bd\u3059\u308b\u524d\u306b\u3001\u7121\u4f5c\u70ba\u5316\u6bd4\u8f03\u8a66\u9a13\u306e\u7d50\u679c\u3092\u5f85\u3064\u7406\u7531\u306f\u307b\u3068\u3093\u3069\u306a\u3044\u3068\u601d\u308f\u308c\u308b\u3002\u5317\u7c73\u3084\u6b27\u5dde\u306b\u4f4f\u3093\u3067\u3044\u308b\u4eba\u306f\u3059\u3079\u3066\u3001\u51ac\u671f\u306f1,000\uff5e4,000 IU\/\u65e5\u306e\u30d3\u30bf\u30df\u30f3D\u3092\u30b5\u30d7\u30ea\u30e1\u30f3\u30c8\u3067\u53d6\u308b\u3079\u304d\u3067\u3042\u308b\u3002\u307e\u305f\u3001\u76ae\u819a\u306e\u8272\u304c\u6fc3\u3044\u4eba\u3084\u4e8b\u52d9\u4ed5\u4e8b\u3092\u3057\u3066\u3044\u308b\u4eba\u306f\u3001\u4e00\u5e74\u4e2d\u30d3\u30bf\u30df\u30f3D\u3092\u6442\u308b\u3079\u304d\u3067\u3042\u308b\u3002\u30d3\u30bf\u30df\u30f3D\u306e\u88dc\u7d66\u306f\u3001\u591a\u5927\u306a\u5065\u5eb7\u52b9\u679c\u3092\u751f\u307f\u51fa\u3059\u305f\u3081\u306e\u5b89\u4fa1\u3067\u304d\u308f\u3081\u3066\u52b9\u679c\u7684\u306a\u65b9\u6cd5\u3067\u3042\u308b\u3002<\/p>\n

\u30d3\u30bf\u30df\u30f3D\u306b\u95a2\u3059\u308b\u8a73\u3057\u3044\u60c5\u5831\u306b\u3064\u3044\u3066\u3001\u8208\u5473\u306e\u3042\u308b\u8aad\u8005\u306f\u4ee5\u4e0b\u306e\u30a6\u30a7\u30d6\u30b5\u30a4\u30c8\u3092\u53c2\u7167\u306e\u3053\u3068\u3002
\nhttp:\/\/www.Grassrootshealth.net,<\/a> http:\/\/www.VitaminDCouncil.org<\/a> \u304a\u3088\u3073
\nhttp:\/\/www.VitaminDWiki.com<\/a>\u3002Grant\uff08\u57f7\u7b46\u8005\uff09\u306f\u3001http:\/\/www.sunarc.org<\/a> \u306e\u30c7\u30a3\u30ec\u30af\u30bf\u30fc\u3067\u3042\u308b\u3002<\/p>\n

\u3053\u306e\u8a18\u4e8b\u306b\u95a2\u3057\u3001\u30ec\u30d3\u30e5\u30fc\u3068\u5bc4\u7a3f\u3092\u3057\u3066\u3044\u305f\u3060\u3044\u305f\u4e0b\u8a18\u306e\u3059\u3079\u3066\u306e\u79d1\u5b66\u8005\u306e\u65b9\u306b\u611f\u8b1d\u306e\u610f\u3092\u8868\u3057\u307e\u3059\u3002<\/h4>\n

Barbara J. Boucher, M.D., Queen Mary University of London, Centre for Diabetes, Blizard Institute, London
\nJohn J. Cannell, M.D., Vitamin D Council, San Luis Obispo, CA
\nBrant Cebulla, Vitamin D Council, San Luis Obispo, CA
\nCedric F. Garland, Dr. P.H., professor of Family and Preventive Medicine in the UCSD School of Medicine, and member of the Moores UC San Diego Cancer Center, LaJolla, CA
\nAfrozul Haq, Ph.D., Institutes of Pediatrics and Laboratory Medicine; Sheikh Khalifa Medical City; Abu Dhabi, United Arab Emirates
\nRobert P. Heaney, M.D., Osteoporosis Research Center, Creighton University Medical Center, Omaha, NE.
\nPerry Holman, Vitamin D Society, Canada
\nJohan E. Moan, M.D., Ph.D., Department of Radiation Biology, The Norwegian Radium Hospital, University of Oslo, Oslo, Norway
\nStefan Pilz, M.D., Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Graz, Austria
\nJ\u00f6rg Reichrath, M.D., Ph.D., Department of Dermatology; The Saarland University Hospital; Homburg\/Saar, Germany.
\nAnd, the Editorial Review Board of the Orthomolecular Medicine News Service, listed further below.<\/p>\n

\u53c2\u8003\u6587\u732e<\/h4>\n

1. Bergman P, Norlin AC, Hansen S, Rekha RS, Agerberth B, Bj\u201drkhem-Bergman L, Ekstr\u201dm L, Lindh JD, Andersson J. Vitamin D3 supplementation in patients with frequent respiratory tract infections: a randomised and double-blind intervention study.\uff08\u547c\u5438\u5668\u611f\u67d3\u75c7\u983b\u767a\u60a3\u8005\u306b\u304a\u3051\u308b\u30d3\u30bf\u30df\u30f3D3\u88dc\u7d66\uff1a\u7121\u4f5c\u70ba\u5316\u4e8c\u91cd\u76f2\u691c\u4ecb\u5165\u8a66\u9a13\uff09 BMJ Open. 2012;2(6). pii: e001663.<\/p>\n

2. Bischoff-Ferrari HA, Willett WC, Orav EJ, Lips P, Meunier PJ, Lyons RA, Flicker L, Wark J, Jackson RD, Cauley JA, Meyer HE, Pfeifer M, Sanders KM, St\u201ehelin HB, Theiler R, Dawson-Hughes B. A pooled analysis of vitamin D dose requirements for fracture prevention.\uff08\u9aa8\u6298\u4e88\u9632\u306b\u5fc5\u8981\u306a\u30d3\u30bf\u30df\u30f3D\u7528\u91cf\u306b\u95a2\u3059\u308b\u30d7\u30fc\u30eb\u89e3\u6790\uff09 N Engl J Med. 2012;367(1):40-9.<\/p>\n

3. Gorham ED, Garland CF, Burgi AA, Mohr SB, Zeng K, Hofflich H, Kim JJ, Ricordi C. Lower prediagnostic serum 25-hydroxyvitamin D concentration is associated with higher risk of insulin-requiring diabetes: a nested case-control study.\uff08\u8a3a\u65ad\u524d\u306e\u8840\u6e0525-\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D\u6fc3\u5ea6\u304c\u4f4e\u3044\u3068\u30a4\u30f3\u30b9\u30ea\u30f3\u4f9d\u5b58\u578b\u7cd6\u5c3f\u75c5\u306e\u30ea\u30b9\u30af\u304c\u5897\u52a0\uff1a\u30cd\u30b9\u30c6\u30c3\u30c9\u30fb\u30b1\u30fc\u30b9\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u7814\u7a76\uff09 Diabetologia. 2012 Dec;55(12):3224-7.<\/p>\n

4. Hollis BW, Wagner CL. Vitamin D and pregnancy: Skeletal effects, nonskeletal effects, and birth outcomes.\uff08\u30d3\u30bf\u30df\u30f3D\u3068\u598a\u5a20\uff1a\u9aa8\u683c\u3078\u306e\u5f71\u97ff\u3001\u9aa8\u683c\u4ee5\u5916\u3078\u306e\u5f71\u97ff\u3001\u304a\u3088\u3073\u51fa\u7523\u7d50\u679c\uff09 Calcif Tissue Int. 2012 May 24. [\u5370\u5237\u306b\u5148\u884c\u3057\u305f\u96fb\u5b50\u51fa\u7248]<\/p>\n

5. Hossein-nezhad A, Holick MF. Optimize dietary intake of vitamin D: an epigenetic perspective.\uff08\u98df\u4e8b\u3067\u306e\u6700\u9069\u306a\u30d3\u30bf\u30df\u30f3D\u6442\u53d6\u91cf\uff1a\u5f8c\u6210\u7684\u89b3\u70b9\uff09 Curr Opin Clin Nutr Metab Care. 2012;15(6):567-79.<\/p>\n

6. Jablonski NG, Chaplin G. Human skin pigmentation, migration and disease susceptibility.\uff08\u4eba\u9593\u306e\u76ae\u819a\u8272\u7d20\u6c88\u7740\u3001\u79fb\u4f4f\u3001\u75be\u60a3\u611f\u53d7\u6027\u3068\u306e\u95a2\u4fc2\uff09 Philos Trans R Soc Lond B Biol Sci. 2012;367(1590):785-92.<\/p>\n

7. Lang PO, Samaras N, Samaras D, Aspinall R. How important is vitamin D in preventing infections?\uff08\u30d3\u30bf\u30df\u30f3D\u306f\u611f\u67d3\u4e88\u9632\u306b\u304a\u3044\u3066\u3069\u306e\u7a0b\u5ea6\u91cd\u8981\u304b\uff1f\uff09 Osteoporos Int. 2012 Nov 17. [\u5370\u5237\u306b\u5148\u884c\u3057\u305f\u96fb\u5b50\u51fa\u7248]<\/p>\n

8. Luxwolda MF, Kuipers RS, Kema IP, Janneke Dijck-Brouwer DA, Muskiet FA. Traditionally living populations in East Africa have a mean serum 25-hydroxyvitamin D concentration of 115 nmol\/l.\uff08\u6771\u30a2\u30d5\u30ea\u30ab\u306b\u6614\u304b\u3089\u4f4f\u3093\u3067\u3044\u308b\u4f4f\u6c11\u306e\u5e73\u5747\u8840\u6e0525-\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D\u6fc3\u5ea6\u306f115 nmol\/L\uff09 Br J Nutr. 2012;108(9):1557-61.<\/p>\n

9. Marshall DT, Savage SJ, Garrett-Mayer E, Keane TE, Hollis BW, Host RL, Ambrose LH, Kindy MS, Gattoni-Celli S. Vitamin D3 supplementation at 4000 international units per day for one year results in a decrease of positive cores at repeat biopsy in subjects with low-risk prostate cancer under active surveillance.\uff084,000 IU\/\u65e5\u306e\u30d3\u30bf\u30df\u30f3D3\u30921\u5e74\u9593\u88dc\u7d66\u3057\u305f\u7d50\u679c\u3001\u7a4d\u6975\u7684\u76e3\u8996\u4e0b\u306e\u4f4e\u30ea\u30b9\u30af\u524d\u7acb\u817a\u30ac\u30f3\u304c\u3042\u308b\u88ab\u9a13\u8005\u306b\u3066\u518d\u751f\u691c\u3067\u306e\u967d\u6027\u30b3\u30a2\u7387\u304c\u4f4e\u4e0b\uff09 J Clin Endocrinol Metab. 2012;97(7):2315-24.<\/p>\n

10. Mostafa GA, Al-Ayadhi LY. Reduced serum concentrations of 25-hydroxy vitamin D in children with autism: relation to autoimmunity.\uff08\u81ea\u9589\u75c7\u5150\u306b\u898b\u3089\u308c\u308b\u4f4e\u3044\u8840\u6e0525-\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D\u6fc3\u5ea6\uff1a\u81ea\u5df1\u514d\u75ab\u3068\u306e\u95a2\u4fc2\uff09 J Neuroinflammation. 2012;9:201.<\/p>\n

11. Pittas AG, Nelson J, Mitri J, Hillmann W, Garganta C, Nathan DM, Hu FB, Dawson-Hughes B; Diabetes Prevention Program Research Group. Plasma 25-hydroxyvitamin D and progression to diabetes in patients at risk for diabetes: an ancillary analysis in the Diabetes Prevention Program.\uff08\u7cd6\u5c3f\u75c5\u306e\u30ea\u30b9\u30af\u304c\u3042\u308b\u60a3\u8005\u306b\u304a\u3051\u308b\u8840\u6f3f25-\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D\u5024\u3068\u7cd6\u5c3f\u75c5\u3078\u306e\u9032\u884c\u3068\u306e\u95a2\u4fc2\uff1a\u7cd6\u5c3f\u75c5\u4e88\u9632\u30d7\u30ed\u30b0\u30e9\u30e0\u306b\u304a\u3051\u308b\u88dc\u52a9\u7684\u89e3\u6790\uff09 Diabetes Care. 2012;35(3):565-73.<\/p>\n

12. Tretli S, Schwartz GG, Torjesen PA, Robsahm TE. Serum levels of 25-hydroxyvitamin D and survival in Norwegian patients with cancer of breast, colon, lung, and lymphoma: a population-based study.\uff08\u30ce\u30eb\u30a6\u30a7\u30fc\u306e\u4e73\u30ac\u30f3\u30fb\u7d50\u8178\u30ac\u30f3\u30fb\u80ba\u30ac\u30f3\u30fb\u30ea\u30f3\u30d1\u816b\u60a3\u8005\u306b\u304a\u3051\u308b\u8840\u6e0525-\u30d2\u30c9\u30ed\u30ad\u30b7\u30d3\u30bf\u30df\u30f3D\u5024\u3068\u751f\u5b58\u7387\u3068\u306e\u95a2\u4fc2\uff1a\u96c6\u56e3\u30d9\u30fc\u30b9\u7814\u7a76\uff09 Cancer Causes Control. 2012;23(2):363-70.<\/p>\n

13. Vacek JL, Vanga SR, Good M, Lai SM, Lakkireddy D, Howard PA. Vitamin D deficiency and supplementation and relation to cardiovascular health.\uff08\u30d3\u30bf\u30df\u30f3D\u306e\u6b20\u4e4f\u3068\u88dc\u7d66\u304a\u3088\u3073\u5fc3\u8840\u7ba1\u7cfb\u306e\u5065\u5eb7\u3068\u306e\u95a2\u4fc2\uff09 Am J Cardiol. 2012;109(3):359-63.<\/p>\n

14. Wagner CL, Taylor SN, Dawodu A, Johnson DD, Hollis BW. Vitamin D and its role during pregnancy in attaining optimal health of mother and fetus.\uff08\u6bcd\u89aa\u3068\u80ce\u5150\u306e\u6700\u9069\u306a\u5065\u5eb7\u72b6\u614b\u3092\u5f97\u308b\u305f\u3081\u306e\u598a\u5a20\u671f\u9593\u4e2d\u306e\u30d3\u30bf\u30df\u30f3D\u3068\u305d\u306e\u5f79\u5272\uff09 Nutrients. 2012;4(3):208-30.<\/p>\n

15. Whitehouse AJ, Holt BJ, Serralha M, Holt PG, Kusel MM, Hart PH. Maternal serum vitamin D levels during pregnancy and offspring neurocognitive development.\uff08\u598a\u5a20\u671f\u9593\u4e2d\u306e\u6bcd\u89aa\u306e\u8840\u6e05\u30d3\u30bf\u30df\u30f3D\u5024\u3068\u3001\u5b50\u306e\u795e\u7d4c\u8a8d\u77e5\u6a5f\u80fd\u306e\u767a\u9054\u3068\u306e\u95a2\u4fc2\uff09 Pediatrics. 2012;129(3):485-93.<\/p>\n

16. Zittermann A, Iodice S, Pilz S, Grant WB, Bagnardi V, Gandini S. Vitamin D deficiency and mortality risk in the general population: A meta-analysis of prospective cohort studies.\uff08\u4e00\u822c\u96c6\u56e3\u306b\u304a\u3051\u308b\u30d3\u30bf\u30df\u30f3D\u6b20\u4e4f\u3068\u6b7b\u4ea1\u30ea\u30b9\u30af\u3068\u306e\u95a2\u4fc2\uff1a\u524d\u5411\u304d\u30b3\u30db\u30fc\u30c8\u7814\u7a76\u306e\u30e1\u30bf\u5206\u6790\uff09 Am J Clin Nutr. 2012;95(1):91-100.<\/p>\n

\u65e5\u672c\u8a9e\u8a33\u76e3\u4fee\uff1a\u5317\u539f\u3000\u5065\uff08\u65e5\u672c\u30aa\u30fc\u30bd\u30e2\u30ec\u30ad\u30e5\u30e9\u30fc\u533b\u5b66\u4f1a\uff09<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

\u6240\u5c5e\u3057\u3066\u3044\u308b\u5b66\u4f1a\u304b\u3089\u30e1\u30eb\u30de\u30ac\u304c\u6765\u3066\u3044\u305f\u306e\u3067\u7d39\u4ecb\u3057\u305f\u3044\u3002 \u79c1\u306e\u30d6\u30ed\u30b0\u3067\u3082\u4f55\u5ea6\u3082\u53d6\u308a\u4e0a\u3052\u3066\u3044\u308b\u304c\u30d3\u30bf\u30df\u30f3D\u3067\u3042\u308b\u3002 \u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u306e\u4e88\u9632\u52b9\u679c\u3001\u304c\u3093\u306e\u4e88\u9632\u52b9\u679c\u3001\u30ac\u30f3\u5e79\u7d30\u80de\u306b\u5bfe\u3059\u308b\u6cbb\u7642\u52b9\u679c\u3001\u306a\u3069\u306a\u3069\u3067\u3042\u308b\u3002 \u8272\u3005\u306a\u610f\u5473\u3067\u6709\u7528\u306a\u3053 […]<\/p>\n","protected":false},"author":6,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[4],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts\/1221"}],"collection":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/comments?post=1221"}],"version-history":[{"count":0,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/posts\/1221\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/media?parent=1221"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/categories?post=1221"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.taiyou-clinic.jp\/blog\/wp-json\/wp\/v2\/tags?post=1221"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}