{"id":1120,"date":"2013-01-11T12:16:41","date_gmt":"2013-01-11T03:16:41","guid":{"rendered":"https:\/\/www.taiyou-clinic.jp\/blog\/?p=1120"},"modified":"2013-01-11T12:16:41","modified_gmt":"2013-01-11T03:16:41","slug":"%e6%9d%b1%e5%a4%a7%e5%8c%bb%e7%a7%91%e7%a0%94%e3%80%81ips%e7%b4%b0%e8%83%9e%e6%8a%80%e8%a1%93%e3%82%92%e5%88%a9%e7%94%a8%e3%81%97%e3%81%a6%e8%80%81%e5%8c%96%e3%81%97%e3%81%9ft%e7%b4%b0%e8%83%9e","status":"publish","type":"post","link":"https:\/\/www.taiyou-clinic.jp\/blog\/archives\/1120","title":{"rendered":"\u6771\u5927\u533b\u79d1\u7814\u3001iPS\u7d30\u80de\u6280\u8853\u3092\u5229\u7528\u3057\u3066\u8001\u5316\u3057\u305fT\u7d30\u80de\u306e\u82e5\u8fd4\u308a\u306b\u6210\u529f"},"content":{"rendered":"<div>\n<p align=\"left\">\u6771\u5927\u533b\u79d1\u7814\u3001iPS\u7d30\u80de\u6280\u8853\u3092\u5229\u7528\u3057\u3066\u8001\u5316\u3057\u305fT\u7d30\u80de\u306e\u82e5\u8fd4\u308a\u306b\u6210\u529f<br 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Receptor:TCR)\u300d\u3068\u547c\u3070\u308c\u308b\u5206\u5b50\u3092\u767a\u73fe\u3057\u3066\u304a\u308a\u3001\u3053\u306eTCR\u3092\u4f7f\u3063\u3066\u6297\u539f\u3092\u8a8d\u8b58\u3059\u308b\u4ed5\u7d44\u307f\u3060\u3002\u7121\u9650\u3068\u3082\u3044\u3048\u308b\u307b\u3069\u3055\u307e\u3056\u307e\u306a\u5f62\u3092\u3068\u308b\u6297\u539f\u3092\u8a8d\u8b58\u3059\u308b\u305f\u3081\u306b\u3001TCR\u3082\u3055\u307e\u3056\u307e\u306a\u5f62\u306e\u3082\u306e\u304c\u7528\u610f\u3055\u308c\u3066\u3044\u308b\u3002<\/p>\n<p>1\u3064\u306eT\u7d30\u80de\u306f\u3042\u308b\u7279\u5b9a\u306e1\u7a2e\u985e\u306e\u6297\u539f\u3092\u8a8d\u8b58\u3059\u308b\u305f\u3081\u306eTCR\u306e\u307f\u3092\u767a\u73fe\u3057\u3001\u3053\u308c\u3092T\u7d30\u80de\u306e\u300c\u6297\u539f\u7279\u7570\u6027\u300d\u3068\u3044\u3046\u3002\u3059\u306a\u308f\u3061\u3001\u304c\u3093\u7d30\u80de\u306b\u767a\u73fe\u3059\u308b\u6297\u539f\u3092\u8a8d\u8b58\u3059\u308bTCR\u3092\u6301\u3063\u305fT\u7d30\u80de\u3001\u30a4\u30f3\u30d5\u30eb\u30a8\u30f3\u30b6\u30a6\u30a4\u30eb\u30b9\u306eHA\u6297\u539f\u3092\u8a8d\u8b58\u3059\u308bTCR\u3092\u6301\u3063\u305fT\u7d30\u80de\u3001\u3068\u3044\u3063\u305f\u3088\u3046\u306b\u3001\u4f53\u306e\u4e2d\u306b\u306f\u81a8\u5927\u306a\u6570\u306e\u5916\u6575\u304b\u3089\u8eab\u3092\u5b88\u308b\u305f\u3081\u306e\u81a8\u5927\u306a\u7a2e\u985e\u306eT\u7d30\u80de\u304c\u5b58\u5728\u3057\u3066\u3044\u308b\u306e\u3067\u3042\u308b\u3002<\/p>\n<p>\u8fd1\u5e74\u3001iPS\u7d30\u80de\u6280\u8853\u306e\u958b\u767a\u306b\u3088\u308a\u3001\u5206\u5316\u304c\u9032\u3093\u3060\u4f53\u7d30\u80de\u3092ES\u7d30\u80de\u3068\u307b\u307c\u540c\u7b49\u306e\u80fd\u529b\u3092\u6301\u3064\u591a\u80fd\u6027\u5e79\u7d30\u80de\u306b\u521d\u671f\u5316\u3059\u308b\u3053\u3068\u304c\u53ef\u80fd\u306b\u306a\u3063\u305f\u3002\u3053\u308c\u306b\u3088\u308a\u3001\"\u81ea\u5206\u306e\u591a\u80fd\u6027\u5e79\u7d30\u80de\"\u304b\u3089\u751f\u4f53\u5916\u3067\u671b\u307f\u306e\u7d30\u80de\u3092\u4f5c\u308b\u3053\u3068\u3078\u306e\u9053\u304c\u958b\u3051\u3064\u3064\u3042\u308b\u3002\u3055\u307e\u3056\u307e\u306a\u75be\u60a3\u306b\u3088\u308a\u3001\u6a5f\u80fd\u4e0d\u826f\u30fb\u4e0d\u5168\u3092\u8d77\u3053\u3057\u305f\u7d30\u80de\u3084\u81d3\u5668\u3092\u7f6e\u304d\u63db\u3048\u3066\u3057\u307e\u3046\u518d\u751f\u533b\u7642\u3092\u5b9f\u73fe\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u3082\u306e\u3068\u3057\u3066\u3001\u5927\u304d\u306a\u671f\u5f85\u304c\u5bc4\u305b\u3089\u308c\u3066\u3044\u308b\u72b6\u6cc1\u3060\u3002<\/p>\n<p>\u82e5\u3055\u3068\u3044\u3046\u5074\u9762\u304b\u3089iPS\u7d30\u80de\u3092\u898b\u3066\u898b\u308b\u3068\u3001iPS\u7d30\u80de\u306f\u53d7\u7cbe\u9593\u3082\u306a\u3044\u7d30\u80de\u3068\u540c\u3058\u6027\u8cea\u3092\u6301\u3064\u304c\u6545\u3001\u7d30\u80de\u306e\u82e5\u3055\u3068\u3057\u3066\u306f\u6975\u3081\u3066\u82e5\u3044\u72b6\u614b\u306b\u3042\u308b\u3002iPS\u7d30\u80de\u3092\u4f5c\u308b\u3053\u3068\u306f\u3001\u5206\u5316\u3057\u3066\u3057\u307e\u3063\u305f\u7d30\u80de\u306b\u591a\u5206\u5316\u80fd(\u4e07\u80fd\u6027)\u3092\u6301\u305f\u305b\u308b\u3053\u3068\u306e\u307f\u306a\u3089\u305a\u3001\u3053\u306e\u82e5\u3055\u306e\u3082\u306e\u3055\u3057\u306e\u4e0a\u3067\u6975\u3081\u3066\u82e5\u3044\u72b6\u614b\u3078\u3068\u5909\u5316\u3055\u305b\u308b\u3053\u3068\u3067\u3082\u3042\u308b\u306e\u3060\u3002<\/p>\n<p>\u7b4b\u7d30\u80de\u3084\u809d\u7d30\u80de\u306a\u3069\u306e\u4f53\u7d30\u80de\u306f\u4f53\u306e\u4e2d\u3067\u3060\u3093\u3060\u3093\u3068\u8001\u5316\u3057\u3066\u3044\u304f\u304c\u3001\u3082\u3057iPS\u7d30\u80de\u304b\u3089\u540c\u3058\u7d30\u80de\u3092\u4f5c\u308a\u51fa\u3059\u3053\u3068\u304c\u3067\u304d\u308c\u3070\u3001\u305d\u308c\u3089\u4f5c\u308a\u51fa\u3057\u305f\u7d30\u80de\u306f\u6750\u6599\u3068\u306a\u3063\u305f\u7d30\u80de\u304b\u3089\u898b\u3066\u76f8\u5bfe\u7684\u306b\u82e5\u3044\u72b6\u614b\u306b\u3042\u308b\u3053\u3068\u304c\u4e88\u60f3\u3055\u308c\u3066\u3044\u305f\u3002<\/p>\n<p>\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u4eca\u56de\u3001\u3042\u308b\u30a6\u30a4\u30eb\u30b9\u6297\u539f\u306b\u7279\u7570\u7684\u306aT\u7d30\u80de\u304b\u3089iPS\u7d30\u80de(T-iPS\u7d30\u80de)\u3092\u4f5c\u6210\u3057\u3001\u305d\u306eT-iPS\u7d30\u80de\u304b\u3089\u518d\u3073T\u7d30\u80de\u3092\u8a98\u5c0e\u3057\u3088\u3046\u3068\u8a66\u307f\u305f\u5f62\u3060\u3002\u3053\u306e\u4e00\u9023\u306e\u64cd\u4f5c\u306b\u3088\u308a\u3001\u75b2\u5f0a\u30fb\u8001\u5316\u3057\u305fT\u7d30\u80de\u3092\u3001\u305d\u306e\u6297\u539f\u7279\u7570\u6027\u3092\u7dad\u6301\u3057\u305f\u307e\u307e\u82e5\u3005\u3057\u3044\u72b6\u614b\u3078\u3068\u56de\u5fa9\u3055\u305b\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u306e\u3067\u306f\u306a\u3044\u304b\u3068\u4eee\u8aac\u3092\u7acb\u3066\u3066\u3001\u7814\u7a76\u306b\u53d6\u308a\u7d44\u3093\u3060\u306e\u3067\u3042\u308b(\u753b\u50cf)\u3002<\/p>\n<p>\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u6162\u6027\u7684\u306b\u30d2\u30c8\u514d\u75ab\u4e0d\u5168\u30a6\u30a4\u30eb\u30b9(HIV-1)\u306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