{"id":1031,"date":"2012-12-06T15:31:01","date_gmt":"2012-12-06T06:31:01","guid":{"rendered":"https:\/\/www.taiyou-clinic.jp\/blog\/?p=1031"},"modified":"2012-12-06T15:31:01","modified_gmt":"2012-12-06T06:31:01","slug":"%e7%99%8c%e3%81%a8nk%e7%b4%b0%e8%83%9e","status":"publish","type":"post","link":"https:\/\/www.taiyou-clinic.jp\/blog\/archives\/1031","title":{"rendered":"\u764c\u3068NK\u7d30\u80de"},"content":{"rendered":"

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\u00a0<\/p>\n

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\u00a0<\/p>\n

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\u00a0<\/p>\n

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\u00a0<\/p>\n

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\n\u30b5\u30a6\u30a2\u30fc\u30fb\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u4ee5\u524dItpkB\u3092\u514d\u75ab\u6a5f\u80fd\u306e\u30ad\u30fc\u8abf\u7bc0\u88c5\u7f6e\u3068\u78ba\u8a8d\u3057\u305f\u3002ItpkB\u306f\u3001IP4\uff08\u3055\u307e\u3056\u307e\u306a\u4ed6\u306e\u91cd\u8981\u306a\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\u5206\u5b50\u306e\u6a5f\u80fd\u3092\u5236\u5fa1\u3059\u308b\u5c0f\u5206\u5b50\u30e1\u30c3\u30bb\u30f3\u30b8\u30e3\u30fc\uff09\u3092\u767a\u751f\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\u4e3b\u306b\u4f5c\u7528\u3059\u308b\u3002IP4\u306f\u3001\u305d\u308c\u304c\u767a\u751f\u3055\u308c\u308b\u7d30\u80de\u578b\u306b\u3088\u3063\u3066\u4fe1\u53f7\u3092\u9001\u308b\u3053\u3068\u3092\u6539\u5584\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u304b\u3001\u963b\u5bb3\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002<\/p>\n

\u00a0<\/p>\n

\u65b0\u3057\u3044\u7814\u7a76\u306f\u3001ItpkB\u304c\u306a\u304f\u306a\u3063\u3066\u3044\u308b\u30de\u30a6\u30b9\u304b\u3089\u306eNatural Killer\u96fb\u6c60\u304c\u9ad8\u3044\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\u3092\u793a\u3057\u3066\u3001\u9175\u7d20\u3092\u6301\u3063\u3066\u3044\u308bNatural Killer\u7d30\u80de\u3088\u308a\u3088\u304f\u6a5f\u80fd\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001ItpkB\u304c\u306a\u304f\u306a\u3063\u3066\u3044\u308b\u30de\u30a6\u30b9\u306f\u3001\u764c\u7d30\u80de\u306e\u7279\u6027\u8868\u9762\u5909\u66f4\u3092\u793a\u3059\u7d30\u80de\u3092\u653b\u6483\u3059\u308b\u969b\u306bItpkB\u3092\u8868\u3057\u3066\u3044\u308b\u30de\u30a6\u30b9\u3088\u308a\u52b9\u679c\u7684\u3067\u3042\u308b\u3002\u300c\u9175\u7d20ItpkB\u306b\u306f\u3001\u5c0f\u5206\u5b50\u306b\u3088\u3063\u3066\u305d\u306e\u975e\u5e38\u306b\u7279\u5b9a\u306e\u6291\u5236\u3092\u5bb9\u6613\u306b\u3059\u308b\u56fa\u6709\u306e\u7279\u5fb4\u304c\u3042\u308b\u300d\u3068\u3001\u30b5\u30a6\u30a2\u30fc\u304c\u8a00\u3063\u305f\u3002\u300c\u6211\u3005\u306e\u6240\u898b\u306f\u3001\u305d\u306e\u3088\u3046\u306a\u5408\u6210\u7269\u304c\u304a\u305d\u3089\u304f\u3001\u6cbb\u7642\u7684\u306bNatural Killer\u7d30\u80de\u6a5f\u80fd\u3092\u6539\u5584\u3059\u308b\u306e\u306b\u7528\u3044\u3089\u308c\u308b\u3053\u3068\u304c\u3067\u304d\u305f\u3053\u3068\u3092\u793a\u5506\u3059\u308b\u3002\u6210\u529f\u3057\u305f\u5834\u5408\u3001\u3053\u308c\u306f\u30dc\u30c8\u30eb\u30cd\u30c3\u30af\u3092\u89e3\u6c7a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u3066\u3001\u764c\u3068\u6226\u3046\u305f\u3081\u306b\u4f53\u306e\u30b9\u30ef\u30c3\u30c8\u30fb\u30c1\u30fc\u30e0\u3068\u4ea4\u6226\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u300d<\/p>\n

\u5b66\u8853\u8a8c\u53c2\u7167\uff1a
\nK.\u30b5\u30a6\u30a2\u30fc\u3001E.\u516c\u5712\u3001S. Siegemund\u3001A. R.\u30d5\u30e9\u30f3\u30b9\u8a9e\u3001J. A.\u30ef\u30fc\u30ec\u3001L.\u30b7\u30e5\u30c6\u30eb\u30f3\u30d9\u30eb\u30af\u3001S.\u30ea\u30b4\u30fc\u3001A. H.\u30e8\u30fc\u30f3\u30bd\u30f3\u3001W. M.\u30e8\u30b3\u30e4\u30de\u3001Y. H.\u30db\u30ef\u30f3\u3002\u30a4\u30ce\u30b7\u30c8\u30fc\u30eb\u56db\u30ea\u30f3\u9178\u30a8\u30b9\u30c6\u30eb\u306f\u3001\u30db\u30b9\u30db\u30a4\u30ce\u30b7\u30c1\u30c93-\u30ad\u30ca\u30fc\u30bc\u30fb\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\u3092\u5236\u5fa1\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001\uff2e\uff2b\u7d30\u80de\u52b9\u679c\u5668\u6a5f\u80fd\u3092\u5236\u9650\u3059\u308b\u3002\u8840\u6db2\u30012012;DOI\uff1a10.1182\/blood-2012-05-429241<\/p>\n

\u8ad6\u6587\u6e90\uff1ahttp:\/\/www.sciencedaily.com\/releases\/2012\/11\/121127191248.htm<\/p>\n

Enhance immunity in the fight against cancer.<\/p>\n

\u00a0<\/p>\n

Study Points to Potential New Therapies for Cancer and Other Diseases<\/a><\/strong><\/p>\n

ScienceDaily (Nov. 27, 2012) \u2014 Researchers at The Scripps Research Institute (TRSI) are fueling the future of cancer treatment by improving a powerful tool in disease defense: the body\u2019s immune system<\/em><\/strong>. By revealing a novel but widespread cell signaling process, the scientists may have found a way to manipulate an important component of the immune system into more effectively fighting disease.<\/p>\n

The study, recently published online ahead of print by the journal Blood, shows that disabling a particular enzyme, called ItpkB, in mice improves the function of a type of immune cell called Natural Killer cells.
\n\u201cThis is an exciting finding because it could possibly lead to the development of drugs that improve Natural Killer cell function,\u201d said TSRI Associate Professor Karsten Sauer, PhD, who led the study. \u201cNatural Killer cells have gained clinical interest as innovative biological therapeutics for certain cancers and also in certain infectious diseases.\u201d<\/p>\n

The Body\u2019s \u2018SWAT Team\u2019
\nNatural Killer cells patrol the body and detect characteristic alterations on the surface of cancer cells or virus-infected cells. Through a complicated and little understood signaling machinery \u2014 a domino effect of molecular reactions in a cell that ultimately produces a certain signal \u2014 Natural Killer cells then destroy such \u201cstressed\u201d cells.\u00a0Compared to other types of immune cells, Natural Killer cells kill these cells quickly. This makes Natural Killer cells important early responders of the immune system. Not surprisingly, researchers have explored engaging this \u201cSWAT team\u201d of the body therapeutically, particularly in blood cancers.\u00a0However, to date, the therapeutic efficacy of Natural Killer cells has been limited. \u201cA key bottleneck is our limited understanding of signaling mechanisms that dampen Natural Killer cell function,\u201d Sauer said.\u00a0Sauer and colleagues\u2019 new research reveals crucial details of this puzzle.<\/p>\n

A Wayto Prime the Attack
\nThe Sauer group had previously identified ItpkB as a key regulator of immune function. ItpkB acts primarily by producing IP4, a small molecule messenger that controls the functions of various other important signaling molecules. IP4 can improve or inhibit signaling depending on the cell type in which it is produced.\u00a0The new research showed that Natural Killer cells from mice lacking ItpkB show elevated signaling and function better than Natural Killer cells that have the enzyme. As a result, mice lacking ItpkB are more effective than mice expressing ItpkB in attacking cells that display characteristic surface changes of cancer cells.\u00a0\u201dThe enzyme ItpkB has unique features that facilitate its highly specific inhibition by small molecules,\u201d said Sauer. \u201cOur findings suggest that such compounds could possibly be used to improve Natural Killer cell function therapeutically. If successful, this could overcome a bottleneck and engage the body\u2019s SWAT team to fight cancer.\u201d<\/p>\n

Journal Reference:
\nK. Sauer, E. Park, S. Siegemund, A. R. French, J. A. Wahle, L. Sternberg, S. Rigaud, A. H. Jonsson, W. M. Yokoyama, Y. H. Huang. Inositol tetrakisphosphate limits NK cell effector functions by controlling phosphoinositide 3-kinase signaling. Blood, 2012; DOI: 10.1182\/blood-2012-05-429241<\/p>\n

Source of Article: http:\/\/www.sciencedaily.com\/releases\/2012\/11\/121127191248.htm<\/a><\/p>\n

 <\/p>\n

 <\/p>\n

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